| Tag | Content |
|---|
| EKPD ID | EKS-BOT-00452 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CK1/CK1 | 490.3 | 1.2E-147 | 9 | 269 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSBTAP00000052708 |
| UniProt Accession | P35508; |
| Protein Name | Casein kinase I isoform delta |
| Protein Synonyms/Alias | CKI-delta; CKId; Tau-protein kinase CSNK1D; |
| Gene Name | CSNK1D |
| Gene Synonyms/Alias | CSNK1D; HCKID; |
| Ensembl Information | |
| Organism | Bos taurus |
| Functional Description | Essential serine/threonine-protein kinase that regulatesdiverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA- binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate (By similarity). |
| Protein Length | 409 |
Protein Sequence
(FASTA) | | MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ 60 | | GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120 | | SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180 | | SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240 | | CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 300 | | ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV 360 | | SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQN SIPFEHHGK 409 |
|
Nucleotide Sequence
(FASTA) | | ATGGAGCTTA GAGTGGGGAA CAGGTACCGG CTGGGCCGGA AGATCGGCAG CGGCTCCTTC 60 | | GGAGACATCT ATCTCGGTAC GGACATTGCT GCAGGAGAAG AAGTTGCCAT CAAGCTTGAA 120 | | TGTGTCAAAA CCAAACACCC TCAGCTCCAC ATTGAGAGCA AAATCTACAA AATGATGCAG 180 | | GGAGGAGTGG GCATCCCCAC CATCCGGTGG TGTGGGGCTG AGGGGGACTA CAACGTCATG 240 | | GTGATGGAAC TGTTGGGACC CAGCCTGGAA GACCTCTTCA ACTTTTGCTC TAGGAAGTTC 300 | | AGTCTCAAAA CCGTCCTACT CCTTGCTGAC CAAATGATTA GTCGTATTGA ATACATACAC 360 | | TCGAAGAACT TCATCCACCG AGATGTGAAG CCGGACAACT TCCTCATGGG GCTGGGTAAG 420 | | AAGGGCAACC TGGTCTACAT CATTGACTTC GGGCTGGCTA AGAAGTACCG GGACGCCCGC 480 | | ACCCACCAGC ACATCCCCTA CCGCGAGAAC AAGAACCTCA CTGGGACGGC GCGGTATGCC 540 | | TCCATCAACA CACACCTTGG CATCGAACAA TCTCGAAGGG ATGACCTGGA GTCTCTGGGC 600 | | TATGTGCTCA TGTACTTCAA CCTGGGCTCA CTGCCCTGGC AGGGCCTGAA GGCTGCTACC 660 | | AAGAGGCAGA AGTATGAGAG GATCAGTGAG AAGAAGATGT CCACTCCCAT CGAGGTGTTG 720 | | TGCAAAGGCT ACCCTTCTGA ATTCGCCACG TACCTAAATT TCTGCCGTTC CTTGCGTTTT 780 | | GACGATAAGC CTGACTACTC ATACCTGAGA CAGCTCTTCA GGAACTTGTT CCATCGCCAG 840 | | GGTTTCTCCT ATGACTACGT GTTCGACTGG AACATGCTCA AATTTGGAGC CAGCCGGGCA 900 | | GCTGACGATG CTGAGCGGGA ACGCCGGGAC CGAGAGGAGC GGTTGAGACA CTCCCGAAAT 960 | | CCAGCCACCC GCGGCCTCCC TTCCACGGCC TCGGGCCGGC TGAGGGGGAC ACAGGAGGTG 1020 | | GCTCCTCCCA CCCCCCTCAC CCCTACCTCA CACACTGCGA ACACCTCTCC TAGGCCCGTG 1080 | | TCCGGCATGG AAAGAGAGCG GAAAGTGAGT ATGCGGCTGC ACCGCGGTGC CCCGGTCAAC 1140 | | ATCTCCTCAT CCGACCTCAC GGGCCGGCAA GATACCTCCC GCATGTCCAC CTCACAGAAT 1200 | | AGCATTCCTT TCGAACATCA CGGCAAGTAG 1230 |
|
| Domain Profile | S: 1 yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev 60 | yr+++kiGsGsfGdiylg+++a+geevaikle++k+k+pql++es++yk++qggvgiP++ | Q: 9 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTI 68 | 89********************************************************** |
| S: 61 ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd 120 | r++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd | Q: 69 RWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD 128 | ************************************************************ |
| S: 121 ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk 180 | +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+ | Q: 129 VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI 188 | ************************************************************ |
| S: 181 eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef 240 | eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef | Q: 189 EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF 248 | ************************************************************ |
| S: 241 atylkyvrklkfeekPdyeyl 261 | atyl+++r+l+f++kPdy+yl | Q: 249 ATYLNFCRSLRFDDKPDYSYL 269 | *******************97 |
|
Domain Sequence
(FASTA) | | YRLGRKIGSG SFGDIYLGTD IAAGEEVAIK LECVKTKHPQ LHIESKIYKM MQGGVGIPTI 60 | | RWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120 | | VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180 | | EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240 | | ATYLNFCRSL RFDDKPDYSY L 261 |
|
| Keyword | ATP-binding; Biological rhythms; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
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| Created Date | 20-Feb-2013 |