EKS-BOT-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	419.1	6.2E-126	244	497	254

Status

Unreviewed

Ensembl Protein

ENSBTAP00000026661

UniProt Accession

E1BPI3;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020018	ENSBTAP00000026661	ENSBTAT00000026661

Organism

Bos taurus

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MGNLCLRLWT YLDRCFPCWW SEEVDKPGVI QNPWADCPPD PPRPPAPEPE RSQGQFFVAL 60

FDYQARTAED LSFHAGDKLQ VLDKSHKGWW LARHLEKRAD SSSQQLQGYI PSNYVAEDRS 120

LQAEPWFFGA IKRTDAEKQL LYSENQTGAF LIRESESQKG DFALSVLDEG VVKHYRIRRL 180

DEGGFFLTRR RTFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID 240

RSSIQLLKRL GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPKLI 300

QLYAVCTLED PIYIITELMR HGSLQEYLQN DAGSKIHLTQ QVDMAAQVAS GMAYLESQNY 360

IHRDLAARNV LVGEHNIYKV ADFGLARVFK VENEDIYESK HEIKLPVKWT APEAIRTNKF 420

SIKSDVWSFG ILLYEIITYG KMPYSGMTGA QVIQMLGQNY RLPQPSNCPL QFYNIMLECW 480

NAEPKDRPTF ETLHWKFEDY FVTESSYSDT NNFL 514

Nucleotide Sequence
(FASTA)

ATGGGTAACC TCTGCCTGAG GCTCTGGACC TACCTGGATC GTTGTTTCCC CTGCTGGTGG 60

TCTGAGGAGG TGGACAAGCC TGGGGTGATT CAGAACCCAT GGGCTGACTG CCCTCCTGAT 120

CCTCCCCGGC CGCCAGCTCC AGAGCCCGAG AGAAGCCAGG GCCAGTTCTT TGTGGCTCTA 180

TTTGATTACC AGGCTCGGAC AGCTGAGGAC CTGAGCTTCC ACGCGGGTGA CAAGCTCCAA 240

GTCCTAGACA AGTCCCACAA GGGCTGGTGG CTGGCCAGGC ACTTGGAGAA AAGGGCCGAC 300

AGCTCCAGCC AGCAGCTGCA GGGCTACATT CCTTCTAACT ACGTGGCTGA AGACAGGAGC 360

CTCCAGGCAG AGCCGTGGTT CTTTGGAGCA ATCAAGAGAA CAGATGCTGA AAAACAGCTA 420

TTATATTCAG AAAACCAGAC GGGAGCTTTT CTAATCAGAG AAAGTGAAAG TCAGAAAGGC 480

GATTTCGCCC TTTCAGTTTT AGATGAAGGG GTTGTGAAAC ACTACAGAAT CAGAAGACTG 540

GATGAAGGGG GCTTTTTCCT CACCCGGAGA AGAACCTTTT CAACACTGAA TGAATTCGTG 600

AGTCATTACA CCAAGACAAG TGATGGCCTG TGTGTCAAGC TGGGAAAACC ATGCTTAAAG 660

ATACAAGTTC CAGCTCCCTT TGATTTGTCA TATAAAACTG TGGACCAGTG GGAGATTGAC 720

CGCAGCTCCA TACAACTTTT GAAGCGATTA GGATCTGGTC AGTTTGGTGA AGTGTGGGAA 780

GGCCTGTGGA ACAATACCAC TCCGGTAGCA GTAAAAACAT TAAAGCCAGG TTCAATGGAT 840

CCAAATGACT TCCTGAGGGA GGCACAGATA ATGAAGAACC TAAGACATCC AAAGCTTATC 900

CAGCTTTATG CTGTTTGCAC TTTAGAAGAT CCAATTTATA TTATTACAGA GTTGATGAGA 960

CATGGAAGTC TGCAAGAATA TCTCCAAAAT GATGCTGGAT CAAAAATCCA TCTGACGCAG 1020

CAGGTAGACA TGGCAGCCCA GGTTGCCTCT GGAATGGCCT ATTTGGAATC CCAGAACTAT 1080

ATTCATAGAG ATTTGGCTGC CAGAAATGTC CTTGTTGGGG AACATAATAT CTACAAAGTG 1140

GCAGATTTTG GACTTGCCAG AGTTTTTAAG GTAGAGAATG AAGACATCTA TGAATCTAAA 1200

CACGAAATAA AGCTGCCGGT GAAGTGGACT GCGCCTGAAG CCATTCGTAC TAATAAATTC 1260

AGCATTAAGT CCGATGTGTG GTCATTTGGA ATCCTTCTTT ATGAAATCAT TACTTATGGC 1320

AAAATGCCTT ATAGTGGTAT GACAGGTGCT CAGGTAATCC AGATGTTGGG TCAAAACTAT 1380

AGACTCCCTC AACCATCTAA CTGTCCATTG CAATTCTACA ATATCATGTT GGAGTGCTGG 1440

AATGCAGAGC CTAAGGACCG GCCAACATTT GAAACACTGC ACTGGAAATT TGAGGATTAT 1500

TTTGTAACAG AGTCTTCATA TTCGGATACA AATAACTTTC TATGA 1545

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 244   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  303

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 304   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLTQQVDMAAQVASGMAYLESQNYIHR  363

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik

Q: 364   DLAARNVLVGEHNIYKVADFGLARVFKvenEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  423

         ************************99887899****************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp ++y+++lecw+++

Q: 424   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLGQNYRLPQPSNCPLQFYNIMLECWNAE  483

         ************************************************************

S: 238   peerPtfetlqevl  251

         p++rPtfetl++++

Q: 484   PKDRPTFETLHWKF  497

         **********9975

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLTQQVD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVEN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLGQNYRLP QPSNCPLQFY NIMLECWNAE 240

PKDRPTFETL HWKF 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

bta:509227

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013