EKS-BOT-00464

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00464

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.6	5.1E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSBTAP00000026712

UniProt Accession

A4FV00; F1N456;

Protein Name

Protein Synonyms/Alias

MAPK10 protein;

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020048	ENSBTAP00000026712	ENSBTAT00000026712

Organism

Bos taurus

Functional Description

Protein Length

426

Protein Sequence
(FASTA)

MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAVLDR NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMVR HKILFPGRDY IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDSLF PADSEHNKLK ASQARDLLSK 300

MLVIDPAKRI SVDDALQHPY INVWYDPAEV EAPPPQIYDK QLDEREHTIE EWKELIYKEV 360

MNSEEKTKNG VVKGQPSPSG AAVNSSESLP PSSSVNDISS MSTDQTLASD TDSSLEASAG 420

PLGCCR 426

Nucleotide Sequence
(FASTA)

ATGAGCAAAA GCAAAGTTGA CAACCAGTTC TATAGCGTGG AAGTGGGAGA CTCAACGTTC 60

ACGGTTCTCA AACGCTACCA GAATCTAAAG CCTATTGGCT CTGGGGCTCA GGGAATAGTC 120

TGCGCTGCGT ATGATGCTGT TCTTGACAGA AATGTGGCCA TTAAGAAGCT CAGCAGACCC 180

TTTCAGAACC AAACGCATGC CAAGAGAGCC TACCGGGAGC TGGTCCTCAT GAAGTGTGTG 240

AATCATAAAA ACATTATTAG TTTATTAAAT GTCTTCACAC CCCAGAAAAC ACTGGAGGAG 300

TTCCAAGATG TTTACTTAGT CATGGAGCTG ATGGATGCTA ACTTGTGTCA GGTGATTCAG 360

ATGGAGTTAG ACCACGAGCG AATGTCTTAC CTGCTCTACC AAATGTTGTG TGGCATCAAG 420

CACCTTCACT CTGCTGGGAT TATTCACAGG GACTTAAAAC CAAGTAACAT TGTAGTCAAG 480

TCTGATTGTA CATTGAAAAT CCTAGACTTT GGGCTGGCCA GAACAGCAGG CACAAGCTTC 540

ATGATGACTC CCTACGTGGT AACACGTTAT TACCGGGCCC CCGAGGTCAT TCTGGGAATG 600

GGCTACAAGG AGAACGTGGA TATATGGTCT GTGGGATGCA TTATGGGAGA AATGGTTCGC 660

CACAAAATCC TGTTTCCAGG AAGGGACTAT ATTGACCAGT GGAATAAGGT TATTGAGCAA 720

CTAGGAACAC CATGTCCAGA ATTCATGAAG AAATTGCAAC CCACCGTAAG AAACTATGTG 780

GAGAATCGGC CCAAGTATGC AGGACTCACC TTCCCCAAGC TCTTTCCAGA TTCCCTCTTC 840

CCAGCGGACT CTGAGCACAA TAAACTCAAA GCCAGCCAAG CCAGAGACTT GCTGTCAAAG 900

ATGCTAGTGA TTGACCCAGC AAAAAGGATA TCAGTGGATG ACGCCTTACA ACATCCGTAC 960

ATCAATGTCT GGTATGACCC TGCTGAAGTG GAGGCGCCCC CACCTCAGAT ATATGACAAA 1020

CAGCTGGATG AGAGAGAGCA CACCATTGAA GAATGGAAAG AACTTATCTA TAAGGAAGTA 1080

ATGAACTCGG AAGAAAAGAC GAAGAATGGC GTTGTGAAAG GACAGCCTTC TCCTTCAGGT 1140

GCAGCCGTGA ACAGCAGTGA GAGCCTCCCT CCTTCCTCAT CCGTCAATGA CATCTCCTCC 1200

ATGTCCACCG ACCAGACCCT GGCATCTGAC ACTGACAGCA GCCTGGAAGC CTCGGCAGGA 1260

CCCCTGGGTT GTTGCAGGTG A 1281

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 261   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

bta:537631

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013