EKS-BOT-00390

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00390

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.0	4.3E-104	1289	1547	259

Status

Unreviewed

Ensembl Protein

ENSBTAP00000026753

UniProt Accession

F1N3T0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020079	ENSBTAP00000026753	ENSBTAT00000026753

Organism

Bos taurus

Functional Description

Protein Length

1554

Protein Sequence
(FASTA)

RQECVLGDSA CKNSESDPED FSDEANTENL YGTSPPSTPR QMKRMSSKHQ RNSVGRPAGR 60

ANLKEKMNAS NQPPHRDTGK TVENVEEYSY KQEKKIRAAL RSTERDHKKN VQCSFMLDSV 120

GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV SVPMPIARTA RQTSRTDCPA DRLKFFETLR 180

LLLKLTSVSK KKDREQRGQE STSAFWFNRS NELIWLELQA WHAGRTINDQ DLFLYTARQA 240

IPDIINEILT FKVNYGSFAF VRNGASLNGT SVEGQFGAPH GTQPAGYSTY HEHLQRQRVS 300

FEQVKRIMEL LEYIEALYPS MQALQKDYEK YAAKDFQDRV QALCLWLNIT KDLNQKLRIM 360

GTVLGIKNLS DIGWPVFEIP SPRSSRGNEP EDEAEDTEGE LKELDSSTEE SEEEQSCGPR 420

APEPRPPADH SRHVQSPPDC VPKKLERLES EDESVGWGAP DWSAEAGVSG HCLTSIYRPF 480

VDKALKQMGL RKLILRLHKL MDGSLQRARI ALVKSDGPVE FSGFPDPMWG SDYVQLSRTP 540

PSSEQKCSTV SWEELRSMDL PSFEPAFLVL CRVLLNVIHE CLKLRLEQRP AGEPSLLSIK 600

QLVRECKEVL KGGLLMKQYY QFMLHEVLDQ LEKTDCNIDA FEEDLHKMLM VYFDYMRSWI 660

QMLQELPQAS HSLKNLLEEE WNFTKEITHY IRGGEAQAGK LFCSSCSLTI KIVMTEWGRF 720

FFSGLHQESC AEFWTSADDS SASDEPGRRS VIEVSRALKE LFHEARERAS KALGFAKMLR 780

KDLEIAAEFI LSAPVRDLLD VLKAKQYVKV QIPGLENLQV FVPDALAEEK SIILQLLNAA 840

TGKDCSKDSD EALIDDYLLL TKHGDRTPDS EASWAAWEAQ PVKVVPPVET VDTLRSMQVD 900

NLLLVVMHSA QLIIHRKAFQ QSIEGLMTLR QEQTSSQPVI AKALQQLKND ALELCNRISD 960

AIDRVDHMFT SEFDAEVDES ESATLQQYYR EAMIQGYNFG FEYHKEVVRL MSGEFKQKIG 1020

DKYISFARKW MNYVLTKCES GRGTRPRWAT QGFDFLQAIE PSFISALPED DFLSLQALMN 1080

ECIGHVIGKP HSPITAIHRN SPRPVKVPRC HSDPPNPHLI IPTPEGFSAR SVPADVRSLG 1140

SPAPAPAAAR PGPSGSDPAP PKPISGAHET RGSSVPENDR LASIAAELQF RSLSRHSSPT 1200

EEREEPAYPK GDSSGSTRRS WELRTLISQT KDTASKQGPI EAIQKSVRLF EEKRYREMRR 1260

KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY GKVYTCINVD TGELMAMKEI 1320

RFQPNDHKTI KETADELKIF EGIKHPNLVR YFGVELHREE MYIFMEYCDE GTLEEVSRLG 1380

LQEHVIRLYS KQITVAINVL HEHGIVHRDV KGANIFLTSS GLIKLGDFGC SVKLKNNAQT 1440

MPGEVNSTLG TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI 1500

MYKVGMGHKP PIPERLSPEG KDFLSHCLES EPRMRWTASQ LLDHSFVKVC TDEE 1554

Nucleotide Sequence
(FASTA)

AGGCAAGAGT GCGTATTGGG AGACTCAGCT TGCAAGAATT CCGAATCCGA TCCTGAGGAC 60

TTTTCAGATG AAGCCAACAC AGAGAACCTT TATGGCACCT CTCCTCCCAG CACGCCTCGG 120

CAGATGAAAC GCATGTCCTC CAAGCACCAG AGGAATAGTG TCGGGAGGCC CGCCGGTCGC 180

GCCAATCTGA AAGAAAAAAT GAATGCATCA AACCAACCTC CACACAGAGA CACTGGAAAA 240

ACTGTGGAGA ACGTGGAAGA ATACAGCTAT AAGCAGGAGA AAAAGATCCG AGCGGCTCTC 300

AGGTCCACGG AGCGGGATCA TAAGAAGAAT GTGCAGTGCT CGTTCATGCT GGACTCAGTT 360

GGGGGCTCTC TGCCCAAAAA GTCCATCCCG GATGTGGATC TCAATAAGCC TTACCTCAGT 420

CTCGGCTGCA GCAATGCTAA GCTTCCGGTC TCTGTGCCCA TGCCGATAGC CAGAACCGCC 480

CGCCAGACTT CCAGGACTGA CTGTCCGGCA GATCGCTTAA AATTTTTTGA AACTCTCCGA 540

CTTCTGCTAA AGCTTACCTC AGTCTCAAAG AAGAAGGACA GGGAGCAAAG AGGCCAGGAA 600

AGCACATCCG CGTTCTGGTT TAACCGATCT AACGAGCTGA TCTGGTTAGA GCTGCAAGCC 660

TGGCACGCCG GCCGGACCAT TAACGACCAG GACCTCTTTT TATACACAGC CCGCCAGGCC 720

ATCCCAGACA TTATCAACGA AATCCTTACC TTCAAAGTTA ACTATGGGAG CTTCGCCTTC 780

GTTAGAAACG GAGCTAGTCT TAACGGTACT TCAGTAGAAG GGCAGTTCGG AGCCCCTCAC 840

GGGACGCAGC CTGCGGGTTA CTCAACCTAT CACGAGCACC TCCAACGCCA GAGGGTGTCC 900

TTCGAGCAGG TCAAACGGAT AATGGAGCTG CTGGAGTACA TAGAGGCACT TTATCCATCG 960

ATGCAGGCTC TTCAAAAGGA TTATGAGAAG TATGCTGCAA AGGACTTCCA GGACAGGGTG 1020

CAGGCGCTCT GTTTGTGGTT AAACATCACA AAGGACTTAA ATCAGAAATT AAGGATTATG 1080

GGCACCGTGT TGGGCATCAA GAATTTATCA GACATTGGCT GGCCGGTGTT TGAAATCCCC 1140

TCCCCGCGAT CATCCAGGGG CAACGAGCCC GAGGATGAGG CGGAGGACAC AGAAGGAGAG 1200

CTGAAGGAGC TGGACAGCAG CACGGAGGAG AGTGAGGAAG AGCAGAGCTG CGGCCCGAGG 1260

GCACCGGAGC CCAGGCCGCC CGCCGACCAC AGCCGCCACG TCCAGTCGCC CCCGGACTGT 1320

GTCCCGAAGA AGCTCGAGAG GCTGGAGTCG GAGGACGAGT CTGTCGGCTG GGGAGCCCCA 1380

GACTGGAGCG CCGAGGCAGG CGTTAGTGGA CACTGTCTGA CCTCTATCTA CAGACCCTTT 1440

GTAGACAAAG CGCTGAAGCA GATGGGCTTA AGGAAGTTGA TTCTAAGGCT TCACAAGCTG 1500

ATGGACGGTT CCTTGCAGCG GGCACGTATA GCACTAGTTA AGAGCGACGG TCCAGTGGAG 1560

TTTTCTGGAT TTCCAGATCC CATGTGGGGT TCAGATTATG TGCAGTTGTC CAGGACGCCG 1620

CCTTCCTCGG AGCAGAAGTG CAGCACCGTG TCCTGGGAGG AGCTGAGGTC CATGGATTTA 1680

CCCTCCTTCG AGCCTGCCTT CCTGGTCCTC TGTCGAGTCC TTCTGAACGT CATTCACGAA 1740

TGTCTCAAGT TAAGGCTGGA ACAGAGGCCC GCTGGAGAGC CATCCCTCTT GAGTATTAAG 1800

CAGCTGGTGA GAGAATGTAA GGAGGTGCTG AAGGGCGGCC TCCTGATGAA GCAGTACTAC 1860

CAGTTCATGC TGCACGAGGT CCTAGACCAG CTGGAGAAGA CCGACTGCAA CATCGACGCC 1920

TTCGAGGAGG ACCTGCACAA AATGCTGATG GTATATTTTG ATTACATGAG AAGCTGGATC 1980

CAAATGCTAC AGGAATTACC TCAAGCATCT CATAGTTTAA AAAATTTGTT AGAAGAAGAA 2040

TGGAATTTCA CCAAAGAAAT AACCCATTAC ATCCGGGGAG GAGAAGCACA GGCTGGAAAG 2100

CTTTTCTGTA GTTCATGTTC ATTGACTATT AAAATTGTGA TGACTGAGTG GGGACGGTTT 2160

TTCTTCTCTG GTTTACATCA GGAGAGCTGT GCGGAATTCT GGACCAGTGC CGACGACAGC 2220

AGCGCTTCAG ATGAACCTGG CAGGAGGTCG GTTATAGAGG TCAGCCGAGC ACTGAAGGAG 2280

CTCTTCCACG AGGCCAGGGA ACGAGCCTCC AAGGCACTGG GGTTTGCCAA GATGCTGAGA 2340

AAGGACCTGG AAATAGCTGC GGAGTTCATA CTCTCGGCCC CGGTTAGAGA CCTTCTGGAC 2400

GTTCTGAAAG CAAAGCAGTA CGTTAAGGTA CAGATTCCTG GCTTAGAAAA CTTGCAGGTG 2460

TTTGTTCCAG ACGCTCTTGC TGAGGAGAAG AGCATTATTT TGCAGTTACT CAATGCAGCT 2520

ACAGGGAAGG ACTGCTCCAA AGATTCAGAT GAAGCACTAA TTGACGACTA TCTACTTTTG 2580

ACCAAGCATG GTGACCGCAC TCCAGACTCG GAGGCCAGCT GGGCCGCCTG GGAGGCGCAG 2640

CCTGTCAAGG TCGTGCCTCC GGTGGAGACA GTGGACACCC TGAGAAGCAT GCAGGTGGAC 2700

AATCTTCTAC TAGTTGTCAT GCACTCTGCG CAGCTCATAA TCCATAGAAA AGCTTTCCAG 2760

CAGTCCATCG AAGGACTCAT GACCCTACGC CAGGAGCAGA CTTCCAGTCA GCCCGTCATC 2820

GCCAAAGCTT TGCAGCAGCT GAAGAATGAT GCCTTAGAGC TCTGCAACCG AATAAGTGAT 2880

GCCATTGACC GAGTGGACCA CATGTTCACT TCAGAATTTG ATGCTGAAGT TGATGAATCT 2940

GAGTCTGCTA CACTGCAGCA GTATTACCGA GAAGCCATGA TCCAAGGGTA CAATTTCGGG 3000

TTCGAGTATC ATAAAGAAGT TGTTCGTTTG ATGTCTGGCG AGTTTAAACA GAAGATAGGA 3060

GACAAGTATA TAAGCTTTGC CCGGAAATGG ATGAATTACG TCCTGACTAA GTGTGAGAGC 3120

GGCAGAGGGA CGAGACCCAG GTGGGCAACT CAAGGTTTTG ACTTCCTGCA AGCCATCGAG 3180

CCTTCGTTCA TCTCTGCTCT GCCAGAAGAC GACTTCCTGA GTTTGCAAGC CCTGATGAAT 3240

GAGTGCATTG GCCATGTGAT AGGAAAGCCG CACAGCCCTA TTACAGCCAT TCATCGGAAT 3300

AGCCCCCGTC CTGTGAAGGT ACCTCGATGC CATAGCGACC CTCCTAACCC TCACCTGATT 3360

ATCCCAACTC CAGAGGGATT CAGCGCCCGG AGCGTGCCCG CGGATGTGCG GAGCCTCGGC 3420

AGCCCCGCGC CCGCGCCTGC CGCCGCTCGT CCTGGCCCCT CGGGCAGCGA CCCAGCACCG 3480

CCCAAGCCCA TCAGCGGTGC CCATGAGACC AGGGGTTCCA GCGTCCCTGA AAATGACCGC 3540

CTGGCTTCCA TCGCAGCTGA ATTGCAGTTC AGGTCGCTGA GCCGCCACTC CAGCCCCACC 3600

GAGGAGCGCG AGGAACCAGC ATATCCAAAA GGTGATTCAA GTGGGTCAAC TCGAAGAAGT 3660

TGGGAACTTC GGACGCTGAT CAGTCAGACC AAGGATACCG CTTCTAAGCA AGGACCCATA 3720

GAAGCCATTC AGAAGTCAGT CCGGCTGTTT GAAGAAAAGC GGTATCGAGA AATGAGGAGG 3780

AAAAACATCA TTGGTCAAGT CTGTGACACC CCCAAGTCTT ACGACAACGT CATGCACGTT 3840

GGCTTGAGGA AGGTGACCTT TAAGTGGCAA AGAGGAAACA AAATCGGGGA AGGGCAGTAC 3900

GGGAAGGTGT ACACCTGCAT CAACGTCGAC ACCGGCGAGC TGATGGCCAT GAAGGAGATT 3960

CGATTTCAAC CCAACGACCA TAAAACCATC AAGGAAACTG CAGACGAGCT GAAAATCTTT 4020

GAAGGCATCA AGCACCCCAA TCTGGTTCGG TATTTTGGTG TGGAGCTACA TAGAGAGGAG 4080

ATGTACATCT TCATGGAGTA CTGTGACGAG GGCACGTTGG AAGAGGTGTC GCGGCTGGGG 4140

CTTCAAGAAC ACGTCATCAG GCTGTATTCG AAACAGATTA CCGTGGCCAT CAACGTCCTG 4200

CACGAGCATG GCATAGTTCA CCGCGACGTT AAAGGTGCCA ACATCTTCCT GACCTCGTCT 4260

GGACTAATCA AGCTGGGGGA TTTCGGATGC TCAGTAAAGC TTAAGAACAA TGCGCAGACC 4320

ATGCCTGGTG AAGTGAACAG CACGCTGGGG ACAGCAGCGT ACATGGCTCC GGAAGTCATC 4380

ACTCGCGCCA AAGGAGAAGG CCACGGGCGT GCGGCTGACA TCTGGAGCCT GGGGTGTGTT 4440

GTCATAGAGA TGGTGACTGG CAAGAGACCT TGGCATGAAT ATGAACACAA CTTTCAGATT 4500

ATGTACAAAG TGGGAATGGG GCACAAGCCG CCGATCCCTG AACGATTAAG CCCCGAAGGG 4560

AAGGACTTCC TCTCTCACTG CCTGGAGAGC GAGCCCCGGA TGCGGTGGAC AGCCAGCCAG 4620

CTCCTCGACC ACTCCTTCGT CAAGGTCTGC ACGGATGAAG AGTGA 4665

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1289  WQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1345

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1346  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITVAINVLHEH  1403

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRD+KgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1404  GIVHRDVKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1463

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1464  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1522

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle++p+ r++a++LL+h+f+

Q: 1523  FLSHCLESEPRMRWTASQLLDHSFV  1547

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIN VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITVAIN VLHEHGIVHR 120

DVKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESEPRMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013