EKS-BOT-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph485.82.3E-146606863258
StatusUnreviewed
Ensembl ProteinENSBTAP00000037611
UniProt AccessionF1MKR1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000020102ENSBTAP00000037611ENSBTAT00000037789
OrganismBos taurus
Functional Description
Protein Length976
Protein Sequence
(FASTA)
MSLNLLDTST IHGDWGWLTY PAHGWDSINE VDESFQPIHT YQVCNVMSPN QNNWLRTSWV 60
PRDGARRVYA EIKFTLRDCN SMPGVLGTCK ETFNLYYLES DRDLGASTQE SQFLKIDTIA 120
ADESFTGADL GVRRLKLNTE VRGVGPLSKR GFYLAFQDIG ACLAILSLRI YYKKCPTMVR 180
NLAAFSEAVT GADSSSLVEV RGQCVRHSEE RDTPKMYCSA EGEWLVPIGK CVCSAGYEER 240
RDACVACELG FYKSAPGDQL CARCPPHSHS AAPAAQACRC DLSYYRAALD PPSAACTRPP 300
SAPVNLISSV NGTSVTLEWA PPLDRGGRSD ITYNAVCRRC PWALGHCETC GSGTRFVPQQ 360
TSLVQASLLV ANLLAHMNYS FWIEAVNGVS DLSPEPRRAA VVNITTNQAA PSQVVVIRQE 420
RAGQTSVSLL WQEPEQPNGI ILEYEIKYYE KDKEMQSYST LKAVTTRATV SGLKPGTRYV 480
FQVRARTSAG CGRFSQAMEV ETGKPRPRYD TRTIVWICLT LITGLVVLLL LLICKKRHCG 540
YSKAFQHSDE EKMHYQNGQA PPPVFLPLHH PPGKIPEPKF YTEPHTYEEP GRTGRGFTRE 600
IEASRIHIEK IIGSGESGEV CYGRLRMPGQ RDVPVAIKAL KAGYTERQRR DFLSEASIMG 660
QFDHPNIIRL EGVVTRGRLA MIVTEYMENG SLDAFLRTHD GQFTIVQLVG MLRGVGAGMR 720
YLSDLGYVHR DLAARNVLVD GNLVCKVSDF GLSRVLEDDP DAAYTTTGGK IPIRWTAPEA 780
IAFRTFSSAS DVWSFGVVMW EVLAYGERPY WNMTNRDVIS SVEEGYRLPA PMGCPHALHQ 840
LMLDCWHKDR AQRPRFSQIV SVLDSLIHSP ESLRATATVH RCPPPAFARS CFDLRGGGGG 900
SGGLTVGDWL DSIRMGRYRD HFAAGGYSSL GMVLRMNAQD VRALGITLMG HQKKILGSIQ 960
TMRAQLTSTQ GPRRHL 976
Nucleotide Sequence
(FASTA)
ATGTCCTTGA ACTTGCTGGA CACGTCCACC ATCCACGGGG ACTGGGGCTG GCTCACGTAT 60
CCGGCTCACG GGTGGGACTC CATCAACGAG GTGGACGAGT CCTTCCAGCC CATCCACACG 120
TACCAGGTAT GCAATGTCAT GAGCCCCAAC CAGAACAACT GGCTGCGGAC CAGCTGGGTG 180
CCCCGTGACG GTGCCCGGCG TGTCTATGCC GAGATCAAGT TCACCCTGCG GGACTGCAAC 240
AGCATGCCCG GCGTGCTGGG CACCTGCAAG GAGACCTTCA ACCTCTACTA CCTGGAGTCG 300
GACCGCGACC TGGGCGCCAG CACGCAGGAG AGCCAGTTCC TCAAGATCGA CACCATCGCG 360
GCCGACGAGA GCTTCACGGG GGCCGACCTG GGCGTGCGGC GCCTCAAGCT CAACACGGAG 420
GTGCGCGGCG TGGGGCCCCT CAGCAAGCGC GGCTTCTACC TGGCCTTCCA GGACATCGGC 480
GCCTGCCTGG CCATCCTGTC CCTCCGCATC TACTACAAGA AGTGCCCCAC CATGGTGCGC 540
AACCTGGCCG CCTTCTCGGA GGCGGTGACG GGAGCCGACT CTTCCTCGCT GGTGGAGGTG 600
CGGGGCCAGT GCGTGCGGCA CTCCGAGGAG CGGGACACGC CCAAGATGTA CTGCAGCGCC 660
GAGGGCGAGT GGCTGGTGCC CATCGGCAAG TGCGTGTGCA GTGCGGGCTA CGAGGAGCGG 720
CGGGACGCCT GCGTGGCCTG TGAGCTGGGC TTCTACAAGT CGGCCCCGGG GGACCAGCTC 780
TGCGCCCGCT GCCCTCCCCA CAGCCACTCT GCGGCCCCTG CCGCCCAGGC CTGCCGCTGC 840
GACCTCAGCT ACTACCGGGC GGCGCTGGAC CCGCCGTCCG CCGCCTGCAC CCGGCCCCCC 900
TCGGCACCGG TGAATCTGAT CTCCAGCGTG AACGGGACGT CTGTGACCCT GGAGTGGGCC 960
CCTCCCCTGG ACCGGGGCGG CCGCAGTGAC ATCACCTACA ACGCTGTGTG CCGCCGCTGC 1020
CCGTGGGCCC TGGGCCACTG CGAGACGTGC GGGAGTGGCA CCCGCTTCGT GCCCCAGCAG 1080
ACCAGCCTGG TGCAGGCCAG CCTCCTGGTG GCCAACCTGC TGGCCCACAT GAACTACTCC 1140
TTCTGGATCG AGGCAGTCAA CGGCGTGTCC GACCTGAGCC CCGAGCCCCG CCGGGCCGCC 1200
GTGGTCAACA TCACCACGAA CCAGGCAGCC CCGTCTCAGG TGGTGGTGAT TCGCCAGGAG 1260
CGAGCGGGGC AGACCAGCGT CTCGCTGCTG TGGCAGGAGC CAGAACAGCC CAACGGCATC 1320
ATCCTGGAGT ACGAGATCAA GTACTACGAG AAGGACAAGG AGATGCAGAG CTACTCCACC 1380
CTCAAGGCGG TCACCACCAG GGCCACTGTC TCGGGCCTCA AGCCGGGCAC CCGCTACGTG 1440
TTCCAGGTCC GAGCTCGCAC CTCGGCCGGC TGTGGCCGCT TCAGCCAGGC CATGGAGGTG 1500
GAGACCGGGA AACCCCGGCC CCGCTATGAC ACCCGGACCA TCGTCTGGAT CTGCTTGACC 1560
CTCATCACTG GCCTGGTTGT GCTTCTCCTC CTGCTCATTT GCAAGAAGAG GCATTGCGGC 1620
TACAGCAAGG CCTTCCAGCA CTCGGATGAG GAGAAGATGC ATTATCAGAA CGGGCAGGCA 1680
CCTCCACCGG TCTTCCTGCC CCTGCACCAC CCTCCAGGGA AGATTCCAGA GCCCAAGTTC 1740
TATACAGAAC CCCACACCTA CGAGGAGCCG GGCCGGACGG GCCGTGGTTT CACCCGAGAG 1800
ATCGAGGCAT CTCGGATCCA CATCGAGAAA ATCATCGGCT CTGGCGAGTC CGGGGAAGTC 1860
TGCTACGGGC GGCTGCGGAT GCCGGGGCAG CGGGACGTGC CCGTGGCCAT CAAGGCCCTC 1920
AAAGCCGGCT ACACGGAGAG ACAGCGGCGG GACTTTCTGA GTGAGGCGTC CATCATGGGT 1980
CAGTTTGACC ACCCCAATAT CATCCGCCTT GAAGGTGTCG TCACCCGCGG CCGTCTGGCA 2040
ATGATCGTGA CTGAGTACAT GGAGAACGGG TCTCTGGATG CATTCCTGAG GACGCACGAC 2100
GGCCAGTTCA CCATCGTGCA GCTGGTGGGC ATGCTCAGAG GCGTGGGCGC CGGCATGCGC 2160
TACCTCTCAG ACTTGGGCTA TGTCCACCGC GACCTGGCCG CTCGCAACGT CCTGGTTGAT 2220
GGCAACCTGG TCTGCAAGGT GTCTGACTTC GGGCTCTCCC GGGTGCTGGA GGATGACCCT 2280
GATGCTGCCT ATACCACCAC GGGAGGCAAG ATCCCCATTC GCTGGACGGC CCCCGAGGCC 2340
ATCGCCTTCC GGACCTTCTC CTCGGCCAGC GACGTGTGGA GTTTCGGGGT GGTCATGTGG 2400
GAGGTGCTGG CCTACGGGGA GCGGCCCTAC TGGAACATGA CCAACCGGGA CGTCATCAGC 2460
TCCGTGGAGG AGGGCTACCG CCTGCCTGCG CCCATGGGCT GCCCCCACGC GCTACACCAG 2520
CTCATGCTTG ACTGCTGGCA CAAAGACCGC GCCCAGCGGC CTCGCTTCTC ACAGATCGTC 2580
AGTGTCCTGG ATTCTCTCAT CCACAGCCCT GAGAGTCTCA GGGCCACAGC CACCGTGCAC 2640
AGGTGTCCAC CCCCCGCCTT TGCCCGGAGC TGCTTTGACC TCCGAGGGGG CGGGGGTGGC 2700
AGCGGGGGCC TCACCGTGGG AGACTGGCTG GACTCCATCC GCATGGGCCG CTACCGGGAC 2760
CACTTCGCTG CCGGGGGTTA CTCCTCCCTG GGCATGGTGC TCCGTATGAA CGCTCAGGAC 2820
GTGCGGGCCC TGGGCATCAC CCTCATGGGC CACCAGAAGA AGATCCTGGG CAGCATCCAG 2880
ACCATGAGGG CCCAGCTGAC CAGCACCCAG GGGCCCCGCC GGCACCTCTG A 2931
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+Ge Gevc Grl++pg+r+++vaik+lkag+te+qrrdflseasi+Gqfdhp
Q: 606   IHIEKIIGSGESGEVCYGRLRMPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHP  665
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+
Q: 666   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDL  725
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lv+ nlvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+r+
Q: 726   GYVHRDLAARNVLVDGNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT  785
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 786   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDC  845
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w+kdra+rp+f+qivs+l
Q: 846   WHKDRAQRPRFSQIVSVL  863
         ***************985
Domain Sequence
(FASTA)
IHIEKIIGSG ESGEVCYGRL RMPGQRDVPV AIKALKAGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQFTI VQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVDGNLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRT 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDVISSVEEG YRLPAPMGCP HALHQLMLDC 240
WHKDRAQRPR FSQIVSVL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-TAR-00021
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043005; C:neuron projection
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0016322; P:neuron remodeling
GO:0043410; P:positive regulation of MAPK cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777; P:protein autophosphorylation
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0006929; P:substrate-dependent cell migration
KEGG
bta:517368;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013