EKS-BOT-00412

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00412

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	481.8	5.0E-145	13	275	263

Status

Unreviewed

Ensembl Protein

ENSBTAP00000027209

UniProt Accession

A7MB69;

Protein Name

Protein Synonyms/Alias

DAPK3 protein;

Gene Name

DAPK3

Gene Synonyms/Alias

DAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020417	ENSBTAP00000027209	ENSBTAT00000027209

Organism

Bos taurus

Functional Description

Protein Length

454

Protein Sequence
(FASTA)

MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS SSRRGVSREE 60

IEREVNILRE IRHPNIITLH DIFENRTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL 120

KQILDGVHYL HSKRIAHFDL KPENIMLLDK NVPNPRIKLI DFGIAHKIEA GNEFKNIFGT 180

PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY 240

FSNTSELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKAIRR RNVRREDSGR KPERRRLKTA 300

RLKEYTIKSH SSMPPNNTYI NFERFSKVLE EVAAAEEGLR GLEHSRRLFH EDLEALTAIY 360

EEKEAWYREE NESLGQDLRR LRQELHKTEA LQRQAQEEAK GALLGASGLK RRFSRLENRY 420

EALAKQVASE MRFVQDLVRA MEQEKLQEGE CSLR 454

Nucleotide Sequence
(FASTA)

ATGTCAACAT TCAGGCAGGA GGATGTGGAA GACCACTATG AGATGGGAGA GGAGCTGGGA 60

AGCGGACAGT TTGCAATTGT GCGGAAGTGC CGGCAGAAGG GTACTGGGAA GGAGTATGCA 120

GCCAAGTTCA TCAAGAAGCG CCGCCTCTCG TCCAGCCGCC GGGGAGTGAG CCGAGAGGAG 180

ATCGAGCGGG AGGTGAACAT CCTGCGGGAG ATCCGGCACC CCAACATCAT CACACTGCAT 240

GACATCTTTG AGAACAGGAC GGACGTGGTG CTTATCCTCG AGCTGGTCTC AGGTGGTGAG 300

CTCTTCGACT TCCTGGCCGA GAAGGAGTCA CTGACCGAGG ACGAGGCCAC CCAGTTCCTC 360

AAGCAGATCC TGGATGGTGT CCACTATCTG CACTCCAAGC GCATCGCCCA CTTCGACCTC 420

AAGCCAGAAA ACATCATGCT CCTGGACAAG AATGTGCCCA ACCCACGGAT CAAGCTCATT 480

GACTTTGGCA TCGCCCACAA GATCGAGGCA GGGAACGAGT TCAAGAACAT CTTTGGGACC 540

CCGGAGTTCG TGGCTCCTGA AATTGTCAAC TATGAGCCCC TGGGTCTGGA GGCAGACATG 600

TGGAGCATTG GCGTTATCAC CTACATCCTG CTGAGTGGCG CGTCCCCGTT CCTGGGTGAA 660

ACCAAGCAGG AGACCCTGAC CAACATCTCG GCTGTGAATT ACGACTTTGA CGAGGAGTAC 720

TTCAGCAACA CCAGCGAGCT GGCGAAGGAC TTCATCCGCC GTCTGCTTGT CAAAGACCCC 780

AAGAGGAGAA TGACCATCGC CCAGAGCCTG GAGCACTCCT GGATCAAGGC CATCCGGCGG 840

AGGAATGTGC GGCGGGAGGA CAGCGGCCGG AAGCCAGAGC GGCGGCGCCT GAAGACGGCA 900

CGCCTCAAGG AGTACACCAT CAAGTCGCAC TCAAGCATGC CCCCCAACAA TACCTATATC 960

AACTTCGAGC GCTTCTCCAA AGTGCTGGAG GAGGTGGCGG CGGCCGAGGA GGGCCTGCGC 1020

GGGCTGGAGC ACAGCCGACG CCTGTTCCAT GAGGACCTTG AGGCGCTGAC GGCCATCTAC 1080

GAGGAGAAGG AGGCCTGGTA CCGTGAGGAG AACGAGAGCC TAGGCCAGGA CCTGCGGCGG 1140

CTGCGCCAGG AGCTGCACAA GACGGAGGCG CTGCAGCGGC AGGCACAGGA GGAGGCCAAG 1200

GGGGCCCTGC TCGGGGCCAG TGGGCTCAAG CGCCGCTTTA GCCGCCTGGA GAACCGCTAC 1260

GAGGCGCTGG CCAAGCAGGT GGCCTCCGAG ATGCGGTTCG TGCAGGATCT GGTACGCGCC 1320

ATGGAGCAGG AGAAGCTGCA AGAGGGGGAG TGCAGCCTCC GCTAG 1365

Domain Profile

S: 1     letgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeir  60

         +e+g+elgsG+fa+vrkcr+k tGkeyaakf+kkrrl+ssrrgvsreeierev++l+eir

Q: 13    YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR  72

         5789********************************************************

S: 61    sepnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylh  120

          +pn+i+lh+++en++dv+lilelv+GGelfd+laekesl+e+eat++lkqil+gv+ylh

Q: 73    -HPNIITLHDIFENRTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLH  131

         .***********************************************************

S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180

         sk+i+h+dlkPeni+lldk+vp+++iklidfG+++kie+g+e+k+i+GtPefvaPeivny

Q: 132   SKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNY  191

         ************************************************************

S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240

         epl+le+dmwsiGvityillsgasPflG+tkqetl+nisavn+df+ee+fs++selakdf

Q: 192   EPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDF  251

         ************************************************************

S: 241   irrllvkdpekrltieeclehswl  264

         irrllvkdp++r+ti+++lehsw+

Q: 252   IRRLLVKDPKRRMTIAQSLEHSWI  275

         ***********************8

Domain Sequence
(FASTA)

YEMGEELGSG QFAIVRKCRQ KGTGKEYAAK FIKKRRLSSS RRGVSREEIE REVNILREIR 60

HPNIITLHDI FENRTDVVLI LELVSGGELF DFLAEKESLT EDEATQFLKQ ILDGVHYLHS 120

KRIAHFDLKP ENIMLLDKNV PNPRIKLIDF GIAHKIEAGN EFKNIFGTPE FVAPEIVNYE 180

PLGLEADMWS IGVITYILLS GASPFLGETK QETLTNISAV NYDFDEEYFS NTSELAKDFI 240

RRLLVKDPKR RMTIAQSLEH SWI 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway

KEGG

bta:525506

;

InterPros

IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013