EKS-BOT-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	407.3	2.0E-122	645	899	255

Status

Unreviewed

Ensembl Protein

ENSBTAP00000033182

UniProt Accession

F1N6H6;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA10

Gene Synonyms/Alias

EPHA10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020510	ENSBTAP00000033182	ENSBTAT00000033263

Organism

Bos taurus

Functional Description

Protein Length

1008

Protein Sequence
(FASTA)

METGAGPHPL RLFICLMPLC LALLLGPGRP GTAEEVILLD SKASQAELGW TALPSNGWEE 60

ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWIGRGRGQR IFVELQFTLR DYSSIPGAAG 120

TCKETFNVYY LETEADLGRG RTRPGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 180

GPLSRQGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAA FPATAAESAF STLVEVTGTC 240

VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD ICEACPPGFY KVSPRRPLCS 300

PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLALRLRWL 360

PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFVP RQVGLRERAA TLLHLRPGAR 420

YTVRVAALNG VSGPAAAAGA TYAQVTVSTG PGAPWEEDEI RRDRVEPQSV SLSWREPIPA 480

GAPGANGTEY EIRYFEKGQS EQTYSTVKTG APAVTVTNLK PATRYVFQIR AASPGPSWET 540

QSFNPSIEVL TPGEATSRSK DQSPAVVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGR 600

DAHDEEELYF HFKVPTRRTF VDPQSCGDPL QAVHLFAKEL DAKSVTLEKS LGTGRFGELC 660

CGCLQLPGRQ ELPVAVHTLR EGCSDSQRLS FLAEALTLGQ FDHSHVVRLE GVVTRGSTLM 720

IVIEYMSHGA LDGFLRRHEG QLVAAQLMGL LPGLASAMKY LSEMGYVHRG LAARRVLVSS 780

ELVCKISGFG RGPRDRAEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGVVMWEVM 840

AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPSPLHRLML DCWQKDPGER PRFSQIHGLL 900

SKMMQDPEPP RCADTTCARP PTPLEDRAFS TFPSFGSVGA WLEALDLGRY KDSFAAAGYG 960

SLEAVAAMTA QDLVSLGISS AEHREDLLSG ISALRARVLQ LQGRGVQV 1008

Nucleotide Sequence
(FASTA)

ATGGAGACCG GCGCCGGCCC ACATCCACTG CGCCTGTTCA TCTGCCTGAT GCCGCTGTGT 60

CTCGCCTTGC TTTTGGGGCC GGGGAGGCCA GGGACCGCAG AGGAAGTCAT CCTTTTGGAT 120

TCCAAAGCTT CCCAAGCTGA GCTGGGCTGG ACTGCACTGC CAAGTAATGG GTGGGAGGAG 180

ATCAGCGGCG TGGACGAGCA CGACCGTCCC ATTCGCACAT ACCAGGTGTG CAACGTGCTG 240

GAGCCCAACC AGGACAACTG GCTGCAGACT GGCTGGATCG GCCGCGGCCG CGGGCAGCGC 300

ATCTTCGTGG AGCTGCAGTT CACACTGCGT GACTACAGCA GCATCCCTGG AGCCGCGGGC 360

ACCTGCAAGG AGACTTTCAA TGTCTACTAC CTGGAAACCG AGGCCGATTT GGGCCGCGGG 420

CGTACCCGCC CAGGTGGCAG CCGGCCCCGT AAGATCGACA CAATCGCGGC AGACGAGAGC 480

TTCACTCAGG GCGACCTGGG TGAGCGCAAG ATGAAGCTGA ACACAGAGGT GCGCGAGATC 540

GGTCCGCTCA GCCGGCAGGG TTTCCACCTG GCCTTCCAGG ACGTGGGCGC ATGCGTGGCT 600

CTAGTCTCTG TGCGAGTCTA CTACAAGCAG TGCCGCGCCA CGGTGCGGGG CTTGGCGGCG 660

TTCCCAGCCA CCGCAGCCGA GAGCGCCTTC TCCACGCTGG TGGAGGTGAC CGGAACATGC 720

GTGGCACACT CAGAAGGGGA GCCCGGCAGC CCCCCGCGCA TGCACTGCGG CGCCGATGGA 780

GAGTGGCTGG TGCCCGTGGG CCGGTGCAGC TGCAGTGCGG GATTCCAAGA ACGCGGTGAC 840

ATCTGTGAAG CCTGTCCCCC AGGGTTTTAC AAGGTGTCCC CGAGGCGGCC CCTCTGCTCA 900

CCGTGCCCAG AGCACAGCCG GGCCCTGGAA AACGCGTCCA CGTTTTGCGT GTGCCAGGAC 960

AGCTATGCGC GCTCGCCCAC CGACCCGCCC TCGGCGTCCT GCACCCGTCC GCCGTCGGCG 1020

CCGCGGGACC TGCAGTACAG CCTGAGCCGC TCGCCGCTGG CGCTGCGGCT GCGCTGGCTG 1080

CCGCCGGCCG ACTCGGGCGG CCGCTCGGAC GTCACGTACT CTCTGCTGTG CCTGCGCTGC 1140

GGCCGCGAAG GCCCGGCTGG CGCGTGCGAG CCATGCGGGC CGCGCGTGGC CTTCGTGCCG 1200

CGCCAGGTGG GGCTGCGGGA GCGCGCCGCC ACGCTGCTGC ACCTGCGGCC CGGCGCGCGC 1260

TACACCGTGC GCGTGGCCGC GCTCAACGGA GTGTCTGGCC CGGCGGCCGC CGCGGGAGCC 1320

ACCTACGCGC AGGTCACGGT CTCCACCGGG CCGGGGGCGC CCTGGGAGGA GGATGAGATC 1380

CGCAGGGACC GAGTGGAGCC CCAGAGCGTG TCTCTGTCGT GGCGGGAGCC CATCCCCGCG 1440

GGAGCCCCAG GGGCCAACGG CACAGAGTAT GAGATCAGAT ACTTCGAGAA GGGTCAGAGT 1500

GAGCAGACTT ACTCGACGGT GAAGACAGGG GCGCCTGCGG TCACTGTCAC CAACCTGAAG 1560

CCGGCTACCC GCTACGTCTT TCAGATCCGG GCAGCTTCCC CAGGGCCCTC CTGGGAGACC 1620

CAGAGCTTCA ACCCCAGCAT TGAAGTGCTG ACCCCAGGGG AGGCCACCTC CAGGTCCAAG 1680

GACCAGAGCC CCGCGGTAGT CGTCACCGTG GTAACCATCT CAGCCCTCCT CGTCCTGGGC 1740

TCTGTGATGA GCGTGCTGGC CATTTGGAGG AGGCCCTGCA GCTATGGCAA AGGAGGTCGG 1800

GACGCCCACG ATGAGGAGGA GCTGTATTTC CACTTCAAAG TCCCAACTCG CCGCACGTTC 1860

GTGGATCCCC AGAGCTGTGG GGACCCGCTG CAAGCCGTGC ATCTGTTTGC CAAGGAGCTG 1920

GATGCGAAAA GCGTCACGCT GGAGAAGAGC CTTGGAACAG GGCGGTTTGG GGAGCTGTGC 1980

TGCGGCTGCC TGCAGCTCCC GGGCCGCCAG GAGCTCCCCG TGGCCGTGCA CACACTGAGG 2040

GAGGGCTGCT CCGACTCTCA GAGGCTCAGC TTCCTGGCCG AGGCCCTCAC CCTGGGCCAG 2100

TTTGACCACA GCCACGTGGT GCGACTGGAG GGCGTGGTCA CCCGAGGAAG CACCCTGATG 2160

ATTGTCATCG AATACATGAG CCATGGGGCC CTGGATGGCT TCCTCAGGCG GCATGAGGGC 2220

CAGCTGGTGG CCGCACAGCT GATGGGGCTG CTGCCCGGCC TGGCATCAGC CATGAAGTAC 2280

CTGTCGGAAA TGGGCTACGT CCACCGGGGC CTGGCTGCAC GCCGGGTGCT GGTCAGCAGC 2340

GAGCTTGTCT GCAAGATCTC TGGCTTCGGC CGGGGCCCCC GGGACCGAGC AGAGGCGGTC 2400

TACACCACCA TGAGTGGCCG GAGCCCCGCG CTGTGGGCCG CCCCCGAGAC GCTTCAGTTT 2460

GGTCACTTCA GCTCCGCCAG CGACGTGTGG AGCTTCGGTG TCGTCATGTG GGAGGTGATG 2520

GCCTTCGGGG AGCGGCCCTA CTGGGACATG TCTGGCCAAG ATGTGATCAA GGCTGTGGAG 2580

GATGGCTTCC GGCTGCCGCC GCCCAGGAAC TGCCCCTCCC CGCTGCACCG ACTGATGCTT 2640

GACTGCTGGC AGAAGGACCC GGGTGAGCGG CCCAGGTTCT CCCAGATCCA CGGCCTCCTG 2700

AGCAAGATGA TGCAGGACCC AGAGCCCCCG AGGTGTGCCG ACACCACCTG TGCCAGGCCT 2760

CCCACGCCCC TGGAGGACCG TGCCTTCTCC ACCTTCCCCT CCTTTGGCTC TGTGGGCGCA 2820

TGGCTGGAGG CCCTGGACCT GGGCCGCTAC AAAGACAGCT TCGCTGCTGC GGGCTATGGG 2880

AGCCTGGAGG CCGTGGCCGC CATGACTGCC CAGGACCTGG TGAGCCTGGG CATCTCATCG 2940

GCGGAACACC GGGAGGACCT CCTCAGCGGG ATCAGCGCCC TGCGGGCCCG GGTGCTCCAG 3000

CTGCAGGGCC GGGGGGTGCA GGTGTGA 3027

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         v++ek +G+G+fGe+c+G+l+lpg++e++va++tl++g++++qr +fl+ea +lGqfdh+

Q: 645   VTLEKSLGTGRFGELCCGCLQLPGRQELPVAVHTLREGCSDSQRLSFLAEALTLGQFDHS  704

         6899********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         +++rleGvvt+++++miv+eym++gald flr+++gq+++ ql+g+l G+as+mkyls+m

Q: 705   HVVRLEGVVTRGSTLMIVIEYMSHGALDGFLRRHEGQLVAAQLMGLLPGLASAMKYLSEM  764

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhr laar++lv+s+lvck+s fG+++   d +ea+ytt++g++p  w+ape++++++

Q: 765   GYVHRGLAARRVLVSSELVCKISGFGRGPR--DRAEAVYTTMSGRSPALWAAPETLQFGH  822

         ****************************99..888*************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         f+sasdvws+G+v+wev+++Gerpywdms qdvika+e+g+rlppp++cp+ l++lmldc

Q: 823   FSSASDVWSFGVVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSPLHRLMLDC  882

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wqkd  erp+f+qi+ +

Q: 883   WQKDPGERPRFSQIHGL  899

         **************875

Domain Sequence
(FASTA)

VTLEKSLGTG RFGELCCGCL QLPGRQELPV AVHTLREGCS DSQRLSFLAE ALTLGQFDHS 60

HVVRLEGVVT RGSTLMIVIE YMSHGALDGF LRRHEGQLVA AQLMGLLPGL ASAMKYLSEM 120

GYVHRGLAAR RVLVSSELVC KISGFGRGPR DRAEAVYTTM SGRSPALWAA PETLQFGHFS 180

SASDVWSFGV VMWEVMAFGE RPYWDMSGQD VIKAVEDGFR LPPPRNCPSP LHRLMLDCWQ 240

KDPGERPRFS QIHGL 255

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005005	; F:transmembrane-ephrin receptor activity

KEGG

bta:540439

;

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013