EKS-BOT-00096

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00096

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	407.1	6.4E-122	2097	2421	325

Status

Unreviewed

Ensembl Protein

ENSBTAP00000027632

UniProt Accession

F1MBL6;

Protein Name

Protein Synonyms/Alias

Gene Name

SMG1

Gene Synonyms/Alias

SMG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020735	ENSBTAP00000027632	ENSBTAT00000027632

Organism

Bos taurus

Functional Description

Protein Length

3637

Protein Sequence
(FASTA)

RTDSASADPD NLKYSSSRDR GGSSSYGLQP SNSAVVSRQR HDDTRIHADI QNDEKGGYSV 60

NGGSGENTYG RKSLGQELRV NNVTSPEFTS IQHGSRALAI KDMRKSQERS MSYSDESRLS 120

NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILAAVHDVL NESKINSSKL 180

LQELRQEGAC CLGLLCASLS YEAEKIFKWI FSKFSSSAKD EVKLLYLCAT YKALETVGEK 240

KAFSSVMQLV MTSLQSILEN VDTPELLCKC VKCILLVARC YPHIFSTNFR DTVDILVGWH 300

IDHTQKPSLT QQVSGWLQSL EPFWVADLAF STTLLGQFLE DMEAYAEDLS HVASGESVDE 360

DVPPPSVSLP KLAALLRVFS TVVRSIGERF SPIRGPPITE AYVTDVLYRV MRCVTAANQV 420

FFSEAVLTAA NECVGVLLGS LDPSMTIHCD MVITYGLDQL ENCQTCGTDY IISVLNLLTL 480

IVEQINTKLP SSFVEKLFIP SSKLLFLRYH KEKEVVAVAH AVYQAVLSLK NIPVLETAYK 540

LILGEMTCAL NNLLHSLQLP DACSEIKHEA FKNHVFNVDN AKFVVIFDLS ALTTIGNAKN 600

SLIGMWALSP TVFALLSKNL MIVHGDLAVH FPAIQYAVLY TLYSHCTRHD HFISSSLSSS 660

SPSLFDGAVI STVTTATKKH FSIILNLLGI LLKKDNLNQD TRKLLMTWAL EVAVLMKKSE 720

TYAPLFSLPS FHKFCKGLLA NTLVEDVNIC LQACSSLHAL SSSLPDDLLQ SRCVDVCRVQ 780

LVHSGTRIRQ AFGKLLKSIP LDVVLSNNNH TEIQEISLAL RSHMSKAPSN TFHPQDFSDV 840

ISFILYGNSH RIGKDNWLER LFYSCQRLDK RDQSTIPRNL LKTDAVLWQW AIWEAAQFTV 900

LSKLRTPLGR AQDTFQTIEG IIRSLAAHTL NPDQDVSQWT TADNDEGHSS NQLRLVLLLQ 960

YLENLEKLMY NAYEGCANAL TSPPKVIRTF FYTNRQTCQD WLTRIRLSIM RVGLLAGQPA 1020

VTVRHGFDLL TEMKTNPSQG NELEVTIMMV VEALCELHCP EAIQGIAVWS SSVVGKNLLW 1080

INSVAQQAEG RFEKASVEYQ EHLCAMTGVD CCISSFDKSV LTLANTGRNS ASPKHSLNGE 1140

SRKTVLSKPT DSSPEVINYL GNKACECYIS IADWAAVQEW QNAVHDLKKS TSSTSLNLKA 1200

DFNYIKSLSS FESGEFIECT EQLELLPGEN ISLLAGGSKE KIDMKKLLPN MLSPDPRELQ 1260

KSIEVQLLRS SVCLATALNH IEQDQKWQSI TENVVKYLKQ TSRIAVGPLR LSTLTVSQSL 1320

PVLSTLQLYC SSALENTVSN RLATEDCLIP LFSEALRSCK QHDVRPWMQA LRYTMYQSQL 1380

LEKIKEQTVP IRSHLMELGL TAAKFARKRG NVSLATRLLA QCSEVQLGKT TTAQDLVQHF 1440

KKLSTQGQVD EKWGPELDIE KTKLLYTAGQ STHAMEMLSS CAISFCKSAK AEHAVAKSIL 1500

TLAKWIQAEW KEISGQLKQV YRAQQQQNFT GLSTLSKNIL TLIELPSVNT MEEEYPRIES 1560

ESTVHIGVGE PDFILGQLYH LSSVQAPEVA KSWAALASWA YRWGRKVVDN ASQGEGVRLL 1620

PREKSEVQNL LPDTITEEEK ERIYGILGQA VCRPAGIQDE DITLQITESE DNEEDDMVDV 1680

IWRQLISSCP WLSELDESAT EGVIKVWRKV VDRIFSLYKL SCSAYFTFLK LNAGQIPLDE 1740

DDPRLHLSHR VEQSTDDMIV MATLRLLRLL VKHAGELRQY LEHGLETTPT APWRGIIPQL 1800

FSRLNHPEVY VRQSICNLLC RVAQDSPHLI LYPAIVGTIS LSSESQASGN KFSSAIPTLL 1860

GNIQGEELLV SECEGGSPPA SQDSNKDEPK SGLNEDQAMM QDCYSKIVDK LSSANPTMVL 1920

QVQMLVAELR RVTVLWDELW LGVLLQQHMY VLRRIQQLED EVKRVQNNNT LRKEEKIAIM 1980

REKHTALMKP IVFALEHVRS ITAAPAETPH EKWFQDNYGD AIENALEKLK TPSNPAKPGS 2040

SWIPFKEIML SLQQRAQKRA SYILRLEEIS PWLAAMTNTE IALPGEVSAR DTVTIHSVGG 2100

TITILPTKTK PKKLLFLGSD GKSYPYLFKG LEDLHLDERI MQFLSIVNTM FATINRQETP 2160

RFHARHYSVT PLGTRSGLIQ WVDGATPLFG LYKRWQQREA ALQAQKAQDS YQTPQNPGIV 2220

PRPSELYYSK IGPALKAVGL SLDVSRRDWP LHVMKAVLEE LMEATPPNLL AKELWSSCTT 2280

PDEWWRVTQS YARSTAVMSM VGYIIGLGDR HLDNVLIDMT TGEVVHIDYN VCFEKGKSLR 2340

VPEKVPFRMT QNIETALGVT GVEGVFRLSC EQVLHIMRRG RETLLTLLEA FVYDPLVDWT 2400

AGGEAGFAGA VYGGGGQQAE SKQSKREMER EITRSLFSSR VAEIKVNWFK NRDEMLVVLP 2460

KLDSSLDEYL SLQEQLTDVE KLQGKLLEEI EFLEGAEGVD HPSHTLQHRY SEHTQLQTQQ 2520

RAVQEAIQVK LNEFEQWITH YQAAFNNLEA TQLASLLQEI STQMDLAKGP PSYVPATAFL 2580

QNAGQAHLIS QCEQLEGEVG ALLQQRRSVL RGCLEQLHHY ATVALQYPKA IFQKHRIEQW 2640

KTWMEELICN TTVERCQELY RKYEMQYAPQ PPPTVCQFIT ATEMTLQRYA ADINSRLIRQ 2700

VERLKQEAVT VPVCEDQLKE IERCIKVFLH ENGEEGSLSL ASVIISALCT LTRRNLMMEG 2760

AASSAGEQLV DLTSRDGAWF LEELCSMSGN VTCLVQLLKQ CHLVPQDLDI PNPMEASEAV 2820

HLANGVYTSL QELNSNFRQI IFPEALRCLM KGEYTLENML HELDSLIEQT TDGVPLQTLV 2880

ESLQAYLRNA AMGLEEETHA HYIDVARMLH AQYGELIQPR NGSVDETPKM SAGQMLLVAF 2940

DGMFAQVETA FGLLVEKLNK MEIPIAWRKI DIIREARSTQ VNFFDDDNHR QVLEEIFFLK 3000

RLQTIKEFFR LCGTFSKTLS GSSSLEDQNT VNGPVQIVNV KTLFRNSCFS EDQMAKPIKA 3060

FTADFVRQLL IGLPNQALGL TLCSFISALG VDIIAQVEAK DFGAESKVSV DDLCKKAVEH 3120

NIQIGKFSQL VMNRATVLAS SYDTAWKKHD LVRRLETSIA SCKTSLQRVQ LHIAMFQWQH 3180

EDLLINRPQA MSVTPPPRSA ILTSMKKKLH TLSQIETSIA TVQEKLAALE ASIEQRLKWA 3240

GGANPALAPV LQDFEATIAE RRNLVLKESQ RASQVTFLCS NIIHFESLRT RTAEALNLDA 3300

ALFELIKRCQ QMCSFASQFN SSVSELELRL LQRVDTTLEH PIGSSEWLLS AHKQLTQDMS 3360

TQRAIQTEKE QQIETVCETI QNLVDNIKTV LTGHNRQLGD VKHLLKAMAK DEEAALADGE 3420

DVPYENSVRQ FLGEYKSWQD NIQTVLFTLV QAMGQVRSQE HVEMLQEITP TLKELKTQSQ 3480

SVYNNLVSFA SPLVTDATNE CSSPTSSATY QPSFAAAVRS NTGQKTQPDV MSQNARKLIQ 3540

KNLATSADTP PSTVPGTGKS VACSPKKAIR DPKTGKAVQE RNSYAVSVWK RVKAKLEGRD 3600

VDPNRRMSVA EQVDYVIKEA TNLDNLAQLY EGWTAWV 3637

Nucleotide Sequence
(FASTA)

AGAACTGATA GTGCATCAGC CGACCCAGAT AATTTAAAAT ACTCTTCATC CAGAGATAGG 60

GGTGGGTCTT CCTCTTATGG ACTGCAGCCT TCAAATTCAG CTGTGGTGTC TCGGCAAAGG 120

CATGATGATA CCAGAATCCA TGCTGACATA CAGAATGACG AAAAGGGTGG CTACAGTGTC 180

AATGGAGGAT CTGGGGAAAA TACTTATGGT CGGAAGTCGT TGGGGCAAGA GCTGAGGGTT 240

AACAATGTGA CCAGCCCTGA GTTTACCAGT ATTCAGCATG GCAGTCGTGC GTTAGCCATC 300

AAAGACATGA GGAAATCACA GGAGCGATCG ATGTCTTATT CTGATGAGTC TCGACTGTCG 360

AATCTTCTTC GGAGGATCAC CCGGGAAGAT GACAGAGACC GAAGGCTGGC TACTGTTAAG 420

CAGTTGAAAG AATTTATTCA GCAACCAGAA AATAAGCTGG TGCTAGTTAA GCAGTTGGAT 480

AATATCTTGG CTGCTGTACA TGATGTGCTT AATGAAAGTA AAATAAACAG TAGCAAATTG 540

CTTCAGGAGT TGAGACAGGA GGGAGCTTGT TGTCTTGGCC TTCTTTGTGC ATCTCTGAGC 600

TATGAGGCTG AGAAGATCTT CAAATGGATT TTTAGCAAAT TTAGCTCATC TGCAAAAGAT 660

GAAGTTAAAC TCCTCTACTT ATGTGCCACC TACAAAGCAC TAGAGACTGT AGGAGAAAAG 720

AAAGCCTTTT CATCTGTAAT GCAGCTTGTA ATGACCAGCC TGCAGTCCAT TCTTGAAAAT 780

GTGGATACAC CAGAATTACT TTGCAAGTGT GTTAAGTGCA TTCTTTTGGT AGCTCGATGT 840

TACCCTCATA TTTTCAGCAC AAATTTTAGG GATACAGTTG ATATATTAGT TGGATGGCAT 900

ATAGATCATA CTCAGAAGCC TTCACTTACA CAACAGGTGT CTGGGTGGTT GCAGAGTTTG 960

GAGCCATTCT GGGTAGCTGA CCTTGCATTT TCTACCACTC TTCTTGGTCA GTTTTTAGAG 1020

GACATGGAGG CATATGCTGA GGACCTCAGC CATGTAGCCT CTGGGGAGTC AGTGGATGAA 1080

GATGTTCCTC CTCCATCAGT GTCCTTACCA AAGCTGGCAG CACTTCTCCG GGTATTCAGT 1140

ACTGTGGTGA GAAGCATTGG GGAACGTTTC AGCCCAATTC GAGGTCCTCC AATTACTGAG 1200

GCATATGTAA CAGATGTTCT GTACAGAGTA ATGAGATGTG TGACGGCTGC AAACCAAGTG 1260

TTTTTTTCTG AGGCTGTGTT GACAGCTGCT AATGAGTGTG TTGGTGTTTT GCTCGGCAGC 1320

TTGGATCCTA GCATGACTAT ACATTGTGAC ATGGTTATTA CATATGGATT AGATCAACTG 1380

GAGAATTGCC AGACTTGTGG TACAGATTAT ATCATCTCAG TCTTGAATTT ACTCACATTG 1440

ATTGTTGAAC AGATAAATAC AAAACTGCCA TCATCATTTG TAGAAAAACT GTTTATACCA 1500

TCATCTAAGC TACTATTTTT GCGTTATCAT AAAGAAAAAG AGGTTGTTGC TGTAGCCCAT 1560

GCTGTTTATC AAGCAGTGCT CAGTCTGAAG AATATTCCTG TTTTAGAGAC TGCCTATAAA 1620

TTAATTTTGG GAGAAATGAC TTGTGCCCTA AACAATCTGC TACATAGTCT ACAACTTCCT 1680

GATGCCTGTT CTGAAATAAA ACATGAGGCT TTTAAGAATC ATGTTTTCAA TGTAGACAAT 1740

GCAAAATTTG TAGTTATATT TGACCTTAGT GCTCTGACTA CAATTGGAAA TGCTAAAAAC 1800

TCACTAATTG GGATGTGGGC CCTGTCTCCA ACTGTGTTTG CACTTCTGAG TAAGAATCTG 1860

ATGATTGTGC ATGGCGACCT GGCTGTTCAT TTCCCTGCCA TTCAGTATGC AGTGCTCTAC 1920

ACATTGTATT CTCATTGTAC CAGGCATGAC CACTTTATAT CTAGTAGTCT TAGTTCATCA 1980

TCCCCGTCCT TGTTTGATGG TGCCGTTATT AGTACTGTAA CTACAGCTAC AAAAAAACAT 2040

TTCTCAATTA TCTTAAATCT CCTGGGAATA TTGCTTAAGA AAGATAATCT TAACCAGGAC 2100

ACAAGGAAAC TGTTAATGAC CTGGGCTTTG GAAGTGGCTG TTTTAATGAA GAAGTCTGAA 2160

ACATATGCAC CTTTATTCTC TCTTCCATCT TTCCATAAAT TTTGCAAAGG CCTTTTAGCC 2220

AACACTCTGG TCGAAGATGT GAATATCTGT CTGCAAGCAT GCAGCAGTCT ACATGCACTG 2280

TCCTCTTCCT TACCAGATGA TCTTTTACAG AGTAGGTGTG TTGATGTTTG CCGTGTTCAG 2340

CTAGTCCATA GTGGAACTCG TATTCGACAA GCATTTGGAA AGCTATTGAA GTCAATCCCT 2400

TTAGATGTTG TCTTGAGCAA TAACAATCAC ACAGAAATTC AAGAAATTTC TTTAGCATTA 2460

AGAAGTCACA TGAGTAAAGC ACCAAGTAAC ACATTCCACC CACAAGATTT CTCTGATGTT 2520

ATTAGTTTTA TTTTGTATGG AAACTCTCAT AGAATAGGGA AGGACAATTG GTTAGAAAGA 2580

TTGTTCTATA GCTGCCAGAG ACTGGATAAA CGTGACCAAT CAACGATTCC CCGCAATCTG 2640

CTAAAGACAG ATGCTGTCCT CTGGCAGTGG GCTATTTGGG AAGCAGCACA GTTCACTGTC 2700

CTTTCTAAGC TGAGGACCCC ACTTGGCAGA GCTCAGGATA CCTTCCAAAC AATTGAAGGT 2760

ATCATTAGAA GTCTTGCAGC TCACACATTA AACCCCGATC AAGATGTTAG TCAGTGGACA 2820

ACTGCAGACA ATGACGAAGG CCACAGTAGC AACCAGCTTA GACTTGTGCT GCTTCTGCAG 2880

TATCTGGAAA ACCTGGAGAA GTTAATGTAT AATGCATATG AAGGATGTGC CAATGCATTA 2940

ACATCGCCTC CCAAGGTCAT TAGGACTTTT TTCTATACCA ATCGCCAAAC TTGTCAAGAC 3000

TGGCTGACTC GGATCCGACT CTCCATCATG AGGGTTGGAT TGTTGGCAGG CCAGCCTGCT 3060

GTGACAGTGA GACACGGCTT CGATTTGCTT ACAGAAATGA AGACAAATCC GTCTCAGGGA 3120

AATGAATTGG AAGTAACTAT CATGATGGTG GTAGAAGCAT TGTGTGAACT TCATTGTCCT 3180

GAAGCTATAC AGGGAATTGC TGTCTGGTCG TCTTCGGTTG TTGGAAAAAA TCTTCTCTGG 3240

ATTAATTCAG TGGCCCAACA GGCTGAAGGG AGGTTTGAAA AGGCCTCTGT GGAGTACCAG 3300

GAGCACCTGT GTGCCATGAC AGGTGTCGAT TGCTGCATCT CTAGCTTCGA CAAATCCGTT 3360

CTCACATTGG CTAATACTGG GCGTAATAGT GCCAGCCCCA AGCATTCTTT GAATGGTGAA 3420

TCCAGAAAAA CTGTGCTTTC CAAACCAACT GATTCTTCTC CTGAGGTTAT AAATTATTTG 3480

GGAAATAAAG CATGTGAGTG CTACATTTCA ATAGCTGATT GGGCTGCTGT ACAGGAGTGG 3540

CAGAATGCTG TCCATGACTT GAAAAAGAGT ACCAGTAGTA CTTCTCTCAA CCTAAAGGCT 3600

GATTTCAACT ACATAAAATC ACTAAGCAGT TTTGAATCTG GAGAATTTAT TGAATGCACT 3660

GAACAATTAG AATTGTTACC AGGAGAAAAT ATCAGTCTAC TTGCTGGAGG ATCAAAAGAA 3720

AAAATAGATA TGAAAAAACT GCTTCCTAAC ATGTTAAGTC CAGATCCAAG AGAACTTCAG 3780

AAATCCATTG AAGTTCAGTT GTTAAGAAGT TCTGTTTGTT TGGCAACTGC TTTAAACCAC 3840

ATAGAACAAG ATCAGAAGTG GCAGTCTATT ACCGAAAATG TGGTGAAGTA CCTGAAGCAA 3900

ACCTCCCGCA TAGCTGTTGG ACCCCTGAGA CTTTCTACTC TAACAGTTTC CCAGTCTCTG 3960

CCAGTCCTAA GTACTTTACA GCTGTATTGC TCTTCTGCTT TGGAGAACAC AGTTTCCAAC 4020

AGACTTGCCA CAGAGGACTG TCTTATTCCA CTCTTTAGTG AAGCTTTGCG TTCATGTAAA 4080

CAGCATGATG TCAGGCCATG GATGCAAGCA TTAAGATACA CGATGTACCA GAGTCAGTTG 4140

TTGGAGAAAA TAAAAGAACA AACAGTTCCA ATTAGAAGCC ATCTCATGGA ATTAGGTCTA 4200

ACAGCAGCAA AATTTGCTAG AAAACGGGGG AATGTGTCAC TTGCAACAAG ATTGCTGGCA 4260

CAGTGTAGCG AGGTTCAGCT GGGAAAGACT ACCACTGCAC AGGATTTAGT CCAGCACTTT 4320

AAAAAACTAT CAACTCAAGG TCAAGTGGAT GAAAAATGGG GGCCTGAACT TGACATTGAA 4380

AAAACGAAAC TGCTATATAC AGCAGGCCAG TCAACACATG CAATGGAGAT GTTGAGTTCC 4440

TGTGCCATCT CTTTCTGCAA GTCTGCCAAA GCTGAGCATG CTGTTGCCAA GTCAATTTTG 4500

ACATTGGCTA AATGGATCCA GGCAGAATGG AAAGAAATCT CAGGACAGCT GAAACAGGTT 4560

TACAGAGCTC AGCAGCAGCA GAACTTCACG GGTCTTTCTA CTTTGTCTAA AAACATACTC 4620

ACTCTAATTG AACTACCATC TGTTAATACG ATGGAGGAAG AGTATCCTCG GATAGAGAGT 4680

GAATCTACAG TACATATTGG AGTTGGGGAA CCTGACTTCA TCTTGGGACA GCTGTATCAT 4740

CTGTCTTCAG TACAGGCACC TGAAGTAGCC AAATCTTGGG CCGCATTGGC TAGTTGGGCT 4800

TACAGGTGGG GCAGAAAGGT GGTTGACAAT GCCAGTCAGG GAGAAGGTGT TCGTCTGTTG 4860

CCTAGAGAAA AATCTGAAGT TCAGAATCTG CTCCCAGACA CCATAACCGA AGAAGAAAAA 4920

GAGAGAATAT ATGGTATTCT TGGTCAGGCT GTGTGTCGCC CAGCGGGGAT TCAGGATGAA 4980

GATATAACGC TTCAGATCAC AGAAAGTGAA GATAATGAGG AAGATGACAT GGTTGATGTT 5040

ATCTGGCGTC AGTTAATATC AAGTTGCCCA TGGCTTTCAG AACTTGATGA AAGTGCAACA 5100

GAAGGAGTCA TTAAAGTGTG GAGGAAAGTT GTGGACAGAA TCTTCAGCCT GTATAAACTG 5160

TCCTGCAGCG CATATTTTAC TTTCCTTAAA CTCAATGCTG GGCAGATTCC TTTAGATGAA 5220

GATGACCCTC GGCTCCATTT AAGCCACAGA GTGGAGCAGA GCACGGATGA CATGATTGTG 5280

ATGGCCACGC TGCGGTTGCT CAGGTTGCTC GTGAAGCACG CTGGGGAGCT TCGGCAGTAT 5340

CTGGAACATG GCTTGGAAAC AACACCTACT GCGCCTTGGA GAGGAATTAT TCCGCAGCTT 5400

TTCTCACGCT TAAACCACCC TGAAGTGTAT GTGCGCCAGA GTATTTGTAA CCTCCTCTGC 5460

CGCGTGGCTC AGGATTCCCC GCATCTCATA CTGTATCCTG CAATAGTGGG CACCATATCG 5520

CTTAGTAGTG AGTCACAGGC TTCAGGAAAT AAATTTTCCT CTGCAATTCC AACTTTACTT 5580

GGCAATATTC AAGGAGAAGA ACTACTGGTT TCTGAATGTG AGGGAGGAAG TCCTCCTGCT 5640

TCTCAAGATA GCAATAAGGA TGAACCTAAA AGTGGACTGA ATGAAGACCA AGCCATGATG 5700

CAGGACTGCT ACAGCAAAAT TGTAGATAAA CTGTCCTCGG CAAACCCAAC TATGGTGTTA 5760

CAGGTTCAGA TGCTTGTGGC TGAGCTGCGC AGGGTCACTG TTCTCTGGGA TGAGCTCTGG 5820

TTGGGAGTTC TGTTACAGCA GCACATGTAT GTCCTGAGAC GAATTCAGCA GTTGGAAGAC 5880

GAGGTGAAGA GAGTCCAGAA CAACAACACC TTACGCAAAG AAGAGAAAAT CGCAATCATG 5940

CGGGAGAAGC ACACAGCTTT GATGAAGCCC ATCGTATTTG CTTTGGAGCA CGTTAGGAGC 6000

ATCACAGCGG CCCCTGCAGA AACACCTCAT GAAAAGTGGT TTCAGGATAA CTATGGTGAT 6060

GCCATTGAAA ATGCTCTAGA AAAGCTGAAA ACACCGTCAA ACCCTGCAAA GCCTGGAAGC 6120

AGCTGGATTC CATTTAAAGA GATAATGCTG AGTTTGCAAC AGAGAGCACA GAAACGTGCA 6180

AGTTACATCT TGCGTCTTGA AGAAATCAGC CCATGGCTGG CTGCCATGAC TAACACTGAA 6240

ATTGCTCTTC CCGGAGAAGT CTCAGCCAGA GATACCGTCA CAATCCACAG TGTTGGTGGA 6300

ACCATCACAA TCTTACCTAC TAAAACCAAG CCAAAGAAAC TTCTCTTTCT AGGATCAGAT 6360

GGGAAGAGCT ATCCTTATCT TTTCAAAGGA TTGGAGGATT TACATCTGGA TGAGAGAATA 6420

ATGCAATTTC TGTCTATTGT AAATACCATG TTTGCAACAA TCAATCGCCA GGAAACACCT 6480

CGTTTCCATG CTCGCCACTA TTCTGTAACA CCACTGGGAA CTCGCTCAGG CCTAATCCAG 6540

TGGGTGGATG GAGCCACGCC CTTATTTGGT CTTTACAAAC GATGGCAACA ACGGGAAGCC 6600

GCCTTGCAAG CACAAAAGGC CCAAGATTCC TACCAAACTC CTCAGAATCC TGGAATCGTA 6660

CCCCGTCCTA GTGAACTTTA TTATAGTAAA ATTGGTCCTG CTTTGAAAGC AGTTGGGCTT 6720

AGTCTGGATG TGTCCCGCCG GGATTGGCCT CTTCATGTGA TGAAGGCAGT GTTAGAAGAG 6780

TTAATGGAGG CCACGCCCCC AAATCTCCTT GCTAAAGAGC TTTGGTCATC ATGTACCACC 6840

CCTGATGAGT GGTGGAGAGT CACACAGTCT TATGCCAGAT CTACTGCAGT CATGTCTATG 6900

GTCGGATACA TAATTGGCCT TGGAGATAGA CATCTGGATA ATGTTCTCAT AGATATGACG 6960

ACTGGAGAGG TTGTTCACAT AGATTACAAT GTTTGCTTTG AAAAAGGTAA AAGCCTTAGA 7020

GTTCCTGAGA AAGTACCTTT TCGAATGACA CAGAACATTG AAACAGCACT GGGTGTAACT 7080

GGAGTAGAAG GTGTTTTTAG GCTTTCATGT GAGCAGGTTC TACACATTAT GCGGCGTGGC 7140

AGAGAGACTC TGCTGACGCT GCTGGAGGCC TTTGTATATG ACCCCCTGGT GGACTGGACA 7200

GCTGGGGGCG AGGCTGGGTT TGCTGGTGCG GTCTATGGTG GAGGGGGCCA GCAGGCTGAG 7260

AGCAAGCAGA GCAAGAGAGA GATGGAACGA GAGATTACTC GCAGCCTTTT TTCTTCGAGA 7320

GTAGCTGAAA TTAAGGTGAA CTGGTTTAAA AACAGAGATG AGATGCTGGT TGTACTTCCC 7380

AAGCTGGACA GCAGCTTAGA TGAATACCTG AGCTTGCAAG AGCAACTAAC AGATGTGGAG 7440

AAACTGCAGG GCAAACTGCT GGAAGAAATT GAGTTTCTAG AAGGAGCTGA AGGAGTGGAT 7500

CATCCTTCTC ATACTCTGCA ACACAGGTAT TCTGAACACA CTCAACTACA GACTCAGCAG 7560

AGAGCTGTTC AGGAAGCAAT CCAGGTGAAG CTGAATGAAT TTGAACAGTG GATAACACAC 7620

TATCAGGCTG CGTTCAATAA TTTGGAAGCT ACACAGCTGG CCAGTTTGCT TCAGGAGATA 7680

AGCACACAGA TGGACCTTGC AAAAGGTCCT CCCAGCTACG TGCCGGCAAC AGCCTTTCTG 7740

CAGAATGCTG GCCAGGCCCA CTTGATTAGC CAGTGTGAGC AGCTAGAAGG GGAGGTTGGT 7800

GCCCTCCTGC AGCAGAGGCG CTCGGTGCTG CGAGGCTGTC TGGAGCAGCT GCATCACTAC 7860

GCAACTGTTG CTCTGCAGTA TCCAAAGGCC ATATTTCAGA AACATCGAAT TGAGCAGTGG 7920

AAGACCTGGA TGGAAGAGCT CATCTGTAAT ACCACAGTAG AACGCTGTCA GGAACTTTAC 7980

AGGAAATATG AAATGCAGTA TGCGCCCCAG CCACCCCCAA CAGTGTGTCA GTTCATCACG 8040

GCCACTGAGA TGACCCTGCA GCGGTACGCA GCCGACATCA ACAGCCGACT TATCAGACAG 8100

GTGGAACGCT TGAAACAGGA AGCTGTCACT GTACCGGTTT GTGAAGATCA GTTGAAAGAA 8160

ATTGAACGTT GTATCAAAGT TTTCCTTCAC GAGAATGGAG AGGAAGGATC TTTGAGTCTA 8220

GCAAGTGTTA TTATTTCTGC CCTTTGTACT CTCACAAGGC GTAACCTAAT GATGGAAGGT 8280

GCAGCGTCGA GTGCTGGAGA GCAGCTGGTT GATCTGACTT CTCGGGATGG AGCCTGGTTC 8340

TTGGAGGAAC TCTGCAGTAT GAGCGGAAAT GTCACATGTC TGGTTCAGTT ACTGAAGCAG 8400

TGTCATTTAG TGCCACAAGA CTTAGACATT CCTAACCCCA TGGAAGCATC TGAGGCCGTT 8460

CATTTGGCTA ATGGTGTATA CACCTCACTT CAGGAATTAA ATTCAAATTT CCGGCAAATC 8520

ATATTTCCAG AAGCACTGAG ATGTTTAATG AAAGGAGAAT ACACGTTAGA AAATATGCTT 8580

CATGAGCTGG ACAGTCTTAT TGAGCAGACA ACTGATGGTG TTCCTCTGCA GACTCTAGTT 8640

GAATCTCTTC AAGCCTATTT AAGAAATGCA GCTATGGGAC TTGAGGAAGA AACACATGCT 8700

CATTACATCG ATGTTGCCAG AATGCTTCAT GCTCAGTATG GTGAATTAAT CCAACCAAGA 8760

AATGGTTCAG TTGATGAAAC ACCAAAAATG TCAGCTGGCC AGATGCTTTT GGTAGCATTT 8820

GATGGCATGT TTGCCCAAGT TGAGACTGCT TTTGGCTTAT TGGTTGAAAA GCTAAATAAG 8880

ATGGAAATTC CTATAGCTTG GCGAAAGATT GACATAATAC GGGAAGCCAG GAGCACTCAG 8940

GTCAATTTTT TTGATGATGA TAATCACCGA CAGGTGCTGG AAGAGATCTT CTTTCTAAAA 9000

CGACTACAGA CAATTAAGGA GTTCTTTCGG CTCTGTGGTA CCTTTTCTAA AACTTTGTCA 9060

GGATCAAGTT CACTTGAAGA TCAGAATACT GTAAATGGGC CTGTACAGAT TGTCAATGTG 9120

AAAACCCTTT TTAGAAACTC TTGTTTCAGT GAAGACCAGA TGGCCAAACC AATAAAGGCA 9180

TTCACAGCTG ACTTTGTGCG GCAGCTCCTG ATTGGACTCC CGAACCAAGC CCTGGGCCTC 9240

ACACTGTGCA GCTTCATCAG TGCTCTAGGG GTAGACATCA TTGCGCAGGT GGAGGCGAAG 9300

GATTTTGGTG CTGAAAGCAA AGTTTCTGTT GACGATCTGT GTAAGAAGGC GGTGGAGCAC 9360

AACATCCAGA TCGGGAAGTT CTCTCAGCTG GTCATGAACA GGGCGACTGT GCTGGCGAGC 9420

TCCTACGACA CTGCCTGGAA GAAGCACGAC TTGGTGCGCA GGCTGGAGAC CAGCATCGCC 9480

TCCTGCAAGA CAAGCCTGCA GCGTGTCCAG CTGCACATCG CCATGTTTCA GTGGCAGCAT 9540

GAAGATCTCC TTATCAATAG ACCACAAGCC ATGTCTGTCA CACCTCCCCC TCGTTCTGCC 9600

ATATTAACCA GCATGAAAAA GAAACTCCAT ACTCTGAGCC AGATTGAAAC TTCAATTGCA 9660

ACAGTTCAGG AGAAACTGGC AGCACTTGAA GCAAGTATTG AACAGCGACT CAAATGGGCA 9720

GGTGGTGCCA ACCCTGCACT GGCACCTGTA CTACAGGATT TTGAAGCAAC AATAGCTGAA 9780

AGAAGAAATC TTGTCCTTAA GGAGAGCCAA AGAGCAAGTC AGGTCACTTT CCTCTGCAGC 9840

AATATCATTC ATTTTGAAAG TTTACGAACT AGAACTGCAG AAGCCTTAAA CCTGGATGCT 9900

GCATTATTTG AACTAATCAA ACGGTGTCAG CAAATGTGTT CATTTGCATC GCAGTTTAAC 9960

AGTTCAGTCT CTGAGTTAGA GCTTCGTTTA TTACAGAGGG TGGACACGAC TCTTGAACAT 10020

CCTATTGGCA GCTCTGAGTG GCTTTTGTCA GCACACAAAC AACTGACCCA GGATATGTCT 10080

ACTCAGAGAG CAATTCAGAC AGAGAAAGAG CAACAAATAG AAACAGTCTG TGAAACAATT 10140

CAGAATCTGG TTGATAATAT AAAGACTGTG CTCACTGGCC ATAACCGGCA GCTTGGAGAT 10200

GTCAAACATC TCCTGAAAGC AATGGCCAAG GATGAAGAAG CTGCTCTGGC AGATGGTGAA 10260

GATGTTCCCT ATGAGAACAG TGTTAGGCAG TTCTTGGGTG AATATAAATC ATGGCAAGAC 10320

AACATTCAGA CAGTGCTGTT TACATTAGTC CAAGCCATGG GTCAGGTTCG AAGTCAAGAA 10380

CATGTTGAAA TGCTCCAGGA AATAACTCCC ACCTTGAAAG AACTGAAAAC GCAAAGTCAG 10440

AGTGTGTATA ATAATTTAGT GAGTTTTGCA TCACCATTAG TGACCGATGC AACAAATGAA 10500

TGTTCGAGTC CAACATCGTC TGCTACTTAT CAACCATCCT TTGCTGCAGC AGTCCGAAGC 10560

AACACTGGCC AGAAGACTCA GCCTGATGTC ATGTCACAGA ACGCTAGAAA GCTGATTCAG 10620

AAAAACCTAG CTACATCAGC AGATACCCCA CCGAGCACCG TTCCGGGAAC TGGCAAGAGT 10680

GTTGCTTGTA GTCCTAAAAA GGCCATCAGA GACCCTAAGA CTGGAAAAGC TGTGCAGGAG 10740

AGAAACTCGT ATGCGGTGAG TGTGTGGAAG AGAGTGAAAG CCAAGCTAGA GGGCCGAGAT 10800

GTTGATCCGA ATAGGAGGAT GTCAGTTGCT GAACAGGTTG ACTATGTCAT TAAGGAAGCA 10860

ACTAATCTAG ATAACTTGGC TCAGCTGTAT GAAGGTTGGA CAGCCTGGGT ATGA 10914

Domain Profile

S: 3     gfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdke  62

         ++  +++il++k+kpkkll++Gsdgk+ypyL+kg+eDl+ der++q++s+vNt++a+ ++

Q: 2097  SVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINR  2156

         566789******************************************************

S: 63    tsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpi..syrykdl  120

         ++++++++r+y+V+pl+trsgli+wv+++++L+ l+k++++++a+l++q++  sy+++++

Q: 2157  QETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAqdSYQTPQN  2216

         **************************************************999*******

S: 121   stvqar.........kpklkhlkls.........levfkevlenlv...pkdllkkllle  159

         + +++r         +p+lk++ ls         l+v+k+vle+l+   p++ll+k+l++

Q: 2217  PGIVPRpselyyskiGPALKAVGLSldvsrrdwpLHVMKAVLEELMeatPPNLLAKELWS  2276

         ***************999999999999*****************99999***********

S: 160   kfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafeka  219

         ++++p+ew++++++y+rs+Av+s+vgyi+gLgdrhl+n+lid++tgevvhid++v+fek+

Q: 2277  SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG  2336

         ************************************************************

S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279

         k+ l+vpekvPFR+T+ni++algvtgveGvfr sce+vl+++r+ +e+llt+Le+f+ydp

Q: 2337  KS-LRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDP  2395

         **.*********************************************************

S: 280   lvdwkk...................k  286

         lvdw+                    +

Q: 2396  LVDWTAggeagfagavyggggqqaeS  2421

         *****988777777666555522222

Domain Sequence
(FASTA)

SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL DERIMQFLSI VNTMFATINR 60

QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN 120

PGIVPRPSEL YYSKIGPALK AVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 180

SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH IDYNVCFEKG 240

KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI MRRGRETLLT LLEAFVYDPL 300

VDWTAGGEAG FAGAVYGGGG QQAES 325

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR014009	; PIK_FAT.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013