EKS-BOT-00080
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00080
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/GSK446.34.8E-134120403284
StatusUnreviewed
Ensembl ProteinENSBTAP00000027660
UniProt AccessionA6QLB8; F1MHW8;
Protein Name
Protein Synonyms/Alias GSK3A protein;
Gene NameGSK3A
Gene Synonyms/Alias GSK3A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000020756ENSBTAP00000027660ENSBTAT00000027660
OrganismBos taurus
Functional Description
Protein Length495
Protein Sequence
(FASTA)
MSGGAPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGSGGGK TSVGAMGGGV 60
GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 120
DIKVIGSGSF GVVYQARLAD TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 180
SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLSIPIIY VKVYMYQLFR SLAYIHSQGV 240
CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 300
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPS REQIREMNPN YTEFKFPQIK 360
AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCPG TQLPNNRPLP 420
PLFNFSPGEL TIQPSLNAIL IPPHLRSPAG TASLTPSSQA LSEAQTSSDW QSTDNTATLP 480
PGLHLLQPPH LLCPL 495
Nucleotide Sequence
(FASTA)
ATGAGCGGTG GCGCGCCTTC GGGGGGCGGC CCTGGGGGCT CGGGCCGGGC GCGGACCAGC 60
TCGTTCGCGG AGCCAGGCGG CGGAGGAGGC GGCGGCGGCG GCGGCCCGGG GGGTTCGGCC 120
TCTGGCCCAG GCGGCAGCGG CGGCGGGAAG ACGTCAGTCG GAGCCATGGG CGGGGGCGTG 180
GGGGCCTCAA GCTCCGGGGG TGGCCCCGGC GGCAGCGGCG GAGGAGGCAG CGGCGGCCCC 240
GGCGCGGGCA CCAGCTTCCC GCCGCCCGGA GTGAAGCTGG GCCGTGACAG TGGGAAGGTG 300
ACCACAGTGG TAGCCACTCT AGGCCAAGGC CCGGAGCGCT CCCAGGAGGT GGCTTACACA 360
GACATCAAAG TGATTGGAAG TGGCTCATTT GGGGTCGTGT ACCAGGCACG GCTGGCAGAC 420
ACCAGGGAAT TGGTGGCCAT CAAGAAGGTT CTCCAGGACA AGAGGTTCAA GAACCGAGAG 480
CTGCAGATTA TGCGTAAGCT GGACCACTGC AATATCGTGA GGCTGAGATA CTTTTTCTAC 540
TCCAGTGGGG AGAAGAAAGA CGAGCTTTAC CTAAACCTGG TGCTGGAATA TGTGCCCGAG 600
ACAGTGTACC GGGTGGCCCG CCATTTTACC AAGGCCAAGT TGAGCATCCC TATCATCTAT 660
GTCAAGGTGT ACATGTACCA GCTCTTCCGG AGCTTGGCCT ACATCCACTC CCAGGGTGTG 720
TGTCACCGCG ACATCAAGCC CCAGAACCTG CTGGTGGACC CCGACACTGC TGTCCTCAAG 780
CTCTGCGATT TTGGCAGTGC AAAACAGTTG GTCCGCGGGG AGCCCAATGT CTCCTACATC 840
TGTTCTCGCT ACTACCGGGC CCCAGAGCTG ATCTTCGGAG CCACCGATTA CACCTCATCC 900
ATCGATGTGT GGTCGGCTGG CTGTGTACTG GCTGAGCTCC TCTTGGGCCA GCCCATCTTC 960
CCTGGGGACA GTGGGGTGGA CCAGCTGGTG GAGATCATCA AGGTGCTGGG GACACCGAGC 1020
CGGGAACAGA TTCGCGAGAT GAACCCCAAC TACACGGAGT TCAAGTTCCC CCAGATTAAA 1080
GCTCATCCCT GGACAAAGGT GTTCAAATCG CGAACGCCGC CCGAGGCCAT CGCGCTCTGC 1140
TCCAGCCTGC TGGAGTACAC CCCCTCCTCG AGGCTCTCGC CGCTGGAAGC CTGCGCCCAT 1200
AGCTTCTTCG ATGAACTGCG ATGTCCTGGA ACCCAGCTCC CCAACAACCG CCCGCTCCCC 1260
CCGCTCTTCA ATTTCAGTCC TGGCGAACTC ACCATCCAAC CATCTCTCAA TGCCATCCTC 1320
ATCCCTCCTC ACTTGAGGTC CCCAGCGGGC ACTGCCTCCC TCACCCCGTC CTCACAAGCT 1380
TTAAGTGAGG CTCAGACCAG CTCGGACTGG CAGTCGACCG ATAACACAGC CACCCTCCCC 1440
CCAGGTCTCC ACCTCCTCCA ACCCCCTCAC CTACTGTGTC CCTTGTAA 1488
Domain Profile
S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61
         +++k+igsGsFg+Vyqa+l++++e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf
Q: 120   TDIKVIGSGSFGVVYQARLADTREL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  178
         789**********************.**********************************
S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121
         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++++vk+y+yQlfr+lay+hs+
Q: 179   FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLSIPIIYVKVYMYQLFRSLAYIHSQ  238
         ************************************************************
S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181
         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt
Q: 239   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  298
         ************************************************************
S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241
         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtp++e+i+emn++y+e+kf++
Q: 299   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIREMNPNYTEFKFPQ  358
         ************************************************************
S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286
         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff
Q: 359   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  403
         ********************************************9
Domain Sequence
(FASTA)
TDIKVIGSGS FGVVYQARLA DTRELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60
YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLSIPII YVKVYMYQLF RSLAYIHSQG 120
VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180
SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP SREQIREMNP NYTEFKFPQI 240
KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00074
EKS-ANC-00071
EKS-CAE-00055
EKS-CAJ-00082
EKS-CAF-00081
EKS-CAP-00080
EKS-CII-00034
EKS-CIS-00077
EKS-DAR-00331
EKS-DRM-00034
EKS-EQC-00079
EKS-FEC-00077
EKS-GAM-00044
EKS-GAG-00064
EKS-GAA-00099
EKS-GOG-00079
EKS-HOS-00083
EKS-ICT-00073
EKS-LAC-00086
EKS-LOA-00076
EKS-MAM-00080
EKS-MAE-00033
EKS-MEG-00060
EKS-MOD-00078
EKS-MUM-00081
EKS-MUP-00081
EKS-MYL-00088
EKS-NOL-00077
EKS-OCP-00051
EKS-ORN-00109
EKS-ORC-00076
EKS-ORL-00101
EKS-OTG-00084
EKS-PAT-00072
EKS-PES-00070
EKS-POA-00074
EKS-PRC-00044
EKS-PTV-00065
EKS-RAN-00077
EKS-SAH-00076
EKS-SUS-00072
EKS-TAG-00115
EKS-TAR-00109
EKS-TEN-00106
EKS-TUT-00070
EKS-VIP-00034
EKS-XET-00076
EKS-XIM-00104
EKS-SAC-00071
EKS-SCP-00065
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003214; P:cardiac left ventricle morphogenesis
GO:0016477; P:cell migration
GO:0071285; P:cellular response to lithium ion
GO:0071407; P:cellular response to organic cyclic compound
GO:0044027; P:hypermethylation of CpG island
GO:0008286; P:insulin receptor signaling pathway
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0032007; P:negative regulation of TOR signaling cascade
GO:0051348; P:negative regulation of transferase activity
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway
GO:0030819; P:positive regulation of cAMP biosynthetic process
GO:2000467; P:positive regulation of glycogen (starch) synthase activity
GO:0045823; P:positive regulation of heart contraction
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006349; P:regulation of gene expression by genetic imprinting
GO:0003073; P:regulation of systemic arterial blood pressure
KEGG
bta:536561;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013