EKS-BOT-00381
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00381
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK316.11.9E-94161396236
StatusUnreviewed
Ensembl ProteinENSBTAP00000053643
UniProt AccessionF1N791;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K12
Gene Synonyms/Alias MAP3K12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000020758ENSBTAP00000053643ENSBTAT00000061092
OrganismBos taurus
Functional Description
Protein Length895
Protein Sequence
(FASTA)
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 60
GGPSPSPGGE PPPEPFANSV LQLHEQDAGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120
LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540
ILKTESLLPK LDAALSGVGL PGCAKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAAVP 600
PHEPGGPGSP VGLGGGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660
GAGDPGSPPP ARGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGDSVGL LGTGREGTAG 720
RGGSRAGSQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELASSQR NRWPQGLKMR 780
QSLSTFSSEN PSDGEEGTAS EPSPSGTPEV GSTNTDERPD ERSDDMCSQG SEIPLDPPAS 840
EVVTGPEPSS LPVPHHDLLR GEQGPPNPED SDCDSTELDN ANSGEALRPP ASLPP 895
Nucleotide Sequence
(FASTA)
ATGGCCTGCC TCCATGAGAC CCGCACACCC TCCCCTTCCT TTGGGGGTTT CGTGTCCACC 60
CTAAGCGAGG CATCCATGCG CAAGCTGGAC CCAGACACTT CCGACTGCAC CCCCGAGAAG 120
GACCTGACGC CCACCCAGTG TGTACTCCGA GACGTAGTGC CACTCGGGGG TCAGGGCGGG 180
GGCGGGCCCA GCCCCTCCCC AGGTGGAGAG CCGCCCCCTG AGCCTTTTGC CAACAGTGTC 240
CTGCAGCTCC ACGAGCAGGA TGCAGGGGGC CCAGGGGGAG CCACTGGGTC CCCTGAGAGT 300
CGGGCGTCCA GGGTCCGAGC GGATGAGGTA CGGCTCCAGT GCCAGAGCGG CAGCGGCTTC 360
CTGGAGGGCC TCTTCGGCTG CCTGCGCCCT GTGTGGACCA TGATCGGCAA AGCCTACTCC 420
ACGGAGCACA AGCAGCAGCA GGAAGACCTT TGGGAGGTCC CCTTTGAGGA AATCCTGGAC 480
CTGCAGTGGG TGGGCTCAGG GGCCCAGGGC GCCGTCTTCC TGGGGCGCTT CCATGGGGAG 540
GAGGTGGCTG TGAAGAAGGT GCGGGACCTG AAGGAAACTG ACATCAAGCA CCTGCGAAAG 600
CTGAAGCACC CAAACATCAT CACCTTCAAG GGTGTGTGCA CCCAGGCTCC CTGCTACTGC 660
ATCCTCATGG AGTTCTGCGC CCAGGGCCAG CTGTACGAGG TGCTGCGGGC TGGCCGCCCC 720
GTCACGCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CCGGCGGCAT GAACTACCTG 780
CACCTGCACA AGATTATCCA TCGGGACCTC AAGTCCCCCA ACATGCTAAT CACCTACGAC 840
GATGTGGTGA AGATCTCCGA TTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCCCCTGAAG TGATCCGCAA CGAACCTGTG 960
TCTGAGAAGG TTGACATCTG GTCCTTTGGC GTGGTGCTGT GGGAGCTGCT GACTGGTGAG 1020
ATCCCCTACA AAGACGTAGA TTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTC 1080
CATCTACCTG TGCCCTCCAG CTGCCCAGAC GGCTTCAAAA TCCTGCTTCG CCAGTGCTGG 1140
AACAGCAAAC CACGAAACCG CCCATCATTC CGACAGATCC TGCTGCATCT GGACATTGCC 1200
TCAGCCGACG TACTCTCCAC ACCCCAGGAG ACTTACTTTA AGTCCCAGGC AGAGTGGCGT 1260
GAAGAGGTAA AGCTGCATTT TGAAAAAATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 1320
GAAGAGGAGC TGGTGATGCG GAGGAGGGAG GAGCTCAGAC ATGCCCTGGA CATTAGGGAA 1380
CACTATGAGC GGAAACTGGA GAGAGCCAAC AACCTGTACA TGGAACTTAA TGCCCTTATG 1440
TTGCAGCTGG AGCTGAAGGA ACGGGAGCTA CTCAGGAGGG AGCAAGCTTT AGAGCGGCGG 1500
TGTCCAGGTC TGCTGAAGTC ACACCCTTCC CGGGGCCTGC TGCACGGGAA CACGATGGAG 1560
AAACTGATCA AGAAGAGGAA TGTCCCACAG AAACTGTCGC CCCACAGCAA AAGGCCAGAT 1620
ATCCTCAAGA CTGAGTCTTT GCTACCCAAA CTAGATGCAG CCCTGAGTGG GGTGGGGCTT 1680
CCTGGGTGTG CTAAGGGCCC CCCCTCACCA GGACGGAGTC GCCGTGGCAA GACTCGTCAC 1740
CGCAAGGCCA GCGCCAAGGG CAGCTGTGGG GACCTGCCTG GGCTTCGTGC AGCTGTGCCA 1800
CCCCATGAAC CTGGGGGACC AGGAAGCCCC GTGGGGCTAG GCGGGGGACC CTCAGCCTGG 1860
GAAGCCTGCC CTCCAGCCCT CCGTGGGCTC CACCATGATC TCCTGCTCCG AAAGATGTCT 1920
TCATCATCGC CAGATCTGCT GTCAGCAGCA TTGGGAGCCC GGGGCCGGGG GGCTACAGGG 1980
GGAGCTGGGG ATCCTGGCTC ACCACCTCCA GCCCGGGGAG ACACGCCCCC AAGCGAGGGC 2040
TCAGCACCTG GCTCCACCAG CCCGGATTCA CCAGGGGGAG CCAAAGGGGA GCCGCCTCCA 2100
CCAGTAGGAC CTGGTGACAG TGTAGGGCTG CTGGGAACTG GAAGGGAAGG GACGGCGGGA 2160
CGGGGAGGAA GCCGGGCTGG GTCCCAGCAC TTGACCCCAG CCGCACTGCT GTACAGGGCT 2220
GCTGTCACCC GAAGTCAGAA ACGCGGCATC TCATCAGAGG AAGAGGAAGG AGAGGTGGAC 2280
AGTGAAGTGG AACTGGCCTC AAGCCAGAGA AACAGGTGGC CTCAGGGCCT GAAAATGCGC 2340
CAGTCACTAT CTACCTTCAG CTCAGAGAAT CCATCGGATG GGGAGGAGGG CACAGCTAGT 2400
GAGCCTTCCC CCAGTGGCAC ACCTGAAGTT GGCAGTACCA ACACAGATGA GCGGCCGGAT 2460
GAACGGTCTG ATGACATGTG CTCGCAGGGC TCAGAAATCC CACTGGACCC ACCAGCTTCT 2520
GAGGTGGTTA CTGGCCCAGA ACCCAGCTCC TTGCCCGTCC CACACCACGA CCTACTCAGA 2580
GGGGAGCAGG GCCCTCCCAA CCCTGAGGAC TCAGACTGTG ACAGCACTGA ACTGGACAAC 2640
GCCAACAGCG GTGAAGCCTT GCGGCCCCCA GCCTCCCTCC CTCCGTGA 2688
Domain Profile
S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63
          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G
Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211
         689**************************9999.........******************
S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123
         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii
Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266
         **************************..99************************...9**
S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182
         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D
Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325
         ***********.99****************99****************************
S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242
         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+
Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385
         ************************************************************
S: 243   kRpsfseivks  253
         +Rpsf++i+ +
Q: 386   NRPSFRQILLH  396
         ********876
Domain Sequence
(FASTA)
LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60
ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120
DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180
IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-ANC-00369
EKS-CAE-00303
EKS-CAJ-00386
EKS-CAF-00381
EKS-CAP-00413
EKS-DAR-00760
EKS-DIO-00060
EKS-DRM-00177
EKS-EQC-00370
EKS-FEC-00368
EKS-GAA-00464
EKS-GOG-00371
EKS-HOS-00388
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-NOL-00348
EKS-OCP-00078
EKS-ORN-00489
EKS-ORC-00358
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-PEM-00201
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00482
EKS-XET-00494
EKS-XIM-00478
Gene Ontology
GO:0033267; C:axon part
GO:0005829; C:cytosol
GO:0030426; C:growth cone
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0016572; P:histone phosphorylation
GO:0000165; P:MAPK cascade
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013