EKS-BOT-00460

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00460

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	447.2	2.4E-134	24	308	285

Status

Unreviewed

Ensembl Protein

ENSBTAP00000023988

UniProt Accession

A6QLR9;

Protein Name

Protein Synonyms/Alias

MAPK14 protein;

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000020783	ENSBTAP00000023988	ENSBTAT00000023988

Organism

Bos taurus

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 60

SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 120

KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180

GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG 240

TPPAYLINRM PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 300

QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES 360

Nucleotide Sequence
(FASTA)

ATGTCTCAGG AGAGGCCCAC GTTCTACCGG CAGGAGCTGA ACAAGACCAT CTGGGAGGTG 60

CCCGAGCGTT ACCAGAACCT GTCCCCGGTG GGCTCCGGCG CCTATGGCTC CGTGTGTGCT 120

GCTTTTGACA CAAAAACTGG GTTACGTGTC GCAGTGAAGA AGCTATCCAG ACCATTTCAG 180

TCCATTATTC ATGCCAAAAG AACCTACAGA GAACTGCGGT TACTTAAACA TATGAAGCAT 240

GAAAATGTAA TTGGTCTGTT GGATGTTTTC ACACCTGCAA GGTCTCTGGA GGAATTCAAT 300

GATGTGTACC TGGTGACCCA TCTCATGGGG GCAGATCTGA ACAACATCGT GAAATGTCAG 360

AAGCTTACAG ATGACCATGT TCAGTTCCTT ATCTACCAGA TTCTCAGAGG TCTCAAGTAT 420

ATACATTCAG CCGACATAAT TCACAGGGAC CTAAAACCTA GTAATCTAGC TGTGAATGAA 480

GACTGTGAGC TGAAGATCTT GGATTTCGGA CTGGCTCGAC ATACAGATGA TGAAATGACA 540

GGCTATGTGG CCACCAGGTG GTACAGGGCT CCTGAGATCA TGCTGAACTG GATGCATTAC 600

AACCAGACAG TTGATATTTG GTCAGTGGGA TGCATAATGG CCGAGCTGTT GACTGGAAGA 660

ACGTTGTTTC CTGGTACAGA CCATATTAAC CAGCTTCAGC AGATTATGCG TCTGACGGGG 720

ACTCCCCCTG CTTATCTCAT TAACAGGATG CCAAGCCATG AGGCAAGAAA CTACATTCAG 780

TCTTTGACCC AGATGCCGAA GATGAACTTT GCAAATGTAT TTATTGGTGC CAATCCCTTG 840

GCTGTCGACC TGCTGGAGAA GATGCTTGTA TTGGACTCAG ATAAGAGAAT CACAGCAGCA 900

CAAGCCCTTG CACATGCCTA CTTCGCCCAG TACCACGATC CTGACGACGA ACCAGTGGCT 960

GATCCTTACG ATCAGTCTTT TGAAAGCAGG GACCTCCTTA TAGACGAATG GAAAAGCCTG 1020

ACCTATGATG AAGTCATCAG CTTTGTGCCG CCACCCCTTG ACCAAGAAGA GATGGAGTCT 1080

TGA 1083

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v++a+d++t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 24    YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  83

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 84    IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  143

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 144   ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+i+ql++i++++gtp +  ++++ s+earnyi

Q: 200   YNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +sl++++k++f+++f  a++ a+dLlek+Lvld+dkRi++++aL+h Y+

Q: 260   QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF  308

         ***********************************************96

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCAAFD TKTGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPA RSLEEFNDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDHINQLQ QIMRLTGTPP AYLINRMPSH EARNYIQSLT 240

QMPKMNFANV FIGANPLAVD LLEKMLVLDS DKRITAAQAL AHAYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0000922	; C:spindle pole
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0001525	; P:angiogenesis
GO:0000902	; P:cell morphogenesis
GO:0071363	; P:cellular response to growth factor stimulus
GO:0071479	; P:cellular response to ionizing radiation
GO:0002062	; P:chondrocyte differentiation
GO:0000077	; P:DNA damage checkpoint
GO:0019395	; P:fatty acid oxidation
GO:0006006	; P:glucose metabolic process
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0030316	; P:osteoclast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032495	; P:response to muramyl dipeptide
GO:0042770	; P:signal transduction in response to DNA damage
GO:0007519	; P:skeletal muscle tissue development
GO:0090400	; P:stress-induced premature senescence
GO:0051146	; P:striated muscle cell differentiation
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

bta:534492

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013