EKS-BOT-00033
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00033
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak337.37.9E-1018231096274
StatusUnreviewed
Ensembl ProteinENSBTAP00000027857
UniProt AccessionE1BEL4;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000020904ENSBTAP00000027857ENSBTAT00000027857
OrganismBos taurus
Functional Description
Protein Length1105
Protein Sequence
(FASTA)
MAPPSEETPL ISQRSCSLSS SEAGALHVLL PPRGPGPPQC LSFSFGDHSA EDLCVCAAKA 60
SGILPVYHSL FALALEDLSC WFPPSHIFSV EDTGTQVLVY RLRFYFPNWF GLEKCHRFGL 120
RKDLTSAILD LPVLEHLFAQ HRHDLVSGRL RVGLSLKEQG ECLSLAVLDL ARMALEQAQR 180
PEELLKTVSY KVCLPPGLRD LIQGLSFVTR RRIRRTVCRA LRGVATCQAD RHSLMVKYIM 240
DLERLDPDRA AETFRVGLPG AAGGQDTPGL LRVAGGSGIA WSPGEHEVLQ PFCDFPEIVD 300
ISIKQAPCIG PAAEHRLVTI TRTDNQILEA EFPGLPAALS FVALVDGYFR LTTDSRHYFC 360
REVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSLPGSYV LRRSPQDFDS YLLTVCVLTP 420
LGPDYKGCLI RCDPTGTFSL AGLGRSHSSL RELLAACWNG GLHVDGVELY LTFCCNPRPK 480
EKSNLIVVRR GCNPPTSSPV QPQFQCQLSQ MTFHKIPADS LQWHENLGHG SFTKIYRGCH 540
HEIVDGEARE TEVLLKVMDA KHKNCMESFL EAASLMSQVS YQHLVLLHGV CMAGDSIMVQ 600
EFVRLGALDT YLRKCGHLVP ASWKLQVIKQ LAYALNYLED KGLPHGNVSA RKVLLAREGT 660
DGNLPFIKLS DPGVSPTVLS LEMLTDRIPW VAPECLQEAR TLGLEADKWG FGATVWEVFS 720
GVTVPISTLE PAKKLQFYQE RQQLPAPKWM ELALLIQQCM AYEPGQRPSF RAVIRDLNSL 780
ITSADYELLS DPTPGTLAPR DGLWNGTQLY ACQDPTIFEE RHLKYISQLG KGNFGSVELC 840
RYDPLGDNTG ALVAVKQLQH SGPEQQRDFQ REIQILKALH SDFIVKYRGV SYGPGRQSLR 900
LVMEYLPSGC LRDFLQRHRA RLDAGRLLLY ASQICKGMEY LGSCRCLHRD LAARNILVES 960
ETHVKIADFG LAKLLPLDKE YYVVREPGQS PIFWYAPESL SDNIFSRQSD VWSFGVVLYE 1020
LFTYSDKNCS PSAEFLRMMG CERDVPALCR LLELLAEGQR LPAPPACPSE VHELMKLCWA 1080
PNPQDRPSFS ALGPQLDALW SGSRG 1105
Nucleotide Sequence
(FASTA)
ATGGCACCTC CAAGTGAGGA GACACCCCTG ATTTCTCAGC GCTCCTGCAG CCTCTCCTCT 60
TCAGAGGCTG GTGCCCTGCA TGTGCTGCTG CCCCCTCGGG GCCCTGGACC CCCACAGTGC 120
CTGTCCTTCT CCTTTGGGGA CCACTCAGCT GAAGACCTGT GTGTTTGCGC TGCTAAGGCC 180
AGTGGCATCC TGCCCGTGTA CCACTCCCTC TTTGCTCTGG CTTTGGAAGA CCTGTCCTGC 240
TGGTTCCCCC CAAGCCACAT CTTCTCCGTG GAGGACACGG GTACCCAGGT CCTCGTCTAC 300
AGGCTCCGCT TTTACTTCCC TAACTGGTTT GGACTAGAGA AGTGCCACCG ATTTGGGCTA 360
CGAAAGGACT TGACCAGCGC CATCTTGGAT CTGCCAGTCC TGGAGCACCT CTTTGCTCAG 420
CACCGCCATG ACCTGGTGAG CGGCCGCCTC CGGGTAGGCC TCAGCCTCAA GGAACAGGGT 480
GAGTGTCTCA GCTTGGCTGT TCTGGACCTG GCCCGGATGG CCCTCGAGCA GGCTCAGCGG 540
CCCGAGGAAT TGCTGAAGAC GGTCAGCTAC AAGGTCTGCC TGCCCCCTGG CCTACGCGAC 600
CTGATCCAGG GTTTGAGCTT CGTGACTCGG AGGCGCATCC GAAGGACAGT GTGCCGGGCC 660
TTGCGCGGGG TGGCGACCTG CCAGGCTGAC AGGCACTCGC TCATGGTCAA GTACATCATG 720
GACCTCGAGA GGCTGGATCC AGACAGGGCT GCCGAGACCT TCCGCGTGGG TCTCCCCGGC 780
GCTGCTGGTG GTCAGGATAC GCCGGGGCTG CTCCGTGTGG CTGGTGGCAG TGGCATCGCC 840
TGGAGCCCAG GAGAACACGA GGTCCTCCAG CCCTTCTGCG ACTTTCCAGA AATCGTGGAT 900
ATCAGCATCA AGCAGGCGCC GTGCATTGGC CCGGCTGCCG AGCACCGCCT GGTCACCATC 960
ACCAGGACAG ACAATCAGAT CCTGGAGGCC GAGTTCCCGG GGCTTCCCGC AGCGTTGTCC 1020
TTCGTGGCGC TCGTGGATGG CTACTTCCGG CTGACCACGG ACTCGAGGCA CTACTTCTGC 1080
AGGGAGGTGG CGCCGCCGCG GCTGCTGGAG GAGGTGGCTG AGCAGTGCCA TGGCCCTATC 1140
ACCCTGGATT TTGCCATCAA CAAACTCAAG ACTGGGGGCT CACTTCCCGG CTCCTACGTC 1200
CTCCGCCGCA GTCCCCAGGA TTTCGACAGC TACCTCCTAA CTGTTTGTGT CCTGACCCCC 1260
CTGGGGCCGG ATTATAAGGG CTGCCTCATC CGGTGCGACC CCACAGGAAC CTTCTCCCTG 1320
GCTGGCCTTG GCCGTTCCCA CAGCAGTCTT CGAGAGCTCC TGGCAGCCTG TTGGAATGGT 1380
GGGTTGCACG TGGATGGGGT TGAGCTGTAC CTCACCTTCT GCTGCAACCC CAGACCTAAA 1440
GAAAAGTCCA ATCTGATTGT GGTCCGGAGA GGCTGCAACC CACCCACATC ATCCCCTGTT 1500
CAGCCCCAAT TCCAGTGCCA GCTGAGTCAG ATGACGTTTC ACAAGATCCC TGCTGACAGC 1560
CTGCAGTGGC ATGAGAACCT AGGTCACGGG TCCTTCACCA AGATTTATCG GGGCTGTCAC 1620
CATGAGATTG TGGATGGGGA GGCCCGCGAG ACAGAGGTAC TGCTCAAAGT GATGGATGCC 1680
AAGCACAAGA ATTGCATGGA GTCATTCCTG GAAGCAGCGA GCTTGATGAG CCAAGTGTCA 1740
TACCAGCATC TCGTATTGCT CCACGGCGTG TGCATGGCTG GAGACAGTAT CATGGTTCAG 1800
GAATTTGTAC GCCTGGGAGC ACTGGACACA TATCTACGCA AGTGTGGCCA CCTAGTGCCA 1860
GCCAGCTGGA AGCTACAGGT GATCAAACAG CTGGCCTATG CCCTCAACTA TCTGGAAGAC 1920
AAAGGTCTCC CTCATGGCAA TGTCTCAGCC CGGAAGGTGC TCTTGGCTCG TGAGGGGACT 1980
GATGGGAACC TGCCTTTCAT CAAGCTGAGT GACCCGGGTG TCAGCCCCAC TGTGCTAAGC 2040
CTGGAGATGC TCACTGACAG GATCCCCTGG GTGGCCCCTG AATGTCTCCA GGAGGCCCGA 2100
ACACTTGGCT TGGAAGCTGA CAAGTGGGGC TTTGGAGCCA CAGTCTGGGA GGTGTTCAGT 2160
GGTGTCACAG TGCCCATCAG CACCCTGGAG CCTGCCAAGA AGCTCCAGTT TTACCAGGAA 2220
CGGCAGCAGT TGCCTGCCCC TAAGTGGATG GAGCTGGCCC TGCTGATCCA ACAGTGCATG 2280
GCCTATGAGC CAGGCCAGAG GCCCTCTTTC CGTGCTGTCA TCCGTGACCT GAACAGCCTC 2340
ATCACTTCAG CAGATTATGA GCTCCTCTCA GACCCCACAC CTGGCACCCT GGCACCCCGT 2400
GATGGGCTCT GGAATGGTAC CCAGCTCTAC GCCTGCCAGG ACCCTACCAT CTTTGAAGAG 2460
AGACACCTCA AATACATCTC ACAGCTGGGC AAGGGCAACT TTGGCAGCGT GGAACTGTGC 2520
CGCTACGACC CGCTGGGCGA CAACACAGGG GCCCTGGTGG CCGTGAAGCA GTTGCAGCAT 2580
AGTGGGCCAG AACAGCAGAG GGACTTCCAG CGGGAGATCC AGATCCTCAA AGCCCTCCAC 2640
AGTGACTTCA TTGTCAAGTA CCGGGGTGTC AGCTATGGCC CAGGCCGCCA GAGCCTGCGG 2700
TTGGTCATGG AGTATCTGCC CAGTGGCTGC CTGCGCGACT TCCTGCAGCG GCACCGCGCC 2760
CGCCTCGACG CTGGCCGCCT GCTCCTCTAC GCCTCACAGA TCTGCAAGGG CATGGAGTAC 2820
CTGGGCTCCT GCCGCTGCCT GCACCGCGAC CTGGCAGCCC GGAACATCCT GGTGGAAAGC 2880
GAGACGCACG TCAAGATCGC CGACTTCGGC CTCGCCAAGC TGCTGCCTCT CGACAAAGAG 2940
TACTACGTGG TCCGCGAGCC AGGCCAGAGC CCCATCTTCT GGTATGCCCC AGAGTCCCTC 3000
TCGGACAACA TCTTCTCGCG CCAGTCGGAT GTCTGGAGCT TCGGGGTCGT CCTGTACGAG 3060
CTCTTCACCT ACAGTGACAA GAACTGTAGC CCCTCAGCCG AGTTCCTGCG GATGATGGGA 3120
TGTGAGAGAG ATGTTCCAGC CCTCTGCCGC CTCCTGGAGC TGCTGGCTGA GGGCCAGAGG 3180
CTGCCCGCAC CTCCCGCCTG TCCTAGTGAG GTTCATGAGC TCATGAAGCT GTGCTGGGCC 3240
CCTAACCCTC AAGACCGGCC ATCATTCAGT GCCCTGGGCC CCCAGCTAGA TGCGCTGTGG 3300
AGTGGAAGCC GGGGATAG 3318
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg++++rdf+re++il++l+++
Q: 823   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPEQQRDFQREIQILKALHSD  882
         799*********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l++ +ll +a+q++k+meYL+
Q: 883   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLDAGRLLLYASQICKGMEYLG  942
         ************************************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         + ++ hrd+aarn+Lve+e +      vk++d+glak+++ d eYy+vre+++s+i+w+a
Q: 943   SCRCLHRDLAARNILVESETH------VKIADFGLAKLLPLDkEYYVVREPGQSPIFWYA  996
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225
         pe+ls++  +s++sdvWsFgv+lyel+t  +k++sp    lr++++e       r+lell
Q: 997   PESLSDNI-FSRQSDVWSFGVVLYELFTySDKNCSPsaefLRMMGCErdvpalcRLLELL  1055
         ********.*******************9999****************************
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265
          e++rlp+p+ cp+e++elm+ c++ +p++rpsF+a+  +l
Q: 1056  AEGQRLPAPPaCPSEVHELMKLCWAPNPQDRPSFSALGPQL  1096
         ***********************************998776
Domain Sequence
(FASTA)
LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PEQQRDFQRE IQILKALHSD 60
FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DAGRLLLYAS QICKGMEYLG 120
SCRCLHRDLA ARNILVESET HVKIADFGLA KLLPLDKEYY VVREPGQSPI FWYAPESLSD 180
NIFSRQSDVW SFGVVLYELF TYSDKNCSPS AEFLRMMGCE RDVPALCRLL ELLAEGQRLP 240
APPACPSEVH ELMKLCWAPN PQDRPSFSAL GPQL 274
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00027
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-ORA-00026
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
EKS-XET-00033
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013