EKS-BOT-00291

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00291

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	376.8	5.1E-113	780	1046	267

Status

Unreviewed

Ensembl Protein

ENSBTAP00000028226

UniProt Accession

A6QLW0;

Protein Name

Protein Synonyms/Alias

BUB1 protein;

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000021181	ENSBTAP00000028226	ENSBTAT00000028226

Organism

Bos taurus

Functional Description

Protein Length

1078

Protein Sequence
(FASTA)

MDNPENVFQM FEAHMQSYKG DDPLGEWESY MQWVEENFPE NKEYLTTLLE HLMKEFLDKK 60

RYHNDPRFIN YCLQFAKCNS DLHQFFEFLY NHGIGTQAAP LYVAWAGHLE AQGERQHANA 120

VFRRGIQNQA EPRELLQQQY RMFQTRLTET HLPTQVRTSE PLHDAQILNQ MVTSSSNPGS 180

NPACISKNQG PQLSGATPAA GDKGEQRVIT ISKSEYSAHP SVADKADVQQ VVMYCKEKLI 240

RGESEFSFEE LRAQKYNLRR KHEQWVNEER HYMKRKEANA LEEQLLKQKM DELHKKLHQV 300

VEMSQENLPS SQGTSEVSPA CLEPHTDSQQ ELRAPGLPAI SQQTSKNVDE KPREASSVPR 360

MANAATTALV SPAANQGVAC PAPLAGQHVT DAVFSGGSRD ARCVNKSTHE FRPQSGAELK 420

EGCETQKVVN TSSFHTTPNT SLGLVQATPS KAQPSPTVHT KEALGFIMNM FQAPTLPDIS 480

DDKEEWPSLS QNEFEAQFQK NAPSSGAWGV NKIISSLSSA FPVFEDGNKE NYGLPQLKNK 540

PAGARTFGER SVSRFPAKPN EVPHTDEFLD DSTVWGVRCN KSLAPSPKSP GDFRSAAQLA 600

STPFHRLPAD CVHPPEDKEN MVANQHTRVA LDSCERNKVE PLKERKCSPV EETSPDPVCP 660

ADGPSASLLH LGQPAVAVLM SEAEQGLKAC KVTDPDFATA EDPAEASAEL QAELMPAGPL 720

GNVDAPNFTV ENPWDEELIL KLLSGLSKPV SSYPNTYEWP CKLPAIKPKT EFQLGSLLVY 780

VDHFIGQGAF AQVYEVTHGD VNNSKNKEKF ALKVQKPPNL WEFYIGTQLM ERLKPSMQHM 840

FIKFYSAHLF QNGSVLVGDL YSYGTLLNAI NLYKNTPEKV MPQALVLAFA IRMLCMIQQV 900

HDCEIIHGDI KPDNFILGNR FLEQDNKDDD LSNGLVLIDL GQSIDMKLFP KGTAFTGKCE 960

TSGFQCIEML SNKPWNYQID YFGVAATIYC MLFGTYMKVK NEGGIWKPEG LFRRLPHLDM 1020

WNEFFHIMLN IPDCHHLPSL DLLRQKLKKT FQEHYTSKIK TLCNRLIVLL LEYKRSRK 1078

Nucleotide Sequence
(FASTA)

ATGGATAACC CGGAAAATGT TTTTCAAATG TTTGAAGCCC ATATGCAGAG CTACAAGGGC 60

GATGACCCAC TTGGTGAATG GGAAAGTTAC ATGCAATGGG TAGAAGAGAA TTTTCCTGAG 120

AATAAAGAAT ACTTAACAAC TTTATTAGAG CATCTAATGA AGGAATTTTT AGATAAGAAG 180

AGATATCACA ATGACCCAAG GTTCATCAAT TATTGTCTAC AATTTGCCAA GTGCAACAGT 240

GACCTTCACC AGTTTTTTGA GTTTCTGTAC AACCACGGTA TCGGAACCCA AGCAGCTCCT 300

CTGTACGTAG CCTGGGCCGG GCATCTGGAA GCCCAGGGGG AGCGGCAGCA CGCCAATGCC 360

GTTTTTCGGA GAGGAATTCA GAACCAGGCC GAACCTAGAG AGCTGCTGCA ACAACAGTAC 420

AGGATGTTTC AGACACGCCT CACTGAAACC CATTTGCCTA CTCAAGTAAG AACCTCAGAA 480

CCTCTGCATG ATGCTCAGAT TTTAAATCAA ATGGTAACAT CAAGCTCAAA TCCAGGAAGT 540

AACCCAGCCT GCATTTCTAA GAATCAGGGT CCACAACTTT CTGGAGCAAC ACCTGCAGCT 600

GGTGATAAAG GGGAACAAAG GGTGATCACG ATTTCCAAAT CAGAATATTC TGCACACCCG 660

TCTGTGGCAG ACAAAGCTGA TGTTCAGCAG GTTGTCATGT ATTGCAAGGA GAAGCTTATT 720

CGCGGAGAAT CGGAGTTTTC CTTTGAAGAG CTGAGAGCCC AGAAATACAA TCTACGGAGA 780

AAGCATGAAC AATGGGTAAA TGAAGAGAGG CATTATATGA AAAGGAAAGA AGCAAATGCT 840

TTGGAAGAAC AACTATTAAA ACAGAAAATG GATGAGCTTC ATAAGAAGTT GCACCAAGTG 900

GTGGAGATGT CGCAGGAGAA CCTGCCCTCT TCCCAGGGGA CATCTGAGGT CAGCCCAGCA 960

TGTTTGGAGC CGCATACAGA CTCCCAGCAG GAACTAAGAG CTCCGGGTCT TCCAGCCATC 1020

TCTCAGCAGA CCTCGAAGAA TGTGGACGAG AAACCCAGAG AGGCATCTTC TGTTCCTCGT 1080

ATGGCGAATG CTGCCACCAC TGCTTTGGTG TCCCCAGCCG CCAACCAGGG TGTAGCTTGC 1140

CCGGCTCCTT TGGCAGGCCA GCACGTGACA GATGCCGTGT TTTCAGGGGG CAGCAGAGAT 1200

GCCAGGTGTG TGAACAAAAG TACTCACGAA TTCAGGCCAC AGAGTGGAGC AGAGTTAAAA 1260

GAAGGGTGTG AAACACAGAA GGTTGTTAAC ACGAGTTCCT TTCACACAAC TCCAAACACA 1320

TCTCTGGGAC TGGTTCAGGC AACACCATCC AAAGCGCAGC CATCACCCAC TGTGCACACG 1380

AAGGAGGCTC TCGGTTTCAT CATGAATATG TTTCAGGCTC CTACACTTCC TGATATTTCT 1440

GATGACAAAG AGGAATGGCC ATCTCTAAGT CAAAATGAGT TCGAAGCCCA GTTTCAAAAA 1500

AATGCACCAT CTTCTGGGGC TTGGGGAGTC AATAAGATCA TCTCTTCTTT GTCATCTGCT 1560

TTTCCTGTAT TTGAAGATGG AAACAAAGAA AATTATGGAT TACCACAGCT GAAAAATAAA 1620

CCTGCAGGAG CCAGGACCTT TGGAGAACGT TCCGTGAGCA GGTTTCCTGC AAAACCAAAT 1680

GAAGTGCCTC ACACTGACGA GTTTCTGGAT GATTCAACCG TGTGGGGTGT CCGCTGCAAC 1740

AAAAGCCTGG CGCCCAGCCC CAAGAGCCCA GGAGACTTTA GGTCCGCCGC GCAGCTGGCG 1800

TCTACACCCT TCCACAGGCT TCCCGCGGAC TGCGTGCACC CACCAGAAGA TAAAGAAAAT 1860

ATGGTAGCAA ACCAGCACAC CCGTGTGGCT TTGGATTCTT GTGAAAGAAA CAAGGTGGAA 1920

CCCTTGAAAG AGAGAAAGTG CAGTCCAGTT GAAGAGACAA GCCCAGACCC AGTGTGCCCC 1980

GCAGATGGCC CTTCGGCATC CTTGCTCCAT CTGGGCCAAC CTGCTGTAGC CGTGCTGATG 2040

AGTGAGGCAG AGCAGGGTCT CAAGGCCTGT AAAGTCACAG ACCCCGACTT TGCCACTGCA 2100

GAGGATCCGG CAGAAGCCAG TGCTGAGCTC CAGGCTGAAC TGATGCCGGC TGGCCCGCTT 2160

GGGAATGTCG ACGCTCCAAA CTTCACTGTT GAGAACCCTT GGGATGAGGA GTTGATTCTC 2220

AAACTTTTAT CCGGGCTTTC TAAACCAGTG AGTTCCTATC CAAATACTTA TGAATGGCCA 2280

TGTAAGCTTC CAGCCATCAA GCCCAAGACT GAATTCCAAT TAGGTTCTTT GCTCGTCTAC 2340

GTTGATCACT TTATTGGACA AGGGGCTTTC GCCCAAGTCT ATGAAGTTAC CCATGGAGAT 2400

GTGAACAACA GCAAAAATAA GGAGAAATTT GCTTTGAAGG TCCAGAAGCC TCCCAACCTC 2460

TGGGAATTCT ACATTGGGAC CCAGCTGATG GAAAGACTAA AGCCAAGTAT GCAACACATG 2520

TTTATCAAAT TTTATTCAGC CCACCTGTTC CAGAATGGCA GCGTGTTAGT AGGAGACCTC 2580

TACAGTTATG GCACATTATT AAATGCCATT AATCTCTATA AAAATACCCC TGAAAAAGTG 2640

ATGCCTCAGG CACTAGTCCT CGCTTTTGCT ATCAGAATGC TCTGCATGAT CCAGCAAGTC 2700

CATGACTGTG AAATCATCCA CGGAGACATC AAGCCAGACA ATTTCATACT CGGAAACAGA 2760

TTTTTGGAAC AAGACAACAA AGATGATGAC TTATCTAACG GCTTGGTCCT GATTGACCTG 2820

GGTCAGAGTA TAGACATGAA ACTTTTTCCC AAAGGAACTG CATTTACAGG AAAGTGTGAA 2880

ACTTCTGGTT TCCAGTGTAT TGAGATGCTC AGTAACAAGC CATGGAACTA CCAGATTGAT 2940

TACTTTGGAG TTGCTGCAAC CATATACTGC ATGCTTTTTG GCACCTACAT GAAAGTGAAA 3000

AATGAAGGGG GCATCTGGAA GCCTGAAGGT CTTTTCAGAA GGCTTCCTCA CTTGGACATG 3060

TGGAATGAAT TTTTTCACAT AATGTTGAAT ATACCCGATT GTCATCATCT TCCATCTTTG 3120

GATTTGTTAA GGCAGAAGCT AAAGAAAACA TTTCAAGAAC ACTATACCAG CAAGATCAAG 3180

ACCCTGTGTA ACAGGCTAAT TGTACTGCTC TTAGAATATA AGCGTTCTCG GAAATAA 3237

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++ ig+Ga+a+vy+ +h    +sk++e++alKv+kp+n WefYI +ql+eRlk ++++

Q: 780   YVDHFIGQGAFAQVYEVTHgdvnNSKNKEKFALKVQKPPNLWEFYIGTQLMERLK-PSMQ  838

         799*****************999999*****************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+lfq++s+lv +++sygtll++in++k++ +kvm+++lv+ +++++l +++

Q: 839   HMFIKFYSAHLFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQALVLAFAIRMLCMIQ  898

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lgnr+ ++ + +d+ ++gl liD+g+siDmkl+p+gt+f+gk

Q: 899   QVHDCEIIHGDIKPDNFILGNRFLEQDNkDDDLSNGLVLIDLGQSIDMKLFPKGTAFTGK  958

         **************************9945566778************************

S: 177   aktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkk  236

         ++t++f+cieml++k+w+Yq+D+fg+aa+i+++lfg+y++v++egg wk++  ++rl++

Q: 959   CETSGFQCIEMLSNKPWNYQIDYFGVAATIYCMLFGTYMKVKNEGGIWKPEGLFRRLPHL  1018

         ************************************************************

S: 237   elwekiferlLNisdastlpsleelveek  265

         ++w+++f+ +LNi+d+++lpsl+ l++ k

Q: 1019  DMWNEFFHIMLNIPDCHHLPSLDLLRQ-K  1046

         *************************95.4

Domain Sequence
(FASTA)

YVDHFIGQGA FAQVYEVTHG DVNNSKNKEK FALKVQKPPN LWEFYIGTQL MERLKPSMQH 60

MFIKFYSAHL FQNGSVLVGD LYSYGTLLNA INLYKNTPEK VMPQALVLAF AIRMLCMIQQ 120

VHDCEIIHGD IKPDNFILGN RFLEQDNKDD DLSNGLVLID LGQSIDMKLF PKGTAFTGKC 180

ETSGFQCIEM LSNKPWNYQI DYFGVAATIY CMLFGTYMKV KNEGGIWKPE GLFRRLPHLD 240

MWNEFFHIML NIPDCHHLPS LDLLRQK 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

bta:514777

;

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013