EKS-BOT-00378
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00378
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK345.12.5E-10388361274
StatusUnreviewed
Ensembl ProteinENSBTAP00000028227
UniProt AccessionE1BFV2;
Protein Name
Protein Synonyms/Alias
Gene NameLOC616014
Gene Synonyms/Alias LOC616014;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000021183ENSBTAP00000028227ENSBTAT00000028227
OrganismBos taurus
Functional Description
Protein Length1050
Protein Sequence
(FASTA)
WAALYDYEAR GEDELSLRRG QLVEVLSQDA AVSGDEGWWA GQVQRRLGIF PANYVAPCRP 60
AAHRTPQPAR QPPPRPGSPV HVDFERLELK ELIGAGGFGQ VYRATWQGQE VAVKAARCDP 120
EQDAAAAAES VRREARLFSM LRHPNIIELR GVCLRQPHLC LVLEFARGGA LNRALAAANA 180
TPDPRAPSPR RARRIPPHVL VNWAVQIARG MLYLHEEAVV PILHRDLKSS NILLLEKIEH 240
DDICNKTLKI TDFGLAREWH RTTRMSAAGT YAWMAPEVIK SSLFSKGSDI WSYGVVLWEL 300
LTGEVPYRGI DGLAVAYGVA VNKLTLPIPS TCPEPFAKLM KECWQQDPHI RPSFASILEQ 360
LTEIEKAVMT EMPQESFHSM QDDWKLEIQQ MFDELRTKEK ELRSREEELT RAALQQKSQE 420
ELLRRREQQL AAREIDVLER ELNILIFQLN QEKPNVKKRK GKFKRSRLKL RDGHRISLPS 480
DFQHKITVQA SPNLDKRRSL NSSSSSPPSS PTVIPRLRAI QLTSDESNKT WGRNTVCRQE 540
EFEDIKRNFK KKGCTWGPNS IQMKERTDGR ESSLKHRMCS PHRIQMCSLY YLKILIRPLS 600
DGNSPWSTIA PHCLLGICNS DSLPENSSLL CACEEPKLAP DGLEHRKPKQ IKSPTQAYID 660
LPLWKDGQRE NPVEPESREE GTPVSPAADT PQGTPPNSLS RSPQRKKTES ALYGCTMLLA 720
SVALGLDIRE LTKAQAPEDP LPKEDRKKRE GIFQRAPKSR RSASPAARLL AVGEGASSTP 780
SPPPSTIANL LSVPSLSTKC LLQTDGEDSF ESSTHISCAP RVPTPDPCPA FGGRGQKSTP 840
MPGLETSRDG WRNPPPSFME LTRGGVSYAA ASKERAASHR RTMSDGSAPQ PPDASFSMSL 900
SNHTLSLPVG AALISAPGAS ELPSEWVWGM PPSLSGPHSD LPSEVPPEKQ RAVHMVPLPH 960
PPPLRSRGGA LQAFPPRAES QPSQAGPAVG GPGPAHSCPL GPKKRTQPHM PSLLDSDVEG 1020
QSRDRTVPLC RMRSRASRPS LYELEKEFLS 1050
Nucleotide Sequence
(FASTA)
TGGGCCGCGC TCTACGACTA CGAGGCGCGC GGCGAGGACG AGCTGAGCCT GCGCCGCGGC 60
CAGCTGGTGG AGGTGCTGTC CCAGGACGCT GCCGTGTCGG GCGACGAGGG CTGGTGGGCC 120
GGCCAGGTGC AGCGACGCCT CGGCATCTTC CCCGCCAACT ACGTGGCGCC GTGCCGCCCG 180
GCCGCCCACC GCACGCCGCA GCCCGCCAGA CAGCCGCCGC CGCGACCCGG CTCGCCCGTG 240
CACGTCGACT TCGAGCGGCT GGAACTAAAG GAGCTCATCG GCGCCGGCGG TTTCGGGCAG 300
GTGTACCGCG CCACCTGGCA GGGCCAGGAG GTGGCGGTGA AGGCGGCGCG CTGCGACCCG 360
GAGCAGGACG CGGCGGCGGC GGCCGAGAGC GTTCGGCGGG AGGCCCGGCT CTTCTCCATG 420
CTGCGGCACC CCAACATCAT CGAGCTGCGC GGCGTGTGCC TGCGGCAGCC GCACCTCTGC 480
CTGGTGCTCG AGTTTGCCCG CGGCGGAGCG CTCAACCGCG CGCTAGCCGC CGCCAATGCG 540
ACCCCGGACC CCCGCGCGCC CTCCCCGCGC CGCGCGCGCC GCATCCCCCC GCACGTGCTG 600
GTCAACTGGG CTGTGCAGAT CGCGCGGGGC ATGCTCTACC TGCACGAGGA GGCGGTGGTG 660
CCCATCCTTC ACCGGGACCT CAAGTCCAGC AACATTTTGC TACTCGAGAA GATAGAGCAT 720
GATGACATCT GCAACAAGAC ACTGAAGATT ACAGACTTCG GCTTGGCGAG AGAATGGCAC 780
AGGACTACCA GGATGAGCGC AGCGGGCACG TACGCCTGGA TGGCCCCGGA AGTTATCAAG 840
TCTTCTTTGT TTTCCAAGGG AAGTGACATC TGGAGCTACG GAGTGGTGCT GTGGGAGCTG 900
CTCACGGGAG AAGTGCCCTA CCGTGGCATT GATGGCTTGG CTGTGGCCTA CGGGGTGGCA 960
GTCAACAAGC TCACTCTGCC CATCCCCTCC ACCTGCCCTG AGCCATTTGC CAAGCTCATG 1020
AAAGAATGCT GGCAACAAGA CCCTCACATT CGACCATCTT TTGCTTCAAT TCTTGAACAA 1080
CTGACTGAAA TTGAAAAGGC AGTTATGACT GAAATGCCTC AAGAGTCCTT TCATTCCATG 1140
CAAGATGACT GGAAACTGGA AATTCAGCAA ATGTTTGATG AGTTGAGAAC AAAGGAAAAG 1200
GAGCTGCGCT CCCGGGAGGA GGAGCTGACG CGGGCCGCCC TGCAGCAAAA GTCGCAGGAG 1260
GAGCTGCTCC GGAGGCGGGA GCAGCAGCTG GCCGCGCGGG AGATCGACGT GCTGGAGCGA 1320
GAGCTCAACA TCCTCATCTT CCAGCTGAAT CAGGAGAAGC CCAACGTCAA GAAGAGGAAG 1380
GGCAAGTTTA AGAGGAGCCG CCTGAAGCTC AGAGACGGCC ATCGCATCAG TTTACCTTCA 1440
GACTTCCAGC ACAAAATAAC CGTACAGGCC TCCCCCAACT TGGACAAACG AAGAAGTCTG 1500
AACAGCAGCA GCTCCAGCCC ACCCAGCAGC CCCACAGTGA TCCCCCGACT CCGAGCAATA 1560
CAGTTGACCT CAGATGAAAG CAATAAAACT TGGGGCAGAA ACACCGTCTG TCGACAAGAA 1620
GAATTTGAAG ATATAAAAAG GAACTTCAAG AAAAAGGGTT GTACCTGGGG TCCAAATTCG 1680
ATTCAAATGA AAGAAAGAAC TGATGGCAGA GAAAGCTCTT TAAAACACAG AATGTGTTCT 1740
CCACACAGAA TCCAAATGTG TTCTCTTTAC TACCTAAAAA TCTTAATAAG ACCTCTCTCA 1800
GATGGCAACA GTCCTTGGTC AACCATAGCT CCACATTGTT TATTAGGAAT TTGTAACTCC 1860
GATTCTTTAC CAGAAAATTC ATCACTCTTA TGTGCTTGTG AAGAGCCAAA ACTTGCCCCT 1920
GATGGATTGG AACACAGAAA ACCAAAGCAG ATAAAATCAC CAACTCAGGC CTACATCGAT 1980
CTACCTCTTT GGAAAGATGG CCAGAGAGAG AACCCGGTGG AACCCGAAAG CCGGGAGGAG 2040
GGAACCCCAG TGAGCCCTGC TGCTGACACT CCTCAGGGGA CCCCTCCAAA CAGTCTGAGC 2100
AGATCCCCCC AGAGAAAGAA AACGGAGTCT GCTCTGTACG GCTGTACCAT GCTGCTGGCA 2160
TCGGTGGCTC TGGGCTTGGA CATAAGAGAG CTCACGAAAG CACAGGCTCC CGAAGACCCA 2220
TTGCCCAAGG AAGACAGGAA GAAACGAGAA GGCATCTTCC AGCGGGCACC TAAGTCTCGC 2280
CGCAGTGCCA GCCCTGCCGC AAGGCTGCTG GCTGTGGGCG AGGGAGCCAG CAGCACCCCC 2340
TCACCCCCAC CGTCCACCAT TGCAAACCTC CTGTCCGTGC CTTCCCTCTC CACCAAGTGC 2400
CTGCTGCAGA CCGACGGTGA AGACTCCTTC GAGAGCAGCA CACACATCTC TTGTGCCCCT 2460
CGGGTGCCCA CTCCAGATCC TTGCCCTGCG TTTGGAGGGA GGGGCCAGAA GTCAACCCCC 2520
ATGCCAGGAC TGGAGACCAG CCGTGATGGG TGGAGAAACC CGCCTCCTTC CTTCATGGAG 2580
CTGACACGTG GGGGCGTTTC TTACGCTGCT GCTTCCAAAG AGAGAGCAGC AAGTCACCGA 2640
AGGACCATGT CTGATGGAAG TGCTCCCCAG CCCCCAGATG CATCGTTTTC AATGTCTCTG 2700
TCTAATCACA CCCTCTCTTT GCCCGTTGGT GCAGCTCTCA TCTCAGCCCC CGGAGCCTCT 2760
GAACTGCCCT CTGAGTGGGT TTGGGGGATG CCCCCCTCCC TGTCTGGACC TCACAGTGAC 2820
CTGCCAAGTG AGGTCCCGCC TGAAAAACAA AGAGCTGTCC ATATGGTGCC TCTGCCTCAC 2880
CCTCCGCCCC TAAGAAGCCG AGGAGGTGCC CTGCAAGCCT TCCCGCCGAG AGCAGAGTCT 2940
CAGCCCTCAC AGGCTGGCCC TGCAGTGGGT GGTCCAGGAC CAGCCCACAG CTGTCCTCTC 3000
GGCCCCAAGA AGAGAACTCA GCCCCACATG CCTTCCTTAC TGGACTCCGA CGTGGAAGGC 3060
CAGAGCCGGG ACCGCACGGT GCCTCTGTGC AGGATGAGGA GCAGAGCGAG CCGACCATCT 3120
CTGTATGAAC TCGAGAAAGA ATTTCTGTCT TAA 3153
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         el+elig+g fg+vy+a+w+++evavK++r + e+  ++++e+++rea+l+s+l+hpnii
Q: 88    ELKELIGAGGFGQVYRATWQGQEVAVKAARCDPEQdaAAAAESVRREARLFSMLRHPNII  147
         689*****************************999878899*******************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhe............kskreidlevlvswalqi  107
         el+Gvcl++p+l+lv+e+++gg+L+++l++            ++ r+i+++vlv+wa+qi
Q: 148   ELRGVCLRQPHLCLVLEFARGGALNRALAAanatpdprapspRRARRIPPHVLVNWAVQI  207
         *****************************99**********99*****************
S: 108   ArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsa  160
         ArGm YLh+ea+++i+hrdLks+n+Ll       +  +ktlki+dFG are++++t+msa
Q: 208   ARGMLYLHEEAVVPILHRDLKSSNILLlekiehdDICNKTLKITDFGLAREWHRTTRMSA  267
         *******************************999999***********************
S: 161   agtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlp  220
         agt+awmaPEv+k++ +s+ sD+wSygvvLWellt+evPy++++ la+ay+va+++l+lp
Q: 268   AGTYAWMAPEVIKSSLFSKGSDIWSYGVVLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP  327
         ************************************************************
S: 221   ipsscpeklkkLmkecwnedpekRpsfseivksl  254
         ips+cpe+++kLmkecw++dp+ Rpsf++i+++l
Q: 328   IPSTCPEPFAKLMKECWQQDPHIRPSFASILEQL  361
         ******************************9986
Domain Sequence
(FASTA)
ELKELIGAGG FGQVYRATWQ GQEVAVKAAR CDPEQDAAAA AESVRREARL FSMLRHPNII 60
ELRGVCLRQP HLCLVLEFAR GGALNRALAA ANATPDPRAP SPRRARRIPP HVLVNWAVQI 120
ARGMLYLHEE AVVPILHRDL KSSNILLLEK IEHDDICNKT LKITDFGLAR EWHRTTRMSA 180
AGTYAWMAPE VIKSSLFSKG SDIWSYGVVL WELLTGEVPY RGIDGLAVAY GVAVNKLTLP 240
IPSTCPEPFA KLMKECWQQD PHIRPSFASI LEQL 274
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00353
EKS-ANC-00364
EKS-CAJ-00380
EKS-CAF-00378
EKS-CHH-00044
EKS-CII-00213
EKS-DAR-00756
EKS-EQC-00376
EKS-FEC-00372
EKS-GAM-00227
EKS-GAG-00324
EKS-GAA-00459
EKS-GOG-00368
EKS-LOA-00393
EKS-MAM-00377
EKS-MAE-00045
EKS-MEG-00317
EKS-MIM-00054
EKS-MOD-00367
EKS-MUM-00410
EKS-MUP-00377
EKS-NOL-00350
EKS-ORN-00484
EKS-ORC-00354
EKS-OTG-00381
EKS-PAT-00358
EKS-PES-00340
EKS-POA-00375
EKS-RAN-00392
EKS-SAH-00346
EKS-SOA-00062
EKS-SUS-00330
EKS-TAG-00454
EKS-TAR-00481
EKS-TEN-00489
EKS-XIM-00475
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013