| Tag | Content |
|---|
| EKPD ID | EKS-BOT-00146 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Csk | 472.4 | 2.7E-142 | 195 | 440 | 246 |
|
| Status | Reviewed |
| Ensembl Protein | ENSBTAP00000028559 |
| UniProt Accession | Q0VBZ0; |
| Protein Name | Tyrosine-protein kinase CSK |
| Protein Synonyms/Alias | C-Src kinase; |
| Gene Name | CSK |
| Gene Synonyms/Alias | CSK; |
| Ensembl Information | |
| Organism | Bos taurus |
| Functional Description | Non-receptor tyrosine-protein kinase that plays animportant role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). |
| Protein Length | 450 |
Protein Sequence
(FASTA) | | MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60 | | PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLCPPE TGLFLVREST NYPGDYTLCV 120 | | SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 180 | | DEFFRSGWAL NMKDLKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240 | | TQLRHSNLVQ LLGVIVEEKS GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300 | | AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360 | | KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420 | | NCWHLDAATR PSFLQLREQL ERIKTHELHL 450 |
|
Nucleotide Sequence
(FASTA) | | ATGTCAGCAA TTCAGGCTGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTT 60 | | CACGGCACTG CTGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 120 | | GTCACCAAGG ACCCCAATTG GTACAAAGCC AAGAACAAGG TGGGCCGTGA GGGCATCATC 180 | | CCAGCCAACT ATGTCCAGAA GCGGGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTCATG 240 | | CCCTGGTTCC ATGGCAAGAT CACGCGGGAA CAGGCAGAGC GGCTCCTGTG CCCACCGGAG 300 | | ACAGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC GCTGTGCGTG 360 | | AGCTGTGATG GCAAGGTGGA GCATTACCGC ATCATGTACC ACGCCAGCAA GCTCAGCATC 420 | | GATGAAGAGG TGTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CTCAGATGCA 480 | | GATGGCCTCT GTACTCGCCT CATCAAGCCA AAGGTCATGG AGGGCACCGT GGCCGCCCAG 540 | | GATGAGTTCT TCCGCAGTGG CTGGGCGCTG AACATGAAGG ACCTGAAGCT GCTGCAGACC 600 | | ATAGGGAAGG GGGAGTTTGG AGACGTGATG CTGGGTGACT ACCGAGGGAA CAAAGTCGCT 660 | | GTCAAGTGCA TTAAGAACGA TGCCACTGCA CAGGCCTTCC TGGCTGAAGC CTCCGTCATG 720 | | ACGCAACTCC GGCATAGCAA CCTGGTACAG CTTCTGGGCG TGATCGTAGA GGAGAAGAGC 780 | | GGGCTGTACA TCGTTACCGA GTACATGGCC AAGGGGAGTC TAGTGGACTA CCTGCGGTCT 840 | | CGGGGTCGGT CGGTGCTTGG CGGAGACTGT CTCCTCAAGT TCTCACTAGA CGTCTGTGAG 900 | | GCCATGGAAT ACCTGGAGGG CAACAACTTC GTGCATCGGG ATCTGGCTGC CCGCAACGTG 960 | | CTGGTGTCTG AGGACAATGT GGCCAAGGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 1020 | | AGCACCCAGG ACACGGGCAA GCTGCCGGTC AAGTGGACAG CCCCCGAGGC CCTAAGAGAG 1080 | | AAGAAATTCT CCACCAAGTC TGATGTGTGG AGTTTCGGGA TCCTTCTCTG GGAAATCTAC 1140 | | TCTTTCGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC GCGGGTGGAG 1200 | | AAGGGCTACA AGATGGATGC CCCCGACGGC TGCCCACCTG CAGTCTACGA GGTCATGAAG 1260 | | AACTGCTGGC ACCTGGATGC CGCCACGCGG CCCTCCTTCC TGCAGCTCCG CGAGCAGCTC 1320 | | GAGCGCATCA AGACCCACGA GCTGCACCTG TGA 1353 |
|
| Domain Profile | S: 1 lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv 60 | lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv | Q: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 | 6899******************************************************** |
| S: 61 ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd 119 | i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd | Q: 255 IVEEKsGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 | ****999***************************************************** |
| S: 120 laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi 179 | laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi | Q: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI 374 | ************************************************************ |
| S: 180 llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa 239 | llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf | Q: 375 LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFL 434 | ************************************************************ |
| S: 240 klkekl 245 | +l+e+l | Q: 435 QLREQL 440 | ***997 |
|
Domain Sequence
(FASTA) | | LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60 | | IVEEKSGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120 | | LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180 | | LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAATRPSFL 240 | | QLREQL 246 |
|
| Keyword | Adaptive immunity; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |