EKS-BOT-00247
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00247
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL314.54.8E-9411263253
StatusUnreviewed
Ensembl ProteinENSBTAP00000028900
UniProt AccessionA9Q1J5; F1MWZ7;
Protein Name
Protein Synonyms/Alias Maternal embryonic leucine zipper kinase;
Gene NameMELK
Gene Synonyms/Alias MELK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000021686ENSBTAP00000028900ENSBTAT00000028900
OrganismBos taurus
Functional Description
Protein Length650
Protein Sequence
(FASTA)
MKDYDELLKY YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIDA 60
LKNLRHQHIC QLYHVIETAN KIFMVLEYCP GGELFDYIIS HDRLSEEETR IVFRQIVSAV 120
AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180
QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMKGQYDVPK WLSPSSVLLL 240
QQMLQVDPKK RIAMRNLLNH PWIMHDYNCP VEWQSNAPLI HLDEDCVTEL SVHHRNNRQT 300
MEDLISLWQY DHLTATYLLL LAKKARGRPV RLRLLSSYGQ ASSTPVTNIK SKNLSLEDMI 360
TSDENYVTGL MSYEWCEDIS SRGVATPQTP QVAKHWTESN DLESTSLTPV LCRASANKLK 420
NKENVYTPKS AVKNEECFVF PEPKTPVNKN QYKREILTTP NHYSTPSKAG NQFLKETPIK 480
MPVNSTGTEK LLTGVISPER RCRSVELNLN QVHVEETPKR KGTKVFGSLE KGLDKVITVL 540
TRSKRKGSVK DGPRRLKPHY NVTTTRLVNP DQLLNEIMSV LPKKHVDFVQ KGYTLKCQTQ 600
SDFGKVTMQF ELEVCQLQKP DVVGIRRQRL KGDAWVYKRL VEDILSSCKV 650
Nucleotide Sequence
(FASTA)
ATGAAAGATT ATGATGAACT TCTCAAATAC TATGAATTAT ATGAAACTAT TGGGACAGGT 60
GGCTTTGCAA AGGTCAAACT TGCCTGCCAT ATCCTCACTG GAGAAATGGT AGCTATAAAA 120
ATCATGGATA AAAATGCACT AGGGAGTGAT TTGCCTCGGG TCAAAACAGA AATTGATGCC 180
TTGAAGAACC TGAGACATCA ACATATATGT CAACTCTACC ATGTGATAGA GACAGCCAAC 240
AAAATATTCA TGGTTCTCGA GTATTGCCCT GGAGGAGAGC TGTTTGACTA CATAATTTCC 300
CACGATCGCC TGTCAGAGGA GGAGACCCGC ATTGTCTTCC GTCAGATAGT GTCTGCAGTT 360
GCTTATGTGC ACAGCCAGGG CTACGCTCAC AGGGACCTCA AACCAGAAAA TTTGTTGTTT 420
GATGAATATC ATAAATTAAA GCTGATTGAC TTTGGTCTCT GTGCAAAACC CAAGGGTAAC 480
AAGGATTATC ACCTGCAGAC CTGCTGTGGG AGTCTTGCTT ATGCAGCACC TGAATTAATT 540
CAAGGCAAAT CATATCTGGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT ACTCTTATAT 600
GTACTTATGT GTGGCTTTCT ACCATTTGAT GACGATAATG TCATGGCTTT GTACAAAAAG 660
ATTATGAAAG GGCAATATGA CGTTCCAAAG TGGCTGTCTC CCAGTAGCGT TCTACTTCTT 720
CAGCAAATGC TACAGGTGGA CCCAAAGAAA CGGATTGCTA TGAGAAATCT CTTGAACCAC 780
CCCTGGATCA TGCACGATTA CAACTGTCCT GTTGAGTGGC AAAGCAATGC TCCTCTTATT 840
CACCTTGATG AAGATTGTGT AACGGAACTT TCTGTACATC ACAGAAATAA CAGGCAAACT 900
ATGGAGGATT TAATTTCACT GTGGCAGTAT GATCACCTCA CAGCTACTTA CCTTCTGCTC 960
CTAGCCAAGA AGGCTCGGGG GAGACCGGTT CGTTTAAGGC TTCTTTCTTC CTATGGACAG 1020
GCCAGCTCAA CGCCAGTCAC AAACATAAAG TCGAAGAATC TGAGTCTAGA AGATATGATC 1080
ACAAGTGATG AAAATTATGT GACTGGATTA ATGAGCTATG AATGGTGTGA AGACATTTCA 1140
TCAAGAGGTG TGGCTACTCC ACAAACACCA CAGGTTGCCA AGCATTGGAC AGAATCAAAT 1200
GACCTGGAAT CTACATCATT AACTCCAGTA TTATGCAGGG CATCTGCCAA TAAATTAAAG 1260
AACAAAGAAA ATGTATATAC TCCTAAGTCT GCTGTAAAGA ATGAAGAGTG CTTTGTATTT 1320
CCTGAGCCAA AGACTCCAGT TAATAAGAAC CAGTATAAAA GAGAAATACT CACTACACCA 1380
AATCATTACA GTACACCCTC AAAAGCTGGA AACCAGTTCC TGAAAGAAAC CCCAATTAAA 1440
ATGCCGGTAA ATTCAACAGG AACAGAGAAG TTACTAACAG GAGTCATTAG CCCTGAGAGG 1500
CGGTGTCGCT CAGTAGAACT CAATCTCAAC CAAGTACATG TAGAGGAAAC TCCAAAAAGA 1560
AAAGGAACCA AAGTGTTTGG GAGCCTTGAG AAGGGGTTGG ATAAGGTTAT CACAGTGCTT 1620
ACCAGGAGCA AAAGGAAAGG CTCTGTCAAA GATGGGCCAA GAAGACTAAA GCCTCACTAT 1680
AATGTGACTA CAACCAGATT AGTGAATCCA GATCAACTCT TGAATGAAAT AATGTCTGTT 1740
CTTCCAAAGA AGCACGTTGA CTTTGTACAG AAGGGCTATA CACTGAAGTG TCAGACACAG 1800
TCAGATTTTG GCAAAGTGAC AATGCAGTTT GAACTAGAAG TGTGCCAGCT TCAAAAACCC 1860
GATGTGGTGG GTATCAGGAG GCAGCGGCTT AAGGGTGATG CCTGGGTTTA CAAGAGATTA 1920
GTGGAAGACA TCCTATCTAG CTGCAAGGTT TAA 1953
Domain Profile
S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60
         y+l +t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l ++k+Ei++lk+l+h++i
Q: 11    YELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS-DLPRVKTEIDALKNLRHQHI  69
         999*******************************88875.589*****************
S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120
         ++l++viet +k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+vsav Y+hs+g +
Q: 70    CQLYHVIETANKIFMVLEYCPGGELFDYIISHDRLSEEETRIVFRQIVSAVAYVHSQGYA  129
         ************************************************************
S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178
         HrDlKpeNll+d+ +++k++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++
Q: 130   HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNkdYHLQTCCGSLAYAAPELIQGKSYLGSE  189
         *************************9665443389*************************
S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238
         +DvWs+G++Ly+l++g lPfd++n+ +l++ki+kg++++pk+ls++   Ll+++L+vdp+
Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMKGQYDVPKWLSPSSVLLLQQMLQVDPK  249
         ************************************************************
S: 239   kRatieeilkhewl  252
         kR+ ++++l+h+w+
Q: 250   KRIAMRNLLNHPWI  263
         *************7
Domain Sequence
(FASTA)
YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIDA LKNLRHQHIC 60
QLYHVIETAN KIFMVLEYCP GGELFDYIIS HDRLSEEETR IVFRQIVSAV AYVHSQGYAH 120
RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180
DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMKGQYDVPK WLSPSSVLLL QQMLQVDPKK 240
RIAMRNLLNH PWI 253
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00232
EKS-ANC-00242
EKS-CAE-00220
EKS-CAJ-00256
EKS-CAF-00258
EKS-CAP-00276
EKS-CII-00148
EKS-CIS-00025
EKS-DAR-00571
EKS-EQC-00244
EKS-FEC-00234
EKS-GAG-00208
EKS-GAA-00309
EKS-GOG-00250
EKS-HOS-00261
EKS-ICT-00236
EKS-LAC-00262
EKS-MAM-00250
EKS-MEG-00190
EKS-MOD-00249
EKS-MUM-00259
EKS-MUP-00255
EKS-MYL-00249
EKS-NOL-00231
EKS-ORN-00325
EKS-ORA-00215
EKS-ORC-00223
EKS-ORL-00312
EKS-OTG-00257
EKS-PAT-00239
EKS-PES-00221
EKS-PEM-00133
EKS-POA-00246
EKS-PTV-00021
EKS-RAN-00248
EKS-SAH-00236
EKS-SUS-00214
EKS-TAG-00265
EKS-TAR-00318
EKS-TAS-00013
EKS-TEN-00311
EKS-XET-00329
EKS-XIM-00316
Gene Ontology
GO:0005938; C:cell cortex
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005509; F:calcium ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0006915; P:apoptotic process
GO:0061351; P:neural precursor cell proliferation
GO:0043065; P:positive regulation of apoptotic process
GO:0046777; P:protein autophosphorylation
KEGG
bta:520088;
InterPros
IPR001772; Kinase-assoc_KA1.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02149; KA1; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50032; KA1; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013