EKS-BOT-00161
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00161
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.31.5E-148415672258
StatusUnreviewed
Ensembl ProteinENSBTAP00000053410
UniProt AccessionF1MNR5;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000021741ENSBTAP00000053410ENSBTAT00000061538
OrganismBos taurus
Functional Description
Protein Length733
Protein Sequence
(FASTA)
MELSMKKFTV RRFFSVYLRK KSRSKSSSLS RLEEEGIVKE IDISHHVKAG FEKADPSQFE 60
LLKVLGQGSY GKVFLVRKVK GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF 120
IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHGLGI 180
IYRDLKPENI LLDEEGHIKI TDFGLSKEAI DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA 240
DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSVEAQSLL RALFKRNPCN 300
RLGAGLDGVE EIKRHPFFVT IDWNKLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS 360
PGVPPSANAH HLFRGFSFVA SSLVQEPSQQ DLHKATVHPI VQQLHGNNIH FTDGYEIKED 420
IGVGSYSVCK RCVHKATDTE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK 480
FVYLVTELMR GGELLDRILR QRYFSEREAS AVLCTITKTM DYLHSQGVVH RDLKPSNILY 540
VDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP EVLKRQGYDA ACDIWSLGIL 600
LYTMLAGFTP FANGPDDTPE DILARIGSGK YALSGGNWDS ISDAAKDVVS KMLHVDPHQR 660
LTAVQVLKHP WIVNREHLSP NQLSRQDVHL VKGAMAATYF ALNRAPQAPR LEPVLSSNLA 720
QRRGMKRLTS TRL 733
Nucleotide Sequence
(FASTA)
ATGGAGCTGA GCATGAAGAA GTTCACGGTG CGCAGGTTCT TCTCCGTGTA CCTGCGCAAG 60
AAGTCGCGCT CCAAGAGCTC CAGTCTTAGC CGACTCGAGG AAGAGGGCAT TGTGAAGGAG 120
ATTGACATCA GTCACCATGT CAAAGCGGGC TTTGAGAAGG CCGACCCTTC CCAGTTTGAA 180
CTGTTGAAAG TTTTGGGACA AGGCTCCTAC GGGAAGGTGT TCTTGGTGAG GAAGGTCAAG 240
GGGTCAGATG CTGGACAGCT CTACGCAATG AAGGTTCTTA AGAAGGCCAC CTTGAAAGTT 300
CGGGACCGAG TCAGGTCAAA GATGGAGAGA GACATCCTGG CAGAAGTGAA TCACCCTTTC 360
ATCGTAAAGC TTCATTATGC CTTCCAGACG GAGGGGAAAC TCTACCTGAT TCTGGACTTC 420
CTGCGCGGAG GGGACCTCTT CACCCGGCTC TCCAAAGAGG TGATGTTCAC GGAGGAGGAC 480
GTCAAGTTCT ACCTGGCGGA GCTGGCCCTG GCCTTGGACC ACCTGCACGG CCTGGGCATC 540
ATCTACAGAG ACCTGAAGCC AGAGAACATC CTCCTGGACG AAGAGGGGCA TATTAAGATC 600
ACAGATTTCG GGCTGAGTAA AGAGGCCATC GACCACGACA AGAGAGCCTA CTCCTTCTGC 660
GGGACGATCG AGTACATGGC GCCTGAGGTG GTGAACCGGA GGGGCCACAC GCAGAGTGCG 720
GACTGGTGGT CCTTCGGCGT GCTCATGTTC GAGATGCTCA CGGGGTCACT GCCGTTCCAG 780
GGGAAGGACA GGAAGGAGAC CATGGCCCTC ATCCTCAAAG CCAAGCTAGG CATGCCGCAG 840
TTCCTCAGCG TGGAGGCCCA GAGTCTGCTG AGAGCGCTCT TCAAACGGAA CCCCTGCAAC 900
CGGCTGGGTG CCGGGCTGGA CGGCGTGGAG GAGATCAAGC GCCACCCTTT CTTCGTCACC 960
ATCGACTGGA ACAAGCTGTA CAGGAAGGAG ATCAAGCCGC CCTTCAAGCC AGCGGTGGGC 1020
AGGCCGGAGG ACACCTTCCA CTTCGACCCT GAGTTCACAG CGAGGACGCC TACAGACTCG 1080
CCCGGCGTAC CCCCCAGCGC CAACGCCCAT CATCTGTTTA GAGGATTCAG TTTCGTGGCC 1140
TCCAGCCTGG TCCAGGAGCC CTCGCAGCAA GATCTGCACA AAGCCACGGT TCACCCCATC 1200
GTGCAGCAGC TTCACGGGAA CAATATCCAC TTCACTGACG GCTACGAGAT CAAGGAGGAC 1260
ATCGGGGTGG GTTCCTACTC CGTGTGCAAG CGCTGCGTGC ACAAAGCCAC AGACACTGAG 1320
TACGCCGTGA AGATCATCGA CAAGAGTAAA AGGGACCCCT CGGAGGAGAT CGAGATTCTC 1380
CTGCGGTACG GCCAGCACCC CAACATCATC ACCCTCAAAG ACGTCTACGA CGACGGGAAG 1440
TTTGTGTACC TGGTGACGGA GCTGATGCGC GGCGGCGAGC TGCTGGACCG CATCCTGCGG 1500
CAGCGGTACT TCTCGGAGCG GGAGGCCAGC GCAGTGCTGT GCACCATCAC CAAGACCATG 1560
GACTACCTGC ACTCGCAGGG AGTTGTTCAC CGGGACCTAA AGCCGAGCAA TATCCTGTAT 1620
GTGGACGAGT CTGGAAACCC TGAATCCATC CGCATCTGTG ACTTCGGGTT TGCCAAGCAG 1680
CTGCGAGCCG AGAACGGGTT GCTTATGACC CCCTGCTACA CGGCCAACTT CGTGGCCCCG 1740
GAGGTCCTGA AGCGGCAGGG CTATGACGCG GCGTGTGACA TCTGGAGCCT GGGGATCCTG 1800
CTCTACACCA TGTTGGCGGG ATTCACCCCT TTTGCAAACG GGCCGGATGA CACCCCTGAG 1860
GACATCTTGG CAAGGATCGG CAGCGGAAAG TACGCCCTTT CCGGGGGGAA CTGGGACTCC 1920
ATCTCTGACG CGGCCAAGGA CGTCGTGTCC AAGATGCTCC ACGTGGACCC TCACCAGCGC 1980
CTGACGGCAG TTCAGGTCCT CAAACACCCT TGGATCGTCA ACAGGGAGCA CCTGTCCCCA 2040
AACCAGCTCA GCAGACAGGA CGTCCACCTG GTGAAGGGAG CCATGGCCGC CACCTACTTC 2100
GCTCTCAACA GAGCCCCTCA GGCCCCGCGG CTGGAGCCCG TGCTGTCGTC CAACCTGGCC 2160
CAGCGCCGGG GCATGAAGAG ACTCACGTCC ACGCGGCTGT AG 2202
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat++e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 415   YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  474
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereasa+l+t++k+++ylh+qGvvhrdlk
Q: 475   VYDDGKFVYLVTELMRGGELLDRILRQRYFSEREASAVLCTITKTMDYLHSQGVVHRDLK  534
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 535   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  594
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+e+ila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 595   WSLGILLYTMLAGFTPFANGPDDTPEDILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  654
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 655   VDPHQRLTAVQVLKHPWI  672
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VTELMRGGEL LDRILRQRYF SEREASAVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEDILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
bta:517953;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013