EPS-BOT-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	118.8	1.8E-34	28	169	142

Status

Unreviewed

Ensembl Protein

ENSBTAP00000028997

UniProt Accession

F1MW70;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000021754	ENSBTAP00000028997	ENSBTAT00000028997

Organism

Bos taurus

Functional Description

Protein Length

345

Protein Sequence
(FASTA)

MLEAQEGSHG WEHQIGSQSR ASSARHMLEV RPGLFLGGAA AVAEPDHLRE AAVTAVLTVD 60

SEEPNFKTGA GVEGLRSLFV PALDKPETDL LSHLDRCVAF IVQARAEGRA VLVHCHSGVS 120

RSVTVITAFM MKTDQLTFEE AYENLKTVKP EAKMNEGFEW QLKLYQAMGC EVDTSSAVYK 180

QYRLQKVTEK YPELQNLPQE LFAVDPSAIS QGLKDGGLYK CRKCRRSLFR SSSVLDHNEG 240

SGPIAFAHKR MTASPMLSAG SQAQCTSYFI EPVQWMESTL LGVMDGQLLC PKCNAKLGSF 300

NWYGEQCSCG RWIAPAFQIH KSRVDETKTL PMWGSQTRET GTRYM 345

Nucleotide Sequence
(FASTA)

ATGTTGGAGG CGCAGGAGGG GAGCCATGGC TGGGAGCACC AGATCGGCAG CCAGAGCCGG 60

GCCAGCTCTG CCAGGCATAT GCTGGAAGTG CGTCCGGGGC TGTTCTTGGG TGGAGCCGCG 120

GCCGTCGCGG AGCCAGACCA CCTGAGGGAG GCGGCCGTCA CGGCAGTGCT GACGGTGGAC 180

TCGGAGGAGC CTAACTTCAA AACGGGGGCT GGGGTCGAGG GTCTACGGAG TCTCTTCGTG 240

CCAGCGCTGG ACAAACCTGA GACCGACCTG CTCAGTCATC TGGACCGCTG TGTGGCCTTC 300

ATCGTCCAGG CTCGCGCCGA GGGCCGCGCG GTGCTGGTGC ACTGTCATTC AGGGGTCAGT 360

CGAAGTGTGA CTGTAATAAC TGCTTTTATG ATGAAGACTG ACCAGCTTAC CTTTGAAGAA 420

GCCTATGAAA ACCTTAAGAC TGTCAAGCCA GAGGCCAAGA TGAATGAGGG GTTTGAGTGG 480

CAACTGAAAT TATACCAGGC AATGGGCTGT GAAGTGGATA CCTCCAGTGC AGTTTATAAA 540

CAATATCGTT TACAAAAGGT TACAGAGAAG TATCCAGAAT TGCAGAACTT ACCTCAAGAA 600

CTCTTTGCTG TTGACCCATC TGCCATTTCA CAAGGATTGA AAGATGGGGG TCTCTACAAA 660

TGTAGAAAGT GCAGGCGATC TTTATTTAGA AGTTCTAGCG TTTTGGATCA TAATGAAGGA 720

AGTGGTCCTA TAGCCTTTGC CCACAAGAGG ATGACGGCAT CCCCCATGCT TTCCGCAGGG 780

AGTCAGGCTC AGTGTACATC TTACTTCATT GAACCTGTAC AGTGGATGGA ATCCACTTTG 840

TTGGGAGTGA TGGATGGACA GCTTCTCTGC CCCAAATGCA ATGCCAAGTT GGGTTCTTTC 900

AACTGGTATG GTGAACAGTG CTCATGTGGC AGATGGATAG CACCCGCTTT TCAAATACAT 960

AAGAGCAGAG TGGACGAAAC GAAAACGCTG CCAATGTGGG GATCACAAAC AAGAGAAACA 1020

GGAACTCGTT ACATGTGA 1038

Domain Profile

S: 3     teilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdD  62

          e+ pgl+lg++a + +  +L+++ +t v+++  +  +++++  +   +g + + +p+ D

Q: 28    LEVRPGLFLGGAAAVAEPDHLREAAVTAVLTVDSEEPNFKTGAGV---EGLRSLFVPALD  84

         5899**********************************9999876...599999******

S: 63    sdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAiea  122

         +++tdll+++d++++fi +a+ +g++vlvHC+ GvsRS+t+++a++mk+ +l++++A+e+

Q: 85    KPETDLLSHLDRCVAFIVQARAEGRAVLVHCHSGVSRSVTVITAFMMKTDQLTFEEAYEN  144

         ************************************************************

S: 123   vkrkrpsiepnegfleQLlelekkl  147

         +k+ +p++++negf +QL +++ ++

Q: 145   LKTVKPEAKMNEGFEWQLKLYQAMG  169

         *********************9886

Domain Sequence
(FASTA)

LEVRPGLFLG GAAAVAEPDH LREAAVTAVL TVDSEEPNFK TGAGVEGLRS LFVPALDKPE 60

TDLLSHLDRC VAFIVQARAE GRAVLVHCHS GVSRSVTVIT AFMMKTDQLT FEEAYENLKT 120

VKPEAKMNEG FEWQLKLYQA MG 142

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

bta:505302

;

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013