EKS-BOT-00298
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00298
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.3E-149722979258
StatusUnreviewed
Ensembl ProteinENSBTAP00000029056
UniProt AccessionF1MCQ7;
Protein Name
Protein Synonyms/Alias
Gene NameLOC505709
Gene Synonyms/Alias LOC505709;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000021798ENSBTAP00000029056ENSBTAT00000029056
OrganismBos taurus
Functional Description
Protein Length1257
Protein Sequence
(FASTA)
VSTMELAAWC RWGLLLALLP PGAAGTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ 60
GNLELTYLPA DASLSFLQEI QEVQGYVLIA HNRVSQVPLQ RLRIVRGTQL FEEHYALAVL 120
DNGDFLESAA PAAGTAPGGL QELQLRSLTE ILKGGVLIQR NPQLCHQDTI LWEDIFHKNN 180
QLPLKQIDTN RSRACAPCSP ACKAPNCWGE SSQDCQSLTR TVCASGCARC KGPQPTDCCH 240
EQCAAGCTGP KHSDCLACLH FNHSGICELH CPALVTYNTD TFESMPNPEG RYTFGASCVT 300
ACPYNYLSTD VGSCTLVCPL NNQEVTAEDG TQRCEKCSKP CAPVCYGLGM EHLREVRAVT 360
SANIQEFAGC KKFGSLAFLP ESFAGDPDSN IAPLQAEQLK VFESLEEITG YLYISAWPDS 420
LPDLSVFQNL RVIRGRVLHD GAYSLTLQGL GISWLGLRSL RELGSGLALI HRNARLCFVH 480
TVPWDQLFQN PHQALLHSAN RPEDECVGEG LACYPLCAQG HCWGPGPTQC VNCSQFLRGQ 540
ECVEECRVLQ GLPREYVKDR YCLPCHPECH PQNGSVTCFG SEADQCVACA HYKDPPFCVA 600
RCPSGVKPDL SFMPIWKFPD EEGICQPCPI NCTHSCVDLD DKGCPAEQRA SPVTSIIAAV 660
VGVLLVVLVG LVFGILIKRR RQKIRKYTMR RLLQETELVE PLTPSGAMPN QAQMRILKET 720
ELRKVKVLGS GAFGTVYKGI WIPDGENVKI PVAIKVLREN TSPKANKEIL DEAYVMAGVG 780
SPYVSRLLGI CLTSTVQLVT QLMPYGCLLD HVREHRGRLG SQDLLNWCVQ IAKGMSYLED 840
VRLVHRDLAA RNVLVKSPNH VKITDFGLAR LLDIDETEYH ADGGKVPIKW MALESILRRR 900
FTHQSDVWSY GVTVWELMTF GAKPYDGIPA REIPDLLEKG ERLPQPPICT IDVYMIMVKC 960
WMIDSECRPR FRELVAEFSR MARDPQRFVV IQNEDMGPAS PLDSTFYRSL LEDDDMGDLV 1020
DAEEYLVPQQ GFFCPDPAPG AAGTAHRRHR STSTRSGGGE LTLGLEPSEE EPPRSPLAPS 1080
EGAGSDVFDG DLGMGAAKGL QPLPQHDSSP LQRYSEDPTV PLSPEADGYV APLTCSPQPE 1140
YVNQPEVHPQ PPSPLEGPLP PPRPAGSTLE RPKTLSPGKN GVVKDVFAFG AAVENPEYLA 1200
PRGRAAPQSH PSPAFSPAFD NLYYWDQDPS ERGTPPSTFE GTPTAENPEY LGLDMPV 1257
Nucleotide Sequence
(FASTA)
GTGAGCACCA TGGAGCTGGC GGCCTGGTGC CGCTGGGGGC TCCTCCTCGC CCTCCTGCCC 60
CCCGGAGCCG CGGGCACCCA AGTGTGCACC GGCACAGACA TGAAGCTGCG GCTGCCGGCC 120
AGTCCCGAGA CCCACCTGGA CATGCTGCGC CACCTCTACC AAGGCTGTCA GGTGGTGCAG 180
GGTAACCTGG AGCTCACCTA TCTGCCTGCT GATGCCAGCC TCTCCTTCCT GCAGGAAATC 240
CAGGAGGTGC AGGGCTATGT GCTCATCGCT CACAATCGAG TGAGTCAGGT CCCACTGCAG 300
AGACTGCGAA TCGTGCGAGG CACCCAGCTT TTTGAGGAAC ACTACGCCCT GGCCGTGCTG 360
GACAATGGAG ACTTTCTGGA AAGTGCTGCC CCTGCTGCAG GCACAGCCCC AGGAGGGCTG 420
CAGGAGCTGC AGCTGCGAAG CCTCACAGAG ATCCTCAAGG GAGGGGTCTT GATCCAGCGG 480
AACCCCCAGC TCTGCCACCA GGACACGATT TTGTGGGAGG ATATCTTCCA CAAGAACAAC 540
CAGCTGCCCC TCAAGCAGAT AGACACCAAC CGCTCACGGG CCTGCGCACC CTGTTCTCCA 600
GCTTGTAAAG CTCCCAACTG CTGGGGAGAA AGTTCTCAGG ACTGTCAGAG CTTGACGCGG 660
ACCGTCTGTG CCAGTGGCTG TGCCCGCTGT AAGGGCCCAC AGCCCACCGA CTGCTGCCAT 720
GAGCAGTGCG CTGCTGGCTG TACTGGCCCC AAGCACTCTG ACTGCCTGGC CTGCCTCCAC 780
TTCAACCACA GCGGCATCTG CGAGCTGCAC TGCCCAGCTC TGGTCACCTA CAACACAGAC 840
ACCTTCGAGT CCATGCCCAA CCCCGAGGGG CGTTATACCT TCGGTGCCAG CTGTGTGACG 900
GCCTGTCCTT ACAACTACCT GTCTACGGAT GTGGGATCCT GCACCCTGGT TTGTCCCCTG 960
AACAACCAAG AGGTGACAGC TGAGGATGGA ACCCAGAGGT GTGAGAAATG CAGCAAGCCC 1020
TGTGCCCCAG TGTGCTATGG TCTGGGCATG GAACACCTGC GGGAGGTGAG GGCGGTCACC 1080
AGTGCCAACA TCCAGGAGTT TGCCGGCTGC AAGAAGTTTG GGAGCCTGGC GTTTCTGCCA 1140
GAGAGCTTTG CAGGGGACCC AGACTCTAAC ATCGCCCCGC TGCAGGCTGA GCAGCTCAAA 1200
GTGTTTGAGT CTCTGGAGGA GATCACAGGT TACCTGTACA TCTCAGCGTG GCCAGACAGC 1260
CTGCCTGACC TCAGCGTCTT CCAGAACCTG CGAGTAATCC GGGGACGAGT TCTGCATGAT 1320
GGTGCCTACT CGCTGACCCT GCAAGGGCTG GGCATCAGCT GGCTGGGGCT GCGCTCGCTG 1380
CGGGAACTGG GCAGCGGGCT GGCCCTCATT CACCGCAACG CCCGCCTCTG CTTCGTACAC 1440
ACGGTGCCCT GGGACCAGCT CTTCCAGAAC CCCCACCAGG CTCTGCTCCA CAGCGCCAAC 1500
AGGCCAGAGG ATGAGTGCGT GGGCGAGGGC CTGGCCTGCT ACCCACTGTG CGCCCAAGGG 1560
CACTGCTGGG GTCCCGGGCC CACCCAGTGC GTCAACTGCA GCCAGTTCCT TCGGGGCCAG 1620
GAATGCGTGG AGGAATGCCG AGTACTGCAG GGGCTCCCCC GGGAGTACGT GAAGGACAGG 1680
TACTGTCTGC CGTGCCACCC CGAGTGTCAT CCCCAGAATG GCTCAGTGAC CTGCTTTGGC 1740
TCGGAGGCTG ACCAATGTGT GGCTTGTGCC CACTACAAGG ATCCTCCCTT CTGCGTGGCT 1800
CGCTGCCCCA GTGGTGTGAA GCCTGACCTC TCCTTCATGC CCATCTGGAA GTTTCCAGAT 1860
GAGGAGGGCA TATGCCAGCC ATGCCCCATC AACTGCACCC ACTCCTGTGT GGACTTGGAT 1920
GACAAGGGCT GCCCCGCCGA GCAGAGAGCC AGCCCTGTGA CATCCATCAT TGCCGCTGTG 1980
GTGGGCGTTC TGCTGGTTGT CCTTGTGGGG CTGGTGTTCG GCATCCTCAT TAAGCGAAGG 2040
CGGCAGAAGA TCCGGAAGTA CACGATGCGG AGGCTGCTGC AGGAGACGGA GCTGGTGGAG 2100
CCTCTGACGC CCAGCGGAGC GATGCCCAAT CAGGCTCAGA TGCGGATCTT AAAAGAGACA 2160
GAGCTGAGGA AGGTGAAGGT GCTAGGATCT GGAGCTTTTG GCACCGTCTA CAAGGGCATC 2220
TGGATCCCTG ATGGGGAAAA TGTGAAAATC CCCGTGGCCA TCAAGGTGTT GAGGGAAAAC 2280
ACATCTCCCA AAGCCAACAA GGAAATCTTG GACGAAGCAT ATGTGATGGC TGGTGTAGGC 2340
TCCCCATATG TGTCCCGCCT CCTGGGCATC TGCCTGACAT CCACAGTGCA GCTGGTGACA 2400
CAGCTGATGC CCTATGGCTG CCTCCTAGAC CACGTTCGAG AACACCGTGG GCGCCTGGGC 2460
TCTCAGGACC TGCTGAACTG GTGTGTGCAG ATTGCCAAGG GGATGAGCTA CTTGGAGGAT 2520
GTGCGGCTCG TGCACAGGGA CCTGGCCGCC CGGAACGTAC TGGTCAAGAG TCCCAACCAT 2580
GTGAAGATTA CAGACTTCGG GCTGGCTCGG CTGCTAGACA TTGACGAGAC AGAGTACCAC 2640
GCGGATGGGG GCAAGGTGCC CATCAAGTGG ATGGCATTGG AGTCCATTCT CCGGCGGCGG 2700
TTTACCCACC AGAGTGACGT GTGGAGCTAT GGTGTGACTG TGTGGGAGCT GATGACTTTT 2760
GGGGCCAAAC CTTATGATGG GATCCCAGCC CGGGAGATTC CTGACCTGCT GGAGAAGGGA 2820
GAACGGCTGC CCCAGCCCCC CATCTGCACC ATTGATGTCT ACATGATCAT GGTCAAATGT 2880
TGGATGATTG ACTCTGAATG TCGGCCGAGG TTCCGGGAGT TAGTGGCTGA ATTCTCCCGC 2940
ATGGCCAGGG ACCCCCAGCG CTTTGTGGTC ATCCAGAATG AAGACATGGG GCCTGCTAGC 3000
CCCCTGGATA GCACCTTCTA CCGCTCGCTG CTGGAGGATG ACGACATGGG CGACCTGGTG 3060
GATGCGGAGG AGTACCTGGT ACCCCAGCAG GGCTTCTTCT GCCCAGACCC TGCCCCGGGT 3120
GCTGCAGGCA CGGCCCATCG CAGGCACCGC AGCACATCCA CCAGGAGTGG CGGTGGTGAG 3180
CTGACACTGG GGCTGGAGCC CTCTGAGGAG GAGCCTCCCA GATCTCCGCT GGCACCTTCC 3240
GAAGGGGCAG GCTCTGATGT GTTTGATGGT GACTTGGGAA TGGGGGCGGC CAAGGGACTG 3300
CAGCCCCTCC CCCAACATGA CTCTAGTCCT CTGCAGCGGT ACAGCGAGGA CCCCACAGTA 3360
CCCCTTTCTC CCGAGGCTGA TGGCTACGTT GCCCCCTTGA CCTGCAGCCC CCAGCCGGAA 3420
TATGTGAACC AGCCAGAGGT TCACCCACAG CCCCCCTCAC CCCTAGAGGG TCCTCTGCCG 3480
CCTCCTCGAC CTGCTGGTTC CACTCTGGAA AGGCCCAAGA CGCTATCCCC TGGGAAGAAT 3540
GGGGTTGTCA AAGACGTTTT TGCCTTTGGG GCTGCCGTGG AGAACCCTGA GTACTTGGCA 3600
CCCCGGGGCA GGGCTGCCCC TCAGTCCCAC CCTTCTCCAG CCTTCAGCCC AGCCTTTGAC 3660
AACCTCTATT ATTGGGACCA GGACCCATCA GAGCGGGGCA CTCCACCCAG CACCTTTGAA 3720
GGGACCCCTA CGGCAGAGAA CCCTGAGTAC TTGGGTCTGG ACATGCCAGT ATGA 3774
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 722   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  781
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 782   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  841
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 842   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  901
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 902   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  961
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 962   MIDSECRPRFRELVAEFS  979
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013