EKS-BOT-00228

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00228

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	383.1	7.2E-115	73	369	297

Status

Unreviewed

Ensembl Protein

ENSBTAP00000011377

UniProt Accession

Q17QH2; F1MYR6;

Protein Name

Protein Synonyms/Alias

MAP2K2 protein;

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000024450	ENSBTAP00000011377	ENSBTAT00000011377

Organism

Bos taurus

Functional Description

Protein Length

400

Protein Sequence
(FASTA)

MLARRKPVLP ALTINPAIAE GPSPTSEGAS EAHLVDLQKK LEELELDEQQ KKRLEAFLTQ 60

KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ 120

VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG 180

LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ 240

GTHYSVQSDI WSMGLSLVEL SIGRYPIPPP DAKELEAIFG RPMVDGAEGE PPSISPRPRP 300

PGRPISGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTQ DFQEFVNKCL IKNPAERADL 360

KMLMNHTFIK RSEVEEVDFA GWLCKTLRLN QPSTPTRTAV 400

Nucleotide Sequence
(FASTA)

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCCGC CATCGCCGAG 60

GGCCCGTCCC CTACCAGCGA GGGCGCCTCC GAAGCACATC TGGTGGACCT CCAGAAGAAG 120

CTAGAGGAGC TAGAGCTCGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT CCTTACCCAG 180

AAGGCCAAGG TTGGTGAGCT CAAGGACGAT GACTTTGAAC GGATCTCCGA GCTGGGAGCC 240

GGCAATGGCG GAGTGGTCAC CAAGGTCCAG CACAGACCTT CGGGCCTCAT CATGGCCAGA 300

AAGCTGATCC ACCTGGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG AGAGCTACAG 360

GTGCTGCATG AGTGCAACTC CCCGTACATT GTGGGCTTCT ACGGGGCCTT CTACAGCGAC 420

GGCGAGATCA GCATCTGCAT GGAGCACATG GATGGCGGCT CCCTGGACCA GGTGTTGAAA 480

GAAGCCAAGA GAATCCCTGA AGAGATCCTG GGCAAGGTCA GCATTGCGGT TCTGCGGGGC 540

CTGGCATACC TCCGGGAGAA ACACCAGATC ATGCACCGAG ACGTGAAGCC GTCCAACATC 600

CTGGTCAACT CCCGGGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 660

GACTCCATGG CCAACTCCTT CGTGGGGACG CGGTCCTACA TGTCTCCGGA GCGGCTACAA 720

GGCACACACT ACTCGGTGCA GTCAGACATC TGGAGCATGG GCCTGTCCCT GGTGGAACTG 780

TCCATCGGCA GGTACCCCAT CCCCCCGCCG GACGCCAAGG AGCTGGAGGC CATATTCGGC 840

CGGCCCATGG TTGATGGCGC AGAAGGAGAA CCTCCTAGCA TCTCTCCACG GCCGAGGCCC 900

CCTGGACGCC CCATCAGCGG TCACGGGATG GACAGCCGGC CTGCCATGGC GATCTTTGAG 960

CTGCTGGACT ACATTGTGAA CGAGCCTCCT CCCAAGCTGC CCAACGGTGT GTTCACCCAG 1020

GACTTCCAGG AGTTTGTAAA TAAATGCCTA ATTAAGAACC CAGCTGAGCG AGCAGACCTG 1080

AAGATGCTCA TGAACCACAC CTTCATCAAG CGGTCCGAGG TGGAAGAAGT GGATTTTGCT 1140

GGCTGGTTGT GTAAAACACT GCGGCTAAAC CAGCCCAGCA CGCCCACACG CACCGCCGTG 1200

TGA 1203

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 73    ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  131

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 132   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  187

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 188   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  246

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvel +gryp++++++

Q: 247   QSDIWSMGLSLVELSIGRYPIPPPDAkeleaifgrpmvdgaegeppsisprprppgrpis  306

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp+  f+++fqefv+kCl+k+++eR++lk+l++h

Q: 307   ghgmdsrpamaIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADLKMLMNH  366

         ************************************************************

S: 257   afi  259

+fi

Q: 367   TFI  369

*97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVELSI GRYPIPPPDA KELEAIFGRP MVDGAEGEPP SISPRPRPPG RPISGHGMDS 240

RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK NPAERADLKM LMNHTFI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005778	; C:peroxisomal membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:2000147	; P:positive regulation of cell motility

KEGG

bta:510434

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013