EKS-BOT-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	353.7	6.5E-106	14	264	251

Status

Unreviewed

Ensembl Protein

ENSBTAP00000026195

UniProt Accession

F1N5S6;

Protein Name

Protein Synonyms/Alias

Gene Name

STK24

Gene Synonyms/Alias

STK24;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000032234	ENSBTAP00000026195	ENSBTAT00000026195

Organism

Bos taurus

Functional Description

Protein Length

423

Protein Sequence
(FASTA)

PGIQNLKADP EELFTKLEKI GKGSFGEVFK GIDNRTQKVV AIKIIDLEEA EDEIEDIQQE 60

ITVLSQCDSP YVTKYYGSYL KDTKLWIIME YLGGGSALDL LEPGPLDETQ IATILREILK 120

GLDYLHSEKK IHRDIKAANV LLSEHGEVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV 180

IKQSAYDSKA DIWSLGITAI ELAKGEPPHS ELHPMKVLFL IPKNNPPTLE GNYSKPLKEF 240

VEACLNKEPS FRPTAKELLK HKFIIRNAKK TSYLTELIDR YKRWKAEQSH EDSSSEDSDT 300

ETDTDGQASG GSDSGDWIFT IREKDPKSLE NGALQPSDLE RNKMKDIPKR PFSQCLSTII 360

SPLFAELKEK SQACGGNLGS IEELRGAIYL AEEACPGISD TMVAQLVQRL QRYSLSGGGT 420

SSH 423

Nucleotide Sequence
(FASTA)

CCTGGGATCC AGAACCTAAA AGCAGATCCA GAAGAGCTTT TTACCAAACT GGAGAAAATC 60

GGGAAGGGCT CCTTCGGCGA GGTGTTCAAA GGCATTGACA ATCGGACTCA GAAAGTAGTC 120

GCCATAAAAA TCATTGACCT GGAGGAGGCA GAAGATGAGA TCGAGGACAT TCAGCAGGAA 180

ATCACAGTGC TGAGTCAGTG TGACAGTCCC TACGTAACCA AATATTACGG ATCCTACCTG 240

AAGGACACTA AATTGTGGAT AATAATGGAA TATCTTGGCG GGGGCTCTGC ACTGGACCTC 300

TTAGAACCTG GCCCTTTAGA TGAAACCCAG ATTGCTACTA TATTAAGAGA AATACTGAAA 360

GGACTTGATT ATTTGCATTC GGAGAAGAAA ATTCACAGAG ATATTAAAGC TGCCAACGTC 420

CTGCTCTCTG AACACGGGGA GGTGAAGCTG GCGGACTTTG GAGTGGCGGG CCAGCTGACA 480

GACACCCAGA TAAAGAGAAA CACCTTCGTG GGCACCCCTT TCTGGATGGC GCCCGAAGTC 540

ATCAAGCAGT CAGCCTACGA CTCAAAGGCG GACATCTGGT CCCTGGGCAT TACGGCCATC 600

GAGCTTGCCA AGGGGGAGCC GCCGCATTCC GAGCTGCATC CCATGAAGGT CCTGTTCCTT 660

ATCCCAAAGA ACAACCCCCC GACGCTGGAA GGGAACTACA GCAAACCCCT CAAGGAGTTC 720

GTGGAGGCCT GTTTGAACAA GGAGCCGAGC TTTAGACCCA CCGCTAAGGA GTTACTGAAG 780

CACAAGTTCA TAATCCGCAA TGCAAAGAAA ACATCCTACT TGACCGAGCT CATCGACAGG 840

TACAAGAGGT GGAAGGCCGA GCAGAGCCAC GAAGACTCCA GCTCGGAAGA CTCCGACACG 900

GAGACGGACA CAGACGGCCA GGCTTCCGGA GGCAGCGACT CGGGGGACTG GATCTTCACG 960

ATCCGGGAGA AGGATCCAAA GAGTCTGGAG AACGGAGCTC TCCAGCCGTC GGATCTGGAA 1020

AGAAACAAGA TGAAGGACAT CCCAAAGAGG CCTTTCTCCC AGTGTTTATC TACGATTATT 1080

TCTCCGCTCT TTGCAGAGCT GAAGGAGAAG AGCCAGGCAT GCGGAGGAAA CCTGGGCTCC 1140

ATCGAGGAGC TGCGCGGGGC CATCTACCTG GCGGAGGAGG CCTGCCCCGG CATCTCGGAC 1200

ACCATGGTGG CCCAGCTGGT GCAGCGGCTG CAGAGATATT CTCTAAGTGG TGGAGGAACT 1260

TCATCCCATT GA 1272

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         ++ le+igkG++g+v+++ +++t+++vaik+i+le+  +++e++q+ei+vl+++++p+++

Q: 14    FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAeDEIEDIQQEITVLSQCDSPYVT  73

         7889*******************************99899********************

S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         +y++s+lk+++lw++meyl gGs+ dl++     +l+E+qia+ilre+lk+L+ylHs+k+

Q: 74    KYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGPLDETQIATILREILKGLDYLHSEKK  130

         *****************************...****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYde  179

         iHrdika+n+Ll+e+geVkL+dfgva ql++t+ kr+t+vgtp+wmAPEvi+  ++ Yd+

Q: 131   IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK--QSAYDS  188

         ****************************************************..9*****

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         kaDiwslGItaiela+gepP+++l+p+k+l++i+kn+pp+l+ +  +sk +kefve+cl+

Q: 189   KADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEFVEACLN  246

         *****************************************776..**************

S: 240   knpekRpsasellkhkFl  257

         k+p++Rp+a+ellkhkF+

Q: 247   KEPSFRPTAKELLKHKFI  264

         *****************7

Domain Sequence
(FASTA)

FTKLEKIGKG SFGEVFKGID NRTQKVVAIK IIDLEEAEDE IEDIQQEITV LSQCDSPYVT 60

KYYGSYLKDT KLWIIMEYLG GGSALDLLEP GPLDETQIAT ILREILKGLD YLHSEKKIHR 120

DIKAANVLLS EHGEVKLADF GVAGQLTDTQ IKRNTFVGTP FWMAPEVIKQ SAYDSKADIW 180

SLGITAIELA KGEPPHSELH PMKVLFLIPK NNPPTLEGNY SKPLKEFVEA CLNKEPSFRP 240

TAKELLKHKF I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030336	; P:negative regulation of cell migration
GO:0046777	; P:protein autophosphorylation
GO:0048679	; P:regulation of axon regeneration

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013