EKS-BOT-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	368.7	2.0E-110	37	321	285

Status

Reviewed

Ensembl Protein

ENSBTAP00000044609

UniProt Accession

Q2TBL8;

Protein Name

Cyclin-dependent kinase 10

Protein Synonyms/Alias

Cell division protein kinase 10;

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000033333	ENSBTAP00000044609	ENSBTAT00000047400

Organism

Bos taurus

Functional Description

Protein Length

361

Protein Sequence
(FASTA)

MGEPEPEQIR LKCVRKEGFF TVPPEHRLGR CRSVKEFEKL NRIGEGTYGI VYRARDTHTD 60

EIVALKKVRM DKEKDGVPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ 120

DLASLLENMP TPFSEAQVKC IVLQVLRGLQ YLHRNFIIHR DLKVSNLLMT DKGCVKTADF 180

GLARAYGIPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT 240

SEIHQVDLIV QLLGTPSENI WPGFSQLPLA SQYSLRKQPY NNLKHKFPWL SEAGLRLMNL 300

LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRATPATSL GTESQSRRGR 360

P 361

Nucleotide Sequence
(FASTA)

ATGGGGGAGC CGGAGCCGGA GCAGATCCGT TTGAAGTGTG TCCGTAAAGA AGGCTTCTTC 60

ACGGTGCCTC CAGAGCACAG GCTGGGACGG TGCCGGAGCG TGAAGGAGTT TGAGAAGCTG 120

AATCGCATTG GGGAAGGCAC CTATGGCATC GTATATCGGG CCCGGGATAC CCACACAGAT 180

GAGATTGTCG CCCTGAAGAA AGTGCGGATG GACAAGGAGA AGGATGGGGT CCCCATCAGC 240

AGCCTTCGAG AGATCACACT GCTGCTTCGC CTCCGCCATC CCAACATTGT GGAGCTGAAG 300

GAGGTGGTTG TGGGGAACCA CCTGGAGAGC ATCTTCCTGG TGATGGGCTA CTGTGAGCAA 360

GACCTGGCCA GCCTTCTGGA GAACATGCCA ACACCCTTCT CTGAGGCCCA GGTCAAGTGC 420

ATCGTGCTGC AGGTGCTCCG GGGCCTCCAG TACCTGCACC GGAATTTCAT CATCCACAGG 480

GATCTGAAGG TCTCTAACTT GCTCATGACG GATAAGGGCT GCGTGAAGAC AGCGGATTTT 540

GGTCTGGCCC GGGCCTATGG CATCCCAGTG AAGCCAATGA CTCCCAAGGT GGTCACACTC 600

TGGTACCGAG CCCCTGAACT GCTGCTGGGA ACCACCACGC AGACCACCAG CATCGACATG 660

TGGGCGGTGG GCTGCATCCT GGCTGAGCTG CTGGCCCATA AGCCCCTTCT CCCCGGCACT 720

TCCGAGATCC ACCAGGTGGA CCTGATCGTG CAGCTGCTGG GGACCCCCAG TGAGAACATC 780

TGGCCGGGCT TCTCTCAGCT GCCGCTGGCC AGCCAGTACA GCCTGCGGAA GCAGCCCTAC 840

AACAACCTGA AGCATAAGTT CCCGTGGCTC TCAGAGGCTG GCCTGCGCCT GATGAACCTC 900

CTCTTCATGT ACGACCCTAA GAAAAGGGCG ACGGCTGGTG ACTGCCTGGA GAGCTCCTAC 960

TTCAAGGAGA AGCCCCTGCC CTGCGAGCCG GAGCTCATGC CCACCTTCCC CCACCATCGT 1020

AACAAGCGTG CCACCCCGGC CACATCCTTG GGCACTGAGA GCCAGAGCCG GCGCGGCAGA 1080

CCCTGA 1086

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+gvpi++lrEi+ll +l+h+ni

Q: 37    FEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNI  96

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 97    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHRN  155

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara++ p+k +t++vvTlwYraPelLlg+++ +

Q: 156   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQT  215

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell++kpl++g+sei+q++ i++llgtpse++wp++s+lp ++ +s+

Q: 216   TSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASqYSL  275

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+l++ l+++dpkkR +a ++l+++yf

Q: 276   RKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYF  321

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD THTDEIVALK KVRMDKEKDG VPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHRNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GIPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAVGCI LAELLAHKPL LPGTSEIHQV DLIVQLLGTP SENIWPGFSQ LPLASQYSLR 240

KQPYNNLKHK FPWLSEAGLR LMNLLFMYDP KKRATAGDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

bta:615171	;
bta:785111	;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013