EKS-BOT-00164
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00164
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb425.67.2E-128415674260
StatusUnreviewed
Ensembl ProteinENSBTAP00000020910
UniProt AccessionF1MQE1;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000039153ENSBTAP00000020910ENSBTAT00000020910
OrganismBos taurus
Functional Description
Protein Length771
Protein Sequence
(FASTA)
MGDEDEDEGC AVELQITEAN LTGHEEKVGV ENFQLLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVNG 120
GEMFTHLYQR QYFREAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKSGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PRKRLGAGPQ GAQEVKDHPF 300
FQGLDWAALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDR NNAVMTDVLE ASGAGDRPGP AALARSVMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ LQSGQEFAVK ILSRRLEENT QREVAALRLC QSHPNVVKLH EVHHDQLHTY 480
LVLELLQGGE LLEHIRKKRH FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DTPGAPVKII DFGFARLRPQ SPAGPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLDGEAW EGVSEEAKEL VRGLLTVDPA 660
KRLKLEGLRG SSWLQDGSAR SSPPLRTPDV LESSGSAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSAAT SRRVSPAPAA PGRAPAAKGT PRRANGPLPP S 771
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGATGAGGA CGAGGGCTGT GCCGTGGAGC TGCAGATCAC CGAAGCCAAC 60
CTGACGGGGC ACGAGGAGAA GGTAGGCGTG GAGAACTTCC AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCAG GCGGGCACGA CGCGGGCAAG 180
CTGTATGCCA TGAAGGTGCT GCGCAAGGCA GCCTTGGTGC AGCGTGCCAA GACACAGGAG 240
CACACGCGCA CCGAGCGCTC GGTGCTGGAG CTGGTGCGCC AGGCACCCTT CCTGGTCACG 300
CTGCACTACG CCTTCCAGAC TGATGCCAAG CTGCACCTCA TCCTGGACTA TGTGAACGGC 360
GGCGAAATGT TCACCCACCT CTACCAGCGC CAGTACTTCA GGGAGGCCGA GGTGCGCGTG 420
TATGGGGGCG AGATCGTGCT GGCCCTGGAG CACCTGCACA AGCTGGGCAT CATCTACCGA 480
GATCTGAAGC TGGAGAATGT GCTGCTGGAC TCCGAGGGTC ACATTGTCCT CACTGACTTT 540
GGGCTTAGCA AGGAGTTCCT GACAGAGGAG AAAGAGCGGA CCTTTTCCTT CTGTGGCACC 600
ATTGAGTACA TGGCCCCTGA AATCATCCGC AGCAAGTCGG GCCATGGCAA GGCTGTGGAC 660
TGGTGGAGCC TTGGCATCCT GCTTTTCGAG CTGCTGACGG GGGCCTCACC CTTCACCCTG 720
GAGGGCGAGA GGAACACGCA GGCAGAGGTG TCTCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCCC GGATCGGGCC AGTGGCACAG GACCTACTGC AGCGGCTACT TTGCAAGGAC 840
CCCAGGAAGC GACTGGGTGC AGGACCCCAG GGGGCACAGG AAGTTAAGGA CCACCCCTTC 900
TTCCAGGGTC TGGACTGGGC TGCTCTGGCT GCTAGGAAGA TTCCAGCCCC GTTCCGACCC 960
CAGATCCGCT CAGAGCTGGA TGTGGGCAAC TTTGCAGAAG AATTTACCCG ACTGGAGCCT 1020
GTCTACTCAC CCCCTGGCAG CCCCCCACCT GGGGACCCTC GCATCTTCCA GGGATACTCC 1080
TTCGTGGCGC CATCCATCTT GTTTGACCGC AACAACGCGG TGATGACCGA TGTGCTGGAA 1140
GCGTCTGGCG CTGGAGACCG GCCCGGCCCG GCGGCGTTGG CCAGGAGCGT CATGATGCAG 1200
GACTCGCCCT TCTTCCAGCA GTACGAACTG GACCTGCGGG AACCCGCGTT GGGCCAGGGT 1260
AGTTTCTCCG TGTGCCGCCG CTGCCGACAG CTACAGAGCG GCCAAGAGTT CGCTGTCAAG 1320
ATCCTCAGTC GCAGGCTGGA GGAGAACACG CAGCGCGAAG TGGCTGCCCT GCGGCTGTGC 1380
CAGTCGCATC CCAACGTGGT GAAGCTGCAC GAAGTGCATC ACGACCAGCT GCACACGTAC 1440
CTGGTCCTGG AGCTGCTGCA GGGCGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGGCAC 1500
TTCAGCGAGT CCGAGGCGAG CCAGATCCTG CGCAGCCTCG TGTCGGCCGT GAGCTTCATG 1560
CACGAGGAGG CGGGCGTAGT GCATCGCGAC CTGAAGCCCG AGAACATCCT GTACGCCGAT 1620
GACACGCCTG GGGCCCCAGT GAAGATCATC GACTTCGGGT TCGCGCGCCT GCGCCCGCAG 1680
AGCCCCGCGG GGCCCATGCA GACGCCCTGC TTCACGCTGC AGTACGCAGC CCCCGAGCTG 1740
CTGGCCCAGC AGGGTTACGA CGAGTCCTGC GACCTCTGGA GCCTCGGCGT TATTCTGTAC 1800
ATGATGCTGT CGGGCCAGGT CCCCTTCCAG GGGGCCTCAG GCCAAGGCGG GCAGAGCCAG 1860
GCCGCGGAGA TCATGTGCAA GATCCGCGAG GGGCGCTTCT CTCTTGACGG AGAGGCCTGG 1920
GAAGGCGTGT CTGAGGAAGC CAAGGAGCTG GTCCGAGGGC TCCTGACTGT GGATCCCGCC 1980
AAGCGGCTGA AGCTCGAGGG GCTGCGGGGC AGCTCGTGGC TGCAGGATGG CAGCGCGCGC 2040
TCTTCGCCTC CGCTGCGGAC ACCGGACGTG CTGGAGTCCT CGGGGTCCGC TGTGCGCTCC 2100
GGGCTCAACG CCACCTTCAT GGCGTTCAAC CGGGGCAAAC GCGAGGGTTT CTTCCTGAAG 2160
AGCGTGGAAA ACGCGCCGCT GGCCAAGCGG CGGAAACAGA AATTACGGAG CGCCGCCACA 2220
TCCCGCCGCG TCTCCCCAGC GCCCGCCGCC CCCGGCCGGG CCCCGGCTGC CAAGGGAACC 2280
CCCCGACGAG CCAATGGCCC CCTACCCCCC TCCTAG 2316
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++ +++qefavki++++ + +t++e+++l+++++hpn+v+l++v++
Q: 415   PALGQGSFSVCRRCRQLQSGQEFAVKILSRRlEENTQREVAALRLCQSHPNVVKLHEVHH  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLQGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWEGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 654   LLTVDPAKRLKLEGLRGSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQLQSG QEFAVKILSR RLEENTQREV AALRLCQSHP NVVKLHEVHH 60
DQLHTYLVLE LLQGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWEGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
bta:523746;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013