EKS-BOT-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	354.0	6.0E-106	13	300	288

Status

Unreviewed

Ensembl Protein

ENSBTAP00000053788

UniProt Accession

E1BC36;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK6

Gene Synonyms/Alias

CDK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000044023	ENSBTAP00000053788	ENSBTAT00000061349

Organism

Bos taurus

Functional Description

Protein Length

326

Protein Sequence
(FASTA)

MEKDGLSRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 60

EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 120

TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 180

VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 240

EDWPRDVALP RLAFHSKSPQ PIEKFVTDID EQGKDLLLKC LTFNPAKRIS AYSALSHPYF 300

HDLERRKENL DSHLPPSQNS SEMNTA 326

Nucleotide Sequence
(FASTA)

ATGGAGAAGG ACGGCCTGAG CCGTGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 60

GAGGGCGCCT ACGGGAAGGT GTTCAAGGCC CGGGACCTGA AGAACGGAGG CCGTTTCGTG 120

GCGCTGAAGC GCGTGCGAGT GCAGACTGGC GAGGAGGGCA TGCCGCTCTC CACCATCCGC 180

GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTCGAGCACC CCAACGTGGT CAGGTTGTTT 240

GACGTGTGTA CAGTGTCACG AACAGACAGA GAAACCAAAC TAACGTTAGT GTTTGAACAC 300

GTTGATCAAG ACTTGACCAC TTATTTGGAT AAAGTGCCAG AACCTGGAGT GCCCACTGAA 360

ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGCCTGG ACTTTCTTCA TTCTCACCGA 420

GTGGTGCATC GTGATCTAAA ACCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAG 480

CTGGCTGACT TCGGCCTTGC TCGCATCTAC AGTTTTCAGA TGGCTCTTAC CTCAGTGGTC 540

GTCACGCTGT GGTACCGAGC TCCGGAAGTC CTGCTTCAGT CCAGCTACGC CACCCCTGTG 600

GATCTCTGGA GCGTTGGCTG CATCTTTGCA GAGATGTTTC GTAGAAAGCC GCTTTTTCGT 660

GGAAGTTCAG ATGTCGACCA ACTAGGAAAA ATCTTGGACG TAATTGGACT CCCGGGAGAA 720

GAGGACTGGC CTAGAGATGT TGCCCTACCC AGGCTGGCTT TTCACTCAAA ATCCCCTCAA 780

CCAATTGAGA AGTTTGTAAC AGACATTGAT GAACAAGGCA AAGACCTGCT TCTGAAGTGC 840

TTGACATTTA ATCCAGCCAA AAGAATATCA GCATACAGTG CCCTGTCTCA CCCATACTTC 900

CACGATCTGG AGAGGCGCAA GGAAAACCTG GATTCCCACC TGCCGCCCAG CCAGAACAGC 960

TCGGAAATGA ATACCGCTTA A 981

Domain Profile

S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56

         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++ +eg+p +++rE+++l++l   +

Q: 13    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLetfE  72

         899*****************888999*****************************98889

S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112

         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k ++ ++++e++k +++qll+g

Q: 73    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG  132

         ************99855569****************************************

S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172

         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L

Q: 133   LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  191

         *****************************************99.****************

S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232

         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +i++++g p e++wp+   lp

Q: 192   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP  250

         *88.5*******************************************************

S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +    f++k+++ +++ v++++e++ dll k+l+++p+kRisa +al+h+yf

Q: 251   RLA--FHSKSPQPIEKFVTDIDEQGKDLLLKCLTFNPAKRISAYSALSHPYF  300

         *87..99999*****************************************9

Domain Sequence
(FASTA)

YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIREV AVLRHLETFE 60

HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PEPGVPTETI KDMMFQLLRG 120

LDFLHSHRVV HRDLKPQNIL VTSSGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180

QSSYATPVDL WSVGCIFAEM FRRKPLFRGS SDVDQLGKIL DVIGLPGEED WPRDVALPRL 240

AFHSKSPQPI EKFVTDIDEQ GKDLLLKCLT FNPAKRISAY SALSHPYF 288

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0000307	; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0043697	; P:cell dedifferentiation
GO:0000080	; P:G1 phase of mitotic cell cycle
GO:0042063	; P:gliogenesis
GO:0002244	; P:hematopoietic progenitor cell differentiation
GO:0060218	; P:hematopoietic stem cell differentiation
GO:0045786	; P:negative regulation of cell cycle
GO:2000773	; P:negative regulation of cellular senescence
GO:0050680	; P:negative regulation of epithelial cell proliferation
GO:0045638	; P:negative regulation of myeloid cell differentiation
GO:0045668	; P:negative regulation of osteoblast differentiation
GO:0007219	; P:Notch signaling pathway
GO:0001954	; P:positive regulation of cell-matrix adhesion
GO:0048146	; P:positive regulation of fibroblast proliferation
GO:0010628	; P:positive regulation of gene expression
GO:0045646	; P:regulation of erythrocyte differentiation
GO:0009615	; P:response to virus
GO:0033077	; P:T cell differentiation in thymus
GO:0003323	; P:type B pancreatic cell development

KEGG

bta:511754

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013