EKS-BOT-00191
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00191
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK485.05.9E-146339604266
StatusUnreviewed
Ensembl ProteinENSBTAP00000053752
UniProt AccessionE1BC64;
Protein Name
Protein Synonyms/Alias
Gene NameLIMK1
Gene Synonyms/Alias LIMK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000044083ENSBTAP00000053752ENSBTAT00000061497
OrganismBos taurus
Functional Description
Protein Length647
Protein Sequence
(FASTA)
MRLTLLCCTW REERMGEEGS ELPVCASCGQ RIYDGQYLQA LNADWHADCF RCCECSASLS 60
HQYYEKDGQL FCKKDYWARY GESCHGCSEH ITKGLVMVAG ELKYHPECFI CLTCGTFIGD 120
GDTYTLVEHS KLYCGHCYYQ TVVTPVIEQI LPDSPGSHLP HTVTLVSIPA SAHGKRGLSV 180
SIDPPHGLPG CSTEHSHTVR VQGVDPGCMS PDVKNSIHVG DRILEINGTP IRNVPLDEID 240
LLIQETSRLL QLTLEHDPHD SLGHGLGSEP SPLGSPAHTP SGEAGSSGRQ KPVLRSCSID 300
RSPGASSLGS PASQRKDLGR SESLRVVCRP HRIFRPSDLI HGEVLGKGCF GQAIKVTHRE 360
TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI GVLYKDKRLN FITEYIKGGT 420
LRGIIKSMDS QYPWSQRVSF AKDIASGMAY LHSMNIIHRD LNSHNCLVRE NKNVVVADFG 480
LARLMVDEKT QPEDLRSLKK PDRKKRYTVV GNPYWMAPEM INGRSYDEKV DVFSFGIVLC 540
EIIGRVNADP DYLPRTMDFG LNVRGFLDRY CPPNCPPSFF PITVRCCDLD PEKRPSFVKL 600
EQWLETLHMH LAGHLPLGPQ LEQLDRGFWE TYRRGESGLP AHPEVPD 647
Nucleotide Sequence
(FASTA)
ATGAGGTTGA CGCTACTTTG TTGTACCTGG AGGGAAGAAC GTATGGGAGA GGAAGGAAGC 60
GAGTTGCCCG TGTGTGCGAG CTGCGGCCAG AGGATCTACG ATGGCCAGTA CCTCCAGGCC 120
CTGAATGCTG ACTGGCACGC AGACTGCTTC AGGTGTTGCG AATGCAGTGC CTCCCTTTCG 180
CACCAGTACT ACGAGAAGGA TGGGCAGCTC TTCTGCAAGA AGGACTATTG GGCCCGCTAT 240
GGCGAGTCTT GCCACGGATG CTCAGAGCAC ATCACCAAGG GGCTGGTCAT GGTGGCCGGG 300
GAGCTGAAAT ATCACCCCGA ATGCTTCATC TGCCTCACAT GTGGAACCTT CATCGGTGAC 360
GGGGACACCT ACACTCTGGT GGAGCACTCC AAGCTGTACT GCGGACACTG CTACTACCAG 420
ACCGTGGTGA CCCCCGTCAT CGAGCAGATT CTGCCCGACT CCCCTGGCTC CCACCTGCCC 480
CACACGGTCA CCCTAGTCTC CATCCCAGCC TCAGCTCATG GCAAACGTGG CCTCTCGGTC 540
TCCATCGACC CCCCTCACGG CCTGCCGGGC TGCAGCACGG AGCACTCTCA CACCGTCCGC 600
GTCCAGGGAG TGGACCCAGG CTGCATGAGC CCAGATGTGA AGAATTCCAT CCATGTCGGG 660
GACCGGATCC TGGAAATCAA TGGCACCCCC ATCCGGAACG TGCCCCTGGA CGAGATTGAT 720
CTGCTGATCC AGGAAACCAG CCGCCTGCTC CAGCTGACTC TGGAGCATGA CCCCCATGAC 780
AGCCTGGGCC ATGGGCTGGG GTCTGAGCCC AGCCCCCTGG GCTCCCCGGC TCACACGCCC 840
AGCGGGGAGG CGGGCAGCTC CGGCCGGCAG AAGCCTGTGC TGAGGAGCTG CAGCATCGAC 900
AGGTCCCCGG GCGCCAGCTC CCTGGGCTCC CCGGCCTCCC AGCGCAAGGA CCTGGGTCGC 960
TCCGAGTCTC TCCGTGTGGT CTGCCGGCCG CACCGCATCT TTCGGCCTTC GGATCTCATC 1020
CATGGGGAGG TGTTGGGCAA AGGCTGCTTC GGCCAGGCCA TCAAGGTGAC GCACCGAGAG 1080
ACGGGCGAGG TGATGGTGAT GAAGGAGCTG ATCCGCTTTG ACGAGGAGAC CCAGCGGACA 1140
TTCCTCAAGG AGGTGAAGGT CATGCGATGC CTGGAGCACC CGAATGTGCT CAAGTTCATC 1200
GGGGTGCTCT ACAAAGACAA GAGGCTCAAC TTCATCACCG AGTACATCAA GGGCGGCACG 1260
CTCCGGGGCA TCATCAAGAG CATGGATAGT CAGTACCCCT GGAGTCAGAG GGTGAGCTTT 1320
GCCAAGGACA TCGCTTCTGG GATGGCCTAC CTCCACTCCA TGAACATCAT CCACCGGGAC 1380
CTCAACTCCC ACAACTGCCT GGTTCGCGAG AACAAGAATG TGGTGGTGGC CGACTTCGGG 1440
CTGGCGCGGC TCATGGTGGA CGAGAAGACG CAGCCCGAGG ACCTGCGGAG CCTCAAGAAG 1500
CCAGACCGGA AAAAGCGGTA CACGGTGGTG GGCAACCCCT ACTGGATGGC GCCCGAGATG 1560
ATCAACGGCC GCAGCTACGA TGAGAAGGTG GATGTGTTCT CGTTCGGGAT CGTCCTGTGC 1620
GAGATCATTG GGCGAGTGAA CGCTGACCCG GACTACCTGC CACGCACCAT GGATTTCGGC 1680
CTCAATGTGC GAGGCTTCCT GGACCGCTAC TGCCCCCCAA ACTGCCCCCC GAGCTTCTTC 1740
CCCATTACCG TGCGCTGCTG TGACCTGGAC CCCGAGAAGA GGCCCTCCTT CGTGAAGCTG 1800
GAGCAGTGGC TGGAGACCCT CCACATGCAC TTGGCTGGCC ACCTGCCGCT GGGCCCACAG 1860
CTGGAGCAGC TGGACAGGGG CTTCTGGGAG ACCTACCGGC GTGGCGAGAG CGGACTGCCC 1920
GCCCACCCCG AGGTCCCTGA CTGA 1944
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r+lehpnvlk
Q: 339   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLK  398
         689*********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119
         fiGvl+kdk+l+++teyi+gGtl+ ++ks++s +pw+qrv++akdiasG++ylhs++iih
Q: 399   FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSqYPWSQRVSFAKDIASGMAYLHSMNIIH  458
         ******************************999***************************
S: 120   rdlnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaP  179
         rdlns+nclvre+k+vvvadfGlarl+v+e++++e+lrslkk drkkr+tvvG+PywmaP
Q: 459   RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEDLRSLKKPDRKKRYTVVGNPYWMAP  518
         ************************************************************
S: 180   evlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPea  239
         e+++g+sydekvdvfsfGivlceii+rv+adPdylPrt+dfgl+v+ f +++++ +cP++
Q: 519   EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPS  578
         ************************************************************
S: 240   flklavvccdldpesrpsfeelekkl  265
         f++++v+ccdldpe+rpsf++le++l
Q: 579   FFPITVRCCDLDPEKRPSFVKLEQWL  604
         ************************97
Domain Sequence
(FASTA)
LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RCLEHPNVLK 60
FIGVLYKDKR LNFITEYIKG GTLRGIIKSM DSQYPWSQRV SFAKDIASGM AYLHSMNIIH 120
RDLNSHNCLV RENKNVVVAD FGLARLMVDE KTQPEDLRSL KKPDRKKRYT VVGNPYWMAP 180
EMINGRSYDE KVDVFSFGIV LCEIIGRVNA DPDYLPRTMD FGLNVRGFLD RYCPPNCPPS 240
FFPITVRCCD LDPEKRPSFV KLEQWL 266
KeywordComplete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00180
EKS-ANC-00185
EKS-CAF-00197
EKS-CAP-00216
EKS-CIS-00229
EKS-DAR-00492
EKS-DIO-00098
EKS-DRM-00101
EKS-EQC-00186
EKS-FEC-00179
EKS-GAM-00108
EKS-GAG-00164
EKS-GAA-00234
EKS-GOG-00189
EKS-HOS-00197
EKS-ICT-00183
EKS-LAC-00202
EKS-LOA-00189
EKS-MAM-00192
EKS-MAE-00074
EKS-MEG-00151
EKS-MIM-00089
EKS-MOD-00190
EKS-MUM-00194
EKS-MUP-00195
EKS-MYL-00196
EKS-OCP-00125
EKS-ORN-00242
EKS-ORA-00170
EKS-ORC-00174
EKS-ORL-00227
EKS-OTG-00197
EKS-PAT-00182
EKS-PES-00169
EKS-POA-00188
EKS-RAN-00185
EKS-SAH-00188
EKS-SUS-00165
EKS-TAG-00217
EKS-TAR-00248
EKS-TEN-00242
EKS-TUT-00179
EKS-XET-00223
EKS-XIM-00238
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005925; C:focal adhesion
GO:0043005; C:neuron projection
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0008270; F:zinc ion binding
GO:0051444; P:negative regulation of ubiquitin-protein ligase activity
GO:0032233; P:positive regulation of actin filament bundle assembly
GO:0045773; P:positive regulation of axon extension
KEGG
bta:535225;
InterPros
IPR011009; Kinase-like_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 2.
PF00595; PDZ; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00132; LIM; 2.
SM00228; PDZ; 1.
Prosites
PS00478; LIM_DOMAIN_1; 2.
PS50023; LIM_DOMAIN_2; 2.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013