EKS-BOT-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	379.2	9.2E-114	187	435	249

Status

Unreviewed

Ensembl Protein

ENSBTAP00000053595

UniProt Accession

E1BNA8;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK6

Gene Synonyms/Alias

PTK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000044091	ENSBTAP00000053595	ENSBTAT00000061122

Organism

Bos taurus

Functional Description

Protein Length

446

Protein Sequence
(FASTA)

GQVPLGPRYM GLWDFEARTA EELSFQAGDL FYVARKEEEW WWAVRLDGAG RALAEGYVPY 60

NYLAEKETVE SEPWFFGRIS RSEALHRLQA MGNEQGSFLI RISEKPGADY VLSVRDQQTV 120

RHYKIWWRAG RLHLNEAVSF PGLSELVDHH KVQSLSHGLR LTSPCRKHEP EPLPHCDDWE 180

RPREEFTLCR KLGSGYFGEV FEGLWKDKVR VAIKVIARAD LLHQHTFQSE IQAMKKLRHK 240

HILALYAVAS AGDPVYIVTE LMPKGSLLEL LRDSDEKALP VSELMDIAAQ VAEGMCYLES 300

QNYIHRDLAA RNILVGENNI CKVGDFGLAR LIKEDIYLSY DHNIPYKWTA PEALSRGHYS 360

IKSDIWSFGV LLHEIFSRGQ MPYPGMSNHE AFLRVESGYR MPRPPECPPT THKLMLSCWH 420

KDPEQRPYFK GLWEKLSSLT RYENPL 446

Nucleotide Sequence
(FASTA)

GGCCAGGTTC CCCTGGGCCC CAGGTACATG GGCCTCTGGG ACTTTGAGGC TCGGACTGCT 60

GAGGAGCTGA GCTTCCAGGC AGGGGACCTC TTCTACGTGG CCAGAAAGGA GGAGGAGTGG 120

TGGTGGGCCG TGAGGCTGGA TGGGGCAGGC CGGGCCCTGG CTGAGGGCTA CGTGCCCTAC 180

AACTACCTGG CTGAGAAGGA GACTGTGGAG TCGGAGCCGT GGTTCTTCGG CCGAATCTCT 240

CGTTCGGAAG CTCTGCACCG ACTGCAGGCC ATGGGCAATG AGCAGGGGTC CTTCCTGATC 300

CGCATCAGCG AGAAGCCAGG CGCCGATTAC GTCCTCTCGG TGCGGGACCA GCAGACCGTG 360

CGCCACTACA AGATCTGGTG GCGGGCCGGC CGGCTGCACC TCAACGAGGC TGTGTCCTTC 420

CCTGGCCTGT CTGAGCTTGT GGATCACCAC AAGGTCCAGA GCCTATCCCA CGGCCTGCGG 480

CTGACCTCGC CCTGCCGGAA GCACGAGCCA GAGCCCCTGC CCCACTGTGA TGACTGGGAG 540

AGGCCACGGG AGGAGTTCAC ACTCTGCAGG AAGCTGGGCT CCGGCTACTT CGGGGAGGTC 600

TTTGAAGGGC TCTGGAAGGA CAAGGTCCGA GTGGCCATCA AGGTGATCGC CCGAGCCGAC 660

CTTCTGCACC AGCACACGTT CCAGTCGGAG ATCCAGGCCA TGAAGAAGCT GCGGCACAAG 720

CACATCCTGG CCCTGTACGC AGTGGCGTCC GCGGGGGACC CGGTGTACAT TGTCACGGAG 780

CTCATGCCCA AGGGGAGCCT GCTGGAGCTG CTGAGGGACT CCGACGAGAA AGCCCTGCCC 840

GTTTCGGAGC TGATGGACAT TGCAGCACAG GTGGCTGAGG GCATGTGCTA CCTGGAATCG 900

CAGAACTACA TCCACCGGGA CCTGGCTGCC AGGAACATCC TCGTGGGGGA AAACAACATC 960

TGCAAAGTCG GGGACTTCGG GCTGGCCAGG CTCATCAAGG AGGACATCTA TCTCTCCTAT 1020

GACCACAACA TCCCTTACAA GTGGACTGCC CCAGAGGCGC TCTCCCGAGG GCATTACTCC 1080

ATCAAGTCTG ACATCTGGTC CTTTGGGGTT CTCCTCCATG AGATTTTCAG CAGGGGTCAG 1140

ATGCCCTATC CAGGCATGTC CAACCACGAG GCCTTCCTGA GGGTGGAGAG CGGCTACCGC 1200

ATGCCCCGCC CCCCAGAGTG CCCGCCCACC ACACACAAGC TGATGCTCTC CTGCTGGCAC 1260

AAGGACCCTG AGCAGAGACC CTACTTCAAA GGGCTGTGGG AGAAGCTCTC CAGCTTAACA 1320

AGGTACGAGA ACCCGCTCTG A 1341

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60

         +l++klG+G+fGev++g+wk++v+va+k++ +++ l++++f++e+q++kklrh+++++ly

Q: 187   TLCRKLGSGYFGEVFEGLWKDKVRVAIKVIARADlLHQHTFQSEIQAMKKLRHKHILALY  246

         799***************************9988699***********************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av+s+++P+yivtelm kGsll++l+++++k+l++++l+d+aaqvaeGm+yle++n+ihr

Q: 247   AVASAGDPVYIVTELMPKGSLLELLRDSDEKALPVSELMDIAAQVAEGMCYLESQNYIHR  306

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dlaarn+lvge++++kv+dfGlarli++d+y + + +++P+kWtaPea++ g+++iksd+

Q: 307   DLAARNILVGENNICKVGDFGLARLIKEDIYLSYD-HNIPYKWTAPEALSRGHYSIKSDI  365

         *******************************9876.99**********************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+++G++PypGm+n+e++ +ve gyr+prp ecp + ++l+l+cw+kdpe+

Q: 366   WSFGVLLHEIFSRGQMPYPGMSNHEAFLRVESGYRMPRPPECPPTTHKLMLSCWHKDPEQ  425

         ************************************************************

S: 241   rPtfetlqev  250

         rP f+ l e+

Q: 426   RPYFKGLWEK  435

         ****999776

Domain Sequence
(FASTA)

TLCRKLGSGY FGEVFEGLWK DKVRVAIKVI ARADLLHQHT FQSEIQAMKK LRHKHILALY 60

AVASAGDPVY IVTELMPKGS LLELLRDSDE KALPVSELMD IAAQVAEGMC YLESQNYIHR 120

DLAARNILVG ENNICKVGDF GLARLIKEDI YLSYDHNIPY KWTAPEALSR GHYSIKSDIW 180

SFGVLLHEIF SRGQMPYPGM SNHEAFLRVE SGYRMPRPPE CPPTTHKLML SCWHKDPEQR 240

PYFKGLWEK 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016477	; P:cell migration
GO:0071300	; P:cellular response to retinoic acid
GO:0060575	; P:intestinal epithelial cell differentiation
GO:0045926	; P:negative regulation of growth
GO:0061099	; P:negative regulation of protein tyrosine kinase activity
GO:0010976	; P:positive regulation of neuron projection development
GO:0046777	; P:protein autophosphorylation
GO:0042503	; P:tyrosine phosphorylation of Stat3 protein
GO:0042506	; P:tyrosine phosphorylation of Stat5 protein

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013