EKS-BOT-00072
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00072
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK313.21.5E-931285285
StatusUnreviewed
Ensembl ProteinENSBTAP00000054058
UniProt AccessionG3MX00;
Protein Name
Protein Synonyms/Alias
Gene NameCDK4
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000045571ENSBTAP00000054058ENSBTAT00000064308
OrganismBos taurus
Functional Description
Protein Length295
Protein Sequence
(FASTA)
YEPVVEIGVG AYGTVYKARD PHSGHFVALK SVRVPSGGGA VGGLPISSVR EVALLQRLEA 60
FEHPNVVRLM DVCATETKAT LVFEHVDQDL RTYLDKGPPP DLPVEITKDL MHQFPRGLDF 120
LHANCIVHRD LKPENILVTN GGTVKLAAFG LARIHSYQMA LTPMVVTVWY RAPEVLLPST 180
YATPVDMWSV GCIFAEMFHR KPLFCGNSEA DQLGKIFDLI GLPPEDDWTR EVSLPQGAFS 240
PRGPRPVQSV VPELEESGAQ LLLEMLTFNP HKRISAFQAL QLSYLHKAEG QTKQT 295
Nucleotide Sequence
(FASTA)
TATGAGCCAG TGGTTGAGAT TGGTGTCGGT GCCTATGGGA CAGTGTATAA GGCCCGTGAT 60
CCCCACAGTG GCCACTTCGT GGCCCTCAAG AGTGTAAGAG TCCCCAGTGG AGGAGGTGCT 120
GTCGGGGGCC TGCCCATCAG TTCTGTTCGG GAGGTGGCCT TACTGCAGCG TCTGGAGGCT 180
TTTGAGCATC CCAATGTTGT CAGGCTCATG GACGTCTGTG CAACGGAGAC CAAAGCGACC 240
CTGGTGTTTG AGCATGTGGA CCAAGACCTA AGGACATATC TGGACAAGGG ACCCCCACCA 300
GACTTGCCAG TGGAGATCAC AAAGGATCTG ATGCACCAGT TTCCAAGAGG CCTGGATTTC 360
CTTCATGCCA ACTGCATCGT TCACCGAGAC CTGAAGCCAG AGAACATTCT GGTGACAAAT 420
GGTGGGACAG TCAAGCTGGC TGCCTTTGGC CTGGCCAGAA TCCACAGCTA CCAGATGGCA 480
CTTACACCTA TGGTTGTTAC AGTCTGGTAT CGTGCTCCAG AAGTTCTTTT GCCATCTACA 540
TATGCAACAC CCGTGGACAT GTGGAGCGTT GGCTGTATCT TCGCAGAGAT GTTTCATCGA 600
AAGCCTCTCT TCTGTGGAAA CTCTGAAGCT GACCAGTTAG GCAAAATCTT TGACCTGATC 660
GGACTGCCCC CAGAGGATGA CTGGACCCGA GAGGTCTCTC TACCCCAAGG AGCCTTTTCC 720
CCCAGAGGGC CCCGCCCAGT GCAGTCGGTG GTCCCTGAGC TGGAGGAATC TGGAGCACAG 780
CTGCTGCTGG AGATGCTGAC TTTTAACCCA CACAAGCGAA TCTCTGCCTT CCAAGCCCTG 840
CAGCTGTCTT ATCTACACAA GGCAGAAGGA CAAACAAAAC AAACA 885
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel..  55
         ye + +ig G+yg+vyka+d ++g++vAlK++r+ +      g+pi+++rE++ll++l  
Q: 1     YEPVVEIGVGAYGTVYKARDPHSGHFVALKSVRVPSGGGavgGLPISSVREVALLQRLea  60
         778889****************************998744449**************988
S: 56    .khknivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegla  114
          +h+n+v+L++v+a +++k +Lvfe+++qdL ++l+k +  +l+ e  k l++q+ +gl+
Q: 61    fEHPNVVRLMDVCA-TETKATLVFEHVDQDLRTYLDKGPPPDLPVEITKDLMHQFPRGLD  119
         89************.99*******************************************
S: 115   ylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlg  174
         +lH+n i+HRDlKp+N+L+++ g++kla fGlar  s ++  +t+ vvT+wYraPe+Ll 
Q: 120   FLHANCIVHRDLKPENILVTNGGTVKLAAFGLARIHSYQMA-LTPMVVTVWYRAPEVLLP  178
         ************************************99998.*****************8
S: 175   akeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpey  234
         ++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++w +  +lp+ 
Q: 179   ST-YATPVDMWSVGCIFAEMFHRKPLFCGNSEADQLGKIFDLIGLPPEDDWTREVSLPQG  237
         85.*******************************************************96
S: 235   kksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
            f+++ ++ ++++v++l+e++ +ll ++l+++p+kRisa +alq +y+
Q: 238   A--FSPRGPRPVQSVVPELEESGAQLLLEMLTFNPHKRISAFQALQLSYL  285
         5..9999***************************************9885
Domain Sequence
(FASTA)
YEPVVEIGVG AYGTVYKARD PHSGHFVALK SVRVPSGGGA VGGLPISSVR EVALLQRLEA 60
FEHPNVVRLM DVCATETKAT LVFEHVDQDL RTYLDKGPPP DLPVEITKDL MHQFPRGLDF 120
LHANCIVHRD LKPENILVTN GGTVKLAAFG LARIHSYQMA LTPMVVTVWY RAPEVLLPST 180
YATPVDMWSV GCIFAEMFHR KPLFCGNSEA DQLGKIFDLI GLPPEDDWTR EVSLPQGAFS 240
PRGPRPVQSV VPELEESGAQ LLLEMLTFNP HKRISAFQAL QLSYL 285
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0000785; C:chromatin
GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005829; C:cytosol
GO:0031965; C:nuclear membrane
GO:0005730; C:nucleolus
GO:0005667; C:transcription factor complex
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0051726; P:regulation of cell cycle
GO:0010468; P:regulation of gene expression
GO:0042493; P:response to drug
GO:0007165; P:signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013