EPS-BOT-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	205.1	1.7E-60	659	904	246

Status

Unreviewed

Ensembl Protein

ENSBTAP00000056022

UniProt Accession

G3N2B1;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000045832	ENSBTAP00000056022	ENSBTAT00000066319

Organism

Bos taurus

Functional Description

Protein Length

1176

Protein Sequence
(FASTA)

LSCLFVLVVG KPHSTGSSER IQLSGTYNVR KGKMHLPVNR WTRRQVILCG TCLIVSSVKD 60

SVAGKMHVLP LIGGKVEEVK KHQHCLAFSS SGPQSQTYYI CFDTFTEYLR WFDKSPRVAS 120

QRISSVDLSC CSLEHLPANL FYSQDLTHLN LKQNFLRQNP SLPTARGLSE LQRFTKLKSL 180

NLSNNHLGDF PLAVCNIPTL AELNMSCNAL RAVPAAVGAM HNLQTFLLDG NFLQTLPAEL 240

ENMHQLSYLG LSFNEFTDLP EVLQKLTAVE KLCMSGNCVG TLRLQALRKM PHIKHVDLRL 300

NVIRNLIADG VDFLPHVTQL DLRDNKLEGL DAVVFTNLEV LHCERNQLVT LNACGCFLKA 360

LYASSNELVQ LDVCPVPNYL SYMDVSRNCL ENVPEWVCES RKLEVLDIGH NQICELPARL 420

FCNSSLRKLL AGHNRMARLP ESLERTSVEV LDVQHNQLLE LPPSLLMKAD SLRFLNASAN 480

KLETLPPATL SEETNSILQE LYLTNNNLTD KCVSLLTGHP HLKVLHMAYN RLQSFPASKM 540

AKLEELEEID LSGNKLKAVP TTIMNCRRMH TVTAHSNCIE VFPEVMQLPE IKCVDLSCNE 600

LSEVTLPENL PPKLQELDLT GNPRLALDHR TLELLNNIRC FKIDQPSAGD ASGAPAVWSH 660

GYTEASGVKN KLCVAALSVN NFCDNQEALY GVFDGDRNVE VPYLLQCTMS DILAEELQKT 720

RDGEECMVNT FIVMQRKLGT AGQKLGGAAV LCHIRHDPVD PGGPFTLTSA NVGKCQTVLC 780

RNGKPLPLSR SYVMSCEEEL RRIKRHKAIV TEDGKVNGVT ESTRILGYTF LHPSVVPRPH 840

VQSVALSPQD EFFILGSKGL WDSLSVEEAV DAVRSVPDAL AAAKKLCTLA QSYGCRESVS 900

AVVVQLSVPE DSFCCCELAA LPPPSPGVFA PAAGVAVRER PADGLGAPSS SSGLASEMSS 960

ELSTSEMSSE VGSTASDEPP PPGPLGEGSP AGPGEPRCAL HPGGAPSAFQ RQLSSATFSS 1020

AFSDNGLDSD DEEPIEGVFS NGSRVEVAAD IHCGRARDGE RRRPPEAADE GVGAVEDEPG 1080

ASRRVDGAAG TMGRRRGNGS VAPQERSHNV IEVAADAPLR RPGGYFAAPA QPDPDDQLII 1140

PPELEEEVKE MMKQRPPAPP RPGPAEPADC SCDTPL 1176

Nucleotide Sequence
(FASTA)

CTAAGCTGTT TGTTTGTGCT TGTTGTAGGC AAACCTCACA GCACCGGTAG CTCTGAGCGG 60

ATTCAGCTCT CAGGAACGTA CAATGTCCGT AAAGGCAAGA TGCACTTGCC AGTGAACCGA 120

TGGACCAGAC GCCAAGTCAT CCTGTGTGGG ACCTGCCTGA TCGTGTCATC TGTGAAGGAC 180

AGCGTGGCCG GGAAGATGCA CGTGCTGCCG CTCATCGGTG GCAAAGTAGA AGAAGTGAAA 240

AAGCACCAGC ACTGTTTAGC ATTTAGTTCT TCTGGACCTC AAAGCCAGAC GTACTACATA 300

TGTTTTGATA CATTCACAGA GTATTTAAGG TGGTTCGACA AGTCTCCAAG GGTCGCATCG 360

CAGCGCATTA GCTCAGTGGA CCTCTCCTGT TGTAGCTTGG AGCATCTGCC TGCCAACCTC 420

TTCTACAGCC AAGACCTCAC TCATCTCAAT TTAAAACAGA ACTTTCTAAG GCAGAATCCC 480

AGTCTACCAA CTGCACGGGG GCTCAGCGAA CTGCAACGGT TCACCAAGTT GAAGAGTCTT 540

AACCTTTCCA ACAACCATTT AGGGGACTTC CCACTAGCGG TCTGCAATAT TCCAACCCTG 600

GCTGAGCTCA ACATGTCGTG CAATGCCCTC CGAGCCGTCC CGGCCGCCGT GGGAGCGATG 660

CACAACTTAC AGACATTTTT GTTGGATGGA AACTTTCTCC AGACCCTTCC TGCTGAGTTG 720

GAGAACATGC ATCAGCTTAG TTATCTTGGT CTTTCTTTCA ATGAATTCAC TGACCTTCCA 780

GAGGTGCTGC AGAAGCTGAC AGCTGTGGAG AAGCTCTGTA TGTCTGGGAA CTGCGTGGGG 840

ACGCTTCGGC TACAGGCGTT AAGAAAAATG CCTCACATTA AGCATGTGGA TCTAAGACTG 900

AACGTAATTA GGAACCTAAT AGCGGACGGA GTGGACTTTC TCCCTCACGT CACTCAGCTC 960

GATCTGCGAG ACAACAAGCT TGAGGGTCTG GATGCTGTGG TTTTCACCAA CCTTGAAGTT 1020

TTACACTGTG AAAGGAATCA GCTGGTGACG TTAAACGCCT GTGGCTGCTT CCTCAAAGCT 1080

CTCTATGCCT CTTCTAACGA GCTTGTCCAG CTTGACGTTT GCCCAGTTCC GAATTATCTG 1140

TCCTACATGG ATGTCTCAAG GAACTGTTTA GAAAACGTAC CTGAGTGGGT CTGTGAAAGC 1200

CGAAAGCTAG AAGTTTTGGA TATTGGCCAT AATCAAATAT GTGAACTTCC TGCACGCCTG 1260

TTTTGCAACA GTAGTCTCCG GAAACTGCTG GCAGGACACA ACCGGATGGC CAGGCTTCCT 1320

GAGAGTCTGG AAAGGACCTC CGTGGAGGTC TTGGATGTGC AACACAACCA GCTCCTGGAG 1380

CTGCCGCCCA GCCTCCTGAT GAAGGCCGAC AGCCTGAGAT TCCTGAATGC GTCTGCAAAC 1440

AAACTGGAAA CCCTCCCTCC AGCCACACTT TCAGAGGAGA CCAACAGCAT CTTACAGGAG 1500

TTGTATTTGA CGAACAACAA CCTCACAGAT AAATGTGTGT CCTTGTTAAC CGGACACCCC 1560

CATCTGAAGG TTCTTCACAT GGCCTACAAC CGACTTCAGA GTTTTCCCGC AAGTAAAATG 1620

GCGAAACTGG AGGAACTTGA AGAGATCGAC CTCAGTGGGA ATAAACTAAA GGCCGTGCCG 1680

ACGACCATCA TGAACTGCAG GCGCATGCAC ACCGTGACAG CTCACTCCAA CTGCATCGAA 1740

GTCTTCCCTG AGGTGATGCA GCTCCCGGAG ATCAAGTGCG TGGACCTGAG CTGTAACGAG 1800

CTAAGCGAAG TCACATTACC AGAAAACCTG CCTCCGAAGC TGCAAGAGCT GGACCTGACT 1860

GGAAACCCCC GGCTCGCCCT TGACCACAGA ACCCTGGAGC TGCTGAATAA TATCCGCTGT 1920

TTCAAGATTG ATCAACCTTC GGCAGGAGAT GCTTCTGGAG CTCCAGCCGT GTGGAGCCAT 1980

GGCTACACCG AAGCTTCAGG GGTGAAAAAC AAGTTGTGTG TGGCAGCCCT GTCGGTGAAT 2040

AACTTCTGCG ATAACCAGGA GGCCCTGTAC GGTGTGTTTG ACGGAGACCG CAACGTGGAG 2100

GTGCCCTACC TGCTCCAGTG CACCATGAGC GACATTCTGG CAGAGGAGCT GCAGAAAACG 2160

AGGGACGGGG AGGAGTGCAT GGTCAACACG TTCATCGTTA TGCAGAGGAA ACTGGGCACA 2220

GCTGGGCAGA AGCTCGGAGG CGCTGCTGTC CTTTGTCACA TCAGGCACGA CCCTGTGGAC 2280

CCCGGAGGAC CCTTCACCCT GACCTCCGCC AATGTGGGCA AGTGCCAGAC GGTGCTGTGT 2340

CGGAACGGCA AGCCGCTGCC CCTCTCCAGG TCGTATGTCA TGAGCTGCGA GGAGGAGCTG 2400

CGGAGAATCA AGCGGCACAA GGCCATCGTC ACCGAGGACG GCAAAGTGAA CGGAGTGACC 2460

GAGTCCACGC GCATCCTGGG CTACACCTTC CTGCACCCCA GCGTGGTGCC CCGCCCACAC 2520

GTGCAGTCCG TGGCCTTAAG CCCCCAGGAC GAGTTCTTCA TCCTGGGCAG CAAGGGGCTG 2580

TGGGACAGCC TGTCCGTGGA GGAGGCCGTG GACGCCGTGC GCAGCGTGCC GGATGCGCTG 2640

GCCGCCGCTA AGAAGCTCTG CACCCTGGCG CAGAGCTACG GCTGCCGCGA GAGCGTGAGC 2700

GCGGTGGTCG TGCAGCTCAG CGTTCCCGAG GACAGCTTCT GCTGCTGTGA ACTGGCCGCC 2760

CTGCCGCCGC CCAGCCCCGG CGTCTTCGCG CCCGCCGCCG GTGTGGCCGT CCGGGAGCGG 2820

CCGGCCGACG GGCTGGGCGC GCCGTCCTCC AGCAGTGGGC TGGCTTCTGA GATGAGCAGC 2880

GAGCTGTCCA CATCGGAGAT GAGCAGTGAG GTGGGCTCCA CGGCCTCGGA CGAGCCGCCG 2940

CCGCCGGGCC CGCTGGGCGA GGGTAGCCCC GCCGGCCCCG GCGAGCCCCG CTGCGCGCTG 3000

CACCCTGGGG GCGCGCCCAG CGCCTTCCAG CGGCAGCTGT CCAGCGCCAC CTTCTCTAGC 3060

GCTTTCTCGG ACAACGGGTT GGACAGCGAC GATGAGGAGC CCATCGAGGG CGTGTTCAGC 3120

AACGGCAGCC GCGTGGAGGT GGCAGCGGAC ATCCACTGCG GCCGCGCCAG GGACGGGGAG 3180

CGCCGGCGGC CGCCCGAGGC CGCCGACGAG GGCGTGGGCG CCGTGGAGGA CGAGCCGGGC 3240

GCGTCGCGGC GCGTGGACGG GGCCGCGGGG ACCATGGGGC GCCGGCGGGG AAACGGCTCT 3300

GTGGCCCCCC AGGAGCGCAG CCACAACGTG ATCGAGGTGG CCGCCGACGC GCCGCTGCGC 3360

AGGCCGGGCG GGTACTTCGC GGCCCCAGCG CAGCCGGACC CCGACGACCA GCTCATCATC 3420

CCCCCGGAGC TGGAGGAGGA GGTGAAGGAA ATGATGAAGC AGCGGCCGCC CGCGCCGCCG 3480

CGCCCGGGCC CCGCGGAACC GGCGGACTGC AGCTGCGACA CGCCGCTCTG A 3531

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 659   SHGYTEASGVKNKLCVAALSVNNFCDNQEA-----LYGVFDGDRNVEVPYLLQCTMSDIL  713

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++r+ ++++ ++F+ ++++l       ++ +k G +av+++i+++

Q: 714   AEELQ----KTRDGEECMVNTFIVMQRKL------GTAGQKLGGAAVLCHIRHDpvdpgg  763

         ***99....99999***************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ + +s+e+El+Ri+++++ v+++   +v+Gv++

Q: 764   pfTLTSANVGKCQTVLCRNGKPLPLSRSYVMSCEEELRRIKRHKAIVTEDG--KVNGVTE  821

         *************************************************99..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ l+++def+iL+s+Glwd +s eeav++vr+v +

Q: 822   STRILGYTFLHPSVVPRPHVQSVALSPQDEFFILGSKGLWDSLSVEEAVDAVRSVPD---  878

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++++vsa+vv

Q: 879   -ALAAAKKLCTLAQSYGCRESVSAVVV  904

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNQEA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTRDGEECMV NTFIVMQRKL GTAGQKLGGA AVLCHIRHDP VDPGGPFTLT SANVGKCQTV 120

LCRNGKPLPL SRSYVMSCEE ELRRIKRHKA IVTEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVALSP QDEFFILGSK GLWDSLSVEE AVDAVRSVPD ALAAAKKLCT LAQSYGCRES 240

VSAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>