EPS-CAF-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	211.2	2.8E-62	867	1112	246

Status

Unreviewed

Ensembl Protein

ENSCAFP00000000107

UniProt Accession

F1PVE1;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000000070	ENSCAFP00000000107	ENSCAFT00000000123

Organism

Canis familiaris

Functional Description

Protein Length

1388

Protein Sequence
(FASTA)

ADLLLPRGPG GRTICASRAS PAPTDSFFGE PGARRALDGA AAGAASDTES FSLSPSAESV 60

SDRLDPYSSG SGSSSSCEEL EGDPAPAPAP APAPALALPG RCAQPRPPSP TASPPPLQPK 120

GPRGVDGPGG AARDRPREEK AAAAAAPGRP PSAPEKAPPP PTLYVQLHGE ATRRLEADEK 180

PLQIQNDYLF QLGFGELWRV QEEGMDSEVG CLIRFYAGKP HSTGSSERIQ LSGMYNVRKG 240

KMQLPVNRWT RRQVILCGTC LIVSSVKDSL TGKMHVLPLI GGKVEEVKKH QHCLAFSSSG 300

PQSQTYYICF DTFTEYLRWL RQVSKVASQR ISSVDLSCCS LEHLPANLFY SQDLTHLNLK 360

QNFLRQNPCL PTARGLNELQ RFTKLKSLNL SNNHLGEFPL AVCNIPTLTE LNVSCNALRA 420

VPAAVGVMHN LQTFLLDGNF LQALPPELEN MHQLSYLGLS FNEFTDIPEI LEKLTAVDKL 480

CMSGNCMETL RLEALRKMPH IKHVDLRLNV IRKLIADEVD FLQHVTQLDL RDNKLGDLDA 540

MIFNNIEVLH CERNQLVTLN ICGYFLKALY AASNELVQLD VYPVPNYLSY MDVSRNCLEN 600

VPEWVCESRK LEVLDIGHNQ ICELPARLFC HSSLRKLLAG HNQLTRLPER LERTSVEVLD 660

VQHNQLLELP PNLLMKADSL RFLNASANKL ETLPPATLSE ETNSILQELY LTNNNLTDKC 720

VPLLTGHPHL KILHMAYNRL QSFPASKMAK LEELEEIDIS GNKLKAIPTT IMNCRRMHTM 780

IAHSNCIEVF PEVMQLPEIK CVDLSCNELS EVTLPENLPP KLQELDLTGN PRLALDHKTL 840

ELLNNIRCFK IDQPSTGDAS GAPAVWSHGY TEASGVKNKL CVAALSVNNF CDNREALYGV 900

FDGDRNVEVP YLLQCTMSDI LAEELQKTKN EEEYMVNTFI VMQRKLGTAG QKLGGAAVLC 960

HIKHDPVDPG GSFTLTSANV GKCQTVLCRN GKPLPLSRSY VMSCEEERKR IKQHKAIITE 1020

DGKVNGVTES TRILGYTFLH PSVVPRPHVQ SVPLTPQDEF FILGSKGLWD SLSSEEAVAA 1080

VRHVPDALAA AKKLCTLAQS YGCHDSLSAV VVQLSVTEDS FCCCELGAGG AGPPPSPGIF 1140

PPSVSMVIKD RPADALGVPS SSSGMASEMS SELSTSEMSS EVGSTASDEP PSGALAESSP 1200

AYASEPRCTL HPGGLASAFQ RQLSSATFSS AFSDNGLDSD DEEPIEGVFS NGSRVEVEVD 1260

IHCGRAREKE AQRLLHVPAE ASDEGIVTSA NEDEPGLPRR PDGAAGTIGR RRPNGSVAPQ 1320

ERSHNVIEVA ADAPLRKPGG YFAAPAQPDP EDQFIIPPEL EEEVKEMMKQ QQQPAGLQPA 1380

PRPSPGDP 1388

Nucleotide Sequence
(FASTA)

GCGGACCTGC TGTTGCCCCG CGGCCCCGGC GGGCGGACGA TATGCGCCTC CCGCGCCAGC 60

CCCGCGCCGA CGGACTCCTT TTTCGGGGAG CCGGGCGCCC GGCGGGCCCT GGACGGCGCG 120

GCGGCGGGCG CGGCCTCCGA CACCGAGAGC TTCAGCCTGA GCCCCAGCGC CGAGAGCGTG 180

TCGGACCGGC TGGACCCCTA CAGCAGCGGC AGCGGCTCCT CGTCGTCGTG CGAGGAGCTG 240

GAGGGTGACC CGGCCCCGGC CCCGGCCCCG GCCCCGGCCC CGGCCCTGGC CCTGCCCGGC 300

CGCTGCGCGC AGCCCCGGCC GCCCTCCCCG ACGGCCTCCC CGCCGCCGCT GCAGCCGAAA 360

GGCCCGCGGG GCGTCGACGG CCCGGGAGGG GCCGCCCGCG ACCGGCCTCG GGAGGAGAAG 420

GCGGCGGCAG CCGCGGCCCC GGGCCGCCCC CCGAGCGCGC CGGAGAAGGC GCCGCCGCCG 480

CCCACCCTGT ACGTGCAGCT CCACGGGGAG GCCACCCGGC GCCTGGAGGC CGACGAGAAG 540

CCGTTGCAGA TCCAGAATGA CTACCTCTTC CAGCTGGGGT TTGGGGAGTT GTGGAGGGTG 600

CAGGAGGAGG GCATGGACTC GGAGGTCGGC TGCCTCATCC GCTTCTACGC AGGAAAACCT 660

CACAGCACCG GTAGCTCTGA ACGGATTCAG CTCTCAGGAA TGTATAATGT CCGTAAAGGC 720

AAAATGCAGT TGCCAGTGAA CCGATGGACC AGACGCCAAG TCATCCTGTG TGGGACCTGC 780

CTAATAGTAT CATCTGTGAA AGACAGCTTG ACCGGAAAGA TGCATGTTTT GCCACTAATT 840

GGTGGAAAAG TAGAAGAAGT GAAAAAGCAC CAGCACTGTT TAGCATTTAG CTCCTCTGGA 900

CCCCAAAGCC AGACCTACTA CATTTGTTTT GATACATTCA CAGAGTATTT AAGGTGGCTT 960

CGACAAGTCT CCAAGGTTGC ATCACAGCGC ATTAGCTCAG TGGACCTCTC ATGTTGTAGC 1020

CTGGAGCATC TGCCTGCCAA CCTCTTCTAC AGCCAAGACC TCACTCATCT CAACTTAAAA 1080

CAAAACTTCC TAAGGCAAAA TCCCTGCCTG CCAACTGCCA GGGGGCTCAA CGAACTGCAA 1140

AGGTTCACCA AGTTGAAGAG TCTTAATCTT TCCAATAATC ATTTAGGAGA ATTTCCGTTA 1200

GCCGTCTGCA ATATTCCAAC CTTGACCGAG CTGAACGTGT CCTGCAATGC TCTTCGAGCA 1260

GTTCCAGCAG CCGTCGGAGT TATGCACAAC TTACAGACAT TTTTGCTGGA TGGAAACTTT 1320

CTCCAGGCGC TTCCTCCTGA GTTGGAGAAC ATGCATCAGC TTAGTTATCT TGGTCTTTCT 1380

TTCAATGAAT TCACTGACAT TCCAGAGATT TTGGAGAAAT TGACTGCTGT GGATAAACTT 1440

TGTATGTCTG GAAACTGTAT GGAGACCCTG AGGCTAGAGG CTTTAAGAAA AATGCCTCAC 1500

ATTAAACATG TGGATCTAAG ACTGAACGTA ATTAGGAAGC TAATAGCAGA TGAAGTGGAC 1560

TTTCTCCAGC ATGTCACTCA GCTTGATCTG CGTGACAATA AGCTTGGTGA TCTAGATGCC 1620

ATGATTTTCA ATAACATTGA AGTTCTACAC TGTGAAAGGA ATCAGCTGGT GACATTAAAC 1680

ATCTGTGGCT ATTTCCTAAA AGCGCTCTAT GCTGCTTCTA ATGAACTTGT TCAACTGGAT 1740

GTTTACCCAG TTCCAAATTA TCTGTCCTAC ATGGATGTTT CACGGAACTG CTTAGAAAAC 1800

GTGCCTGAGT GGGTATGTGA AAGCCGAAAG CTAGAAGTTT TGGATATTGG CCATAATCAA 1860

ATATGTGAAC TTCCTGCACG CTTATTTTGT CACAGCAGTC TCCGGAAGCT GCTGGCTGGA 1920

CATAACCAGC TGACAAGGCT ACCTGAAAGG CTAGAAAGGA CCTCAGTGGA GGTCTTGGAT 1980

GTGCAACACA ACCAGCTCCT GGAGCTGCCA CCGAACCTTC TCATGAAGGC CGACAGCCTG 2040

AGATTCCTGA ATGCCTCTGC AAACAAACTG GAAACCCTTC CTCCAGCCAC TCTTTCTGAA 2100

GAGACGAACA GCATCTTACA GGAGTTATAT TTGACAAATA ACAACCTCAC AGATAAATGT 2160

GTGCCCTTGT TAACAGGACA CCCTCATCTG AAGATCCTTC ACATGGCCTA TAACCGACTA 2220

CAAAGTTTTC CAGCAAGCAA AATGGCAAAG CTGGAAGAAC TTGAAGAAAT TGACATCAGT 2280

GGAAATAAAC TAAAAGCTAT CCCGACAACC ATCATGAATT GCCGGCGCAT GCACACCATG 2340

ATTGCTCACT CTAATTGCAT TGAAGTCTTT CCTGAAGTTA TGCAGCTCCC AGAAATCAAG 2400

TGCGTGGACC TGAGCTGTAA TGAGCTAAGT GAAGTCACTT TACCCGAAAA CCTGCCTCCA 2460

AAACTTCAAG AACTAGACCT GACTGGAAAC CCCCGACTTG CCCTCGATCA CAAGACCCTG 2520

GAACTGCTGA ATAATATCCG CTGTTTCAAG ATTGATCAAC CTTCAACAGG AGATGCATCT 2580

GGAGCCCCAG CTGTATGGAG CCATGGCTAC ACTGAAGCCT CAGGGGTGAA AAACAAGTTG 2640

TGCGTTGCAG CCCTGTCGGT GAACAACTTC TGCGACAACC GGGAGGCCCT CTATGGGGTG 2700

TTTGATGGAG ACCGTAATGT GGAGGTGCCC TACCTTCTCC AGTGCACTAT GAGTGACATT 2760

TTGGCTGAAG AGCTGCAGAA AACAAAAAAT GAAGAAGAAT ACATGGTCAA TACGTTCATT 2820

GTTATGCAAA GGAAACTTGG AACAGCCGGA CAGAAACTTG GAGGTGCTGC TGTCCTCTGT 2880

CATATCAAGC ATGACCCTGT GGACCCAGGA GGATCCTTCA CCTTGACCTC TGCTAACGTG 2940

GGCAAGTGCC AAACGGTTCT CTGTCGGAAC GGGAAGCCGT TGCCTCTGTC CAGATCATAT 3000

GTCATGAGCT GTGAAGAAGA ACGGAAGAGA ATTAAACAGC ACAAGGCCAT TATCACGGAG 3060

GACGGCAAGG TGAACGGCGT GACGGAGTCC ACGCGCATCC TGGGCTACAC CTTCCTGCAC 3120

CCCAGCGTGG TGCCGCGCCC CCACGTGCAG TCGGTGCCCC TGACCCCCCA GGACGAGTTC 3180

TTCATCCTGG GCAGCAAGGG CTTGTGGGAC AGCCTGTCCA GCGAGGAGGC GGTGGCCGCC 3240

GTGCGCCACG TGCCCGACGC CCTGGCCGCC GCCAAGAAGC TGTGCACCCT GGCCCAGAGC 3300

TACGGCTGCC ACGACAGCCT GAGCGCCGTG GTGGTGCAGC TCAGCGTCAC GGAGGACAGC 3360

TTCTGCTGCT GCGAGCTGGG CGCGGGGGGC GCCGGGCCGC CGCCCAGCCC CGGCATCTTC 3420

CCGCCGTCCG TCAGCATGGT GATCAAGGAC CGGCCGGCCG ACGCGCTGGG TGTGCCGTCC 3480

TCCAGCAGCG GCATGGCCTC CGAGATGAGC AGCGAGCTGT CCACGTCCGA GATGAGCAGC 3540

GAGGTGGGCT CCACGGCCTC GGACGAGCCG CCGTCGGGCG CGCTGGCCGA GAGCAGCCCG 3600

GCCTACGCCA GCGAGCCCCG CTGCACGCTG CACCCCGGGG GCCTGGCCAG CGCCTTCCAG 3660

CGCCAGCTGT CCAGCGCCAC CTTCTCCAGC GCCTTCTCCG ACAACGGCCT GGACAGCGAC 3720

GACGAGGAGC CCATCGAGGG CGTCTTCAGC AACGGCAGCC GCGTGGAGGT CGAGGTGGAC 3780

ATCCACTGCG GCCGCGCCAG GGAGAAGGAG GCGCAGCGCC TGCTGCACGT GCCGGCCGAG 3840

GCCAGCGACG AGGGCATCGT CACCAGCGCC AACGAGGACG AGCCGGGGCT GCCCCGGAGG 3900

CCGGACGGCG CGGCGGGGAC CATCGGGCGG CGCAGGCCCA ACGGCTCGGT GGCGCCCCAG 3960

GAGAGGAGCC ACAACGTGAT CGAGGTGGCC GCCGACGCGC CGCTCCGCAA GCCCGGGGGC 4020

TACTTCGCGG CGCCGGCCCA GCCGGACCCC GAGGACCAGT TCATCATCCC CCCGGAGCTG 4080

GAGGAGGAGG TCAAGGAGAT GATGAAGCAG CAGCAGCAGC CTGCGGGCCT GCAGCCGGCG 4140

CCAAGGCCGA GCCCCGGGGA CCCG 4164

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 867   SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  921

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++ik++

Q: 922   AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIKHDpvdpgg  971

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ + +s+e+E++Ri+++++ ++++   +v+Gv++

Q: 972   sfTLTSANVGKCQTVLCRNGKPLPLSRSYVMSCEEERKRIKQHKAIITEDG--KVNGVTE  1029

         *99*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s++lt++def+iL+s+Glwd +s+eeav++vr+v +

Q: 1030  STRILGYTFLHPSVVPRPHVQSVPLTPQDEFFILGSKGLWDSLSSEEAVAAVRHVPD---  1086

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d++sa+vv

Q: 1087  -ALAAAKKLCTLAQSYGCHDSLSAVVV  1112

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIKHDP VDPGGSFTLT SANVGKCQTV 120

LCRNGKPLPL SRSYVMSCEE ERKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVPLTP QDEFFILGSK GLWDSLSSEE AVAAVRHVPD ALAAAKKLCT LAQSYGCHDS 240

LSAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>