EKS-CAF-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	450.1	3.4E-135	4	286	283

Status

Unreviewed

Ensembl Protein

ENSCAFP00000000121

UniProt Accession

E2QW70;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK2

Gene Synonyms/Alias

CDK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000000082	ENSCAFP00000000121	ENSCAFT00000000140

Organism

Canis familiaris

Functional Description

Protein Length

298

Protein Sequence
(FASTA)

MENFQKVEKI GEGTYGVVYK AKNKVTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60

PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120

HRVLHRDLKP QNLLINAEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 180

STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 240

PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL 298

Nucleotide Sequence
(FASTA)

ATGGAGAACT TCCAAAAAGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 60

GCCAAAAACA AAGTGACGGG AGAAGTGGTG GCGCTTAAAA AAATCCGCCT GGACACTGAG 120

ACGGAGGGTG TACCCAGTAC TGCTATACGA GAGATCTCCC TGCTTAAGGA GCTTAACCAC 180

CCGAACATTG TCAAGCTATT GGATGTCATC CACACAGAAA ACAAACTCTA CCTGGTTTTT 240

GAATTTCTGC ACCAGGATCT GAAGAAATTT ATGGATGCTT CTGCTTTGAC TGGCATTCCT 300

CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCCTT CTGCCATTCT 360

CATCGGGTTC TGCACCGAGA CCTCAAACCT CAGAATCTGC TTATCAACGC AGAGGGGGCC 420

ATCAAGCTAG CAGACTTTGG ATTAGCCAGA GCCTTTGGAG TCCCTGTTCG TACTTACACC 480

CATGAGGTGG TGACCCTGTG GTACCGAGCA CCTGAAATCC TTCTGGGCTG CAAGTACTAC 540

TCCACAGCCG TAGATATCTG GAGCTTGGGC TGCATCTTTG CTGAGATGGT GACCCGACGG 600

GCCTTATTCC CTGGAGATTC TGAAATTGAC CAACTTTTCC GGATCTTTCG GACTCTGGGG 660

ACCCCAGATG AAGTGGTTTG GCCAGGAGTT ACTTCTATGC CTGATTATAA GCCGAGTTTC 720

CCCAAGTGGG CCCGGCAAGA TTTTAGCAAA GTTGTTCCTC CCTTGGATGA AGATGGACGG 780

AGCTTGCTTT CGCAAATGCT GCACTACGAC CCCAACAAGC GGATTTCGGC AAAGGCAGCT 840

CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCACCTTCG ACTCTGA 897

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++k+ekigeGtyg+vykak+k tgevvAlKkirl++e+egvp+ta+rEisllkel+h+ni

Q: 4     FQKVEKIGEGTYGVVYKAKNKVTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         vkLl+v++ +++klyLvfefl+qdLkk++++++ ++++l  +ks+l+qll+gla++Hs++

Q: 64    VKLLDVIH-TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR  122

         ********.99*************************************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi++eg +klaDfGlaraf++p++tyt+evvTlwYraPe+Llg+k+Yst

Q: 123   VLHRDLKPQNLLINAEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST  182

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpk  240

         avDiWs+gci+ae++tr++lf+g+seidql+rif++lgtp+e vwp+v+++p+yk sfpk

Q: 183   AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK  242

         ************************************************************

S: 241   kkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++++++v+ l+e++++ll+++l++dp+kRisak+al+h++f

Q: 243   WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF  286

         ******************************************98

Domain Sequence
(FASTA)

FQKVEKIGEG TYGVVYKAKN KVTGEVVALK KIRLDTETEG VPSTAIREIS LLKELNHPNI 60

VKLLDVIHTE NKLYLVFEFL HQDLKKFMDA SALTGIPLPL IKSYLFQLLQ GLAFCHSHRV 120

LHRDLKPQNL LINAEGAIKL ADFGLARAFG VPVRTYTHEV VTLWYRAPEI LLGCKYYSTA 180

VDIWSLGCIF AEMVTRRALF PGDSEIDQLF RIFRTLGTPD EVVWPGVTSM PDYKPSFPKW 240

ARQDFSKVVP PLDEDGRSLL SQMLHYDPNK RISAKAALAH PFF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0015030	; C:Cajal body
GO:0000781	; C:chromosome, telomeric region
GO:0000793	; C:condensed chromosome
GO:0000307	; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005768	; C:endosome
GO:0005667	; C:transcription factor complex
GO:0000805	; C:X chromosome
GO:0000806	; C:Y chromosome
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0035173	; F:histone kinase activity
GO:0032298	; P:positive regulation of DNA-dependent DNA replication initiation
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0006813	; P:potassium ion transport
GO:0007265	; P:Ras protein signal transduction
GO:0060968	; P:regulation of gene silencing

KEGG

cfa:100855704

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013