EKS-CAF-00306
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00306
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR456.62.8E-137400656257
StatusUnreviewed
Ensembl ProteinENSCAFP00000000139
UniProt AccessionF1PVC5;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000000097ENSCAFP00000000139ENSCAFT00000000159
OrganismCanis familiaris
Functional Description
Protein Length1030
Protein Sequence
(FASTA)
MEVDKNGSKM CEPCGGLCPK ACEGTGSGSR FQTVDSSNID GFVNCTKILG NLDFLITGLN 60
GDPWHKIPAL DPEKLNVFRT VREITGYLNI QSWPPHMHNF SVFSNLTTIG GRSLYNRGFS 120
LLIMKNLNIT SLGLRSLKEI SAGRIYISAN KQLCYHHSLN WTRLLRGPPE ERLDIKHNRP 180
RRDCVAEGKV CDPLCSSGGC WGPGPGQCLS CRNYSRGGVC VTHCNFLNGE PREFAHEAEC 240
FSCHPECQPM EGTATCNGSG SDACAQCAHF RDGPHCVSSC PNGVLGAKGP IYKYPDTHNE 300
CRPCHENCTQ GCKGPELQDC LGQTLALISK THLAVGLTVV VGLAVIFLIL GGTLLYWRGR 360
RIQNKRAMRR YLERGESIEP LDPSEKANKV LARIFKETEL RKLKVLGSGV FGTVHKGVWI 420
PEGESIKIPV CIKVIEDKSG RQSFQDVTDH MLAIGSLDHA HIVRLLGLCP GSSLQLVTQY 480
LPLGSLLDHV RQHRGALGPQ LLLNWGVQIA KGMYYLEEHG MVHRNLAARN VLLKSPSQVQ 540
VADFGVADLL PPDDKQLLHS EAKTPIKWMA LESIHFGKYT HQSDVWSYGV TVWELMTFGA 600
EPYAGLRLAE VPDLLEKGER LAQPQICTID VYMVMVKCWM IDENIRPTFK ELANEFTRMA 660
RDPPRYLVIK RESGPGIPPG AEPPALTNKE LEEVELEPEL ELDLDLETEE DGLAATLNSA 720
LGLPVGTLNR PRGSQSLLSP SSGYMPMNQG NLGDTCQESA ICGTGERCPR PASLHPMPRG 780
RLASESSEGH VTGSEAELQE KASMCRSRSR SPRPRGDSAY HSQRHSLLTP VTPLSPPGLE 840
EEDVNGYVMP DAHLKGTPSS REGTLSSVGI SSVLGTEEEE EDEEYEYMNR RRRHSPPRHP 900
RPSSLEELGY EYMDVGSDLS ASLGSTQSCP LNPVPLMPAA GTTPDEDYEY MNRRHAGGAP 960
GGDYAAMGAC PAAEQGYEEM RAFQGPGNHA PHVHCARLKP LRSLEATDSA FDNPDYWHSR 1020
LFPKADAQRT 1030
Nucleotide Sequence
(FASTA)
ATGGAAGTAG ATAAAAATGG CTCCAAGATG TGTGAACCTT GTGGGGGGCT GTGCCCCAAA 60
GCCTGTGAGG GGACAGGCTC CGGGAGCCGC TTCCAGACTG TGGACTCGAG CAACATTGAT 120
GGATTTGTGA ACTGCACCAA GATCCTGGGC AACCTGGACT TTCTGATCAC TGGCCTCAAT 180
GGAGACCCCT GGCACAAGAT CCCTGCCTTG GACCCTGAGA AGCTCAATGT CTTCCGGACA 240
GTACGGGAGA TCACAGGTTA CCTGAACATC CAGTCCTGGC CTCCCCACAT GCACAACTTC 300
AGTGTCTTTT CCAACCTGAC AACCATTGGG GGCAGAAGCC TATACAACCG GGGTTTCTCT 360
TTGCTGATCA TGAAGAACTT GAATATAACA TCTTTGGGCC TCCGATCTTT GAAAGAAATT 420
AGTGCTGGGC GTATTTACAT AAGTGCCAAC AAGCAACTCT GCTACCACCA TTCTCTGAAC 480
TGGACCAGGC TGCTTCGGGG GCCTCCAGAA GAGAGGCTGG ACATCAAGCA TAATCGGCCC 540
CGCAGAGACT GCGTGGCAGA GGGCAAAGTG TGTGATCCCC TGTGCTCCTC TGGGGGATGC 600
TGGGGCCCAG GTCCTGGTCA GTGCCTGTCC TGTCGAAACT ACAGCCGAGG AGGTGTCTGT 660
GTGACCCACT GCAACTTTCT AAATGGGGAG CCTCGTGAGT TTGCCCATGA AGCTGAATGC 720
TTCTCCTGCC ACCCGGAGTG CCAACCCATG GAGGGGACTG CCACATGCAA TGGCTCGGGC 780
TCTGATGCCT GTGCTCAGTG TGCCCATTTT CGAGATGGGC CGCACTGTGT GAGCAGCTGC 840
CCCAATGGAG TCCTCGGTGC CAAGGGCCCC ATCTACAAGT ACCCAGACAC TCACAATGAA 900
TGTCGGCCCT GCCACGAGAA TTGCACCCAG GGGTGTAAGG GACCAGAGCT ACAAGACTGT 960
TTAGGTCAAA CACTGGCACT GATCAGCAAA ACCCATCTGG CAGTGGGCTT AACAGTGGTA 1020
GTGGGATTGG CAGTGATTTT CCTGATCCTG GGAGGCACTT TACTCTATTG GCGTGGGCGC 1080
CGGATTCAGA ATAAGAGGGC TATGCGGCGC TACTTGGAAC GGGGTGAGAG CATAGAGCCT 1140
CTGGATCCCA GTGAGAAGGC TAACAAAGTC TTGGCCAGAA TCTTCAAAGA AACAGAGCTG 1200
AGGAAGCTTA AAGTCCTTGG CTCAGGCGTC TTTGGAACCG TGCACAAAGG AGTATGGATT 1260
CCTGAGGGTG AATCAATCAA GATTCCAGTC TGCATTAAAG TCATCGAGGA CAAGAGTGGA 1320
CGGCAGAGTT TTCAAGATGT GACGGATCAT ATGCTGGCCA TTGGCAGCCT AGACCATGCC 1380
CACATTGTAC GGCTGCTGGG ACTGTGCCCA GGGTCATCTC TGCAGCTCGT CACTCAGTAC 1440
TTGCCTCTGG GTTCCCTGCT GGATCATGTG AGACAACACC GTGGAGCACT GGGGCCCCAG 1500
CTGCTGCTCA ATTGGGGAGT ACAGATTGCC AAGGGGATGT ACTACCTTGA GGAGCATGGT 1560
ATGGTGCATA GGAACCTGGC GGCCCGAAAT GTGCTACTGA AGTCACCAAG TCAGGTCCAG 1620
GTGGCAGATT TTGGGGTGGC TGACCTGCTG CCCCCCGATG ATAAGCAACT ACTACACAGT 1680
GAGGCCAAGA CTCCAATTAA GTGGATGGCC CTGGAGAGTA TCCACTTTGG AAAATACACA 1740
CATCAGAGTG ACGTCTGGAG TTATGGAGTG ACAGTTTGGG AGCTGATGAC CTTTGGGGCA 1800
GAGCCCTATG CTGGGCTACG ATTGGCCGAA GTACCAGATC TGCTAGAGAA GGGGGAGCGA 1860
TTGGCACAGC CCCAGATCTG TACCATTGAT GTCTACATGG TCATGGTCAA GTGCTGGATG 1920
ATTGATGAGA ACATCCGTCC AACCTTTAAA GAACTAGCCA ATGAGTTCAC CAGGATGGCC 1980
CGAGACCCCC CACGGTATCT GGTCATAAAG AGAGAGAGTG GGCCTGGAAT TCCCCCCGGG 2040
GCAGAGCCCC CTGCTCTGAC AAACAAGGAA CTGGAGGAGG TGGAGCTGGA GCCAGAACTG 2100
GAGCTAGATC TGGACTTGGA GACGGAGGAG GATGGCCTGG CGGCCACACT AAACTCTGCC 2160
CTCGGTTTGC CAGTTGGAAC ACTTAATCGG CCCCGTGGGA GCCAGAGCCT CTTAAGCCCA 2220
TCATCTGGAT ATATGCCTAT GAACCAGGGT AACCTTGGGG ACACCTGCCA GGAGTCTGCC 2280
ATTTGTGGGA CTGGTGAGCG GTGCCCCCGT CCAGCCTCTT TGCACCCAAT GCCACGGGGA 2340
CGCCTGGCAT CAGAGTCCTC AGAGGGCCAT GTGACAGGGT CCGAGGCTGA GCTCCAGGAG 2400
AAGGCATCAA TGTGTAGAAG CCGGAGCCGG AGCCCACGGC CACGAGGAGA CAGTGCCTAC 2460
CATTCCCAGC GCCACAGCCT GCTCACTCCT GTCACCCCAC TCTCCCCACC AGGGTTGGAG 2520
GAAGAGGATG TCAATGGATA TGTCATGCCA GATGCACACC TCAAAGGTAC TCCCTCCTCC 2580
CGGGAAGGCA CCCTTTCTTC AGTGGGCATC AGTTCTGTCC TGGGTACTGA AGAAGAGGAG 2640
GAAGATGAGG AGTATGAATA TATGAACCGG AGGAGAAGAC ACAGTCCACC TCGTCACCCT 2700
AGGCCCAGTT CTCTCGAGGA GCTGGGTTAT GAGTACATGG ATGTGGGATC AGACCTCAGC 2760
GCTTCCCTGG GCAGCACACA GAGTTGCCCA CTCAACCCTG TGCCCCTCAT GCCCGCTGCT 2820
GGCACAACCC CAGATGAGGA CTATGAATAT ATGAATCGGC GACATGCTGG AGGAGCTCCT 2880
GGGGGAGACT ATGCAGCCAT GGGGGCCTGC CCAGCCGCTG AGCAAGGGTA TGAAGAGATG 2940
AGAGCTTTCC AGGGGCCTGG AAACCATGCT CCGCATGTCC ACTGTGCCCG CCTCAAACCT 3000
CTACGTAGTT TAGAAGCCAC TGACTCCGCT TTCGATAATC CTGATTACTG GCATAGCAGG 3060
CTTTTCCCCA AGGCTGATGC TCAGAGAACA TAA 3093
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh
Q: 400   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQDVTDHMLAIGSLDH  459
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 460   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  519
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 520   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  579
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 580   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  639
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 640   MIDENIRPTFKELANEF  656
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQDVTD HMLAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAP-00335
EKS-EQC-00291
EKS-FEC-00285
EKS-HOS-00306
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORC-00282
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-SUS-00263
EKS-TUT-00065
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013