EKS-CAF-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	541.6	4.3E-163	98	355	258

Status

Unreviewed

Ensembl Protein

ENSCAFP00000037727

UniProt Accession

F1PA42;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000000217	ENSCAFP00000000309	ENSCAFT00000000342
ENSCAFG00000000217	ENSCAFP00000037727	ENSCAFT00000046374

Organism

Canis familiaris

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MTVKTEAARG ALTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 60

SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 120

EAFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN 180

GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD 240

FGLCKENIEH NGTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 300

NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK NHVFFSLINW 360

DDLINKKITP PFNPNVSGPS DLRHFDPEFT EEPVPNSIGR SPDSILLTAS VKEAAEAFLG 420

FSYAPPMDSF L 431

Nucleotide Sequence
(FASTA)

ATGACGGTGA AGACCGAGGC TGCTAGGGGC GCCCTCACCT ACTCCAGAAT GAGGGGGATG 60

GTAGCGATCC TCATCGCTTT CATGAAACAG AGGAGGATGG GCCTGAACGA CTTTATTCAG 120

AAGATTGCCA ATAACTCCTA TGCATGCAAA CACCCTGAAG TTCAGTCCAT TTTGAAGATC 180

TCCCAACCTC AGGAGCCCGA GCTTATGAAT GCCAACCCCT CCCCCCCGCC AAGTCCTTCT 240

CAGCAAATCA ACTTGGGACC ATCATCCAAT CCTCATGCTA AACCATCTGA CTTTCACTTC 300

TTGAAAGTGA TTGGGAAAGG CAGTTTTGGG AAGGTTCTTC TAGCAAGACA CAAGGCAGAG 360

GAGGCATTCT ATGCAGTCAA AGTTTTACAG AAGAAAGCGA TCCTGAAAAA GAAGGAGGAA 420

AAGCATATTA TGTCGGAACG GAATGTTCTA CTGAAGAATG TGAAACACCC TTTCCTGGTG 480

GGCCTTCACT TCTCTTTCCA GACTGCTGAC AAATTGTACT TTGTCCTCGA CTACATCAAC 540

GGTGGAGAGT TGTTCTACCA TCTCCAGAGG GAGCGTTGCT TCCTGGAACC ACGGGCTCGT 600

TTCTATGCTG CTGAAATAGC CAGTGCCTTG GGTTACCTGC ACTCTCTGAA CATCGTTTAT 660

AGAGACTTAA AACCAGAGAA TATTTTGCTG GATTCACAGG GACACATTGT CCTTACTGAC 720

TTTGGCCTCT GCAAGGAGAA CATCGAACAC AATGGCACAA CGTCCACCTT CTGCGGCACG 780

CCCGAGTATC TCGCACCTGA GGTGCTTCAT AAGCAGCCTT ATGACAGGAC CGTGGACTGG 840

TGGTGCCTGG GGGCCGTCTT ATATGAGATG CTCTATGGCC TGCCTCCTTT TTACAGCCGC 900

AATACAGCTG AGATGTATGA TAACATTCTG AACAAGCCGC TCCAGCTGAA GCCAAATATC 960

ACCAATTCCG CCAGACACCT CCTGGAGGGC CTCCTGCAGA AAGACCGGAC AAAGAGGCTG 1020

GGCGCCAAGG ATGACTTTAT GGAGATTAAG AATCATGTCT TCTTCTCCCT AATTAACTGG 1080

GATGATCTCA TTAATAAGAA GATTACTCCC CCTTTCAACC CAAATGTGAG TGGACCTAGT 1140

GACCTGCGGC ACTTTGACCC TGAGTTTACT GAAGAGCCAG TCCCCAACTC CATTGGCAGG 1200

TCCCCCGACA GCATCCTCCT CACAGCCAGC GTCAAGGAAG CGGCCGAGGC CTTCCTAGGC 1260

TTTTCCTATG CACCTCCTAT GGACTCTTTC CTCTGA 1296

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 98    FHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  157

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 158   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  217

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 218   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  277

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 278   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  337

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eiknhvff

Q: 338   KRLGAKDDFMEIKNHVFF  355

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEAFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKNHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013