EPS-CAF-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	70.6	1.5E-19	87	239	153

Status

Unreviewed

Ensembl Protein

ENSCAFP00000030595

UniProt Accession

F6XJ85;

Protein Name

Protein Synonyms/Alias

Laforin;

Gene Name

EPM2A

Gene Synonyms/Alias

EPM2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000000329	ENSCAFP00000030595	ENSCAFT00000035347

Organism

Canis familiaris

Functional Description

Protein Length

281

Protein Sequence
(FASTA)

MFSNQPVCPP FSMSEFWKLG VPDQRAVKSG NGPHHDRCCT YNENNLVDGV YCLPIGHWIE 60

ATGHTNEMKH TTDFYFNIAG HQAMHYSRIL PNIWLGSCPR QVEHITIKLK HELGITAVMN 120

FQTEWDIVQN SSGCNRYPEP MTPDTMIKLY KEEGLVYIWM PTPDMSTEGR VQMLPQAVCL 180

LHALLENGHT VYVHCNAGVG RSTAAVCGWL QYVMGWNLRK VQYFLMAKRP AVYIDEDALA 240

RAEEDFFQKF GKYSMRLFHY LRYLERKPKF REFSQLPSIT W 281

Nucleotide Sequence
(FASTA)

ATGTTTTCAA ACCAACCTGT TTGTCCTCCT TTCTCCATGT CAGAATTCTG GAAGTTGGGA 60

GTCCCAGATC AGAGAGCTGT CAAATCTGGC AATGGACCTC ACCACGACCG TTGCTGTACT 120

TATAATGAAA ACAACTTGGT AGATGGTGTT TACTGTCTCC CAATAGGACA CTGGATTGAG 180

GCCACTGGGC ACACCAATGA GATGAAGCAC ACCACAGACT TCTATTTTAA TATTGCAGGC 240

CACCAAGCCA TGCATTATTC AAGAATTTTA CCAAATATCT GGCTGGGTAG CTGCCCTCGT 300

CAAGTGGAAC ATATAACCAT CAAACTGAAG CATGAATTGG GAATCACAGC TGTAATGAAT 360

TTCCAGACTG AATGGGATAT TGTACAGAAT TCCTCAGGCT GTAACCGCTA CCCAGAACCT 420

ATGACTCCAG ACACCATGAT TAAACTGTAC AAGGAAGAAG GCTTGGTCTA CATCTGGATG 480

CCGACACCAG ATATGAGCAC TGAAGGCCGA GTACAGATGC TGCCCCAAGC CGTCTGTCTC 540

CTGCACGCGC TGCTCGAGAA TGGACACACC GTGTACGTTC ACTGCAACGC CGGGGTCGGC 600

AGGTCCACCG CGGCCGTCTG TGGCTGGCTC CAGTATGTGA TGGGCTGGAA TCTGAGGAAG 660

GTGCAGTACT TCCTCATGGC CAAAAGGCCA GCTGTGTACA TTGATGAAGA CGCACTGGCC 720

CGGGCAGAAG AAGACTTTTT TCAGAAATTT GGGAAGTACT CTATGAGGCT GTTTCATTAC 780

CTCCGATACC TAGAGAGAAA ACCAAAGTTC AGAGAGTTCA GTCAACTGCC CAGCATCACA 840

TGGTGA 846

Domain Profile

S: 3     teilpglylgdqataldrreLs...klgitvvinaslsvikvq...........viPe..  46

         ++ilp+++lg+    +++ +++   +lgit v+n  ++   vq            +P+

Q: 87    SRILPNIWLGSCPRQVEHITIKlkhELGITAVMNFQTEWDIVQnssgcnrypepMTPDtm  146

         799********9999999887432367999999976654333311111122222356622

S: 47    ..ylikkgityknipvdDsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlv  104

           ++ ++g  y  +p  D  ++  +q++++a+++++   e+g+ v+vHC+aGv+RS++ v

Q: 147   ikLYKEEGLVYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAAV  206

         2145578999**************************************************

S: 105   laYLmkveglslsdAieavkrkrpsiepnegfl  137

         +++L +v+g++l+++   +++krp+++ +e+ l

Q: 207   CGWLQYVMGWNLRKVQYFLMAKRPAVYIDEDAL  239

         ***************************999876

Domain Sequence
(FASTA)

SRILPNIWLG SCPRQVEHIT IKLKHELGIT AVMNFQTEWD IVQNSSGCNR YPEPMTPDTM 60

IKLYKEEGLV YIWMPTPDMS TEGRVQMLPQ AVCLLHALLE NGHTVYVHCN AGVGRSTAAV 120

CGWLQYVMGW NLRKVQYFLM AKRPAVYIDE DAL 153

Keyword

Complete proteome; Hydrolase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335	; P:peptidyl-tyrosine dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782

; DSPc; 1.

SMARTs

Prosites

PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013