EKS-CAF-00422

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00422

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/VEGFR	576.3	2.3E-173	848	1172	325

Status

Unreviewed

Ensembl Protein

ENSCAFP00000036790

UniProt Accession

F1PE37;

Protein Name

Protein Synonyms/Alias

Gene Name

FLT4

Gene Synonyms/Alias

FLT4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000000482	ENSCAFP00000000712	ENSCAFT00000000771
ENSCAFG00000000482	ENSCAFP00000036790	ENSCAFT00000047300

Organism

Canis familiaris

Functional Description

Protein Length

1336

Protein Sequence
(FASTA)

MQRGAALCLR LWLCLGLLDG ESGLARGYSM TPPTLNITEE THIIDSGDSL SISCRGQHPL 60

EWSWPGAQEM PATREKDGED MGVVQDCEGT DTRPYCKVLL LPEAHANNTG SYRCYYKYIK 120

ARIEGTTAAS TYVFVRDLEQ PFINKPDTLL VNRKDSMWVP CLVSFPGLNI TLRSQNLALQ 180

PDGQELVWDD RRGMRVPTPL LRDALYLQCE TTWGGQAFLS NPFLVHITGN ELYDIQLFPK 240

KSLELLVGEK LVLNCTVWAE FNSGVTFDWD YPGKQAERGK WVPERRSQQT HTELSSILTI 300

YNVSQNDLGP YVCEANNGIQ RFRESTEVIV HEKPFISVEW LKGPVLEATA GDELVKLPVK 360

LAAYPLPEFQ WYKDKKSVSG RHSPHALVLK EVTEASAGIY TLALWNSAAS LQRNISLELV 420

VNVPPHIHEK EASSPSTYSR HSRQALTCTA YGVPPPLSVQ WHWRPWTPCK TFTKRSLSRR 480

QQRDHMPQCQ DWREVTTQDA VNPIESLDTW TEFVEGKNKT VSKLVIQDAN VSAMYKCVVF 540

NKVGQDERLI YFYVTNIPDG FSIESEPSEE PLEGQEVRLS CRADNYTYEH LRWYRLNLST 600

LHDAHGNPLL LDCKNVHLFA TPLAARLEEV APGARHTTLS LTIPSVAPEH EGDYVCEVQD 660

RRSHDKHCHK KYLSVQALEA PRLTQNLTDL LVNVSDSLEM RCPVAGAHVP SILWYKDERL 720

LEEESGIDLA DSNQKLSIQR VREEDAGRYL CSVCNAKGCV NSSASVAVEG SEDKGSMEIV 780

ILVGTGVIAV FFWVLLLLIF CNMRRPAHAD IKTGYLSIIM DPGEVPLEEQ CEYLSYDASQ 840

WEFPRERLHL GRVLGHGAFG KVVEASAFGI HKGSSCDTVA VKMLKEGATA SEHRALMSEL 900

KILIHIGNHL NVVNLLGACT KPNGPLMVIV EFCKYGNLSN FLRAKREAFS PCAEKSPEQR 960

RRFRTLVEGA RADRRRPGSS ERALLSRLLM GKGGAGRAPP GPGAQDLWLS PLTMEDLVCY 1020

SFQVARGMEF LASRKCIHRD LAARNILLSE SDVVKICDFG LARDIYKDPD YVRKGSARLP 1080

LKWMAPESIF DKVYTTQSDV WSFGVLLWEI FSLGASPYPG VQINEEFCQR LKEGTRMRAP 1140

ELATPAIRSI MLSCWSGDPK ERPAFSELVE ILGDLLQGRG QQEDEDCMAP CGSQSLEEGS 1200

FLQASTTALH AAKADIEDSP LSLHPHSLAT RYYNCVSFPG CLARGTQTQG PSRMKTFEEF 1260

PMTLTTYKAS VDNQTDSGMV LASEEFEQLE SRYRQESGLS CKGSGRNVDM TRVHPDSQGW 1320

RQRPDQGAQG GQLFHR 1336

Nucleotide Sequence
(FASTA)

ATGCAACGGG GAGCCGCGCT GTGCCTGCGC CTGTGGCTCT GCCTCGGACT GCTCGACGGC 60

GAGAGCGGCC TGGCAAGGGG CTACTCCATG ACCCCCCCAA CTCTAAACAT CACGGAGGAG 120

ACACACATCA TTGACTCCGG TGACAGCCTA TCCATCTCCT GCAGGGGGCA GCACCCCCTT 180

GAGTGGTCCT GGCCAGGGGC TCAGGAGATG CCAGCCACCA GGGAGAAGGA TGGCGAGGAC 240

ATGGGAGTTG TGCAAGACTG CGAGGGCACG GACACCAGAC CCTACTGCAA GGTGCTGCTG 300

CTGCCCGAGG CACACGCCAA CAACACAGGC AGCTACCGCT GCTACTACAA GTACATCAAG 360

GCCCGCATCG AGGGCACCAC AGCCGCCAGC ACCTACGTGT TTGTGAGAGA CTTGGAGCAG 420

CCATTCATCA ACAAGCCAGA CACGCTCCTG GTCAACAGGA AGGATTCCAT GTGGGTGCCC 480

TGCCTGGTGT CTTTCCCCGG CCTCAACATC ACGCTGAGAT CGCAAAACTT AGCACTGCAG 540

CCTGATGGGC AGGAGCTGGT GTGGGACGAC CGCCGGGGCA TGCGGGTGCC CACGCCACTG 600

CTGCGCGATG CACTGTACCT GCAGTGCGAG ACCACCTGGG GTGGCCAGGC CTTCCTCTCC 660

AATCCCTTCC TCGTGCATAT CACAGGCAAT GAGCTCTATG ACATCCAGCT GTTCCCCAAG 720

AAGTCGCTGG AGCTGCTGGT CGGGGAGAAG CTGGTCCTGA ACTGCACAGT GTGGGCTGAA 780

TTCAACTCGG GTGTCACCTT CGACTGGGAC TACCCAGGGA AGCAGGCAGA GCGGGGTAAG 840

TGGGTGCCAG AGCGGCGCTC CCAGCAGACT CACACAGAGC TGTCCAGCAT CCTGACCATC 900

TACAACGTCA GTCAGAATGA CCTGGGCCCC TATGTGTGTG AGGCCAACAA TGGCATCCAG 960

CGATTCCGGG AGAGCACCGA GGTCATCGTG CATGAAAAGC CCTTCATCAG CGTCGAATGG 1020

CTCAAGGGTC CTGTCCTGGA GGCCACGGCA GGAGATGAGC TGGTGAAGCT GCCTGTGAAG 1080

CTAGCGGCAT ACCCTCTACC GGAGTTCCAA TGGTACAAGG ACAAGAAGTC AGTGTCTGGG 1140

CGCCACAGTC CACATGCCCT GGTGCTCAAG GAGGTGACGG AGGCCAGCGC GGGCATCTAC 1200

ACCCTCGCCC TGTGGAACTC TGCGGCCAGC CTGCAGCGCA ACATCAGCCT GGAGCTGGTG 1260

GTGAATGTGC CCCCCCACAT CCACGAGAAG GAGGCTTCCT CCCCCAGCAC CTACTCCCGC 1320

CACAGTCGCC AGGCCCTCAC CTGCACTGCC TACGGGGTGC CCCCCCCTCT CAGTGTCCAG 1380

TGGCACTGGC GGCCATGGAC ACCCTGCAAG ACCTTCACCA AGCGCAGCCT CAGCCGGCGG 1440

CAGCAGAGAG ACCACATGCC ACAGTGCCAG GACTGGCGAG AGGTGACCAC CCAGGATGCC 1500

GTGAACCCCA TCGAGAGCCT GGACACCTGG ACCGAGTTTG TGGAGGGGAA GAATAAGACG 1560

GTGAGCAAGC TGGTGATCCA GGATGCCAAC GTGTCTGCCA TGTACAAGTG TGTGGTCTTC 1620

AACAAAGTGG GCCAGGACGA GCGGCTCATC TACTTCTACG TGACCAACAT CCCCGATGGC 1680

TTCAGCATAG AATCCGAACC ATCGGAGGAG CCCCTAGAGG GCCAAGAGGT GCGCCTGAGC 1740

TGCCGGGCAG ACAACTACAC CTACGAGCAT CTGCGTTGGT ACCGCCTCAA CTTGTCCACG 1800

CTGCACGATG CTCATGGGAA CCCGCTGCTG CTCGACTGCA AAAACGTGCA CCTCTTCGCT 1860

ACGCCGCTGG CAGCCCGCCT GGAGGAGGTG GCGCCAGGGG CGCGCCACAC CACGCTCAGC 1920

CTGACCATCC CCAGCGTGGC ACCTGAGCAC GAAGGCGACT ACGTATGCGA GGTGCAGGAC 1980

CGTCGCAGCC ACGACAAGCA CTGCCACAAG AAGTACCTGT CGGTGCAGGC CCTGGAAGCC 2040

CCGCGGCTCA CGCAGAACTT GACCGACCTC CTGGTGAACG TGAGCGACTC CCTGGAGATG 2100

AGGTGCCCGG TGGCCGGGGC ACACGTGCCC AGTATCTTGT GGTACAAAGA CGAGAGGCTG 2160

CTGGAGGAAG AGTCCGGAAT CGACCTGGCA GACTCGAACC AGAAGCTCAG CATACAGCGC 2220

GTGCGTGAGG AGGACGCGGG CCGCTATCTG TGCAGCGTCT GCAATGCCAA GGGCTGCGTC 2280

AACTCCTCTG CCAGCGTGGC CGTGGAAGGC TCCGAGGATA AAGGCAGCAT GGAGATCGTG 2340

ATCCTTGTCG GCACTGGGGT CATCGCTGTC TTCTTCTGGG TCCTCCTTCT CCTCATCTTC 2400

TGTAACATGA GGAGGCCAGC CCACGCAGAT ATCAAGACGG GCTACCTGTC CATCATCATG 2460

GACCCGGGGG AGGTGCCTCT GGAGGAGCAG TGTGAATACC TGTCCTATGA TGCCAGCCAG 2520

TGGGAGTTCC CCCGGGAGCG GCTGCACCTT GGGAGAGTCC TAGGCCATGG AGCCTTCGGG 2580

AAGGTGGTGG AAGCCTCGGC TTTTGGAATT CACAAGGGCA GCAGCTGTGA CACCGTGGCT 2640

GTGAAAATGC TGAAAGAGGG CGCCACAGCC AGCGAGCACC GCGCCCTGAT GTCGGAGCTC 2700

AAGATCCTAA TCCACATCGG TAACCACCTC AACGTGGTCA ACCTCTTGGG CGCGTGCACC 2760

AAGCCCAACG GCCCCCTCAT GGTGATCGTG GAGTTCTGCA AGTACGGCAA TCTCTCCAAC 2820

TTCCTGCGGG CCAAGCGGGA GGCCTTCAGC CCCTGTGCGG AGAAGTCCCC TGAGCAGCGA 2880

AGGCGCTTCC GCACCCTGGT GGAAGGTGCC AGAGCTGACC GGAGGAGGCC GGGAAGCAGC 2940

GAGAGGGCCC TACTGTCCCG GCTCCTCATG GGCAAGGGCG GGGCAGGGCG GGCGCCTCCG 3000

GGCCCGGGAG CCCAGGACTT GTGGCTGAGC CCGCTGACCA TGGAAGACCT TGTCTGCTAC 3060

AGCTTCCAGG TGGCCCGAGG GATGGAGTTC CTGGCCTCAC GCAAGTGTAT CCACAGGGAC 3120

CTGGCTGCTC GGAACATCTT GCTGTCAGAA AGCGATGTGG TGAAGATCTG TGACTTCGGC 3180

CTGGCCCGAG ACATCTACAA AGACCCTGAC TATGTGCGAA AGGGCAGTGC CCGGCTGCCA 3240

CTGAAGTGGA TGGCCCCTGA GAGCATCTTC GATAAGGTGT ATACCACGCA GAGTGATGTA 3300

TGGTCCTTTG GGGTGCTGCT CTGGGAGATC TTCTCCCTGG GGGCCTCCCC CTACCCGGGG 3360

GTGCAGATCA ATGAGGAGTT CTGCCAGAGG CTGAAAGAGG GCACACGGAT GAGAGCCCCG 3420

GAGCTGGCCA CTCCTGCCAT ACGCAGCATC ATGCTGAGCT GCTGGTCAGG AGACCCCAAA 3480

GAGAGGCCTG CATTCTCGGA GCTGGTGGAG ATCCTGGGGG ACCTGCTCCA GGGCAGGGGC 3540

CAACAGGAGG ATGAGGACTG CATGGCCCCC TGTGGCTCTC AGAGCTTGGA GGAGGGCAGC 3600

TTCTTGCAGG CGTCCACCAC GGCCCTGCAT GCTGCCAAGG CCGACATCGA GGACAGCCCA 3660

CTGAGCCTGC ACCCACACAG CCTGGCCACC AGATATTACA ACTGTGTGTC TTTTCCGGGG 3720

TGCCTAGCCA GAGGGACTCA GACCCAGGGC CCCTCCAGGA TGAAAACATT CGAAGAATTT 3780

CCCATGACCC TGACCACCTA CAAGGCTTCC GTGGATAACC AGACGGACAG TGGGATGGTG 3840

CTGGCCTCTG AGGAGTTTGA GCAGCTGGAG AGCAGGTACA GACAAGAAAG CGGGCTCAGC 3900

TGTAAAGGAT CGGGCCGGAA TGTGGACATG ACCAGGGTGC ACCCCGACAG CCAGGGGTGG 3960

CGACAGCGGC CAGACCAGGG GGCGCAGGGA GGCCAGCTCT TCCACAGATG A 4011

Domain Profile

S: 1     lklGkslGeGafGkvveasafgikkeetcktvavkmlkegatasevrallselkilihiG  60

         l+lG++lG+GafGkvveasafgi+k ++c+tvavkmlkegatase+ral+selkilihiG

Q: 848   LHLGRVLGHGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG  907

         79**********************************************************

S: 61    khlnvvnllGactkakgpllviveyckyGnlsnylrskrdefvlykekaaelrkkkeale  120

         +hlnvvnllGactk++gpl+vive+ckyGnlsn+lr+kr++f++++ek++e+r+++++l+

Q: 908   NHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRAKREAFSPCAEKSPEQRRRFRTLV  967

         *********************************************************998

S: 121   .alevdkkrsvsssrslassgfkeekslsdveeeeeaedlykepltledlisysfqvarG  179

          ++++d++r++ss+r+l s+ ++ ++++ ++     a+dl+++plt+edl++ysfqvarG

Q: 968   eGARADRRRPGSSERALLSRLLMGKGGAGRAPPGPGAQDLWLSPLTMEDLVCYSFQVARG  1027

         89**********************************************************

S: 180   meflasrkvihrdlaarnillsennvvkicdfGlardiykdpdyvrkgdarlPlkWlale  239

         meflasrk+ihrdlaarnillse++vvkicdfGlardiykdpdyvrkg+arlPlkW+a+e

Q: 1028  MEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPE  1087

         ************************************************************

S: 240   sifdkvystksdvWsyGvllWeifslgasPyPgvqineelikrlkeGtrlraPelatpei  299

         sifdkvy+t+sdvWs+GvllWeifslgasPyPgvqinee+++rlkeGtr+raPelatp+i

Q: 1088  SIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKEGTRMRAPELATPAI  1147

         ************************************************************

S: 300   yeimldcWkkdPeerPafaelvekl  324

         ++iml+cW++dP+erPaf+elve+l

Q: 1148  RSIMLSCWSGDPKERPAFSELVEIL  1172

         **********************986

Domain Sequence
(FASTA)

LHLGRVLGHG AFGKVVEASA FGIHKGSSCD TVAVKMLKEG ATASEHRALM SELKILIHIG 60

NHLNVVNLLG ACTKPNGPLM VIVEFCKYGN LSNFLRAKRE AFSPCAEKSP EQRRRFRTLV 120

EGARADRRRP GSSERALLSR LLMGKGGAGR APPGPGAQDL WLSPLTMEDL VCYSFQVARG 180

MEFLASRKCI HRDLAARNIL LSESDVVKIC DFGLARDIYK DPDYVRKGSA RLPLKWMAPE 240

SIFDKVYTTQ SDVWSFGVLL WEIFSLGASP YPGVQINEEF CQRLKEGTRM RAPELATPAI 300

RSIMLSCWSG DPKERPAFSE LVEIL 325

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084	; P:vascular endothelial growth factor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009137	; Tyr_kinase_VEGFR3_rcpt_N.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 5.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832	; VEGFRECEPTOR.
PR01835	; VEGFRECEPTR3.

Created Date

20-Feb-2013