EKS-CAF-00392

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00392

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.7	6.1E-104	1290	1548	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000030813

UniProt Accession

E2R9L4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000000760	ENSCAFP00000030813	ENSCAFT00000035540
ENSCAFG00000000760	ENSCAFP00000030815	ENSCAFT00000035541

Organism

Canis familiaris

Functional Description

Protein Length

1555

Protein Sequence
(FASTA)

MREAAAAAEL VPPPAFAVTP AAAAMEEPPP PPPGPEPEPE PEPEPERCRA ARQECTVGDS 60

ACKNSESDPE DFSDEINTEN LYGTSPPSTP RQMKRMSTKH QRNNVGKPAN RSGLKEKMNA 120

PNQPPHKDTG KTMENVEEYS YKQEKKIRAA LRTTERDHKK NVQCSFMLDS VGGSLPKKSI 180

PDVDLNKPYL SLGCSNAKLP VSVPMPIPRT ARQTSRTDCP ADRLKFFETL RLLLKLTSVS 240

KKKDRETGET KNTSAFWFNR SNELIWLELQ AWHAGRTIND QDLFLYTARQ AIPDIINEIL 300

TFKVNYGSFA FVRNGASFNG TSVEGQCRAP HGTKIVCYST YHEHLQRQRV SFEQVKRIME 360

LLEYMEALYP SLQALQKDYE KYAAKDFQDR VQALCLWLNI TKDLNQKLRI MGTVLGIKNL 420

SDIGWPVFEI PSPRSSKGNE PEDEGDDTEG DLKELDSSTD ESEEEQLSGP RAPEPTQPID 480

TNFSIHSQDC VLKKLERLES EDDSFGWGAP DCSTEAGFSR HCLTSIYRPF VDKALKQMGL 540

RKLILRLHKL MDGSLQRARI ALVKSDHPVE FSEFPDPMWG SDYVQLSRTP PSSEQKGSTV 600

SWDELKSMDL PSFEPAFLVL CRVLLNVIHE CLKLRLEQRP AGEPSLLSIK QLVRECKEVL 660

KGGLLMKQYY QFMLHEVLAD LQKTDCNIDA FEEDLHKMLM VYFDYMRSWI QMLQQLPQAS 720

HSLKNLLEEE WNFTKEITHY IRGGEAQAGK LFCDIAGMLL KSTGSFLEFG LQESCAEFWT 780

SADDSNASDE IRRSVIEISR ALKELFHEAR ERASKALGFA KMLRKDLEIA AEFILSAPIR 840

DLLDVLKSKQ YVKVQIPGLE NLQVFVPDTL AEEKNIILQL LNAAAGKDCS KESDDVLIDA 900

YLLLTKQSDR ARDSEDSWAS WEVRPVKIVP QVETVDTLRS MQVDNLLLVV MQSAHLTIQR 960

KAFQQSIEGL MTLRQEQTSS QPVIARALQQ LKNDALELCN RISDAIDRVD HMFTSEFDAE 1020

VDESESVTLQ QYYREAMIQG YNFGFEYHKE VVRLMSGEFR QKIGDKYISF ARKWMNYVLT 1080

KCESGRGTRP RWATQGFDFL QAIEPAFISA LPEDDFLSLQ ALMNECIGHV IGKPHSPVTA 1140

IHRNSPRPVK VPRCHSDPPN PHLIIPTPEG FRGSSVPEND RLASIAAELQ FRSLSRHSSP 1200

TEERDEPAYP KGDSSGSARR SWELRTLISQ TKDSASKQGP IEAIQKSVRL FEEKRYREMR 1260

RKNIIGQVCD TPKSYDNVMH VGLRKVTFKW QRGNKIGEGQ YGKVYTCISV DTGELMAMKE 1320

IRFQPNDHKT IKETADELKI FEGIKHPNLV RYFGVELHRE EMYIFMEYCD EGTLEEVSRL 1380

GLQEHVIRLY SKQITIAINV LHEHGIVHRD IKGANIFLTS SGLIKLGDFG CSVKLKNNAQ 1440

TMPGEVNSTL GTAAYMAPEV ITRAKGEGHG RAADIWSLGC VVIEMVTGKR PWHEYEHNFQ 1500

IMYKVGMGHK PPIPERLSPE GKDFLSHCLE SEPRMRWTAS QLLDHSFVKV CTDEE 1555

Nucleotide Sequence
(FASTA)

ATGAGAGAAG CCGCCGCCGC CGCCGAGCTG GTCCCCCCGC CCGCCTTCGC CGTCACGCCC 60

GCCGCCGCCG CCATGGAGGA GCCGCCGCCG CCGCCGCCGG GACCCGAGCC CGAGCCCGAG 120

CCCGAGCCCG AGCCCGAGCG CTGCCGGGCG GCGAGGCAAG AGTGCACAGT GGGAGATTCA 180

GCTTGCAAGA ATTCTGAGTC TGATCCAGAG GATTTTTCAG ATGAAATCAA TACGGAGAAC 240

CTTTATGGCA CCTCTCCCCC CAGCACACCT CGGCAGATGA AACGCATGTC CACCAAACAC 300

CAGAGGAATA ACGTGGGGAA GCCTGCCAAT CGATCTGGTT TGAAAGAAAA AATGAATGCA 360

CCAAACCAGC CTCCACACAA AGACACTGGA AAAACCATGG AGAATGTGGA AGAATATAGC 420

TATAAGCAGG AGAAGAAGAT CCGAGCTGCT CTTAGGACAA CAGAGCGTGA TCATAAGAAA 480

AATGTGCAGT GCTCGTTCAT GTTGGACTCA GTGGGTGGGT CTTTGCCCAA AAAATCAATT 540

CCAGATGTGG ATCTTAATAA GCCTTACCTC AGTCTTGGCT GCAGCAATGC TAAGCTTCCG 600

GTATCTGTGC CCATGCCTAT ACCCAGAACT GCACGCCAGA CTTCTAGGAC TGACTGTCCA 660

GCAGATCGCT TAAAGTTTTT TGAGACTTTA CGACTTCTGC TAAAGCTTAC CTCAGTCTCA 720

AAGAAGAAGG ACAGGGAGAC AGGAGAAACG AAAAATACAT CTGCTTTCTG GTTTAACCGA 780

TCTAATGAAC TGATCTGGTT AGAGCTACAA GCCTGGCACG CAGGACGGAC CATTAATGAC 840

CAGGACCTCT TTTTATATAC AGCCCGTCAA GCCATCCCTG ATATTATTAA TGAAATCCTT 900

ACTTTCAAAG TTAATTATGG GAGCTTTGCC TTTGTTAGAA ATGGAGCTAG TTTTAATGGT 960

ACTTCAGTAG AAGGGCAGTG CAGAGCCCCT CATGGAACAA AAATTGTGTG TTACTCAACA 1020

TATCATGAGC ATCTCCAACG CCAGAGAGTG TCATTTGAGC AGGTAAAGCG GATAATGGAG 1080

CTGCTGGAGT ACATGGAAGC ACTTTATCCA TCGTTGCAGG CTCTTCAAAA GGACTATGAA 1140

AAATATGCTG CAAAAGACTT CCAGGACAGG GTGCAGGCAC TCTGTTTGTG GTTAAACATC 1200

ACAAAGGACT TAAATCAGAA GTTAAGGATT ATGGGCACTG TTTTGGGCAT CAAGAATTTA 1260

TCAGACATTG GCTGGCCAGT GTTTGAAATC CCTTCTCCTC GATCGTCCAA AGGCAATGAG 1320

CCAGAAGATG AGGGTGATGA CACAGAAGGG GACTTGAAAG AGTTGGATAG TAGTACGGAT 1380

GAGAGTGAAG AAGAACAACT CTCAGGTCCA AGGGCACCAG AGCCCACACA GCCCATTGAC 1440

ACCAATTTCA GCATCCATTC ACAGGATTGT GTACTGAAGA AGCTTGAGAG GCTTGAGTCT 1500

GAGGATGATT CTTTTGGCTG GGGAGCACCA GACTGCAGCA CAGAGGCAGG CTTTAGTAGA 1560

CATTGTCTGA CTTCTATTTA TAGGCCATTT GTAGACAAAG CCCTGAAGCA AATGGGGTTA 1620

AGAAAGTTAA TTTTAAGACT TCACAAGCTG ATGGACGGTT CCTTGCAAAG GGCACGTATA 1680

GCACTGGTAA AGAGTGACCA TCCAGTGGAG TTTTCCGAAT TTCCAGACCC CATGTGGGGT 1740

TCCGATTATG TGCAGTTATC CAGGACACCA CCTTCCTCGG AGCAGAAGGG CAGCACTGTG 1800

TCGTGGGACG AGCTAAAGTC CATGGACTTA CCCTCCTTCG AACCTGCCTT CCTGGTGCTC 1860

TGTCGAGTCC TTCTGAATGT GATACATGAG TGTCTGAAGT TAAGACTGGA GCAGAGGCCT 1920

GCTGGAGAAC CATCTCTCTT AAGTATTAAG CAGCTGGTGA GGGAGTGTAA AGAGGTGCTA 1980

AAGGGCGGCC TTCTGATGAA GCAGTACTAC CAGTTCATGC TGCACGAGGT GCTGGCCGAC 2040

CTGCAGAAGA CTGACTGCAA CATCGACGCC TTTGAGGAGG ACCTGCACAA AATGCTGATG 2100

GTGTATTTTG ATTACATGAG AAGCTGGATC CAAATGCTGC AGCAGTTACC TCAAGCATCC 2160

CATAGTCTAA AAAACCTGTT AGAAGAAGAG TGGAATTTCA CCAAAGAAAT AACCCATTAC 2220

ATCCGGGGAG GAGAAGCCCA GGCTGGAAAA CTTTTCTGTG ACATTGCAGG GATGCTGCTG 2280

AAGTCAACAG GGAGTTTTTT AGAGTTCGGC TTGCAGGAGA GCTGTGCAGA GTTCTGGACC 2340

AGCGCTGACG ACTCCAATGC CTCAGACGAA ATAAGGAGAT CCGTTATAGA GATCAGTCGA 2400

GCTCTGAAGG AGCTTTTTCA CGAAGCTAGA GAAAGAGCCT CCAAGGCGCT TGGATTTGCT 2460

AAAATGTTGA GAAAGGACCT GGAAATAGCA GCAGAGTTCA TACTTTCAGC CCCCATTAGA 2520

GACCTTCTGG ATGTTCTGAA ATCAAAACAG TATGTTAAGG TACAGATTCC TGGCTTAGAA 2580

AACTTGCAAG TGTTTGTTCC AGACACTCTT GCTGAGGAGA AGAACATTAT TTTGCAGTTA 2640

CTCAATGCAG CCGCAGGAAA AGATTGCTCG AAAGAGTCAG ATGATGTACT GATTGATGCC 2700

TATCTGTTGC TAACCAAGCA GAGTGATCGC GCTCGGGATT CAGAGGATAG TTGGGCCTCA 2760

TGGGAAGTGC GACCTGTCAA AATTGTGCCT CAGGTCGAGA CCGTCGACAC CCTGAGAAGC 2820

ATGCAGGTGG ATAACCTTTT ACTAGTTGTC ATGCAGTCTG CACATCTCAC CATCCAGAGA 2880

AAAGCTTTCC AGCAGTCCAT CGAGGGACTC ATGACTCTCC GCCAGGAGCA GACGTCCAGT 2940

CAGCCGGTCA TCGCCAGAGC TTTACAGCAG TTAAAAAATG ATGCACTAGA GCTTTGCAAC 3000

AGAATAAGCG ATGCCATTGA CCGAGTGGAC CACATGTTCA CTTCAGAATT TGATGCGGAA 3060

GTTGATGAAT CAGAGTCTGT CACATTGCAA CAGTACTACC GAGAGGCAAT GATTCAGGGC 3120

TACAACTTTG GGTTCGAGTA TCATAAAGAA GTTGTTCGTT TGATGTCTGG AGAATTTAGA 3180

CAGAAGATAG GAGACAAATA TATAAGCTTT GCCCGGAAAT GGATGAACTA TGTCCTAACT 3240

AAATGTGAGA GTGGTCGAGG TACAAGACCC AGGTGGGCAA CCCAAGGTTT TGACTTTCTA 3300

CAAGCCATTG AACCTGCCTT TATTTCAGCT TTGCCAGAAG ATGACTTCTT GAGTCTTCAA 3360

GCCTTGATGA ATGAGTGCAT TGGCCATGTG ATAGGAAAGC CACACAGTCC TGTTACAGCT 3420

ATTCATCGGA ACAGTCCCCG CCCTGTGAAG GTACCACGAT GCCATAGTGA CCCTCCCAAC 3480

CCACATCTAA TTATCCCGAC TCCAGAGGGA TTCAGGGGTT CCAGTGTCCC TGAGAATGAC 3540

CGGTTGGCTT CTATAGCCGC CGAGTTACAG TTTCGGTCCT TGAGCCGCCA CTCAAGCCCC 3600

ACGGAGGAGC GCGACGAACC AGCGTATCCA AAAGGTGATT CAAGTGGGTC AGCTCGAAGA 3660

AGTTGGGAAC TTCGGACACT TATCAGCCAG ACTAAGGACA GTGCTTCCAA ACAAGGACCC 3720

ATAGAAGCTA TCCAGAAATC AGTCCGACTG TTTGAAGAAA AGAGGTATCG AGAAATGAGG 3780

AGAAAGAATA TCATTGGTCA AGTTTGTGAT ACCCCTAAAT CATATGATAA CGTTATGCAT 3840

GTAGGTTTGA GGAAGGTGAC CTTCAAGTGG CAAAGAGGAA ACAAAATTGG GGAGGGGCAG 3900

TATGGGAAGG TCTACACCTG TATCAGTGTT GACACTGGCG AATTGATGGC TATGAAGGAG 3960

ATCCGATTTC AACCTAATGA CCATAAAACT ATCAAGGAAA CTGCAGACGA ATTGAAAATC 4020

TTTGAGGGCA TCAAACACCC CAATCTGGTT CGGTATTTTG GTGTGGAGCT TCATAGAGAA 4080

GAAATGTACA TCTTCATGGA ATACTGTGAC GAGGGGACAT TAGAAGAGGT GTCAAGGCTG 4140

GGACTTCAGG AGCATGTCAT TAGGCTGTAT TCAAAGCAGA TCACCATCGC AATCAACGTC 4200

CTCCATGAGC ATGGCATCGT TCACCGTGAC ATCAAAGGTG CCAATATCTT CCTAACCTCC 4260

TCTGGACTCA TCAAGCTGGG GGATTTTGGA TGCTCAGTAA AGCTTAAAAA CAACGCACAG 4320

ACCATGCCGG GAGAAGTGAA TAGCACACTG GGGACAGCAG CATACATGGC TCCAGAAGTC 4380

ATCACTCGTG CAAAAGGAGA AGGCCATGGG CGTGCCGCTG ATATCTGGAG TCTGGGCTGT 4440

GTCGTCATAG AGATGGTGAC CGGCAAGAGG CCTTGGCATG AATATGAACA CAACTTTCAG 4500

ATTATGTATA AAGTGGGAAT GGGGCACAAG CCACCCATCC CTGAGAGACT AAGCCCGGAA 4560

GGAAAGGACT TCCTTTCTCA CTGCCTTGAA AGTGAGCCCA GGATGAGGTG GACGGCCAGC 4620

CAGCTCCTCG ACCATTCCTT CGTCAAGGTC TGCACAGATG AAGAATGA 4668

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1290  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1346

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1347  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEH  1404

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1405  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1464

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1465  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1523

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle++p+ r++a++LL+h+f+

Q: 1524  FLSHCLESEPRMRWTASQLLDHSFV  1548

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITIAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESEPRMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013