EKS-CAF-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.21.9E-148436693258
StatusUnreviewed
Ensembl ProteinENSCAFP00000001202
UniProt AccessionF6UWI0;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000000828ENSCAFP00000001202ENSCAFT00000001310
OrganismCanis familiaris
Functional Description
Protein Length754
Protein Sequence
(FASTA)
MGCAENARPQ GMRLLPAGRG AMILSMRKFT VRRFFSVYLR KKSRSKSSSL SRLEEEGTVK 60
EIDISHHVKE GFEKADPSQF ELLKVLGQGS YGKVFLVRKT KGSDTGQLYA MKVLKKATLK 120
VRDRVRSKME RDILAEVNHP FIVKLHYAFQ TEGKLYLILD FLRGGDLFSR LSKEVMFTEE 180
DVKFYLAELA LALDHLHGLG IIYRDLKPEN ILLDEEGHIK ITDFGLSKEA IDHDKRAYSF 240
CGTIEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGSLPF QGKDRKETMA LILKAKLGMP 300
QFLSMEAQSL LRALFKRNPC NRLGAGIDGV EEIKRHPFFV TIDWNKLYRK EIKPPFKPAV 360
GRPEDTFHFD PEFTARTPTD SPGVPPSANA HHLFRGFSFV ASSLVQEPSQ QDLHKATVHP 420
IVQQLHGNNI HFTDGYEIKE DIGVGSYSVC KRCVHKATEA EYAVKIIDKS KRDPSEEIEI 480
LLRYGQHPNI ITLKDVYDDG KFVYLVMELM RGGELLDRIL RQRYFSEREA SDVLRTITKT 540
MDYLHSQGVV HRDLKPSNIL YMDESGNPES IRICDFGFAK QLRAENGLLM TPCYTANFVA 600
PEVLKRQGYD AACDIWSLGT LLYTMLAGFT PFANGPDDTP EEILARIGSG KYALSGGNWD 660
SISDAAKDVV SKMLHVDPHQ RLTAVQVLKH PWIVNREYLS QNQLSRQDVH LVKGAMAATY 720
FALNRTPQAP RLEPVLSSNL AQRRGMKRLT STRL 754
Nucleotide Sequence
(FASTA)
ATGGGATGCG CCGAGAATGC GCGTCCTCAG GGCATGCGGC TCCTCCCGGC TGGGCGCGGG 60
GCGATGATCC TGAGCATGAG GAAGTTCACC GTGCGCAGGT TCTTCTCCGT GTACCTGCGC 120
AAGAAGTCGC GCTCCAAGAG CTCCAGTCTA AGTCGACTCG AGGAGGAAGG CACCGTCAAG 180
GAGATTGACA TTAGCCACCA TGTCAAGGAA GGGTTTGAAA AGGCCGACCC TTCCCAGTTT 240
GAACTGCTGA AGGTGTTAGG ACAAGGATCC TACGGGAAGG TGTTCCTGGT GAGGAAGACC 300
AAGGGATCTG ACACTGGGCA GCTGTACGCA ATGAAAGTCC TTAAGAAAGC TACCTTGAAA 360
GTTCGGGACC GAGTCCGATC GAAGATGGAG AGAGACATTT TGGCAGAAGT GAATCACCCT 420
TTCATTGTAA AGCTTCATTA TGCCTTTCAG ACAGAAGGAA AGCTCTACCT GATACTGGAC 480
TTCCTGCGAG GAGGGGACCT CTTCAGCCGG CTCTCCAAAG AGGTGATGTT CACCGAGGAG 540
GATGTCAAGT TCTACCTGGC TGAGCTGGCT TTGGCTTTAG ATCACCTCCA TGGCCTGGGG 600
ATCATCTACA GAGACCTGAA GCCCGAGAAC ATCCTGCTGG ACGAAGAGGG ACACATCAAG 660
ATCACAGATT TTGGGCTGAG TAAGGAGGCC ATCGACCACG ACAAGAGAGC GTACTCGTTC 720
TGCGGGACGA TAGAGTACAT GGCCCCCGAG GTGGTGAACC GGCGGGGACA CACGCAGAGC 780
GCCGACTGGT GGTCCTTCGG CGTGCTCATG TTTGAGATGC TCACGGGATC TCTGCCGTTC 840
CAGGGGAAGG ACAGAAAGGA GACCATGGCC CTCATCCTCA AAGCCAAGCT GGGCATGCCG 900
CAGTTCCTCA GCATGGAAGC CCAGAGTCTG CTGAGAGCCC TCTTCAAACG GAACCCGTGC 960
AACCGACTTG GTGCTGGCAT CGACGGGGTG GAAGAGATCA AGCGGCATCC TTTCTTTGTG 1020
ACCATAGACT GGAATAAGCT GTACAGGAAG GAGATCAAGC CGCCGTTCAA GCCAGCAGTG 1080
GGCAGGCCCG AGGACACCTT CCACTTTGAC CCCGAGTTCA CAGCACGGAC GCCCACAGAC 1140
TCACCCGGTG TCCCCCCCAG CGCCAATGCA CATCATCTGT TTAGAGGATT CAGTTTTGTG 1200
GCCTCAAGTC TGGTCCAGGA GCCCTCGCAA CAAGATCTGC ACAAAGCCAC GGTCCATCCC 1260
ATCGTGCAGC AGCTACATGG AAACAACATC CACTTCACTG ATGGCTATGA GATCAAAGAG 1320
GACATCGGGG TGGGCTCCTA CTCCGTGTGC AAGCGCTGTG TGCACAAAGC TACTGAGGCA 1380
GAGTATGCCG TGAAGATAAT CGATAAGAGT AAAAGAGACC CCTCGGAAGA GATCGAGATT 1440
CTCCTGAGGT ACGGGCAGCA CCCAAACATC ATCACCCTCA AAGACGTCTA CGACGACGGG 1500
AAGTTCGTGT ACCTGGTGAT GGAGCTGATG CGCGGCGGAG AGCTCCTGGA CCGCATCCTC 1560
CGGCAGCGCT ACTTCTCGGA GCGGGAGGCC AGCGACGTGC TGCGCACCAT TACCAAGACC 1620
ATGGACTACC TCCACTCCCA GGGGGTGGTT CATCGAGACC TGAAGCCGAG TAATATACTG 1680
TATATGGATG AGTCTGGAAA CCCTGAATCC ATCCGAATCT GTGACTTTGG GTTTGCCAAG 1740
CAGCTCCGAG CTGAGAACGG ACTGTTGATG ACACCCTGCT ACACAGCAAA CTTCGTTGCC 1800
CCAGAGGTCC TGAAGCGGCA AGGCTACGAT GCAGCATGTG ACATCTGGAG TTTGGGGACC 1860
CTCTTATACA CCATGCTGGC GGGATTTACC CCGTTTGCAA ATGGACCAGA TGATACTCCT 1920
GAGGAGATTT TGGCTCGGAT TGGCAGTGGG AAGTATGCCC TTTCTGGAGG GAACTGGGAC 1980
TCAATCTCAG ATGCTGCAAA GGACGTCGTG TCCAAGATGC TCCATGTGGA TCCTCATCAG 2040
CGCCTGACAG CGGTTCAAGT CCTGAAACAC CCGTGGATTG TGAACAGAGA GTACCTGTCG 2100
CAAAACCAGC TCAGCCGACA AGACGTCCAC CTGGTGAAGG GTGCCATGGC CGCCACCTAC 2160
TTTGCTCTGA ACAGAACTCC GCAGGCCCCG CGGCTGGAGC CGGTGCTGTC GTCCAACCTG 2220
GCTCAGCGCA GGGGCATGAA GAGACTCACG TCCACCAGGC TATAG 2265
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat+ e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 436   YEIKEDIGVGSYSVCKRCVHKATEAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  495
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas++lrt++k+++ylh+qGvvhrdlk
Q: 496   VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLRTITKTMDYLHSQGVVHRDLK  555
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 556   PSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  615
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 616   WSLGTLLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  675
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 676   VDPHQRLTAVQVLKHPWI  693
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATEAEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLR TITKTMDYLH SQGVVHRDLK 120
PSNILYMDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGTLLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
EKS-XIM-00198
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
cfa:612448;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013