EPS-CAF-00040

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00040

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	89.5	3.6E-25	57	335	279

Status

Unreviewed

Ensembl Protein

ENSCAFP00000001917

UniProt Accession

F1PLP7;

Protein Name

Protein Synonyms/Alias

Gene Name

TAB1

Gene Synonyms/Alias

TAB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001332	ENSCAFP00000001917	ENSCAFT00000002071
ENSCAFG00000001332	ENSCAFP00000041055	ENSCAFT00000047133

Organism

Canis familiaris

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

KNAHAQSVLQ GDEQQPSWTD DLPLCHLSGV GSASNRCYSA DGKGTESHPP EDSWLKFRSE 60

NNCFLYGVFN GYDGNRVTSF VAQRLSAELL LGQLSAEHAE ADVRRVLLQA FDVVERSFLE 120

SIDDALAEKA SLQSQLPEGV PQHQLPPQYQ KILERLKALE REISGGAMAV VAVLLSNKLY 180

VANVGTNRAL LCKSTVDGLQ VTQLNVDHTT ENEDELFRLS QLGLDAGKIK QVGIICGQES 240

TRRIGDYKVK YGYTDIDLLS AAKSKPIIAE PEIHGAQPLD GVTGFLVLMS EGLYKALEAA 300

HGPGQANQEI AAMIDTEFAK QTSLDAVAQA VVDRVKRIHS DTFASGGERA KFCPRHEDMT 360

LLVRNFGYPL GEMSQPTPSP APGGRVYPVS VPYSSAQSTS KTSVTLSLVM PSQGQLVNGA 420

HSASTLDEAT PTLTNQSPTL TLQSTNTHTQ SSSSSSDGGL FRSRPVHSLP PGEDGRVEPY 480

VDFAEFYRLW SVDHGEQSVM TAP 503

Nucleotide Sequence
(FASTA)

AAAAATGCAC ATGCTCAGAG TGTACTCCAA GGAGATGAGC AGCAGCCGAG CTGGACAGAT 60

GACCTCCCTC TCTGCCACCT CTCTGGGGTT GGGTCAGCTT CCAACCGCTG CTACTCTGCT 120

GACGGCAAGG GCACTGAGAG CCACCCCCCA GAGGACAGCT GGCTCAAGTT CAGGAGTGAG 180

AACAACTGCT TCCTGTATGG AGTCTTTAAT GGCTATGATG GCAACCGAGT GACCAGCTTC 240

GTGGCCCAGC GGCTGTCTGC GGAGCTCCTG CTGGGCCAGC TCAGTGCCGA GCATGCTGAG 300

GCAGATGTGC GGCGTGTGCT GCTGCAGGCC TTCGATGTGG TGGAGAGGAG CTTCCTGGAG 360

TCCATTGATG ACGCATTGGC CGAGAAGGCA AGCCTCCAGT CTCAGCTGCC AGAGGGTGTC 420

CCTCAGCACC AGCTGCCTCC TCAGTATCAG AAGATCCTCG AAAGACTCAA GGCTCTGGAG 480

AGGGAGATTT CGGGAGGAGC CATGGCTGTC GTGGCGGTCC TTCTCAGCAA CAAGCTCTAC 540

GTCGCCAATG TCGGTACAAA TCGTGCCCTG TTATGCAAAT CCACGGTGGA CGGCCTGCAG 600

GTGACACAGC TGAACGTGGA CCACACCACG GAGAATGAGG ACGAGCTCTT CCGCCTCTCT 660

CAGCTGGGTT TGGATGCAGG AAAGATCAAG CAGGTGGGAA TCATCTGTGG GCAGGAGAGC 720

ACCAGGCGCA TAGGGGATTA CAAGGTCAAG TATGGCTACA CAGACATCGA CCTACTGAGC 780

GCCGCCAAGT CGAAGCCGAT TATCGCAGAG CCCGAAATCC ATGGTGCACA GCCCCTGGAC 840

GGGGTGACTG GCTTCCTGGT GCTGATGTCG GAGGGGCTCT ACAAGGCTCT GGAGGCAGCC 900

CACGGGCCTG GCCAGGCCAA CCAGGAGATT GCTGCCATGA TCGACACTGA GTTCGCCAAG 960

CAGACTTCCC TGGATGCGGT GGCCCAGGCC GTGGTGGACC GGGTAAAGCG TATCCACAGT 1020

GACACCTTTG CCAGTGGCGG CGAACGTGCC AAGTTCTGCC CGAGGCATGA GGACATGACC 1080

CTGCTGGTGA GGAACTTTGG CTACCCTCTG GGAGAGATGA GTCAGCCCAC ACCATCCCCA 1140

GCACCAGGAG GACGTGTGTA CCCCGTATCC GTGCCGTACT CCAGCGCCCA GAGCACCAGC 1200

AAGACCAGCG TGACCCTCTC CCTCGTCATG CCCTCCCAGG GCCAGCTGGT CAATGGGGCC 1260

CACAGCGCTT CCACCCTGGA CGAAGCCACT CCCACCCTCA CCAACCAGAG CCCGACCCTG 1320

ACCCTGCAGT CCACCAACAC GCACACCCAG AGCAGCAGCT CCAGCTCGGA CGGGGGCCTC 1380

TTCCGTTCCC GGCCTGTGCA CTCGCTCCCG CCTGGTGAGG ATGGCCGTGT CGAGCCTTAC 1440

GTGGACTTTG CTGAATTTTA CCGCCTCTGG AGTGTGGACC ATGGCGAGCA GAGTGTGATG 1500

ACAGCCCCGT AG 1512

Domain Profile

S: 28    spekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstd  87

          +++++   ++gv++G  g++v++f++++l+  l     s e  e++v+++l +aF  ++

Q: 57    FRSENN-CFLYGVFNGYDGNRVTSFVAQRLSAELLLGQLSAEHAEADVRRVLLQAFDVVE  115

         444444.589********************976655555599******************

S: 88    eel................................kvleeksldidk..sGstavvalik  113

         + +                                k+le+ +  +++   G+ avva++

Q: 116   RSFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKALEREisGGAMAVVAVLL  175

         *******************************999966666655555566999********

S: 114   dsklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilkdga  166

         ++klyvanvG  ra+Lc++  +   + +l +dH++++edEl R+++ g   g++ +

Q: 176   SNKLYVANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVG--  233

         *****************9663366699*********************9777777665..

S: 167   RvlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliLasDG  211

          ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L s G

Q: 234   IICG-QESTRRIGDYKVKygytdidllsaaksKPIIAEPEIHGAQPlDGVTGFLVLMSEG  292

         6677.69************************999*******98765155555********

S: 212   lwdvvs........neeavslvrdvlekkeaeqeaakkLvkla  246

         l++ ++        n+e+ +++     k+++++++a+ +v++

Q: 293   LYKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVDRV  335

         ***9863333333366666666666667788888888877765

Domain Sequence
(FASTA)

FRSENNCFLY GVFNGYDGNR VTSFVAQRLS AELLLGQLSA EHAEADVRRV LLQAFDVVER 60

SFLESIDDAL AEKASLQSQL PEGVPQHQLP PQYQKILERL KALEREISGG AMAVVAVLLS 120

NKLYVANVGT NRALLCKSTV DGLQVTQLNV DHTTENEDEL FRLSQLGLDA GKIKQVGIIC 180

GQESTRRIGD YKVKYGYTDI DLLSAAKSKP IIAEPEIHGA QPLDGVTGFL VLMSEGLYKA 240

LEAAHGPGQA NQEIAAMIDT EFAKQTSLDA VAQAVVDRV 279

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013