EKS-CAF-00469

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00469

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	362.2	2.1E-108	15	305	291

Status

Unreviewed

Ensembl Protein

ENSCAFP00000001927

UniProt Accession

E2RLC0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001338	ENSCAFP00000001927	ENSCAFT00000002081

Organism

Canis familiaris

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

MCAAEVDDHV AQRYLLKRRL GKGAYGIVWK AVDRRTGEVV AIKKIFDAFR DKTDAQRTFR 60

EITLLQELGD HPNIIRLLDV IRAENDRDIY LVFESMDTDL NAVICKGRLL RDVHKRYIFY 120

QLLRATKYIH SGRVIHRDQK PSNILLDSSC VVKLCDFGLA RPLSSLPEEP AGQALTDYVA 180

TRWYRAPEVL LSSSWYTPGV DMWSLGCILG EMLRGRPLFP GTSTLHQLEL ILETIPPPSK 240

EDLLALGSSY SASILPCLGA RPRHTLDTLL PPDTPPEALD LLGRLLVFAP NRRLSAAQAL 300

QHPYVQRFHC PAREWTLDSA VRLPVLEGVQ LSVPEYRRRV YQMILERRGD GRVPGEKGLG 360

GTPRGTEPSG PRAHLLKPRA IHQLSPGSPA QKPGRRPQSS PGRQGAHDEA CGAKNLPRQS 420

SAPLLQPPPP GGPGRGDRPP GAAGAAAAPS APSWVEPSGK GAAPSLASQT AAQVTVQALI 480

RSDWHPRRGE RAAGARRVPR ALPADAPREP RPGRRMFSAS ASQGAQGAAR AALGGYSQAY 540

GTVCRSALGR LPLLPGPRA 559

Nucleotide Sequence
(FASTA)

ATGTGCGCCG CGGAGGTGGA CGACCACGTA GCCCAGCGAT ACCTGCTCAA GCGGCGGCTG 60

GGGAAGGGGG CCTACGGCAT TGTGTGGAAG GCAGTGGATA GGAGGACTGG AGAGGTCGTG 120

GCCATCAAGA AAATCTTCGA TGCCTTTAGA GACAAGACAG ATGCCCAGAG AACGTTCCGG 180

GAAATCACGC TGCTCCAGGA ACTTGGGGAC CATCCCAACA TCATCCGCCT CCTGGACGTG 240

ATCCGGGCGG AGAATGACAG GGACATTTAC CTGGTGTTTG AGTCTATGGA CACTGACCTG 300

AACGCCGTCA TCTGTAAGGG CAGGCTGCTG AGGGACGTCC ACAAGCGCTA CATCTTCTAC 360

CAGCTTCTGC GGGCCACCAA GTACATCCAC TCAGGACGCG TCATCCACCG GGACCAGAAG 420

CCGTCCAACA TCCTCCTGGA CTCCAGCTGC GTGGTGAAGC TCTGCGACTT TGGGCTTGCG 480

CGCCCCCTCA GCAGCCTCCC TGAGGAGCCT GCGGGCCAGG CCCTGACAGA TTACGTGGCC 540

ACGCGCTGGT ACCGGGCTCC AGAGGTGCTG CTGTCCTCGA GCTGGTACAC CCCTGGGGTG 600

GACATGTGGA GTCTGGGCTG CATCCTGGGG GAGATGCTTC GGGGGAGGCC CCTGTTCCCT 660

GGCACATCCA CACTCCACCA GCTGGAGCTG ATCCTGGAAA CCATCCCTCC ACCATCCAAG 720

GAGGACCTCC TGGCTCTTGG CTCAAGCTAC AGCGCCTCTA TCCTGCCCTG CCTGGGGGCT 780

CGGCCACGGC ACACGCTGGA CACTCTCCTG CCGCCGGACA CGCCCCCGGA GGCCTTGGAT 840

CTCCTCGGGA GACTCCTGGT GTTTGCCCCC AACAGGCGGC TTAGCGCAGC CCAGGCCCTG 900

CAGCACCCCT ACGTGCAGAG GTTCCACTGC CCGGCCCGTG AGTGGACACT GGACTCGGCC 960

GTGCGGCTCC CAGTGCTCGA GGGAGTTCAG CTCTCCGTCC CCGAGTATCG CAGGCGCGTC 1020

TATCAGATGA TCCTGGAGCG CAGGGGTGAT GGCCGCGTCC CCGGAGAGAA GGGCCTGGGG 1080

GGCACCCCCC GGGGGACAGA GCCCAGTGGG CCCCGGGCGC ACCTGCTCAA ACCCAGGGCC 1140

ATCCATCAGC TGTCTCCGGG CTCGCCTGCA CAGAAGCCGG GACGCAGACC TCAGAGCAGC 1200

CCGGGTCGCC AGGGCGCCCA CGACGAAGCC TGCGGAGCCA AGAACCTTCC CCGGCAGAGC 1260

TCGGCCCCCC TGCTGCAGCC TCCGCCGCCA GGAGGTCCCG GGAGAGGGGA CAGGCCCCCT 1320

GGGGCGGCGG GGGCGGCGGC GGCCCCCTCG GCGCCCTCGT GGGTGGAGCC CAGCGGGAAG 1380

GGGGCGGCGC CCTCCCTGGC CTCGCAGACC GCCGCCCAGG TGACCGTCCA GGCCCTGATC 1440

CGGAGCGACT GGCACCCGCG CCGCGGGGAG AGGGCGGCCG GCGCGCGGCG GGTCCCACGC 1500

GCGCTCCCCG CGGATGCCCC GCGCGAGCCC CGGCCGGGCC GGAGGATGTT CAGCGCCTCG 1560

GCCTCGCAGG GCGCTCAGGG CGCGGCCAGG GCGGCGCTCG GGGGCTACTC TCAAGCCTAC 1620

GGGACCGTCT GCCGCTCGGC GCTGGGCCGC CTGCCCCTGC TCCCCGGGCC CCGCGCCTAG 1680

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE++ll+el +h+Ni

Q: 15    LLKRRLGKGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQELgDHPNI  74

         56789*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i+lldv+++e+     +d+Ylv+e m+tdL++vi +   l+d h ++++yq+lr++ky+H

Q: 75    IRLLDVIRAEN----DRDIYLVFESMDTDLNAVICKGrLLRDVHKRYIFYQLLRATKYIH  130

         ********999....9******************9997899*******************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         s +viHrD+KPsN+l+++ c +k++dFGlar  ++  e+     lt+yvatrwYraPe+l

Q: 131   SGRVIHRDQKPSNILLDSSCVVKLCDFGLARPLSSLPEEPagqaLTDYVATRWYRAPEVL  190

         ********************************887776667788****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls++ yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+ile+++ ps+e+l ++ s+

Q: 191   LSSSWYTPGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSKEDLLALGSSY  250

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

          ++++  l  ++++++++l+p  + +ealdLl +lLv++p++R+s+++aL+hpY+

Q: 251   SASILPCLGARPRHTLDTLLPPdTPPEALDLLGRLLVFAPNRRLSAAQALQHPYV  305

         *******************9875889****************************7

Domain Sequence
(FASTA)

LLKRRLGKGA YGIVWKAVDR RTGEVVAIKK IFDAFRDKTD AQRTFREITL LQELGDHPNI 60

IRLLDVIRAE NDRDIYLVFE SMDTDLNAVI CKGRLLRDVH KRYIFYQLLR ATKYIHSGRV 120

IHRDQKPSNI LLDSSCVVKL CDFGLARPLS SLPEEPAGQA LTDYVATRWY RAPEVLLSSS 180

WYTPGVDMWS LGCILGEMLR GRPLFPGTST LHQLELILET IPPPSKEDLL ALGSSYSASI 240

LPCLGARPRH TLDTLLPPDT PPEALDLLGR LLVFAPNRRL SAAQALQHPY V 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013