EKS-CAF-00410

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00410

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Trk	561.8	2.5E-169	538	805	268

Status

Unreviewed

Ensembl Protein

ENSCAFP00000001979

UniProt Accession

E2RKA1;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

NTRK2

Gene Synonyms/Alias

NTRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001380	ENSCAFP00000001979	ENSCAFT00000002138

Organism

Canis familiaris

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MSSWTRWHGP AMARLWGFCW LVVGFWRAAL ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 60

NSADPENITE IYIANQKRLE IINEDDVEAY AGLKNLTIVD SGLKFVAHKA FLKNSNLQHI 120

NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQETKSSPE TQDLYCLNES 180

SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNLYW DVGNLVSKHM 240

NETSHMQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 300

WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYK 360

LVAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 420

DVADKSGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKGPASV ISNDDDSASP 480

LHHISNGSNT PSSSEGGPDA VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL 540

KRELGEGAFG KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI 600

VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ SQMLHIAQQI 660

AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM 720

PPESIMYRKF TTESDVWSLG VVLWEIFTYG KQPWYQLSNN EVIECITQGR VLQRPRTCPQ 780

EVYELMLGCW QREPHMRKNI KGIHTLLQNL AKASPVYLDI LG 822

Nucleotide Sequence
(FASTA)

ATGTCGTCCT GGACGAGGTG GCATGGACCC GCCATGGCGC GGCTCTGGGG CTTCTGCTGG 60

CTGGTCGTGG GCTTCTGGAG GGCTGCCCTC GCCTGTCCCA CGTCCTGCAA ATGCAGCGCC 120

TCTAGGATCT GGTGCAGCGA CCCTTCTCCG GGCATCGTGG CGTTTCCGAG GTTGGAGCCC 180

AACAGTGCAG ACCCTGAGAA CATCACCGAA ATTTACATTG CCAATCAGAA AAGGTTGGAA 240

ATCATCAACG AAGATGATGT TGAAGCTTAT GCAGGATTGA AGAATCTGAC GATTGTGGAC 300

TCTGGATTAA AATTTGTGGC TCATAAAGCA TTTCTGAAAA ACAGCAACTT ACAGCACATC 360

AATTTTACCC GAAATAAACT GACAAGCTTG TCTAGGAAAC ATTTTCGTCA CCTTGACTTG 420

TCTGAGCTGA TCCTGGTGGG CAATCCATTT ACATGTTCCT GTGATATTAT GTGGATCAAG 480

ACTCTTCAGG AGACTAAATC CAGCCCAGAA ACTCAGGATT TGTACTGCCT AAATGAAAGC 540

AGCAAGAATA TTCCCCTGGC AAACCTGCAG ATACCCAATT GTGGTTTGCC ATCAGCAAAT 600

TTGGCTGCAC CTAACCTCAC CGTGGAGGAG GGAAAGTCTA TCACATTATC TTGTAGTGTT 660

GCAGGCGATC CAGTTCCGAA TTTGTACTGG GATGTCGGTA ATCTGGTTTC CAAACATATG 720

AATGAAACAA GCCACATGCA GGGCTCCTTG AGGATAACTA ACATTTCATC TGATGACAGT 780

GGAAAACAAA TCTCCTGTGT GGCAGAAAAT CTTGTAGGAG AAGACCAAGA TTCTGTCAAC 840

CTCACTGTAC ATTTTGCTCC AACTATCACA TTTCTCGAAT CTCCAACCTC AGACCACCAC 900

TGGTGCATTC CATTCACTGT GAAAGGCAAC CCCAAACCAG CGCTTCAGTG GTTCTATAAC 960

GGGGCAATAT TGAATGAGTC CAAATACATC TGTACTAAAA TCCATGTTAC CAATCACACG 1020

GAGTACCATG GCTGCCTCCA GCTGGATAAT CCCACTCACA TGAACAATGG GGACTACAAG 1080

TTAGTAGCCA AGAATGAGTA TGGGAAAGAT GAGAAACAGA TTTCTGCTCA CTTCATGGGC 1140

TGGCCTGGAA TTGATGATGG TGCCAACCCA AATTATCCCG ACGTAATTTA TGAAGATTAC 1200

GGGACTGCAG CAAATGACAT TGGGGACACC ACAAACAGAA GTAACGAAAT CCCTTCTACA 1260

GATGTTGCTG ACAAAAGCGG TCGGGAACAT CTTTCGGTCT ATGCTGTGGT GGTAATTGCA 1320

TCTGTGGTGG GATTTTGTCT GCTGGTGATG CTGTTTCTGC TGAAGTTGGC AAGACACTCC 1380

AAGTTTGGCA TGAAAGGCCC AGCTTCAGTT ATCAGCAATG ATGATGACTC TGCCAGCCCC 1440

CTCCACCACA TCTCCAATGG GAGTAACACC CCATCATCTT CAGAGGGCGG CCCCGATGCC 1500

GTCATCATTG GAATGACCAA GATCCCTGTC ATTGAAAATC CCCAGTACTT TGGCATCACC 1560

AACAGTCAGC TCAAGCCAGA CACATTTGTT CAGCACATCA AGAGACATAA CATTGTTCTG 1620

AAAAGGGAGC TAGGCGAAGG AGCCTTTGGA AAAGTTTTCC TAGCTGAATG CTATAACCTC 1680

TGTCCTGAGC AGGACAAGAT CTTGGTGGCA GTGAAGACAC TGAAGGATGC CAGTGACAAC 1740

GCACGCAAGG ACTTTCACCG CGAGGCTGAG CTGCTGACCA ACCTCCAGCA CGAGCACATC 1800

GTCAAGTTCT ATGGTGTCTG CGTGGAGGGT GACCCGCTCA TCATGGTCTT TGAGTACATG 1860

AAGCACGGGG ACCTCAACAA GTTCCTCAGG GCCCATGGGC CTGATGCTGT GCTGATGGCC 1920

GAAGGCAACC CGCCGACGGA GCTCACCCAG TCCCAGATGC TGCACATTGC CCAGCAGATA 1980

GCAGCAGGAA TGGTCTACCT GGCGTCCCAG CACTTTGTGC ACCGAGATCT GGCCACCCGC 2040

AACTGCCTGG TTGGCGAGAA CCTCCTGGTG AAAATCGGGG ACTTCGGGAT GTCCCGGGAC 2100

GTGTACAGCA CCGACTACTA CAGGGTCGGT GGCCACACAA TGCTGCCCAT TCGCTGGATG 2160

CCTCCAGAGA GCATCATGTA CAGGAAGTTC ACCACAGAAA GTGATGTCTG GAGCCTGGGA 2220

GTCGTGTTAT GGGAGATCTT CACGTACGGC AAACAGCCCT GGTACCAGCT GTCCAACAAC 2280

GAGGTGATAG AATGCATCAC GCAGGGCCGA GTCTTGCAGC GACCTAGAAC GTGCCCCCAG 2340

GAGGTCTATG AGTTGATGCT GGGGTGCTGG CAGCGGGAGC CCCATATGAG GAAAAACATC 2400

AAGGGTATCC ACACCCTCCT TCAGAACTTG GCCAAGGCAT CTCCAGTCTA CCTGGATATT 2460

CTAGGCTAG 2469

Domain Profile

S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60

         ivlkrelgegafgkvflaecynl+pe+dk+lvavk+lkdas++arkdf+reaelltnlqh

Q: 538   IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH  597

         89**********************************************************

S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegepkgelglsqllaia  120

         ehivk+yGvc+egdpl++vfeymkhGdlnkflrahgpda+l++eg+p++el++sq+l+ia

Q: 598   EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIA  657

         ************************************************************

S: 121   kqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtmlpi  180

         +qiaaG+vylasqhfvhrdlatrnclvge+llvkigdfgmsrdvystdyyrvgg+tmlpi

Q: 658   QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI  717

         ************************************************************

S: 181   rwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerpra  240

         rw+ppesi+yrkfttesdvwslGvvlwei+tyGkqp+yqlsn+eviecitqGrvl+rpr+

Q: 718   RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT  777

         ************************************************************

S: 241   cpkevydlmlgcwqrepqkrlnikeiya  268

         cp+evy+lmlgcwqrep++r+nik i++

Q: 778   CPQEVYELMLGCWQREPHMRKNIKGIHT  805

         **************************97

Domain Sequence
(FASTA)

IVLKRELGEG AFGKVFLAEC YNLCPEQDKI LVAVKTLKDA SDNARKDFHR EAELLTNLQH 60

EHIVKFYGVC VEGDPLIMVF EYMKHGDLNK FLRAHGPDAV LMAEGNPPTE LTQSQMLHIA 120

QQIAAGMVYL ASQHFVHRDL ATRNCLVGEN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 180

RWMPPESIMY RKFTTESDVW SLGVVLWEIF TYGKQPWYQL SNNEVIECIT QGRVLQRPRT 240

CPQEVYELML GCWQREPHMR KNIKGIHT 268

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005887	; C:integral to plasma membrane
GO:0043195	; C:terminal button
GO:0005524	; F:ATP binding
GO:0060175	; F:brain-derived neurotrophic factor-activated receptor activity
GO:0035584	; P:calcium-mediated signaling using intracellular calcium source
GO:0021954	; P:central nervous system neuron development
GO:0021987	; P:cerebral cortex development
GO:0007631	; P:feeding behavior
GO:0014047	; P:glutamate secretion
GO:0007612	; P:learning
GO:0060291	; P:long-term synaptic potentiation
GO:0042490	; P:mechanoreceptor differentiation
GO:2000811	; P:negative regulation of anoikis
GO:0001764	; P:neuron migration
GO:0048709	; P:oligodendrocyte differentiation
GO:0048935	; P:peripheral nervous system neuron development
GO:0010628	; P:positive regulation of gene expression
GO:0010976	; P:positive regulation of neuron projection development
GO:0051896	; P:regulation of protein kinase B signaling cascade
GO:0032314	; P:regulation of Rac GTPase activity
GO:0046548	; P:retinal rod cell development
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000483	; Cys-rich_flank_reg_C.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000372	; LRR-contain_N.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020455	; Tyr_kin_neurotrophic_rcpt_2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR020777	; Tyr_kinase_NGF_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07679	; I-set; 2.
PF01462	; LRRNT; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 1.
SM00082	; LRRCT; 1.
SM00013	; LRRNT; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR01939	; NTKRECEPTOR.
PR01941	; NTKRECEPTOR2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013