EKS-CAF-00461

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00461

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	427.9	2.1E-128	26	308	283

Status

Unreviewed

Ensembl Protein

ENSCAFP00000001972

UniProt Accession

E2RKA7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001382	ENSCAFP00000001972	ENSCAFT00000002131

Organism

Canis familiaris

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

MSFTRKKGFY RQDVNKTAWE LPKTYVSPTH VGSGAYGAVC CAIDKRSGEK VAIKKLSRPF 60

QSEIFAKRAY RELQLLKHMQ HENVIGLLDV FTPASSLRSF HDFYLVMPFM QTDLQKIMGM 120

EFSEDKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT 180

GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLSQILKVTG 240

VPGAEFVQKL NDKAAKSYIQ ALPQSPKKDF SQLFPCASPQ ATDLLEKMLE LDVDKRLTAS 300

QALAHPFFEP FRDPEEETEA SQPFNDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR 360

SGMKLQ 366

Nucleotide Sequence
(FASTA)

ATGAGCTTCA CCCGGAAAAA GGGCTTCTAC AGGCAGGACG TCAACAAGAC CGCCTGGGAG 60

CTGCCCAAGA CCTACGTGTC GCCGACGCAC GTGGGCAGCG GGGCCTACGG CGCAGTGTGC 120

TGTGCCATCG ACAAGCGGTC AGGGGAGAAG GTGGCCATCA AGAAGCTGAG CCGGCCCTTC 180

CAGTCTGAGA TCTTTGCCAA ACGTGCCTAC CGAGAGCTGC AGCTGCTGAA GCACATGCAG 240

CATGAAAACG TCATCGGGCT CCTGGATGTC TTCACCCCAG CCTCCTCCCT GCGCAGCTTC 300

CATGACTTCT ACCTGGTGAT GCCCTTCATG CAGACAGACC TGCAGAAGAT CATGGGGATG 360

GAGTTCAGTG AAGACAAGAT CCAGTACCTG GTGTATCAGA TGCTCAAGGG TCTCAAGTAC 420

ATCCACTCAG CTGGGGTCGT CCACAGGGAC CTGAAGCCGG GCAACCTGGC CGTGAACGAG 480

GACTGCGAGC TGAAGATCTT GGATTTTGGG CTGGCCCGGC ATGCGGATGC TGAAATGACC 540

GGCTATGTGG TGACCCGCTG GTACCGGGCC CCCGAGGTGA TCCTCAGCTG GATGCACTAC 600

AACCAGACTG TGGACATCTG GTCTGTGGGC TGCATCATGG CAGAGATGCT GACAGGGAAA 660

ACTCTGTTCA AGGGGAAAGA TTACCTGGAC CAGCTGTCCC AGATCCTCAA AGTGACCGGG 720

GTCCCGGGTG CAGAATTTGT GCAGAAGTTG AACGACAAAG CAGCCAAATC CTATATCCAG 780

GCCCTGCCAC AGAGCCCCAA GAAGGATTTT TCTCAGCTCT TCCCGTGCGC CAGCCCCCAG 840

GCTACAGACC TGCTGGAGAA GATGCTGGAG CTGGACGTGG ACAAGCGCCT GACGGCCTCG 900

CAGGCCCTCG CCCACCCTTT CTTTGAACCC TTCCGAGACC CTGAGGAGGA GACAGAGGCC 960

TCGCAGCCCT TTAATGATTC CTTAGAACAT GAGAAACTCA CGGTGGATGA ATGGAAGCAG 1020

CACATCTACA AGGAGATCGT GAACTTCAGC CCCATTGCCC GGAAGGACTC ACGGCGCCGG 1080

AGCGGCATGA AGCTGCAGTG A 1101

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii  61

          s +++g+Gayg v+ a+dkr++e+vaikklsrpfq+e+ akr++REl+llk+++heN+i

Q: 26    VSPTHVGSGAYGAVCCAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELQLLKHMQHENVI  85

         566899******************************************************

S: 62    klldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsa  121

          lldvftp+++l++++d+Ylv+ +m+tdL+k++ ++ +s+++i++l+yq+l+glky+Hsa

Q: 86    GLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGME-FSEDKIQYLVYQMLKGLKYIHSA  144

         **********************************99.9**********************

S: 122   nviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkey  181

         +v+HrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++ls+++y

Q: 145   GVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHY  200

         **********************************....**********************

S: 182   tkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyik  241

         +++vDiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p +ef++k++++ a++yi+

Q: 201   NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLSQILKVTGVPGAEFVQKLNDKAAKSYIQ  260

         ************************************************************

S: 242   slpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          lp+ +kkdf++lfp as++a dLlek+L+ld dkR+++++aL+hp++

Q: 261   ALPQSPKKDFSQLFPCASPQATDLLEKMLELDVDKRLTASQALAHPFF  308

         **********************************************95

Domain Sequence
(FASTA)

VSPTHVGSGA YGAVCCAIDK RSGEKVAIKK LSRPFQSEIF AKRAYRELQL LKHMQHENVI 60

GLLDVFTPAS SLRSFHDFYL VMPFMQTDLQ KIMGMEFSED KIQYLVYQML KGLKYIHSAG 120

VVHRDLKPGN LAVNEDCELK ILDFGLARHA DAEMTGYVVT RWYRAPEVIL SWMHYNQTVD 180

IWSVGCIMAE MLTGKTLFKG KDYLDQLSQI LKVTGVPGAE FVQKLNDKAA KSYIQALPQS 240

PKKDFSQLFP CASPQATDLL EKMLELDVDK RLTASQALAH PFF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013