EKS-CAF-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	515.0	6.7E-155	89	382	294

Status

Unreviewed

Ensembl Protein

ENSCAFP00000002020

UniProt Accession

E2RA10;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001411	ENSCAFP00000042842	ENSCAFT00000049729
ENSCAFG00000001411	ENSCAFP00000002020	ENSCAFT00000002183

Organism

Canis familiaris

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE 60

EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF 360

CSEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 420

PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK 465

Nucleotide Sequence
(FASTA)

ATGGCAATGA CAGGCTCAAC ACCTTGTTCC TCCATGAGTA ATCACACAAA GGAAAGAGTG 60

ACCATGACCA AAGTGACACT GGAGAATTTT TATAGCAACC TTATCGCTCA ACATGAAGAA 120

CGAGAAATGA GACAAAAGAA GTTAGAAAAA GTGATGGAAG AAGAAGGCCT AAAAGATGAA 180

GAGAAACGAC TGAGGAGATC CGCGCATGCT CGGAAGGAAA CAGAGTTTCT TCGTTTGAAG 240

AGAACAAGAC TTGGATTGGA AGATTTTGAG TCCTTAAAAG TGATAGGCAG AGGAGCATTT 300

GGTGAGGTGC GGCTTGTTCA GAAGAAAGAT ACAGGGCATG TGTATGCAAT GAAAATACTC 360

CGTAAAGCAG ATATGCTTGA AAAAGAGCAG GTTGGCCACA TTCGTGCGGA GCGTGACATT 420

CTAGTGGAGG CAGACAGTTT GTGGGTTGTG AAAATGTTCT ATAGTTTTCA GGATAAGCTA 480

AACCTCTACC TAATCATGGA GTTCCTGCCT GGAGGGGACA TGATGACCCT ATTAATGAAA 540

AAAGATACCC TGACAGAAGA GGAGACTCAG TTTTATATAG CAGAAACAGT ATTAGCCATA 600

GACTCTATTC ACCAACTTGG ATTCATCCAC AGAGACATCA AGCCAGACAA CCTTCTCCTG 660

GACAGCAAGG GCCATGTGAA GCTTTCTGAC TTCGGCCTTT GCACAGGACT GAAGAAAGCA 720

CATAGGACAG AATTTTATAG GAATCTGAAC CACAGCCTCC CCAGTGATTT CACTTTCCAG 780

AACATGAATT CCAAAAGGAA AGCAGAAACC TGGAAAAGAA ATAGACGTCA GCTAGCCTTC 840

TCCACAGTAG GCACTCCCGA CTACATTGCT CCTGAAGTGT TCATGCAGAC CGGGTACAAC 900

AAGCTCTGTG ATTGGTGGTC GCTTGGGGTG ATCATGTATG AGATGCTCAT CGGGTACCCA 960

CCTTTCTGTT CTGAGACCCC CCAAGAGACC TATAAGAAGG TGATGAACTG GAAAGAAACT 1020

CTGACTTTTC CTCCAGAAGT TCCTATCTCT GAGAAAGCCA AGGACCTTAT TTTGAGATTC 1080

TGCTCTGAGT GGGAACATAG AATTGGAGCC CCTGGAGTTG AGGAAATCAA AAGTAATTCT 1140

TTTTTTGAAG GCGTTGACTG GGAACATATC AGAGAGAGAC CTGCTGCAAT ATCTATTGAA 1200

ATCAAAAGCA TTGATGATAC CTCAAACTTC GATGAATTTC CAGAATCTGA TATTCTTAAG 1260

CCAACAGTAG CTACAAGTAA TCACCCTGAG ACTGACTACA AGAACAAAGA CTGGGTCTTC 1320

ATCAATTACA CATACAAGCG CTTTGAGGGC CTGACGGCTC GGGGGGCAAT ACCTTCCTAC 1380

ATGAAAGCAG CTAAATAG 1398

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl+fp+ev++se+akdli r++ ++e+r+g+ Gv+eik+++ff

Q: 325   ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCSEWEHRIGAPGVEEIKSNSFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLTFPPEVP ISEKAKDLIL RFCSEWEHRI GAPGVEEIKS NSFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

cfa:481766

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013