EKS-CAF-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	334.5	4.4E-100	60	311	252

Status

Unreviewed

Ensembl Protein

ENSCAFP00000041801

UniProt Accession

J9P812;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001879	ENSCAFP00000002760	ENSCAFT00000002976
ENSCAFG00000001879	ENSCAFP00000041801	ENSCAFT00000046483

Organism

Canis familiaris

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MEGAAAPAAR DGPDLRPGAP GSPPEVVAGA TAAPAAAAPE PRKPHGVKRH HHKHNLKHRY 60

ELQETLGKGT YGKVKRATER FSGRVVAIKS IRKDKIKDEQ DMVHIRREIE IMSSLNHPHI 120

ISIYEVFENK DKIVIIMEYA SKGELYDYIS ERRRLSERET RHFFRQIVSA VHYCHKNGVV 180

HRDLKLENIL LDDNCNIKIA DFGLSNLYQK DKFLQTFCGS PLYASPEIVN GRPYRGPEVD 240

SWALGVLLYT LVYGTMPFDG FDHKNLIRQI SSGEYREPTQ PSDARGLIRW MLMVNPDRRA 300

TIEDIANHWW VNWGYKSSVC DCDALHNSES PLLARIIDWH HRSTGLQAEA DAKIKGLAKP 360

GASEVMLERQ RSLKKSKKEN DFAQSGQDPM PESPNKLTSK RPKGILKKRS NSEHRSHSTG 420

FIEGVVSPAL PSAFKIEPDV CRTGVAVPSS PEADVPGKLS PKQSATMPKK GILKKTQQRE 480

SGYYSSPERS ESSELLDSQD GPGSGLPSPS PPDPARGPVL GLSCRRKGIL KHSSKYSAGS 540

TDPALASPDV PTLESLLEPG APPEGLSRSY SRPSSVISDD SVLSSDSFDL LDLQENRPAR 600

QRLRSCVSAE NFLQIQDFEG LQNRPRPQYL KRYRNRLGDS SFSLLMDMDD VTQVYKKALE 660

ICNKLN 666

Nucleotide Sequence
(FASTA)

ATGGAGGGGG CCGCTGCTCC CGCGGCCCGG GACGGCCCCG ACTTGCGGCC GGGGGCTCCG 60

GGCTCTCCCC CGGAGGTGGT GGCGGGGGCG ACTGCAGCCC CGGCGGCGGC GGCCCCCGAG 120

CCCAGGAAGC CGCACGGGGT GAAGCGGCAT CACCACAAGC ACAACTTGAA GCACCGCTAC 180

GAGCTGCAGG AGACCCTGGG CAAAGGCACC TACGGCAAAG TCAAGAGGGC CACCGAGAGG 240

TTCTCGGGCC GAGTGGTTGC TATAAAATCC ATTCGTAAGG ACAAAATTAA GGATGAACAA 300

GACATGGTTC ACATCAGACG AGAGATTGAG ATCATGTCAT CCCTCAACCA TCCTCATATC 360

ATCAGTATTT ATGAAGTGTT TGAGAACAAA GATAAGATTG TGATCATCAT GGAGTACGCA 420

AGCAAGGGGG AGCTGTACGA TTACATCAGC GAGCGGAGAC GCCTCAGCGA GAGGGAGACC 480

AGACACTTCT TCCGGCAGAT TGTCTCCGCT GTGCACTATT GTCACAAGAA TGGTGTGGTC 540

CACCGGGATC TGAAGCTGGA AAACATCCTG CTGGATGACA ACTGCAATAT TAAGATTGCT 600

GACTTTGGGC TTTCCAACCT GTACCAGAAG GACAAGTTCT TGCAAACATT TTGTGGGAGC 660

CCACTCTATG CTTCTCCTGA GATTGTCAAT GGAAGACCTT ACCGGGGGCC AGAGGTGGAC 720

AGCTGGGCCC TGGGTGTGTT GCTTTACACT CTCGTTTATG GAACAATGCC CTTCGATGGT 780

TTTGATCACA AAAACCTCAT TCGGCAGATC AGCAGTGGAG AGTACCGGGA GCCCACGCAG 840

CCGTCAGACG CTCGAGGACT CATTCGGTGG ATGCTGATGG TGAACCCCGA CCGCCGGGCC 900

ACCATCGAGG ACATTGCCAA CCACTGGTGG GTGAACTGGG GTTATAAGAG CAGCGTCTGT 960

GACTGCGACG CCCTCCACAA CTCTGAGTCC CCGCTCTTGG CTCGCATCAT TGATTGGCAC 1020

CACCGGTCCA CGGGGCTGCA GGCTGAGGCC GATGCCAAAA TCAAGGGCCT GGCCAAACCC 1080

GGCGCCTCTG AGGTCATGCT GGAGCGCCAG CGGTCACTGA AGAAGTCCAA GAAAGAGAAT 1140

GATTTCGCGC AGTCTGGCCA GGACCCGATG CCGGAGAGCC CGAATAAGCT GACTTCCAAG 1200

AGGCCCAAAG GGATCCTGAA GAAGCGGAGC AACAGCGAGC ATCGCTCCCA CAGCACGGGC 1260

TTCATCGAAG GTGTGGTGAG CCCCGCCTTA CCGTCTGCTT TCAAGATAGA GCCCGACGTG 1320

TGCCGGACCG GGGTGGCCGT CCCCAGCTCC CCCGAGGCCG ACGTGCCCGG CAAGCTCAGC 1380

CCCAAGCAGT CGGCCACCAT GCCCAAGAAG GGCATCCTCA AGAAGACGCA GCAGCGAGAG 1440

TCGGGTTACT ACTCGTCGCC GGAGCGCAGC GAGTCCTCGG AGCTGCTGGA CAGTCAGGAC 1500

GGGCCGGGCA GCGGCCTCCC TTCCCCCAGC CCCCCAGACC CCGCCCGGGG GCCCGTCCTC 1560

GGCCTCTCCT GCCGCAGGAA GGGCATCTTG AAACACAGCA GCAAGTACTC GGCGGGGAGC 1620

ACGGACCCGG CCCTCGCCAG CCCCGATGTG CCCACACTGG AATCCTTGCT GGAGCCCGGC 1680

GCGCCCCCCG AGGGCCTCTC CCGGAGCTAC AGCCGGCCCT CCAGCGTCAT CAGCGATGAC 1740

AGCGTCCTGT CCAGCGACTC CTTCGACTTG CTGGATTTGC AGGAGAACCG GCCGGCCCGC 1800

CAGCGCCTGC GCAGCTGCGT GTCCGCGGAG AACTTCCTGC AGATCCAGGA CTTCGAGGGG 1860

CTCCAGAACC GGCCGCGACC CCAGTACCTG AAGCGGTACC GGAACCGGCT GGGAGACAGC 1920

AGCTTCTCCC TCCTCATGGA CATGGACGAT GTGACTCAGG TCTACAAGAA AGCGCTGGAG 1980

ATCTGCAACA AGCTTAACTA G 2001

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 60    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLNHPH  119

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 120   IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  179

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 180   VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  239

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+p++

Q: 240   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR  298

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 299   RATIEDIANHWWV  311

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLNHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPDRR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013