EKS-CAF-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.3	1.5E-110	89	373	285

Status

Unreviewed

Ensembl Protein

ENSCAFP00000037269

UniProt Accession

E2RG46;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK14

Gene Synonyms/Alias

CDK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001898	ENSCAFP00000037269	ENSCAFT00000049748
ENSCAFG00000001898	ENSCAFP00000002791	ENSCAFT00000003009

Organism

Canis familiaris

Functional Description

Protein Length

423

Protein Sequence
(FASTA)

MSTRNCQGMD SVIKPLDTIP EDKKVRVQRT QSTFDPFEKP ANQVKRVHSE NNACINFKSS 60

STGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY ATVYKGKSKV NGKLVALKVI 120

RLQEEEGTPF TAIREASLLK GLKHANIVLL HDIIHTKETL TLVFEYVHTD LCQYMDKHPG 180

GLHPDNVKLF LFQLLRGLSY IHQRYILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH 240

TYSNEVVTLW YRPPDVLLGS TEYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 300

LVLGTPNEDT WPGVHSLPHF KPERFTLYSS KNLRQAWNKL SYVNYAEDLA SKLLQCSPKN 360

RLSAQAALSH EYFSDLPPRL WELTDMSSIF TVPNVRLQPE AGESMRAFGK NNSYGKSLSN 420

SKH 423

Nucleotide Sequence
(FASTA)

ATGTCTACAC GGAACTGCCA GGGAATGGAC TCAGTGATCA AACCCCTGGA CACAATTCCT 60

GAGGATAAAA AAGTCAGGGT TCAGAGGACA CAGAGCACTT TTGACCCATT TGAGAAACCA 120

GCTAATCAAG TAAAGAGGGT GCATTCTGAG AACAATGCTT GCATTAACTT TAAGTCCTCC 180

TCCACTGGCA AAGAGTCTCC GAAAGTCAGG CGGCACTCCA GCCCCAGCTC GCCGACAAGT 240

CCCAAATTTG GAAAAGCTGA CTCCTACGAA AAACTGGAAA AACTAGGGGA AGGATCTTAT 300

GCTACAGTAT ACAAAGGGAA AAGCAAAGTA AATGGGAAGT TGGTAGCTCT GAAGGTGATC 360

AGGCTGCAAG AAGAAGAAGG TACACCTTTC ACAGCTATCA GGGAAGCTTC TCTGTTAAAA 420

GGACTAAAAC ACGCTAATAT TGTGCTGCTT CATGACATTA TCCACACCAA GGAGACACTG 480

ACACTTGTGT TTGAATATGT GCACACTGAT TTATGTCAGT ACATGGACAA GCACCCTGGA 540

GGGCTGCATC CAGATAATGT GAAGTTGTTT TTATTTCAGT TGCTGCGAGG GCTGTCTTAC 600

ATCCACCAGC GTTATATTTT GCACAGAGAC CTGAAACCAC AGAACCTTCT GATCAGTGAC 660

ACGGGGGAGT TAAAGCTGGC AGATTTCGGT CTTGCAAGAG CAAAATCCGT CCCTAGCCAC 720

ACATACTCCA ATGAAGTGGT TACCTTGTGG TATAGACCTC CAGATGTCCT CCTGGGCTCA 780

ACAGAATATT CCACCTGCCT TGACATGTGG GGAGTCGGCT GCATCTTTGT TGAAATGATC 840

CAAGGAGTTG CTGCTTTTCC AGGAATGAAA GACATTCAGG ATCAACTTGA ACGAATATTT 900

CTGGTTCTTG GAACGCCAAA TGAGGACACG TGGCCTGGAG TTCATTCTTT ACCACATTTT 960

AAGCCAGAAC GCTTTACCCT GTACAGCTCT AAAAACCTTA GGCAAGCATG GAATAAGCTC 1020

AGCTATGTGA ATTATGCAGA GGATCTGGCC TCCAAGCTCC TACAATGTTC CCCAAAGAAC 1080

AGACTATCAG CACAGGCTGC CTTGAGCCAC GAGTATTTTA GTGACCTGCC CCCACGGCTA 1140

TGGGAACTGA CCGATATGTC TTCTATTTTT ACTGTCCCAA ATGTAAGATT GCAGCCAGAA 1200

GCTGGAGAAA GCATGCGGGC CTTTGGGAAA AACAATAGTT ATGGAAAAAG TCTATCAAAT 1260

AGCAAGCATT GA 1272

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 89    YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  147

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++++vk +l+qll+gl+y+H++

Q: 148   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY  205

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 206   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST  265

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k ++f

Q: 266   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVHSLPHFKpERF  325

         ************************99679***************************9999

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         + +++k+l++ ++kl+  + a dl +kll+++pk+R+sa++al+h+yf

Q: 326   TLYSSKNLRQAWNKLSyvNYAEDLASKLLQCSPKNRLSAQAALSHEYF  373

         99**********999975669**************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPDNVK LFLFQLLRGL SYIHQRYILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVHSLP HFKPERFTLY 240

SSKNLRQAWN KLSYVNYAED LASKLLQCSP KNRLSAQAAL SHEYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013