EKS-CAF-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	494.8	5.2E-149	369	619	251

Status

Unreviewed

Ensembl Protein

ENSCAFP00000002868

UniProt Accession

F1PBW9;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000001942	ENSCAFP00000002868	ENSCAFT00000003088

Organism

Canis familiaris

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

VSLTTPRDRI KEKREREKKG IFLSLLFLLF FIIKNNLFYY SSDNQKKYRK GFIDVSKIKC 60

VEIVKNDDVV IPCQNKYPFQ VVHDANTLYV FAPSAQSRDR WVKKLKEEIK NNNNIMIKYH 120

PKFWADGSYQ CCRQTEKLAP GCEKYNLFES SIKKALPPAP ETKKRRPPPP IPPEEEDNSE 180

EIVVAMYDFQ ATEAHDLRLE RGQEYIILEK NDVHWWRARD KYGSEGYIPS NYVTGKKSNN 240

LDQYEWYCRN TNRSKAEQLL RSEDKEGGFM VRDSSQPGMY TVSLYTKFGG EGSSGFRHYH 300

IKETTTSPKK YYLAEKHAFG SIPEIIEYHK HNAAGLVTRL RYPVSTKEKN APTTAGFSYE 360

KWEINPSELT FMRELGSGLF GVVRLGKWRA QYKVAIKAIK EGAMCEEDFI EEAKVMMKLT 420

HPKLVQLYGV CTQQKPIYIV TEFMERGCLL NFLRQRQGHL SRDMLLSMCQ DVCEGMEYLE 480

RNSFIHRDLA ARNCLVNEAG VVKVSDFGMA RYVLDDQYTS SSGAKFPVKW CPPEVFNYSR 540

FSSKSDVWSF GVLMWEIFTE GKMPFEKNTN YEVVTMVTRG HRLYRPKLAS KYVYEVMLRC 600

WQEKPEGRPS FEDLLRTIDE LVECEETFGR 630

Nucleotide Sequence
(FASTA)

GTTTCCTTAA CTACTCCAAG AGACAGGATA AAAGAGAAGA GAGAGAGAGA AAAAAAAGGG 60

ATCTTCCTTT CTCTACTTTT CCTTCTATTC TTTATCATAA AAAATAATCT CTTTTATTAC 120

AGTTCTGACA ATCAGAAAAA ATACAGGAAG GGATTTATTG ATGTTTCAAA AATCAAGTGT 180

GTGGAAATAG TGAAGAATGA TGATGTTGTT ATTCCCTGCC AAAATAAATA CCCATTTCAG 240

GTGGTTCACG ATGCCAACAC ACTCTATGTT TTTGCACCTA GTGCACAAAG CAGGGACCGG 300

TGGGTGAAGA AGTTAAAAGA AGAAATAAAG AACAACAATA ATATCATGAT TAAATATCAT 360

CCTAAATTCT GGGCAGACGG AAGTTATCAG TGTTGCAGAC AAACTGAAAA ATTAGCCCCT 420

GGATGTGAAA AATATAATCT TTTTGAGAGT AGTATAAAAA AAGCACTACC TCCAGCACCA 480

GAAACAAAGA AGCGAAGGCC TCCCCCACCA ATTCCACCTG AAGAAGAGGA TAATAGTGAA 540

GAAATCGTTG TAGCCATGTA CGATTTCCAA GCAACAGAGG CACATGATCT CAGATTAGAG 600

AGAGGACAAG AGTATATTAT ATTAGAAAAG AATGATGTTC ATTGGTGGAG AGCAAGAGAT 660

AAATACGGGA GTGAAGGATA TATCCCAAGT AATTATGTAA CAGGAAAGAA ATCAAACAAC 720

TTAGACCAAT ATGAGTGGTA TTGCAGAAAC ACGAACAGAA GCAAAGCAGA GCAGCTTCTC 780

AGAAGTGAAG ATAAAGAAGG TGGTTTTATG GTAAGGGATT CCAGTCAACC AGGCATGTAC 840

ACCGTCTCCC TTTATACAAA GTTTGGAGGG GAGGGCTCAT CAGGTTTCAG GCATTATCAT 900

ATAAAGGAAA CAACAACATC CCCAAAGAAG TATTATCTGG CCGAAAAACA TGCTTTTGGT 960

TCAATTCCCG AGATTATTGA ATATCATAAG CACAACGCAG CAGGACTTGT CACGAGGCTG 1020

CGGTACCCAG TTAGTACGAA GGAGAAGAAT GCACCAACCA CTGCAGGATT CAGCTATGAA 1080

AAATGGGAGA TCAACCCTTC AGAGCTGACC TTTATGAGGG AACTGGGGAG CGGACTGTTC 1140

GGAGTGGTGA GGCTCGGCAA GTGGAGAGCC CAGTACAAGG TGGCGATCAA AGCTATCAAG 1200

GAAGGTGCCA TGTGTGAGGA AGACTTTATA GAAGAAGCTA AAGTGATGAT GAAGCTGACA 1260

CACCCGAAGC TAGTGCAGCT TTACGGTGTG TGCACCCAGC AGAAACCAAT TTACATCGTC 1320

ACTGAGTTCA TGGAAAGGGG CTGTCTTCTG AATTTCCTCC GACAGAGACA AGGTCATTTG 1380

AGTAGAGATA TGCTGCTGAG CATGTGTCAA GATGTGTGTG AAGGGATGGA GTACCTGGAG 1440

AGAAACAGCT TCATCCACAG AGATCTGGCT GCCAGAAATT GTCTAGTAAA TGAGGCAGGA 1500

GTTGTGAAAG TGTCAGATTT TGGAATGGCC AGGTATGTCC TGGATGATCA ATACACAAGT 1560

TCTTCTGGTG CAAAATTTCC AGTGAAGTGG TGTCCACCCG AGGTGTTTAA TTACAGCCGC 1620

TTTAGTAGCA AATCGGACGT CTGGTCATTT GGTGTTTTAA TGTGGGAAAT ATTCACTGAA 1680

GGCAAGATGC CCTTTGAGAA AAACACCAAC TATGAAGTGG TAACCATGGT TACCCGGGGC 1740

CACCGACTCT ACAGGCCGAA GCTGGCGTCC AAATATGTAT ACGAGGTGAT GCTGAGATGT 1800

TGGCAGGAGA AACCAGAGGG AAGGCCTTCC TTTGAAGATT TGCTGCGCAC GATAGATGAA 1860

CTAGTCGAGT GCGAAGAAAC TTTTGGACGA TGA 1893

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikaikegam+eedfieeakvmmkl+hpklvqly

Q: 369   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIKEGAMCEEDFIEEAKVMMKLTHPKLVQLY  428

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr+++++l++++ll+mc+dvcegmeyler+sfihrd

Q: 429   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHLSRDMLLSMCQDVCEGMEYLERNSFIHRD  488

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ vvkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 489   LAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  548

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwe+f+egk+p+ek++n+evv++v+rg+rlyrpklask+vyevm +cw+ekpe+r

Q: 549   SFGVLMWEIFTEGKMPFEKNTNYEVVTMVTRGHRLYRPKLASKYVYEVMLRCWQEKPEGR  608

         ************************************************************

S: 241   ptfkellsale  251

         p+f++ll+++

Q: 609   PSFEDLLRTID  619

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IKEGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HLSRDMLLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVNE AGVVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEIF TEGKMPFEKN TNYEVVTMVT RGHRLYRPKL ASKYVYEVML RCWQEKPEGR 240

PSFEDLLRTI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013