EKS-CAF-00073
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00073
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK336.91.1E-10013300288
StatusUnreviewed
Ensembl ProteinENSCAFP00000002945
UniProt AccessionE2RLM4;
Protein Name
Protein Synonyms/Alias
Gene NameCDK6
Gene Synonyms/Alias CDK6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000001998ENSCAFP00000002945ENSCAFT00000003170
OrganismCanis familiaris
Functional Description
Protein Length326
Protein Sequence
(FASTA)
MEKDGLSRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIP 60
ASGVLRHLET FEHPSVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 120
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 180
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 240
EDWPRDVALP RQAFHSKSPQ PIEKFVTDID EQGKDLLLKC LTFNPAKRIS AYSALSHPYF 300
HDLERCKENL DSHLPPSQNS SEMNTA 326
Nucleotide Sequence
(FASTA)
ATGGAGAAGG ACGGCCTGAG CCGCGCGGAC CAGCAGTACG AGTGCGTGGC GGAGATCGGG 60
GAGGGTGCCT ACGGGAAGGT GTTCAAGGCC CGGGACCTGA AGAACGGAGG CCGTTTCGTG 120
GCGCTGAAGC GCGTGCGGGT GCAGACGGGC GAAGAGGGCA TGCCGCTCTC CACCATCCCC 180
GCGAGTGGCG TGCTGAGGCA CCTGGAGACC TTCGAGCACC CCAGCGTGGT CAGATTGTTT 240
GATGTATGCA CAGTGTCACG AACAGACAGA GAAACGAAAC TAACATTAGT GTTTGAACAT 300
GTTGATCAAG ACTTGACCAC TTATTTGGAT AAAGTCCCAG AGCCGGGAGT GCCCACTGAA 360
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGCCTGG ACTTTCTTCA TTCTCACCGA 420
GTAGTGCATC GCGATTTAAA ACCACAGAAC ATTTTAGTGA CCAGCAGTGG ACAAATAAAA 480
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCTCTTAC TTCAGTGGTC 540
GTCACACTGT GGTACAGAGC TCCAGAAGTC CTGCTTCAGT CCAGCTATGC CACCCCCGTG 600
GACCTCTGGA GTGTTGGCTG CATATTTGCA GAAATGTTTC GTAGAAAGCC TCTTTTTCGT 660
GGAAGTTCAG ATGTCGATCA ACTTGGAAAA ATCTTGGACG TAATTGGACT CCCAGGAGAA 720
GAGGACTGGC CTAGAGATGT CGCCCTACCC AGGCAGGCTT TCCACTCAAA ATCTCCTCAA 780
CCGATTGAGA AGTTTGTGAC AGACATTGAT GAACAAGGCA AAGACCTCCT TCTGAAGTGC 840
TTAACATTTA ATCCAGCCAA AAGAATATCT GCCTACAGTG CCCTGTCTCA CCCATACTTC 900
CATGACCTGG AGAGGTGCAA GGAAAACTTG GATTCCCATC TGCCGCCCAG CCAGAACAGC 960
TCAGAGATGA ACACAGCCTG A 981
Domain Profile
S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56
         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++ +eg+p +++    +l++l   +
Q: 13    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTGEEGMPLSTIPASGVLRHLetfE  72
         899*****************888999**********************999999988889
S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112
         h+ +v+L +v++     +++kl+Lvfe+++qdL+++l+k ++ ++++e++k +++qll+g
Q: 73    HPSVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG  132
         ************99855569****************************************
S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172
         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L
Q: 133   LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  191
         *****************************************99.****************
S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232
         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +i++++g p e++wp+   lp
Q: 192   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP  250
         *88.5*******************************************************
S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         +   +f++k+++ +++ v++++e++ dll k+l+++p+kRisa +al+h+yf
Q: 251   RQ--AFHSKSPQPIEKFVTDIDEQGKDLLLKCLTFNPAKRISAYSALSHPYF  300
         95..599999*****************************************9
Domain Sequence
(FASTA)
YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIPAS GVLRHLETFE 60
HPSVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PEPGVPTETI KDMMFQLLRG 120
LDFLHSHRVV HRDLKPQNIL VTSSGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180
QSSYATPVDL WSVGCIFAEM FRRKPLFRGS SDVDQLGKIL DVIGLPGEED WPRDVALPRQ 240
AFHSKSPQPI EKFVTDIDEQ GKDLLLKCLT FNPAKRISAY SALSHPYF 288
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00064
EKS-ANC-00063
EKS-BOT-00069
EKS-CAJ-00065
EKS-CAP-00067
EKS-CII-00028
EKS-CIS-00069
EKS-DAR-00082
EKS-EQC-00067
EKS-FEC-00067
EKS-GAM-00030
EKS-GAG-00055
EKS-GAA-00084
EKS-GOG-00073
EKS-HOS-00071
EKS-LAC-00069
EKS-LOA-00067
EKS-MAM-00067
EKS-MEG-00052
EKS-MOD-00066
EKS-MUM-00071
EKS-MUP-00071
EKS-MYL-00072
EKS-NOL-00064
EKS-OCP-00043
EKS-ORN-00088
EKS-ORA-00061
EKS-ORC-00065
EKS-ORL-00078
EKS-OTG-00072
EKS-PAT-00061
EKS-PES-00062
EKS-PEM-00037
EKS-POA-00064
EKS-PRC-00041
EKS-RAN-00064
EKS-SOA-00030
EKS-TAG-00057
EKS-TAR-00088
EKS-TEN-00090
EKS-TUT-00063
EKS-XET-00063
Gene Ontology
GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0043697; P:cell dedifferentiation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0042063; P:gliogenesis
GO:0002244; P:hematopoietic progenitor cell differentiation
GO:0060218; P:hematopoietic stem cell differentiation
GO:0045786; P:negative regulation of cell cycle
GO:2000773; P:negative regulation of cellular senescence
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045638; P:negative regulation of myeloid cell differentiation
GO:0045668; P:negative regulation of osteoblast differentiation
GO:0007219; P:Notch signaling pathway
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0010628; P:positive regulation of gene expression
GO:0045646; P:regulation of erythrocyte differentiation
GO:0009615; P:response to virus
GO:0033077; P:T cell differentiation in thymus
GO:0003323; P:type B pancreatic cell development
KEGG
cfa:609920;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013