EKS-CAF-00401
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00401
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR612.23.7E-184593950358
StatusUnreviewed
Ensembl ProteinENSCAFP00000003038
UniProt AccessionF1PUX6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameCfa.33978
Gene Synonyms/Alias Cfa.33978;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000002057ENSCAFP00000003038ENSCAFT00000003270
OrganismCanis familiaris
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTSLLALLI LGCLLAGPSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWHYP 60
TSEEENPNVE IRNEENNSGL FVTVLEVVNA SAAHTGLYTC YYNHTQTDEN EIEGRHIYIY 120
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LLSNDGVVHA SYDSRQGFNG 180
TFSVGPYICE ATVRGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLRVPEA TVKDSGDYEC AARQATKEVK 300
EMKKVTISVH EKGFIEIKPN FSQLEAVDLH EVKHFVVDVQ AYPPPRISWL KDNLTLIENL 360
TEITTDIERT QEIRYRSKLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSTGG QTVRCIAEGT PLPDIEWMIC KDIKKCNNET SWAILANNIS NIITEVHPRD 480
RSTVEGRVTF TRVEETIAVR CLAKNLLGAE SRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSRHPEK PKKELDIFGL NPADDSTRSY 720
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWHSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGSLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCTTCTGGC ACTCCTGATC TTAGGCTGTC TCCTCGCAGG GCCCAGCCTA 60
ATCCTCTGCC AGCTTTCATT ACCCTCGATC CTTCCAAATG AAAATGAAAA GGTCGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGTTG GCATTACCCC 180
ACGTCTGAAG AAGAGAACCC CAATGTGGAG ATCAGAAATG AGGAGAACAA CAGTGGCCTT 240
TTTGTGACCG TGTTGGAAGT GGTCAACGCG TCGGCGGCGC ACACGGGGCT GTACACTTGC 300
TATTACAACC ACACTCAGAC AGACGAAAAC GAGATCGAAG GCAGGCACAT CTACATCTAT 360
GTGCCAGACC CGGATGTCGC CTTCGTACCT CTAGGAATGA CAGATTATTT AGTCATCGTG 420
GAGGATGATG ACTCTGCCAT CATACCTTGT CGTACAACTG ATCCTGAGAC TCCGGTCACC 480
TTACTCAGCA ATGATGGGGT GGTACATGCG TCCTATGACA GCAGACAGGG CTTTAATGGG 540
ACCTTCAGCG TTGGGCCGTA TATCTGCGAA GCCACTGTCA GGGGCAAGAA GTTCCAGACC 600
ATCCCATTTA ATGTTTATGC TTTAAAAGCA ACGTCAGAAC TTGATCTAGA AATGGAAGCT 660
CTTAAAACTG TGTATAAGTC AGGGGAGACG ATTGTGGTCA CCTGCGCCGT CTTTAACAAC 720
GAGGTGGTGG ACCTTCAATG GACCTACCCT GGAGAGGTGA AAGGCAAAGG CATCACCATG 780
TTGGAGGAAA TAAAGGTCCC GTCCATCAAA TTGGTGTACA CTCTGAGGGT CCCCGAGGCC 840
ACGGTGAAAG ATAGTGGAGA TTATGAATGT GCTGCCCGCC AGGCCACCAA GGAAGTCAAA 900
GAGATGAAGA AAGTCACCAT TTCTGTCCAT GAGAAAGGGT TCATTGAAAT CAAACCCAAC 960
TTCAGCCAGT TGGAAGCTGT TGACCTACAC GAAGTCAAGC ATTTCGTGGT GGACGTGCAG 1020
GCCTACCCAC CTCCCAGGAT ATCCTGGCTG AAGGACAACC TGACTCTGAT TGAAAATCTC 1080
ACAGAGATCA CCACTGACAT AGAAAGGACT CAGGAAATAA GGTATCGAAG CAAATTAAAG 1140
CTGATCCGTG CTAAGGAGGA GGACAGTGGC CATTACACTA TCGTCGTTCA AAATGAGGAT 1200
GACGTCAAGA GCTATACTTT CGAACTCTTA ACTCAAGTTC CCTCGTCTAT TCTGGACTTG 1260
GTCGATGACC ACCACGGCTC TACTGGGGGA CAGACCGTGA GATGCATCGC TGAAGGGACA 1320
CCTCTTCCTG ATATTGAATG GATGATTTGC AAGGATATTA AGAAATGTAA TAATGAAACC 1380
TCCTGGGCGA TTTTGGCCAA CAATATCTCA AACATTATCA CGGAGGTCCA CCCCCGAGAC 1440
AGGAGTACTG TGGAGGGCCG GGTGACCTTC ACCAGAGTGG AGGAGACCAT CGCCGTTCGA 1500
TGTCTGGCCA AGAATCTCCT TGGGGCCGAG AGCCGAGAGC TGAAGCTGGT GGCTCCCACG 1560
CTGCGTTCTG AGCTCACGGT GGCAGCTGCA GTCCTGGTGC TATTGGTGAT TGTGATCATC 1620
TCACTTATCG TCCTGGTTGT CATTTGGAAA CAGAAACCGA GGTATGAAAT TCGTTGGAGG 1680
GTCATTGAAT CCATCAGCCC TGATGGACAT GAATATATTT ACGTGGACCC GATGCAGCTG 1740
CCTTATGACT CAAGATGGGA GTTTCCAAGA GATGGACTTG TGCTTGGTCG GATCCTGGGA 1800
TCTGGTGCGT TTGGGAAAGT GGTTGAAGGA ACTGCCTATG GATTAAGCCG CTCCCAGCCG 1860
GTCATGAAAG TCGCAGTGAA GATGCTGAAA CCCACAGCCA GATCCAGTGA AAAACAAGCT 1920
CTCATGTCGG AACTGAAGAT AATGACTCAC CTGGGGCCGC ATTTAAACAT TGTGAACTTG 1980
CTGGGAGCCT GTACCAAGTC AGGCCCCATT TACATCATCA CCGAGTACTG CTTCTATGGG 2040
GATTTGGTCA ACTATTTGCA TAAGAATAGA GATAGCTTCC TGAGCCGCCA CCCGGAGAAG 2100
CCAAAGAAAG AGTTGGACAT TTTTGGATTG AACCCTGCTG ATGACAGCAC ACGGAGTTAC 2160
GTTATTTTGT CTTTTGAAAA CAACGGTGAC TACATGGACA TGAAGCAAGC TGACACCACA 2220
CAGTATGTCC CCATGCTGGA AAGGAAAGAG GTTTCTAAGT ACTCGGACAT CCAGAGATCG 2280
CTGTATGATC GTCCAGCCTC GTACAAGAAG AAATCTATGT TAGACTCCGA AGTCAAAAAC 2340
CTCCTTTCGG ATGATAACTC AGAAGGCCTT ACTTTGTTGG ATTTGTTGAG CTTCACCTAT 2400
CAAGTTGCGC GAGGAATGGA GTTTTTGGCT TCGAAAAATT GTGTCCACCG GGACCTGGCT 2460
GCTCGAAACG TCCTCCTGGC ACAAGGGAAA ATCGTGAAGA TCTGCGACTT CGGCCTGGCC 2520
AGAGACATCA TGCACGATTC AAACTATGTG TCTAAAGGCA GTACCTTTCT CCCCGTGAAG 2580
TGGATGGCTC CCGAGAGCAT CTTCGACAAC CTCTACACCA CGCTGAGTGA CGTCTGGTCC 2640
TACGGCATCC TGCTCTGGGA GATCTTTTCC CTTGGCGGCA CACCCTACCC TGGCATGATG 2700
GTGGATTCTA CTTTCTACAA TAAGATCAAG AGTGGATACC GGATGGCCAA GCCTGACCAC 2760
GCCACCAGTG AAGTCTATGA GATCATGGTG AAGTGCTGGC ACAGTGAACC GGAGAAGAGA 2820
CCCTCCTTTT ACCACCTGAG CGAGATCGTG GAGAATCTGC TGCCTGGACA ATATAAGAAG 2880
AGTTACGAGA AGATTCACCT GGACTTCCTG AAGAGCGACC ACCCCGCCGT GGCGCGTATG 2940
CGCGTGGACT CAGACAACGC CTACATCGGC GTCACCTACA AAAACGAGGA GGACAAGCTG 3000
AAGGACTGGG AGGGCAGCCT GGACGAGCAG AGGCTGAGCG CCGACAGCGG CTACATCATC 3060
CCCCTGCCCG ACATCGACCC GGTGCCCGAG GAGGAAGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCGCAGA CCTCAGAAGA AAGCGCTATC GAGACAGGTT CCAGCAGCTC TACCTTCATC 3180
AAGAGAGAGG ACGAAACCAT CGAGGACATC GACATGATGG ACGACATTGG AATAGACTCC 3240
TCAGACCTGG TAGAGGACAG CTTCCTGTGA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  709
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 710   LnPADDSTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  769
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWHSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP 120
ADDSTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WHSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
cfa:442860;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013