EKS-CAF-00421
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00421
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/VEGFR603.51.3E-1818331159327
StatusUnreviewed
Ensembl ProteinENSCAFP00000003064
UniProt AccessionQ2XPT7;
Protein Name
Protein Synonyms/Alias VEGFR2;
Gene NameCfa.24332
Gene Synonyms/Alias Cfa.24332;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000002079ENSCAFP00000003064ENSCAFT00000003300
OrganismCanis familiaris
Functional Description
Protein Length1355
Protein Sequence
(FASTA)
MESKALLAIA LWLCVETGAA SGGLPSVSLH PPRLSIQKDI LTIMANTTLQ ITCRGQRDLD 60
WLWPNNQSGS EKRVEVTECS DSFFCKMLTI PKVMGNDTGA YKCFYRDTDM ASVIYVYVQD 120
YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD 180
SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YKIYDVILSP PHGVELSVGE 240
RLVLNCTVRT ELNVGLDFNW EYPSLKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS 300
DQGWYTCAAS SGLMTKRNST FIRVHEKPFV AFGSGMESSV EATVGDRVRI PVKYLGYPPP 360
EIKWYKNGRP IESNHTIKVG HVLTIMEVSE KDTGNYTVIL TNPISKEKQS HVISLVVNVP 420
PQIGEKSLIS PVDSYQYGTT QSLTCTVYAV PPPHHIRWYW QLEECAYKPA QAVLMTNPYT 480
CKEWRNVDDF QGGNKIEVNK NQFALIEGKN KTVSTLVIQA ANVSALYKCE AVNKVGRGER 540
VISFHVIRGP EITLQPDTQP TEQESVSLWC TADRTTFENL TWYKSGPQAL AVHAGEVPTP 600
VCKNLDALWR MNATTFSNGT SDILILELQN VSLQDQGDYV CFAQDRKTKK RHCVVRQLTV 660
LERVAPMITG NLENQTTSIG ETIEVSCTTS GNPPPQITWF KDNETLVEDS GIILKDGNRN 720
LTIRRVRKED EGLYTCQACS VLGCAKVEAF FIVEGAQEKT NLEVIILVGT AVIAMFFWLL 780
LVIVLRTVKR ANGGELKTGY LSIVMDPDEL PLDEHCERLP YDASKWEFPR DRLKLGKPLG 840
RGAFGQVIEA DAFGIDKTAT CKTVAVKMLK EGATHSEHRA LMSELKILIH IGHHLNVVNL 900
LGACTKPGGP LMVIVEFCKF GNLSTYLRSK RNEFVPYKTK GARFRQGKEY VGEITMDPKR 960
RLDSITSSQS SASSGFVEEK SLSDVEEEEV SEDLYKNFLT LEHLICYSFQ VAKGMEFLAS 1020
RKCIHRDLAA RNILLSEKNV VKICDFGLAR DIYKDPDYVR KGDARLPLKW MAPETIFDRV 1080
YTIQSDVWSF GVLLWEIFSL GASPYPGVKI DEEFCRRLKE GTRMRAPDYT TPEMYQTMLD 1140
CWHGEPNQRP TFSELVEHLG NLLQANAQQD GKDYIVLPIS ETLSMEEDSG LSLPTSPVSC 1200
MEEEEVCDPK FHYDNTAGIS QYLQNSKRKS RPVSVKTFED IPLEEPEVKV IPDDNQTDSG 1260
MVLASEELKT LEDRTKLAPS FSGLMPSKSK ESVASEGSNQ TSGYQSGYHS DDTDTTVYSS 1320
EEAELLKLME IGPQAGSAAQ ILQPDSGPTL SSPPV 1355
Nucleotide Sequence
(FASTA)
ATGGAGAGCA AGGCGCTGCT GGCCATCGCT CTGTGGCTCT GCGTGGAGAC CGGGGCTGCC 60
TCCGGGGGTT TGCCTAGTGT TTCCCTTCAT CCACCCAGAC TCAGCATACA AAAAGACATA 120
CTTACAATTA TGGCTAATAC AACTCTCCAG ATTACTTGCA GGGGACAGAG GGACTTGGAC 180
TGGCTCTGGC CCAACAATCA GAGTGGCTCT GAGAAAAGAG TGGAGGTGAC TGAGTGCAGT 240
GACAGCTTCT TTTGTAAGAT GCTCACGATT CCAAAAGTGA TGGGAAATGA TACTGGAGCC 300
TACAAGTGCT TCTATCGGGA CACTGACATG GCCTCGGTCA TTTATGTCTA CGTTCAAGAT 360
TACAGGTCTC CATTTATTGC TTCTGTTAGC GACCAACATG GAGTCGTGTA CATCACTGAG 420
AACAAAAATA AAACTGTGGT GATTCCATGT CTTGGGTCCA TTTCCAACCT CAATGTGTCA 480
CTTTGTGCAA GGTATCCAGA AAAGAGGTTT GTTCCTGATG GAAACAGAAT TTCCTGGGAC 540
AGTAAGAAAG GCTTTACTAT CCCCAGCTAC ATGATCAGCT ATGCTGGCAT GGTCTTCTGC 600
GAAGCAAAAA TTAATGATGA AAGTTACCAG TCTATTATGT ACATAGTTGT GGTTGTAGGG 660
TACAAGATTT ATGATGTGAT TCTCAGCCCC CCTCACGGAG TTGAGCTGTC TGTTGGAGAG 720
AGGCTTGTCT TAAATTGTAC TGTAAGAACT GAACTAAACG TAGGGCTTGA CTTCAACTGG 780
GAATACCCTT CTTTGAAGCA TCAGCATAAA AAACTTGTTA ACCGGGACCT AAAAACCCAG 840
TCTGGGAGTG AGATGAAGAA ATTTTTGAGC ACCTTGACTA TAGATGGTGT AACCCGGAGT 900
GACCAAGGGT GGTACACCTG TGCAGCTTCC AGTGGGCTGA TGACCAAGAG GAACAGCACA 960
TTCATCAGGG TCCACGAAAA ACCCTTTGTT GCTTTTGGTA GTGGCATGGA ATCTTCGGTG 1020
GAAGCCACTG TGGGAGATCG TGTCAGAATC CCTGTGAAGT ACCTTGGTTA CCCTCCCCCT 1080
GAAATAAAAT GGTATAAAAA TGGAAGACCC ATTGAGTCCA ATCACACAAT AAAAGTGGGG 1140
CATGTCCTGA CGATTATGGA AGTGAGTGAA AAAGATACAG GAAATTATAC TGTCATCCTT 1200
ACCAACCCCA TTTCAAAGGA GAAACAGAGC CACGTGATAT CTCTGGTTGT GAATGTCCCG 1260
CCCCAGATCG GTGAGAAATC CCTGATCTCT CCGGTGGATT CCTACCAGTA TGGCACCACG 1320
CAGTCGCTGA CATGCACGGT CTACGCCGTC CCCCCTCCGC ACCACATCCG CTGGTACTGG 1380
CAGCTGGAGG AGTGCGCCTA CAAGCCCGCC CAAGCTGTCT TAATGACAAA CCCATACACT 1440
TGTAAAGAAT GGAGAAACGT GGATGACTTC CAGGGGGGAA ATAAAATTGA AGTCAACAAG 1500
AATCAGTTTG CCCTAATTGA AGGAAAGAAC AAAACTGTAA GTACCCTTGT TATCCAAGCA 1560
GCCAATGTGT CAGCTTTGTA CAAATGCGAA GCCGTCAATA AAGTTGGGAG AGGAGAGAGG 1620
GTCATCTCCT TCCACGTGAT CAGGGGCCCT GAAATCACTT TGCAACCGGA CACCCAGCCA 1680
ACCGAGCAGG AGAGCGTGTC TTTGTGGTGC ACTGCAGACA GAACTACGTT TGAGAACCTC 1740
ACGTGGTACA AGTCTGGCCC ACAGGCTCTG GCAGTCCATG CGGGAGAGGT GCCCACACCT 1800
GTTTGCAAGA ACTTGGATGC TCTTTGGAGA ATGAATGCCA CCACGTTCTC TAATGGCACA 1860
AGTGACATTT TGATCCTGGA GCTCCAGAAT GTGTCCTTGC AGGACCAAGG AGACTATGTG 1920
TGCTTCGCTC AGGACAGGAA GACCAAGAAA AGACATTGTG TGGTCAGACA GCTCACAGTT 1980
TTAGAGCGCG TGGCGCCCAT GATCACCGGA AACCTGGAGA ATCAGACTAC AAGTATTGGT 2040
GAAACCATTG AAGTTTCATG CACCACATCT GGGAATCCCC CTCCACAGAT TACCTGGTTT 2100
AAAGATAACG AGACACTTGT GGAAGACTCA GGCATTATAC TGAAAGATGG GAACCGGAAC 2160
CTCACCATCC GTAGGGTGAG GAAGGAGGAT GAAGGCCTCT ACACCTGCCA GGCATGCAGT 2220
GTTCTTGGGT GTGCAAAAGT GGAGGCATTT TTCATAGTAG AAGGTGCCCA GGAGAAGACG 2280
AACTTGGAAG TCATTATTCT AGTAGGCACG GCAGTGATTG CCATGTTCTT CTGGTTATTA 2340
CTTGTCATCG TTCTACGGAC CGTTAAGCGG GCCAATGGAG GGGAACTGAA GACAGGCTAC 2400
TTGTCCATCG TCATGGATCC AGATGAACTC CCCTTGGATG AGCACTGTGA ACGCCTGCCT 2460
TATGATGCCA GCAAATGGGA GTTCCCCAGG GACCGGCTAA AACTAGGTAA GCCTCTTGGC 2520
CGTGGGGCCT TTGGCCAAGT GATTGAAGCA GATGCCTTTG GAATCGACAA GACAGCAACT 2580
TGCAAGACAG TGGCCGTCAA AATGTTAAAA GAAGGAGCAA CACACAGTGA ACACCGAGCC 2640
CTCATGTCTG AACTCAAGAT CCTCATTCAT ATTGGCCACC ATCTCAATGT GGTCAATCTC 2700
CTGGGTGCCT GTACCAAGCC GGGAGGGCCA CTCATGGTGA TTGTGGAATT TTGCAAGTTT 2760
GGAAACCTGT CAACTTACTT AAGGAGCAAG AGAAATGAAT TTGTCCCCTA CAAGACCAAA 2820
GGGGCCCGAT TCCGTCAGGG GAAAGAATAC GTTGGGGAAA TCACTATGGA TCCAAAGCGC 2880
CGCTTGGACA GCATCACCAG TAGTCAGAGT TCGGCCAGTT CTGGGTTTGT TGAAGAAAAA 2940
TCCCTCAGTG ATGTGGAGGA AGAGGAAGTC TCCGAAGATC TGTACAAGAA CTTCCTGACC 3000
TTGGAGCATC TCATCTGTTA CAGCTTCCAG GTGGCCAAGG GCATGGAGTT TTTGGCATCA 3060
CGGAAGTGTA TCCACAGGGA CCTGGCGGCA CGAAACATCC TCTTGTCGGA GAAGAACGTG 3120
GTTAAGATCT GTGACTTTGG CTTGGCCCGG GATATTTATA AAGACCCAGA TTATGTCAGA 3180
AAAGGAGACG CTCGCCTCCC TTTGAAATGG ATGGCTCCAG AGACGATTTT TGACAGAGTG 3240
TACACAATTC AGAGTGATGT GTGGTCTTTT GGTGTCTTGC TCTGGGAAAT ATTTTCCTTA 3300
GGTGCTTCTC CGTATCCTGG AGTAAAGATT GATGAAGAAT TTTGTAGGCG ATTGAAAGAA 3360
GGCACCAGAA TGAGGGCCCC TGATTATACC ACACCAGAAA TGTACCAGAC CATGCTTGAC 3420
TGCTGGCATG GGGAACCCAA TCAGAGACCC ACGTTTTCCG AGTTGGTGGA ACATTTGGGA 3480
AATCTGCTAC AGGCTAATGC TCAGCAGGAT GGCAAAGACT ACATTGTTCT CCCCATATCA 3540
GAGACTTTGA GCATGGAAGA GGATTCTGGA CTCTCTCTGC CTACCTCACC TGTTTCCTGT 3600
ATGGAGGAAG AGGAAGTGTG TGACCCCAAA TTCCATTATG ACAACACAGC AGGAATCAGC 3660
CAGTATCTGC AGAACAGTAA GCGAAAGAGC CGGCCCGTGA GTGTAAAAAC ATTTGAAGAT 3720
ATCCCATTGG AAGAACCAGA AGTAAAAGTA ATCCCAGATG ACAACCAGAC GGACAGTGGT 3780
ATGGTCCTTG CCTCAGAAGA GCTGAAAACC CTGGAAGACA GAACCAAATT AGCTCCATCT 3840
TTTAGTGGAC TGATGCCCAG CAAGAGCAAG GAGTCTGTGG CATCCGAAGG CTCTAACCAA 3900
ACGAGTGGCT ACCAGTCCGG CTATCACTCC GATGACACGG ATACCACTGT GTACTCCAGC 3960
GAGGAGGCCG AACTTTTAAA GCTGATGGAG ATTGGACCAC AAGCTGGCAG TGCAGCCCAG 4020
ATTCTCCAGC CTGACTCTGG GCCCACATTG AGCTCTCCTC CTGTTTAA 4068
Domain Profile
S: 1     lklGkslGeGafGkvveasafgikkeetcktvavkmlkegatasevrallselkilihiG  60
         lklGk lG+GafG+v+ea+afgi+k++tcktvavkmlkegat+se+ral+selkilihiG
Q: 833   LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIG  892
         79**********************************************************
S: 61    khlnvvnllGactkakgpllviveyckyGnlsnylrskrdefvlykekaaelrkkkeale  120
         +hlnvvnllGactk++gpl+vive+ck+Gnls+ylrskr+efv+yk+k+a++r+ ke++ 
Q: 893   HHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKEYVG  952
         ************************************************************
S: 121   alevdkkr...svsssrslassgfkeekslsdveeeeeaedlykepltledlisysfqva  177
         ++++d kr   s++ss+s+assgf+eekslsdveeee +edlyk++ltle+li+ysfqva
Q: 953   EITMDPKRrldSITSSQSSASSGFVEEKSLSDVEEEEVSEDLYKNFLTLEHLICYSFQVA  1012
         ****9988899*************************************************
S: 178   rGmeflasrkvihrdlaarnillsennvvkicdfGlardiykdpdyvrkgdarlPlkWla  237
         +Gmeflasrk+ihrdlaarnillse+nvvkicdfGlardiykdpdyvrkgdarlPlkW+a
Q: 1013  KGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA  1072
         ************************************************************
S: 238   lesifdkvystksdvWsyGvllWeifslgasPyPgvqineelikrlkeGtrlraPelatp  297
         +e+ifd+vy+++sdvWs+GvllWeifslgasPyPgv+i+ee+++rlkeGtr+raP+++tp
Q: 1073  PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTP  1132
         ************************************************************
S: 298   eiyeimldcWkkdPeerPafaelvekl  324
         e+y++mldcW+++P++rP+f+elve+l
Q: 1133  EMYQTMLDCWHGEPNQRPTFSELVEHL  1159
         *************************97
Domain Sequence
(FASTA)
LKLGKPLGRG AFGQVIEADA FGIDKTATCK TVAVKMLKEG ATHSEHRALM SELKILIHIG 60
HHLNVVNLLG ACTKPGGPLM VIVEFCKFGN LSTYLRSKRN EFVPYKTKGA RFRQGKEYVG 120
EITMDPKRRL DSITSSQSSA SSGFVEEKSL SDVEEEEVSE DLYKNFLTLE HLICYSFQVA 180
KGMEFLASRK CIHRDLAARN ILLSEKNVVK ICDFGLARDI YKDPDYVRKG DARLPLKWMA 240
PETIFDRVYT IQSDVWSFGV LLWEIFSLGA SPYPGVKIDE EFCRRLKEGT RMRAPDYTTP 300
EMYQTMLDCW HGEPNQRPTF SELVEHL 327
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00391
EKS-ANC-00407
EKS-BOT-00420
EKS-CAJ-00427
EKS-CAP-00448
EKS-DAR-00815
EKS-EQC-00414
EKS-FEC-00403
EKS-GAG-00355
EKS-GOG-00413
EKS-HOS-00428
EKS-ICT-00401
EKS-LAC-00436
EKS-LOA-00431
EKS-MAM-00420
EKS-MEG-00349
EKS-MOD-00411
EKS-MUM-00452
EKS-MUP-00414
EKS-MYL-00415
EKS-NOL-00383
EKS-ORN-00539
EKS-ORA-00369
EKS-ORC-00394
EKS-OTG-00424
EKS-PAT-00399
EKS-PES-00374
EKS-PEM-00231
EKS-POA-00412
EKS-PTV-00121
EKS-RAN-00434
EKS-SAH-00390
EKS-SUS-00373
EKS-TAG-00490
EKS-TAR-00531
EKS-TEN-00532
EKS-TUT-00131
EKS-XET-00532
Gene Ontology
GO:0009897; C:external side of plasma membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048754; P:branching morphogenesis of a tube
GO:0055074; P:calcium ion homeostasis
GO:0035584; P:calcium-mediated signaling using intracellular calcium source
GO:0045165; P:cell fate commitment
GO:0048469; P:cell maturation
GO:0016477; P:cell migration
GO:0045446; P:endothelial cell differentiation
GO:0030097; P:hemopoiesis
GO:0048286; P:lung alveolus development
GO:0001945; P:lymph vessel development
GO:2000352; P:negative regulation of endothelial cell apoptotic process
GO:0001541; P:ovarian follicle development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0010595; P:positive regulation of endothelial cell migration
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0051894; P:positive regulation of focal adhesion assembly
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0050927; P:positive regulation of positive chemotaxis
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0043129; P:surfactant homeostasis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0001570; P:vasculogenesis
KEGG
cfa:482154;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013106; Ig_V-set.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009136; Tyr_kinase_VEGFR2_rcpt.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
PF07686; V-set; 1.
SMARTs
SM00409; IG; 5.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 5.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
PR01834; VEGFRECEPTR2.
Created Date20-Feb-2013