EKS-CAF-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	344.0	7.8E-103	849	1120	272

Status

Unreviewed

Ensembl Protein

ENSCAFP00000003097

UniProt Accession

E2RPW6;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000002102	ENSCAFP00000003097	ENSCAFT00000003337

Organism

Canis familiaris

Functional Description

Protein Length

1132

Protein Sequence
(FASTA)

MGMACLTMTE MEGTSESPIH QNGDIPGNAN SVKQIDPLLQ VYLYHSLEKA EEEYLKFPTG 60

EYVAEEICVA ASKACGITPV YHSMFALMSE TERIWYPPNH VFHIDESTKH NVLYRIRFYF 120

PYWYCNGSNR TYRHGISRGA EAPLLDDFVM AYLFAQWRHD FLHGWIKIPV THETQEECLG 180

MAVLDMMRLA KEKDQTPLDI YSSISYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIEQF 240

SHCKATARNL KLKYLINLET LQSAFYTEQF EVKEPGRGPS GEEIFATIII TGNGGIQWSR 300

GKRKESETLT EQDLQLYCDF PDIIDVTIKQ ASQEGSNESR IVTIHKQDGK NLEIELSSLR 360

EALSFVSLID GYYRLTADAH HYLCKEVAPP MVLENIQSNC HGPILMDFAI SKLKKAGNQT 420

GLYVLRCSPK DFNKYFLTFA IERENVIEYK HCLITKNENG EYNLSGTKKS FRNLKDLLNC 480

YHMETVRSDS IIFQFTKCCP PKLKDKSNLL VFRTNGVSDV PTSPTLQRHN NVNQMVFHKI 540

RNEDLMFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600

MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINIFWK LEVAKQLAWA 660

MHFLEEKALI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720

PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWTEL 780

ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFPGAFEDQD 840

PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900

ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960

CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 1020

YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE 1080

LLKNNGRLPR PDGCPDEIYL IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG 1132

Nucleotide Sequence
(FASTA)

ATGGGAATGG CTTGCCTTAC AATGACAGAA ATGGAAGGAA CATCCGAATC TCCTATACAT 60

CAGAATGGTG ATATTCCTGG AAATGCTAAT TCTGTGAAGC AAATAGACCC ACTCCTACAG 120

GTGTATCTTT ATCATTCTCT TGAGAAAGCT GAAGAAGAAT ATCTGAAGTT TCCAACTGGG 180

GAGTATGTTG CAGAAGAAAT TTGTGTTGCT GCTTCTAAAG CTTGTGGAAT CACACCTGTG 240

TATCATAGTA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAACCAC 300

GTCTTCCATA TTGATGAATC AACCAAGCAC AATGTACTCT ACAGAATAAG ATTTTACTTC 360

CCTTACTGGT ATTGTAACGG CAGCAACAGA ACCTATCGGC ACGGAATATC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGACGA CTTTGTCATG GCTTATCTTT TTGCTCAGTG GCGGCATGAT 480

TTTTTACATG GATGGATAAA AATACCCGTG ACTCATGAAA CACAGGAAGA ATGTCTTGGA 540

ATGGCTGTGC TAGATATGAT GAGACTAGCC AAAGAAAAGG ATCAAACCCC ACTGGATATC 600

TATAGCTCTA TCAGCTACAA GACATTCTTA CCCAAATGTG TTCGAGCAAA GATTCAAGAC 660

TATCATATTT TGACAAGGAA ACGAATAAGG TACAGATTTC GCAGATTTAT TGAGCAGTTC 720

AGCCATTGCA AAGCCACTGC CAGAAACTTG AAACTTAAGT ACCTTATAAA TCTGGAAACT 780

CTTCAGTCTG CCTTCTACAC AGAGCAATTT GAAGTAAAAG AACCTGGAAG AGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900

GGGAAACGTA AAGAAAGTGA GACACTGACA GAACAGGATT TACAGTTATA TTGTGACTTT 960

CCTGATATTA TTGATGTTAC TATTAAGCAA GCAAGCCAAG AAGGCTCAAA TGAAAGTAGA 1020

ATTGTAACTA TCCATAAGCA AGATGGTAAA AATCTGGAAA TTGAACTTAG CTCATTAAGA 1080

GAAGCTTTGT CCTTTGTGTC ATTAATTGAT GGCTATTATA GATTAACTGC AGATGCACAT 1140

CATTACCTCT GTAAAGAAGT AGCACCTCCA ATGGTCCTTG AAAATATACA AAGCAACTGT 1200

CATGGCCCAA TTTTAATGGA TTTTGCTATC AGTAAACTGA AGAAAGCAGG TAATCAGACT 1260

GGACTCTATG TACTTCGATG CAGCCCTAAG GACTTTAATA AATATTTCCT GACTTTTGCC 1320

ATTGAGCGAG AAAATGTCAT CGAATATAAG CACTGTTTGA TTACAAAAAA TGAAAATGGA 1380

GAATACAACC TCAGTGGGAC CAAGAAGAGC TTCCGTAATC TTAAAGATCT TTTGAACTGC 1440

TACCACATGG AGACTGTTCG CTCAGACAGC ATAATTTTCC AGTTTACCAA ATGCTGTCCC 1500

CCAAAATTGA AAGATAAGTC AAACCTTCTA GTCTTCAGAA CCAATGGCGT TTCTGATGTA 1560

CCAACATCAC CAACATTACA GAGGCATAAT AATGTGAACC AAATGGTGTT CCACAAAATC 1620

AGAAATGAAG ATTTGATGTT TAACGAAAGT CTTGGCCAAG GCACTTTTAC AAAAATTTTT 1680

AAAGGTGTGA GAAGAGAAGT AGGAGACTAT GGTCAACTGC ATGAAACAGA AGTTCTTTTA 1740

AAAGTTCTTG ATAAAGCACA CAGAAATTAT TCAGAGTCTT TCTTTGAAGC AGCCAGCATG 1800

ATGAGCCAGC TTTCTCATAA GCATCTGGTT TTAAATTATG GAGTATGTGT CTGTGGAGAG 1860

GAGAATATTC TGGTTCAGGA ATTTGTAAAA TTTGGATCAT TAGATACATA TCTGAAAAAG 1920

AATAAGAATT CTATAAATAT ATTTTGGAAA CTTGAAGTGG CTAAACAGTT GGCATGGGCA 1980

ATGCATTTTC TAGAAGAGAA AGCACTTATT CATGGAAATG TGTGTGCCAA AAATATTCTG 2040

CTTATCAGAG AAGAAGACAG GAAGACAGGA AATCCTCCTT TCATCAAACT TAGTGATCCT 2100

GGCATTAGTA TTACAGTTTT GCCAAAGGAC ATTCTTCAGG AGAGAATACC ATGGGTACCA 2160

CCTGAATGCA TTGAAAATCC TAAAAATCTA AATTTGGCGA CAGACAAATG GAGTTTTGGT 2220

ACCACTTTGT GGGAAATCTG CAGTGGAGGA GATAAGCCTC TGAGTGCTTT GGATTCTCAG 2280

AGAAAGCTAC AGTTTTATGA AGATAGACAC CAACTTCCTG CACCAAAGTG GACAGAATTA 2340

GCAAATCTTA TTAATAATTG TATGGATTAT GAACCAGATT TTAGACCTTC TTTCAGAGCC 2400

ATCATACGAG ATCTTAATAG TTTGTTTACT CCAGATTATG AACTATTAAC AGAAAATGAC 2460

ATGTTACCAA ATATGAGAAT TGGTGCCCTA GGGTTTCCTG GTGCTTTTGA AGACCAAGAC 2520

CCTACACAGT TTGAAGAGAG ACACTTGAAA TTTCTACAGC AACTTGGCAA GGGTAATTTT 2580

GGCAGTGTGG AGATGTGCCG ATATGACCCT CTACAAGACA ACACTGGGGA GGTGGTAGCT 2640

GTGAAGAAGC TCCAGCACAG TACTGAAGAG CACCTGAGAG ACTTTGAGAG GGAAATTGAA 2700

ATCCTTAAAT CCCTGCAGCA TGACAACATT GTAAAGTACA AGGGAGTGTG CTACAGTGCT 2760

GGCCGGCGTA ATCTAAGATT AATTATGGAA TATTTACCAT ATGGAAGTTT ACGAGACTAC 2820

CTCCAAAAAC ATAAAGAACG AATAGATCAT AAAAAACTTC TGCAGTATAC ATCTCAGATA 2880

TGCAAGGGCA TGGAGTATCT TGGTACAAAA AGGTATATAC ACAGGGATCT GGCAACAAGG 2940

AATATATTGG TGGAGAATGA AAACAGGGTT AAAATTGGAG ATTTTGGGTT AACCAAAGTC 3000

TTGCCACAAG ACAAAGAATA CTACAAAGTG AAAGAACCTG GTGAAAGTCC CATATTCTGG 3060

TATGCTCCAG AATCATTGAC AGAGAGCAAG TTTTCTGTGG CTTCAGATGT CTGGAGCTTT 3120

GGAGTGGTTC TATATGAACT TTTCACATAT ATTGAGAAGA GTAAAAGTCC ACCAGCGGAA 3180

TTTATGCGTA TGATTGGCAA CGACAAGCAA GGACAGATGA TTGTGTTTCA TTTGATAGAA 3240

CTCCTAAAGA ATAATGGAAG ATTACCAAGA CCAGATGGAT GCCCAGATGA GATTTATTTG 3300

ATCATGACAG AATGCTGGAA TAATAATGTG AATCAGCGGC CCTCTTTCAG AGACCTAGCT 3360

CTTCGAGTGG ATCAGATAAG GGACAACATG GCTGGATGA 3399

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 849   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  908

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+

Q: 909   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  968

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 969   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1022

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1023  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1081

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlp+p+ cp+e++ +mt+c++++ +qrpsFr+++

Q: 1082  LKNNGRLPRPDgCPDEIYLIMTECWNNNVNQRPSFRDLA  1120

         ************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YLIMTECWNN NVNQRPSFRD LA 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0061180	; P:mammary gland epithelium development
GO:0030099	; P:myeloid cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013