EKS-CAF-00436
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00436
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Syk490.97.8E-148176424249
StatusUnreviewed
Ensembl ProteinENSCAFP00000003440
UniProt AccessionF1PJS1;
Protein Name
Protein Synonyms/Alias
Gene NameCfa.47613
Gene Synonyms/Alias Cfa.47613;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000002371ENSCAFP00000003440ENSCAFT00000003716
OrganismCanis familiaris
Functional Description
Protein Length457
Protein Sequence
(FASTA)
MPWYHSSLTR EEAERKLYSG SQTDGKFLLR PRKEQGTYAL SLIYGKTVYH YLISQDKAGK 60
YCIPEGTKFD TLWQLVEYLK LKADGLIYCL KDACPNTNAS SEAAAPTLPA HPSTFTQAHR 120
RIDTLNSDGY TPEPARLASS EKAQSMPMDT SVYESPYSDP EELKDKKLFL KRENLLMADI 180
ELGCGNFGSV RQGVYRMRKK QIDVAIKVLK HSTEKTDKDE MMREAQIMHQ LDNPYIVRLI 240
GVCQAEALML VMEMAGGGPL HKFLLGKKEE IPISNVAELL HQVSMGMKYL EEKNFVHRDL 300
AARNVLLVNR HYAKISDFGL SKALGADDSY YTARSAGKWP LKWYAPECFN FRKFSSRSDV 360
WSYGVTMWEA FSYGQKPYKK MKGPEVIAFI EQGKRMECPL ECPPEMYTLM KDCWIYKWED 420
RPDFQAVEQR MRAYYYSVAS KAEDLPGCGK GVEASSV 457
Nucleotide Sequence
(FASTA)
ATGCCCTGGT ACCACAGCAG CCTGACACGC GAGGAGGCAG AGCGCAAACT CTATTCGGGC 60
TCGCAGACCG ACGGCAAGTT CCTGTTGAGG CCCCGGAAGG AGCAGGGCAC GTATGCACTG 120
TCCCTGATCT ATGGGAAAAC AGTGTACCAC TACCTCATCA GCCAGGACAA GGCAGGCAAA 180
TACTGTATTC CTGAGGGGAC CAAGTTTGAC ACGCTCTGGC AGCTGGTAGA GTACCTGAAG 240
CTAAAGGCAG ATGGGCTCAT CTACTGCCTG AAGGACGCTT GCCCCAACAC CAACGCCAGC 300
TCAGAGGCTG CTGCTCCCAC ACTTCCAGCC CACCCATCCA CGTTCACCCA AGCTCACAGG 360
CGGATTGACA CCCTCAACTC AGATGGATAC ACCCCTGAAC CAGCACGCCT AGCATCCTCA 420
GAGAAAGCAC AGTCAATGCC CATGGACACG AGTGTGTATG AGAGCCCCTA CAGCGATCCT 480
GAGGAGCTCA AGGACAAGAA GCTCTTCCTG AAGCGTGAGA ACCTCCTCAT GGCTGACATA 540
GAACTCGGCT GTGGCAACTT TGGCTCAGTA CGCCAGGGCG TCTACCGCAT GCGCAAGAAG 600
CAGATTGATG TGGCCATCAA GGTGCTGAAG CATAGCACGG AGAAGACAGA CAAGGATGAG 660
ATGATGCGTG AGGCACAGAT CATGCACCAG CTGGACAACC CCTACATTGT GCGGCTCATC 720
GGTGTCTGCC AGGCCGAGGC CCTCATGCTC GTCATGGAGA TGGCGGGCGG TGGGCCCCTG 780
CACAAGTTCC TGCTTGGGAA GAAGGAGGAG ATCCCTATCA GCAATGTGGC AGAGCTGCTG 840
CACCAGGTGT CCATGGGGAT GAAGTACCTG GAGGAGAAAA ACTTTGTGCA CCGTGACCTG 900
GCGGCCCGCA ATGTCCTGCT AGTCAACCGG CACTACGCCA AGATCAGTGA CTTTGGTCTC 960
TCCAAGGCAC TGGGTGCCGA CGACAGCTAT TACACTGCCC GCTCAGCGGG GAAGTGGCCA 1020
CTCAAGTGGT ATGCGCCCGA GTGCTTCAAC TTCCGCAAGT TCTCCAGCCG CAGTGATGTC 1080
TGGAGCTACG GGGTCACCAT GTGGGAGGCC TTCTCCTATG GCCAGAAGCC CTACAAGAAG 1140
ATGAAGGGCC CTGAGGTCAT AGCCTTCATT GAGCAGGGCA AGAGGATGGA GTGCCCCCTA 1200
GAGTGTCCAC CTGAAATGTA CACACTCATG AAGGACTGTT GGATCTACAA GTGGGAGGAC 1260
CGCCCAGACT TCCAAGCTGT GGAGCAGCGC ATGCGGGCCT ACTATTATAG CGTGGCAAGC 1320
AAGGCTGAGG ACCTCCCGGG GTGTGGAAAG GGGGTTGAAG CTTCTTCTGT CTGA 1374
Domain Profile
S: 1     lvedkelGsGnfGsvkkGyyrmkkkrlevaikvlkeadekadkdellreasvmqqldnky  60
         l++d+elG+GnfGsv++G+yrm+kk+++vaikvlk+++ek+dkde++rea++m+qldn+y
Q: 176   LMADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKHSTEKTDKDEMMREAQIMHQLDNPY  235
         579*********************************************************
S: 61    ivrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknf  120
         ivrliG+++aealmlvme+a++Gpl+k+ll+k+eei+ +nv+el+hqv+mGmkyleeknf
Q: 236   IVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPISNVAELLHQVSMGMKYLEEKNF  295
         ************************************************************
S: 121   vhrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfs  180
         vhrdlaarnvllv+rhyakisdfGlskal+ad+syy+arsaGkwp+kwyapec+n+rkfs
Q: 296   VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECFNFRKFS  355
         ************************************************************
S: 181   sksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwk  240
         s+sdvws+Gvt+weafsyGqkpyk++kg+ev+a++e+G+r+ecp ecp+e+y lm++cw+
Q: 356   SRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVIAFIEQGKRMECPLECPPEMYTLMKDCWI  415
         ************************************************************
S: 241   ykvedrpdf  249
         yk+edrpdf
Q: 416   YKWEDRPDF  424
         ********9
Domain Sequence
(FASTA)
LMADIELGCG NFGSVRQGVY RMRKKQIDVA IKVLKHSTEK TDKDEMMREA QIMHQLDNPY 60
IVRLIGVCQA EALMLVMEMA GGGPLHKFLL GKKEEIPISN VAELLHQVSM GMKYLEEKNF 120
VHRDLAARNV LLVNRHYAKI SDFGLSKALG ADDSYYTARS AGKWPLKWYA PECFNFRKFS 180
SRSDVWSYGV TMWEAFSYGQ KPYKKMKGPE VIAFIEQGKR MECPLECPPE MYTLMKDCWI 240
YKWEDRPDF 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00407
EKS-BOT-00437
EKS-CAJ-00442
EKS-CAP-00470
EKS-CIS-00192
EKS-DIO-00086
EKS-DRM-00206
EKS-EQC-00428
EKS-ERE-00039
EKS-FEC-00418
EKS-GAG-00368
EKS-GOG-00429
EKS-HOS-00444
EKS-ICT-00420
EKS-LOA-00447
EKS-MAM-00436
EKS-MIM-00075
EKS-MOD-00427
EKS-MUM-00469
EKS-MUP-00431
EKS-NOL-00398
EKS-OCP-00104
EKS-ORC-00410
EKS-OTG-00441
EKS-PAT-00413
EKS-POA-00428
EKS-PRC-00042
EKS-RAN-00450
EKS-SAH-00406
EKS-SUS-00387
Gene Ontology
GO:0005829; C:cytosol
GO:0001772; C:immunological synapse
GO:0042101; C:T cell receptor complex
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043366; P:beta selection
GO:0006955; P:immune response
GO:0035556; P:intracellular signal transduction
GO:0045060; P:negative thymic T cell selection
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046638; P:positive regulation of alpha-beta T cell differentiation
GO:0046641; P:positive regulation of alpha-beta T cell proliferation
GO:0050850; P:positive regulation of calcium-mediated signaling
GO:0045059; P:positive thymic T cell selection
GO:0046777; P:protein autophosphorylation
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013