EKS-CAF-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.8	1.6E-140	136	423	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000040830

UniProt Accession

F1PS63;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000002528	ENSCAFP00000040830	ENSCAFT00000044556
ENSCAFG00000002528	ENSCAFP00000003684	ENSCAFT00000003989

Organism

Canis familiaris

Functional Description

Protein Length

434

Protein Sequence
(FASTA)

MCIAEIDLIP RDRPFVCAPS SKTGSVTTTY CCNQDHCNKI ELPTVGKPSS GLGPVELAAV 60

IAGPVCFVCI SLMLMVYICH NRTVIHHRVP NEEDPSLDRP FISEGTTLKD LIYDMTTSGS 120

GSGLPLLVQR TIARTIVLQE SIGKGRFGEV WRGKWRGEEV AVKIFSSREE RSWFREAEIY 180

QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST 240

ASGLAHLHME IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP 300

NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG IHEDYQLPYY 360

DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK IMRECWYANG AARLTALRIK 420

KTLSQLSQQE GIKM 434

Nucleotide Sequence
(FASTA)

ATGTGCATAG CTGAAATTGA CCTGATTCCT CGAGACAGAC CATTTGTATG TGCACCATCT 60

TCAAAAACTG GGTCTGTTAC TACAACCTAT TGCTGCAACC AGGACCACTG CAATAAAATA 120

GAACTCCCAA CTGTTGGAAA GCCATCATCT GGCCTTGGTC CCGTTGAACT GGCAGCTGTC 180

ATTGCTGGAC CAGTCTGCTT CGTCTGCATC TCACTTATGT TGATGGTTTA TATCTGCCAT 240

AACCGTACCG TCATTCACCA TCGAGTGCCA AATGAAGAGG ATCCTTCCTT AGATCGCCCT 300

TTTATTTCAG AGGGCACTAC ATTAAAAGAC TTAATTTATG ATATGACAAC ATCAGGTTCT 360

GGATCAGGTT TACCATTGCT TGTTCAGAGA ACAATTGCAA GAACTATTGT ATTACAAGAA 420

AGTATTGGCA AAGGTCGATT TGGAGAAGTT TGGCGAGGAA AGTGGAGAGG AGAAGAAGTT 480

GCTGTTAAAA TCTTCTCCTC TAGAGAAGAG CGCTCATGGT TCCGTGAGGC AGAGATTTAT 540

CAGACCGTAA TGTTACGTCA TGAAAACATC TTGGGATTTA TAGCGGCAGA CAATAAAGAC 600

AATGGTACAT GGACTCAGCT CTGGTTGGTG TCAGATTATC ATGAGCATGG ATCCCTCTTT 660

GATTATTTGA ACAGATACAC AGTTACTGTG GAAGGAATGA TAAAACTTGC TTTGTCCACA 720

GCAAGTGGAC TTGCGCATCT CCACATGGAG ATTGTTGGTA CCCAAGGGAA ACCAGCCATT 780

GCTCATAGAG ATTTGAAATC TAAGAATATC TTGGTAAAGA AGAATGGAAC TTGCTGTATT 840

GCAGACTTAG GACTGGCAGT GAGACATGAT TCAGCCACAG ATACCATTGA TATTGCTCCA 900

AATCACAGAG TGGGAACAAA AAGGTATATG GCCCCCGAAG TTCTAGATGA TTCCATAAAT 960

ATGAAACACT TTGAATCCTT CAAACGTGCC GACATCTATG CAATGGGCTT AGTATTCTGG 1020

GAAATAGCTC GACGATGTTC CATTGGTGGA ATTCATGAAG ATTACCAGCT GCCTTATTAT 1080

GATCTTGTAC CTTCTGATCC ATCAGTTGAA GAAATGAGAA AAGTTGTTTG TGAACAGAAG 1140

TTAAGGCCAA ATATTCCAAA CAGATGGCAG AGTTGTGAAG CCTTGAGAGT AATGGCTAAA 1200

ATTATGAGAG AATGTTGGTA TGCCAATGGA GCAGCGAGGC TTACAGCTTT GCGGATTAAG 1260

AAAACATTGT CACAACTCAG TCAACAGGAA GGCATCAAAA TGTAG 1305

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 136   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  195

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 196   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  255

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 256   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  313

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 314   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  372

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 373   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  423

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013